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Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

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Journal of Traditional chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang HUANG Zheng HUANG Peiyan YANG Mengning ZHANG Zhihui NI Guangxia College of Acupuncture-Moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China key laboratory of Acupuncture and Medicine Research of ministry of education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FTH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FTH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FTH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

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Inducing piezoelectricity in distorted rutile TiO_(2)for enhanced tetracycline hydrochloride degradation through photopiezocatalysis

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Journal of Advanced Ceramics 2024年第3期13卷 323-331页

作者： Taotao Xia Lizhen Lu Haoyu Zhang Jinghui Wang Zonghe Huang Hongyang Wang Weiyi Yang Shuang Gao Qi Li key laboratory of Advanced Technologies of Materials(ministry of education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Various material design strategies have been developed to enhance photocatalytic performance of TiO_(2).However,no report is available on applications of the photopiezocatalysis strategy on TiO_(2)due to its lack of *** we developed a low-temperature molten salt etching process to create rutile TiO_(2)nanoparticles by etching[MgO_(6)]octahedrons away from MgTiO_(3)by molten NH_(4)Cl,during which a lattice distortion occurred in TiO_(2).The lattice distortion broke the structure symmetry of rutile TiO_(2)and subsequently endowed these rutile TiO_(2)nanoparticles with an unusual piezoelectric response with the maximum effective piezoelectric coefficient(d_(33))of~41.6 pm/V,which had not previously been found in TiO_(2)***,the photopiezocatalysis strategy was applied for the first time to enhance the photocatalytic performance of these TiO_(2)*** creation of lattice distortion to induce piezoelectricity could be extended to other photocatalysts that the photopiezocatalysis strategy has not been applied to and may generate novel functionalities for various technical applications.

关键词： photocatalysis TiO_(2) piezocatalysis molten salt etching process photopiezocatalysis

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Understand the Temperature Sensing Behavior of Solid-state Polymerized PEDOT Hybrid Based on X-ray Scattering Studies

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chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-Feng Liu Ze-Kun Zhou Zhen Liu Yi-Shu Zeng Peng Zhang School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PEDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PEDOT hybrids consisting of PEDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PEO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PEDOT:PSS/PEO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PEDOT:PSS/PEO hybrid. It demonstrated that PEDOT formed conductive paths in the hybrids, which were not destroyed by the PEO crystallization. As temperature increased, the PEO crystals' melting and the accompanying reorganization of PEDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PEDOT hybrid Structure-property correlation X-ray scattering

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Gut-targeted therapies for type 2 diabetes mellitus: A review

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World Journal of Clinical Cases 2024年第1期12卷 1-8页

作者： Tian-Cheng Xu Yun Liu Zhi Yu Bin Xu key laboratory of Acupuncture and Medicine Research of ministry of education Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin *** global prevalence of T2DM has reached epidemic proportions,affecting approximately 463 million adults worldwide in *** treatments for T2DM include lifestyle modifications,oral antidiabetic agents,and insulin ***,these therapies may carry side effects and fail to achieve optimal glycemic control in some ***,there is a growing interest in the role of gut microbiota and more gut-targeted therapies in the management of *** gut microbiota,which refers to the community of microorganisms that inhabit the human gut,has been shown to play a crucial role in the regulation of glucose metabolism and insulin *** in gut microbiota composition and diversity have been observed in T2DM patients,with a reduction in beneficial bacteria and an increase in pathogenic *** dysbiosis may contribute to the pathogenesis of the disease by promoting inflammation and impairing gut barrier *** gut-targeted therapies have been developed to modulate the gut microbiota and improve glycemic control in *** potential approach is the use of probio-tics,which are live microorganisms that confer health benefits to the host when administered in adequate *** randomized controlled trials have demonstrated that certain probiotics,such as Lactobacillus and Bifidobacterium species,can improve glycemic control and insulin sensitivity in T2DM *** may include the production of short-chain fatty acids,the improvement of gut barrier function,and the reduction of *** gut-targeted therapy is fecal microbiota transplantation(FMT),which involves the transfer of fecal material from a healthy donor to a *** has been used successfully in the treatment of Clostridioides difficile infection and is now being investigated as a potential therapy for T2DM.A recent rand

关键词： Type 2 diabetes mellitus Gastroenterology Bacteria Implanted device

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Species’ geographical range, environmental range and traits lead to specimen collection preference of dominant plant species of grasslands in Northern China

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Plant Diversity 2024年第3期46卷 353-361页

作者： Jingya Zhang Cui Xiao Xiaoyu Duan Xin Gao Hao Zeng Rong'an Dong Gang Feng Keping Ma ministry of education key laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia key laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China State key laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China

Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection *** study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory *** Forest models were then used to find the most parsimonious multivariate *** results showed that interannual variation in specimen number between 1900 and 2020 was *** number of these species in southeast China was notably lower than that in northwest *** range and geographical range of species had significant positive correlations with specimen *** addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal *** findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting *** correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate.

关键词： Biological specimen Collection preference Dominant plant species Environmental range Geographical range Species traits

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Polyaspers A and B,the First Ergosterol-Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus ***507

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chinese Journal of Chemistry 2024年第7期42卷 743-751页

作者： Hong Hu Lanqin Li Zhengyi Shi Xueqi Lan Yeting Zhang Xinye Huang Xincai Hao Qun Zhou Weiguang Sun Changxing Qi Yonghui Zhang Hubei key laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhanHubei 430030China Hubei key laboratory of Wudang Local chinese Medicine Research Hubei Engineering Technology Center for Comprehensive Utilization of Medicinal PlantsCollege of PharmacyHubei University of MedicineShiyanHubei 442000China

Psoriasis is a chronic immune-mediated inflammatory skin disease and the TNF-αis an important therapeutic target of this *** our continuous study of bioactive natural products from fungi,the first ergosterol-polyether adducts,polyaspers A(1)and B(2),along with two known ergosterols,(36,5α,6α,22E)-5,6-epoxy-3-hydroxyergosta-8,22-dien-7-one(3)and calvasterol B(4),were iso-lated from Aspergillus *** elucidation was accomplished by extensive spectroscopic analysis and single-crystal X-ray diffraction *** A and B possessing an unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system,and their biosynthetic path-ways were proposed to include intermolecular cyclization and Diels-Alder *** screen of these isolates showed that 1-3 could improve the cell viability in an actinomycin D/TNF-αinduced L929 cells death model,with the EC50 values of 49.85,46.75 and 4.99μmol/L,respectively,and the activity of 3 was even comparable with that of the positive control *** bioactive investigations discovered 3 could suppress the inflammatory response simulated with TNF-αin HaCaT *** an imiquimod-induced psoriasis murine model,3 significantly restrained the development of psoriasis symptoms and reduced the expression of IL-17 and IL-23,presenting an anti-psoriatic *** such,those ergosterol derivatives,might serve as lead compounds for the development of novel TNF-αinhibitory agents in the clinical treatment of psoriasis.

关键词： Psoriasis Aspergillus sp.TJ507 TNF-α Ergosterol-polyether adducts Inflammatory skin disease

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Hierarchical multihead self-attention for time-series-based fault diagnosis

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chinese Journal of Chemical Engineering 2024年第6期70卷 104-117页

作者： Chengtian Wang Hongbo Shi Bing Song Yang Tao key laboratory of Smart Manufacturing in Energy Chemical Process of the ministry of education East China University of Science and TechnologyShanghai 200237China

Fault diagnosis is important for maintaining the safety and effectiveness of chemical *** the multivariate,nonlinear,and dynamic characteristic of chemical process,many time-series-based data-driven fault diagnosis methods have been developed in recent ***,the existing methods have the problem of long-term dependency and are difficult to train due to the sequential way of *** overcome these problems,a novel fault diagnosis method based on time-series and the hierarchical multihead self-attention(HMSAN)is proposed for chemical ***,a sliding window strategy is adopted to construct the normalized time-series ***,the HMSAN is developed to extract the time-relevant features from the time-series process *** improves the basic self-attention model in both width and *** the multihead structure,the HMSAN can pay attention to different aspects of the complicated chemical process and obtain the global dynamic ***,the multiple heads in parallel lead to redundant information,which cannot improve the diagnosis *** the hierarchical structure,the redundant information is reduced and the deep local time-related features are further ***,a novel many-to-one training strategy is introduced for HMSAN to simplify the training procedure and capture the long-term ***,the effectiveness of the proposed method is demonstrated by two chemical *** experimental results show that the proposed method achieves a great performance on time-series industrial data and outperforms the state-of-the-art approaches.

关键词： Self-attention mechanism Deep learning Chemical process Time-series Fault diagnosis

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A deep reinforcement learning approach to gasoline blending real-time optimization under uncertainty

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chinese Journal of Chemical Engineering 2024年第7期71卷 183-192页

作者： Zhiwei Zhu Minglei Yang Wangli He Renchu He Yunmeng Zhao Feng Qian key laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

The gasoline inline blending process has widely used real-time optimization techniques to achieve optimization objectives,such as minimizing the cost of ***,the effectiveness of real-time optimization in gasoline blending relies on accurate blending models and is challenged by stochastic ***,we propose a real-time optimization algorithm based on the soft actor-critic(SAC)deep reinforcement learning strategy to optimize gasoline blending without relying on a single blending model and to be robust against *** approach constructs the environment using nonlinear blending models and feedstocks with *** algorithm incorporates the Lagrange multiplier and path constraints in reward design to manage sparse product *** abstracted states facilitate algorithm convergence,and the normalized action vector in each optimization period allows the agent to generalize to some extent across different target production *** these well-designed components,the algorithm based on the SAC outperforms real-time optimization methods based on either nonlinear or linear *** even demonstrates comparable performance with the time-horizon based real-time optimization method,which requires knowledge of uncertainty models,confirming its capability to handle uncertainty without accurate *** simulation illustrates a promising approach to free real-time optimization of the gasoline blending process from uncertainty models that are difficult to acquire in practice.

关键词： Deep reinforcement learning Gasoline blending Real-time optimization Petroleum Computer simulation Neural networks

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Organic interfacial engineering of gold nanowires for selective glycerol electrooxidation

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chinese Chemical Letters 2024年第3期35卷 502-507页

作者： Zhe Wang Qingling Hong Boqiang Miao Tianjiao Wang Yu Ding Pujun Jin Pei Chen Yu Chen key laboratory of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry(Ministry of Education)Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710062China

The selective electrochemical conversion of glycerol into value-added products is a green and sustainable strategy for the biomass *** this work,Au nanowires(Au-NW)modified with polyethyleneimine(PEI)molecule(Au-NW@PEI)is obtained by an up-bottom post-modification *** characterization,molecular dynamics simulation and density functional theory demonstrate that the loose-packed PEI monolayer firmly and uniformly distribute on the Au-NW surface due to the strong Au-N *** experiments and product analysis display that PEI modification significantly enhance the electro-activity of Au-NW for the glycerol electro-oxidation reaction(GEOR)due to the electronic ***,the steric hindrance and electrostatic effect of PEI layer make the optimizing adsorption of intermediates ***,the selectivity of C3 product glyceric acid over Au-NW@PEI is increased by nearly 20%.The work thus indicates that the rational design of metal-organic interface can effectively elevate the electro-activity and selectivity of Au nanostructures,which may have wide application in biomass development.

关键词： Glycerol electrooxidation reaction Organic interface engineering Gold-based nanomaterials Electrocatalysis Selectivity

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Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue Cai Weiming Shi Zhao-Hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-Min Yue State key laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of chinese Academy of Sciences Beijing 100049China Beijing National laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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