检索结果-南通市图书馆

Chinese Medical Journal 1994年第12期 10-13页

作者：李武 M.Crombach U.Schonian 杨英珍 B.Maisch 陈灏珠 Laboratory of Cardio-Immunology Department of Internal Medicine / Cardiology Klinikum der Philipps Universitat Marburg 350443 Marburg Germany

Cytomegalovirus (CMV) genes were detected by in situ hybridization in 25 Chinese patients with viral myocarditis (VMC). The positive hybridization signals werre found in cardiomyocytes (6 cases, 24%), capillary endothelial cells (4 cases, 16%) and interstitial cells (7 cases, 28%). The difference between VMC and control group (16 cases died of brain trauma and 10 cases of congenital heart diseases was statistically significant. There was no definite pathomorphological relationship between the detection of CMV genes and myocardial lesions. The results suggest that CMV infection may be one of the causes of myocarditis and chronic stimulation of the immune system induced by CMV may be a possible pathogenesis of this disease.

关键词： VMC DETECTION Of CYTOMEGALOVIrUS GENOME BY IN SITU HYBrIDIZATION IN PArAffIN EMBEDDED ENDOMYOCArDIAL BIOPSY SPECIMENS Of VIrAL MYOCArDITIS EMB In

在线全文

学校读者我要写书评

暂无评论

驱动堆中长寿命核废料碘的嬗变研究

高能物理与核物理 2001年第9期25卷 926-932页

作者：万俊生 r.Brandt 西北核技术研究所西安710024 kernchemie Philipps-University marburg

利用理论模拟和实验手段对加速器驱动的快中子堆消除常规反应堆排放的核废料碘进行了研究 .实验中 ,利用加速器加速质子使其能量达到1 0GeV ,并轰击重金属铅靶 ,利用靶中产生的次级中子诱发核废料12 9I的嬗变 ,使其嬗变为稳定同位素130... 详细信息

利用理论模拟和实验手段对加速器驱动的快中子堆消除常规反应堆排放的核废料碘进行了研究 .实验中 ,利用加速器加速质子使其能量达到1 0GeV ,并轰击重金属铅靶 ,利用靶中产生的次级中子诱发核废料12 9I的嬗变 ,使其嬗变为稳定同位素130 Xe .对实验嬗变效率进行了理论模拟验证 ,进而拓宽到研究的驱动堆体系中 .堆芯区的核燃料为乏燃料铀和钚。

关键词：加速器驱动反应堆核废料碘嬗变核废料处理

Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with Xenf-mediated sigmatropic rearrangement as a prerequisite

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第11期11卷 3655-3664页

作者： Zhiguo Liu Wei Li Peng Zhang Jie fan fangbo Zhang Caixia Wang Shuming Li Yi Sun Shilin Chen Wenbing Yin Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of Mycology CAS Key Laboratory of Microbial Physiological and Metabolic EngineeringInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institut für Pharmazeutische Biologie und Biotechnologie Fachbereich PharmaziePhilipps-Universitat MarburgMarburg 35037Germany

Tyrosine-decahydrofluorene derivatives feature a fused[6.5.6]tricarbocyclic core and a 13-membered para-cyclophane ***,we identified new xenoacremones A,B,and C(1-3)from the fungal strain Xenoacremonium sinensis ML-31 and elucidated their biosynthetic pathway using gene deletion in the native strain and heterologous expression in Aspergillus *** hybrid polyketide synthaseenonribosomal peptide synthetase(PKS-NrPS)XenE together with enoyl reductase XenG were confirmed to be responsible for the formation of the tyrosine-nonaketide *** skeleton was subsequently dehydrated by XenA to afford a pyrrolidinone *** catalyzed a novel sigmatropic rearrangement to yield a key cyclohexane intermediate as a prerequisite for the formation of the multi-ring *** oxidation catalyzed by XenD supplied the substrate for XenC to link the para-cyclophane ether,which underwent subsequent spontaneous Diels-Alder reaction to give the end ***,the results indicated that three novel enzymes Xenf,XenD,and XenC coordinate to assemble the[6.5.6]tricarbocyclic ring and para-cyclophane ether during biosynthesis of complex tyrosine-decahydrofluorene derivatives.

关键词： Tyrosine-decahydrofluorene Biosynthesis PKS-NrPS Xenoacremone Heterologous expression

Chemically Induced and Light-Independent Cryptochrome Photoreceptor Activation

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2008年第1期1卷 4-14页

作者： Gesa rosenfeldt rafael Munoz Viana Henning D. Mootz Albrecht G. von Arnim Alfred Batschauera fB Biologie-pflanzenphysiologie Philipps-Universitat Karl-von-Frisch-Str. 8 35032 Marburg Germany universitat Dortmund FB Chemie-Chemische Biologie Otto-Hahn-Str. 6 44227 Dortmund Germany University of Tennessee Department of Biochemistry Cellular and Molecular Biology Waiters Life Sciences M407 Knoxville TN 37996-0840 USA

The cryptochrome photoreceptors of higher plants are dimeric proteins. Their N-terminal photosensory domain mediates dimerization, and the unique C-terminal extension （CCT） mediates signaling. We made use of the human fK506binding protein （fKBP） that binds with high affinity to rapamycin or rapamycin analogs （rapalogs）. The fKBP-rapamycin complex is recognized by another protein, frB, thus allowing rapamycin-induced dimerization of two target proteins. Here we demonstrate by bioluminescence resonance energy transfer （BrET） assays the applicability of this regulated dimer- ization system to plants. furthermore, we show that fusion proteins consisting of the C-terminal domain of Arabidopsis cryptochrome 2 fused to fKBP and frB and coexpressed in Arabidopsis cells specifically induce the expression of cryptochrome-controlled reporter and endogenous genes in darkness upon incubation with the rapalog. These results demonstrate that the activation of cryptochrome signal transduction can be chemically induced in a dose-dependent fashion and uncoupled from the light signal, and provide the groundwork for gain-of-function experiments to study specifically the role of photoreceptors in darkness or in signaling cross-talk even under light conditions that activate members of all photoreceptor families.

关键词： C-terminal extension (CCT) fK506-binding protein (fKBP) bioluminescence resonance energy transfer (BrET)

Layer-by-layer nanostructured protein loaded nanoparticles: A feasibility study using lysozyme as model protein and chitosan as coating material

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 64-65页

作者： Cuifang Cai Shirui Mao Thomas Kissel School of Pharmacy Shenyang Pharmaceutical UniversityWenhua Road 103110016 ShenyangChina Department of Pharmaceutics and Biopharmacy Phillips-Universitat of MarburgKetzerbach 63D-35032 MarburgGermany

Stabilization of proteins in delivery devices and design of appropriate protein carriers are major research issues due to the extreme sensitivity of ***,negatively charged nanoparticles,consisting of poly(lactic-co-glycolic acid)(PLGA)and poly(styrene-co-4–styrene-sulfonate)(PSS),showed considerably high loading capacity for positively charged model protein lysozyme depending on the surface charge density of nanoparticles.

关键词： Chitosan Nanoparticles Lysozyme Electrostatic interaction Protein carrier Layer-by-layer

44GeV或18GeV ^(12)C离子轰击Cu靶或Pb靶时中子产额的研究

在线全文

学校读者我要写书评

暂无评论

核技术 1996年第10期19卷 622-624页

作者：郭士伦王玉兰涂彩清萨本豪郑玉明刘咏莲郑文芑扈秀华 Brandt r Vater P Kulakov B A Krivopustov M I Butsev V S Bradnova V 中国原子能科学研究院 kernchemie FB14University Marburg.D-35032.Marburg.Germany Joint Institute for Nuclear research.Dubna Russia

用ＣＲ－３９迭层探测器测量了４４ＧｅＶ或１８ＧｅＶ１２Ｃ离子轰击Ｃｕ靶或Ｐｂ靶时中子产额与入射粒子能量以及靶核质量的关系。当入射能量由１８ＧｅＶ增至４４ＧｅＶ时，Ｃｕ靶的中子产额增大２．１２±０．１９倍，Ｐｂ靶的中子... 详细信息

用ＣＲ－３９迭层探测器测量了４４ＧｅＶ或１８ＧｅＶ１２Ｃ离子轰击Ｃｕ靶或Ｐｂ靶时中子产额与入射粒子能量以及靶核质量的关系。当入射能量由１８ＧｅＶ增至４４ＧｅＶ时，Ｃｕ靶的中子产额增大２．１２±０．１９倍，Ｐｂ靶的中子产额增大２．０４±０．１５倍。Ｐｂ靶和Ｃｕ靶中子产额之比在４４ＧｅＶ和１８ＧｅＶ分别为２．５４±０．２０和２．５６±０．２０。

关键词： ^(12)C离子中子产额人射能量关系靶质量关系

Assessment of Water Quality of the Trans-Boundary Zarafshan river in the Territory of Uzbekistan

在线全文

学校读者我要写书评

暂无评论

Journal of Water resource and Protection 2013年第1期5卷 17-26页

作者： rashid Kulmatov Christian Opp Michael Groll Dilafruz Kulmatova Department of Applied Ecology National University of UzbekistanTashkentUzbekistan Department of Geography Philipps-Universitat MarburgMarburgGermany

The Zarafshan river is a main trans-boundary river of the Aral Seabasin. As the main water resource, the Zarafshan river water is mainly used by the republics ofTajikistanandUzbekistan. We explored the trends of space-time pollution of river water with ammonium, nitrates, phosphates, biological oxygen demand (ВОD), fluorine and some heavy metals at seven water sampling points along theZarafshanriver inUzbekistan. The experimental data showed that the water quality of the Zarafshanriver in 2002-2009 has undergone a considerable transformation, even by the length of the river. The chemical composition of the Zarafshan river water underwent changes due to the agricultural collector-drainage discharges and the sewage of the cities of Samarkand and Navoi. The water pollutants of the Zarafshan river, as a con- sequence of the agricultural pollution, consisted of mineralization, ammonium, nitrate, phosphate, and pesticides. Therefore, it is necessary to monitor the chemical composition of the large agricultural collector-drainage discharges into the river. The main sources of the heavy metals (primarily arsenic and zinc) in the Zarafshan river water were probably ore processing manufactures located interritoryofTajikistan.

关键词： Trans-Boundary river Zarafshan river Water Pollution Water Discharge Collector-Drainage Discharge Sewage

further Studies of BUrSTS and Spallation in High-Energy Heavy Ion reactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nuclear Science and Technology 2017年第1期7卷 35-57页

作者： reza Hashemi-Nezhad reinhard Brandt Valery Ditlov Maria Haiduc Elena firu Alina Tania Neagu Eberhard Ganssauge Wolfram Westmeier School of Physics University of Sydney Sydney Australia kernchemie FB Chemie Philipps Universit&#228 t marburg Marburg Germany Institute of Theoretical and Experimental Physics Moscow Russia Bucharest Institute of Space Science Bucharest Romania fB Physik Philipps Universit&#228 t marburg Marburg Germany Dr. Westmeier GmbH Ebsdorfergrund Germany

Aspects of BUrSTS and Spallation reactions induced by high-energy heavy ions in thick targets (>10 cm thick) will be investigated: BUrSTS are reviewed from a historical and phenomenological point-of-view. Details of interactions in nuclear emulsions will be compared for irradiations of 72 GeV 22Ne-ions from Dubna with irradiations of 72 GeV 40Ar-ions from Berkeley. Measured correlations in individual interactions between multiplicities of “minimum ionizing particles”, ns, and “black prongs”, nb, will be shown as “ns-vs.-nb” per event for BUrSTS and separately for Spallation in interactions of 72 GeV 22Ne-ions. Monte Carlo calculations, based on the MCNPX 2.7 code, have been carried out for 72 GeV 22Ne interacting in nuclear emulsions: The correlation between ns and nb in Spallation reactions could be understood. However, “ns-vs.-nb” correlations from BUrST-interactions could not be reproduced with this model for events with small numbers of heavy prongs nh ≤ 10. for large numbers of heavy prongs with nh > 10 one could find some agreement between experiments and calculations, however, not in all details. further experimental and theoretical studies are necessary before one has a complete understanding of BUrST interactions in high-energy heavy ion reactions.

关键词： High-Energy HI reaction BUrST Spallation MCNPX

Comment on the recent Start of a New “IUPAC-Project”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Nuclear Science and Technology 2018年第3期8卷 121-127页

作者： reinhard Brandt Valery Ditlov Elena firu Eberhard Ganssauge Maria Haiduc reza Hashemi-Nezhad Alina Tania Neagu Wolfram Westmeier kernchemie FB Chemie Philipps-Universit&auml t marburg Marburg Germany Institute of Theoretical and Experimental Physics Moscow Russia Bucharest Institute of Space Science Bucharest Romania fB Physik Philipps-Universit&auml t marburg Marburg Germany School of Physics The University of Sydney Sydney Australia Dr. Westmeier GmbH Ebsdorfergrund Germany

The opening of a new IUPAC-project is highly appreciated. In the year 2009, the IUPAC had published an article “Discovery of the element with atomic number 112 (IUPAC Technical report)” [1]* which contains a section on the work of the Marinov collaboration. It appears that this section is not always in agreement with conventional standards for scientific publications. This present comment focuses on these formal questions.

关键词： IUPAC Project 2017-014-2-200 eka-Hg Unresolved Problems

相对论重离子核反应产生的中子能量和通量的固体径迹测定

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

核技术 1992年第4期15卷 222-224页

作者：郭士伦郝秀红王玉兰沈冠仁 r.Brandt P.Vater M.Heck H.Barth G.Haase 中国原子能科学研究院北京102413 kernchemie University of MarburgGermany

在苏联杜布纳联合核子研究所同步稳相加速器上用Cr-39探测器测量了44GeV ^(12)C+Cu(厚靶)核反应产生的中子能量和通量。测量表明.这一核反应释放的中子的平均能量为15.8±2.8MeV,当入射重离子数目为6×10^(11)时,与^(12)C束成～70°方向... 详细信息

在苏联杜布纳联合核子研究所同步稳相加速器上用Cr-39探测器测量了44GeV ^(12)C+Cu(厚靶)核反应产生的中子能量和通量。测量表明.这一核反应释放的中子的平均能量为15.8±2.8MeV,当入射重离子数目为6×10^(11)时,与^(12)C束成～70°方向,距靶～60cm处的中子积分通量为(4.5±0.3)×10~9cm^2。这一方法可用来测量相对论重离子核反应释放的中子的角分布和每个入射重离子或每次核反应可产生的中子平均数目。

关键词：重离子核反应中子能量中子通量