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Comparative analysis of the microbiome of sympatric wintering Bean Geese,Domestic Ducks,humans,and soil at Shengjin Lake of China reveals potential public risk to human health

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Avian Research 2024年第2期15卷 279-286页

作者： Gang Liu Na Xu Chongyang Yu college of Life Sciences Anhui Medical UniversityHefei 230032China

The gut microbiota of migratory waterbirds is affected by various complex factors,including cross-species transmission,which increases the risk of pathogen spreading among sympatric animals and poses a potential public health risk to *** this study,we investigated the microbial communities of wintering Bean Geese(Anser fabalis),Domestic Ducks(*** domesticus),humans,and soil using high-throughput sequencing of the 16S rRNA gene region in Shengjin Lake,*** total,6,046,677 clean reads were obtained,representing 41,119 operational taxonomic units(OTUs)across the four *** dominant microbial phyla were the Proteobacteria,Firmicutes,Bacteroidota,and *** Sorensen similarity index and alpha and beta diversity results showed that the gut microbial communities of Bean Geese and Domestic Ducks were more similar to those of the other *** analysis revealed that Faecalibacterium prausnitzii,Pseudomonas fragi,and Bradyrhizobium elkanii were hubs of the three major *** common microbiomes were iden-tified in Bean Geese,Domestic Ducks,humans,and soil in Shengjin Lake.A total of 96 potential pathogens were identified among the four groups,with 20 specific potentially pathogenic microbiomes found in the gut of Bean *** of these pathogens are responsible for significant financial losses in the poultry industry and pose risks to human *** pneumoniae,Morganella morganii,Escherichia coli,and Ralstonia insidiosa are potential core pathogens found in the four groups at Shengjin Lake that can cause diseases in humans and an-imals and facilitate cross-species transmission through various ***,humans are at risk of con-tracting these pathogens from migratory birds because of their frequent contact with domestic ***,further studies are required to explore the potential pathogenic species and transmission pathways among sympatric wintering Bean Geese,Domestic Ducks,humans,and soil.

关键词： Microbiome Migratory waterbird Pathogens Poultry Sympatric species

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Comparative Analysis of Machine Learning Models for Stock Price Prediction: Leveraging LSTM for Real-Time Forecasting

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Journal of Computer and Communications 2024年第8期12卷 52-80页

作者： Bijay Gautam Sanif Kandel Manoj Shrestha Shrawan Thakur Department of Computing Softwarica College of IT and E-Commerce Kathmandu Nepal

The research focuses on improving predictive accuracy in the financial sector through the exploration of machine learning algorithms for stock price prediction. The research follows an organized process combining Agile Scrum and the Obtain, Scrub, Explore, Model, and iNterpret (OSEMN) methodology. Six machine learning models, namely Linear Forecast, Naive Forecast, Simple Moving Average with weekly window (SMA 5), Simple Moving Average with monthly window (SMA 20), Autoregressive Integrated Moving Average (ARIMA), and Long Short-Term Memory (LSTM), are compared and evaluated through Mean Absolute Error (MAE), with the LSTM model performing the best, showcasing its potential for practical financial applications. A Django web application “Predict It” is developed to implement the LSTM model. Ethical concerns related to predictive modeling in finance are addressed. Data quality, algorithm choice, feature engineering, and preprocessing techniques are emphasized for better model performance. The research acknowledges limitations and suggests future research directions, aiming to equip investors and financial professionals with reliable predictive models for dynamic markets.

关键词： Stock Price Prediction Machine Learning LSTM ARIMA Mean Squared Error

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Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1259-1270页

作者： Gan-Bin Li Chen-Tong Wang Xiao Zhang Xiao-Yuan Qiu Wei-Jie Chen Jun-Yang Lu Lai Xu Bin Wu YiXiao Guo-Le Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and *** To analyze the clinical features and risk factors of *** Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)*** on the occurrence of IFD,patients were categorized into IFD and non-IFD *** clinical characteristics and treatment approaches for patients with IFD were *** regression analysis was performed to identify the risk factors of *** The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,*** most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and *** patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ileus tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective *** A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for *** attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics.

关键词： Colon cancer,Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors

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OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第11期19卷 2513-2521页

作者： Wenzhi Chen Shishi Jiang Shu Li Cheng Li Renshi Xu Department of Neurology Jiangxi Provincial People’s HospitalXiangya Hospital Jiangxi Hospital of Central South UniversityThe Clinical College of Nanchang Medical CollegeThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Amyotrophic lateral sclerosis is a neurodegenerative disease,and the molecular mechanism underlying its pathology remains poorly ***,inflammation is known to play an important role in the development of this *** identify driver genes that affect the inflammatory response in amyotrophic lateral sclerosis,as well as potential treatment targets,it is crucial to analyze brain tissue samples from patients with both sporadic amyotrophic lateral sclerosis and C9orf72-related amyotrophic lateral ***,in this study we used a network-driven gene analysis tool,NetBID2.0,which is based on SJARACNe,a scalable algorithm for the reconstruction of accurate cellular networks,to experimentally analyze sequencing data from patients with sporadic amyotrophic lateral *** results showed that the OSMR gene is pathogenic in amyotrophic lateral sclerosis and participates in the progression of amyotrophic lateral sclerosis by mediating the neuroinflammatory ***,there were differences in OSMR activity and expression between patients with sporadic amyotrophic lateral sclerosis and those with C9orf72-related amyotrophic lateral *** findings suggest that OSMR may be a diagnostic and prognostic marker for amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis driver neuroinflammation OSMR C9ORF72 neurodegenerative disease pathogenesis oxidative stress protein misfolding mitochondrial dysfunction

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Interdecadal variation of drought patterns and associated influencing factors in the north-south transitional zone of China

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Journal of Geographical Sciences 2024年第7期34卷 1253-1279页

作者： DONG Qingdong ZHU Lianqi DUAN Zheng WANG Liyuan CHEN Chaonan LI Yanhong ZHU Wenbo GURUNG Sher Bahadur The college of Geography and Environmental Science Henan UniversityKaifengHenan475004China Department of Physical Geography and Ecosystem Science Lund UniversityLundS-22362Sweden Central Department of Geography Tribhuvan UniversityKathmandu44600Nepal

In the context of global warming,escalating water cycles have led to a surge in drought frequency and ***,multidecadal fluctuations in drought and their multifaceted influencing factors remain inadequately *** study examined the multidecadal changes in drought characteristics(frequency,duration,and severity)and their geographical focal points within China's north-south transitional zone,the Qinling-Daba Mountains(QDM),from 1960 to 2017 using the Standardized Precipitation Evapotranspiration Index(SPEI).In addition,a suite of eight scenarios,correlation analysis,and wavelet coherence were used to identify the meteorological and circulation factors that influenced drought *** results indicate the following:(1)From 1960 to 2017,the QDM experienced significant interdecadal variations in drought frequency,duration,and severity,the climate was relatively humid before the 1990s,but drought intensified ***,the 1990s marked the period of the longest drought duration and greatest severity,while the years spanning 2010 to 2017 experienced the highest frequency of drought events.(2)Spatially,the Qinling Mountains,particularly the western Qinling Mountain,exhibited higher drought frequency,duration,and severity than the Daba *** disparity can be attributed to higher rates of temperature increase and precipitation decrease in the western Qinling Mountain.(3)Interdecadal variations in droughts in the QDM were directly influenced by the synergistic effects of interdecadal fluctuations in air temperature and *** factors modulate temperature and precipitation through phase transitions,thereby affecting drought dynamics in the *** Atlantic Multidecadal Oscillation emerges as the primary circulation factors influencing temperature changes,with a mid-1990s shift to a positive phase favoring *** East Asian Summer Monsoon and El Ni?o-Southern Oscillation are the main circulation factors a

关键词： drought standardized precipitation evapotranspiration index multidecadal shift transitional zone Qinling-Daba Mountains

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Exhaustive review of acceleration strategies for Monte Carlo simulations in photon transit

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 5-21页

作者： Louzhe Xu Zijie Zhu Ting Li Institute of Biomedical Engineering Chinese Academy of medical Sciences&Peking Union medical college Tianjin 300192 P.R.China

Monte Carlo simulation techniques have become the quintessence and a pivotal nexus of inquiry in the realm of simulating photon movement within biological *** the stochastic sampling of tissue archetypes delineated by explicit optical characteristics,Monte Carlo simulations possess the theoretical capacity to render unparalleled accuracy in the depiction of exceedingly intricate ***,the quintessential challenge associated with Monte Carlo simulation methodologies resides in their extended computational duration,which significantly impedes the re¯nement of their ***,this discourse is speci¯cally dedicated to exploring innovations in strategies and technologies aimed at expediting Monte Carlo *** delves into the foundational concepts of various acceleration tactics,evaluates these strategies concerning their speed,accuracy,and practicality,and amalgamates a comprehensive overview and critique of acceleration methodologies for Monte Carlo ***,the discourse envisages prospective trajectories for the employment of Monte Carlo techniques within the domain of tissue optics.

关键词： medical optics photon transport simulation Monte Carlo simulation acceleration

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B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 27-34页

作者： LI Xi LIN Xiangquan CHEN Dongdong LIU Hui the Third Clinical medical college Fujian Medical University Department of Orthopedics Fuzhou Second HospitalFuzhou 350007China

OBJECTIVE:To explore the relationship between autophagy and apoptosis regulated by puerarin during ***:In this study,the effects of puerarin on the autophagic activity and apoptosis level of osteoblast precursors(MC3T3-E1 cells)was ***,the roles of puerarin on B-cell lymphoma-2(Bcl-2)phosphorylation at different sites in osteoblast precursors were *** effect of puerarin on the interaction between Bcl-2 and autophagy regulatory molecule or pro-apoptotic molecule was also investigated using Co-immunoprecipitation *** addition,the effect of puerarin on mitochondrial membrane potential of osteoblast precursors was also identified by mitochondrial membrane potential fluorescence probe ***:Our results showed that puerarin can promote the autophagic activity and apoptosis level of *** addition,puerarin promoted Bcl-2phosphorylation at Ser70 site,and the dissociation of Bcl-2-Beclin1 ***,puerarin could enhance the binding of Bcl-2-Bcl-2-Associated X(Bax)complex in MC3T3-E1 ***,puerarin increased the mitochondrial membrane potential of MC3T3-E1 ***:Therefore,puerarin promotes Beclin1into autophagy flux through Bcl-2 phosphorylation at Ser70,thereby enhancing autophagy of osteoblast precursors,which mediates its anti-apoptotic role during ***,the dissociation of Bcl-2-Beclin1 complex is conducive to the binding of Bcl-2-Bax complex,which resists the apoptosis of osteoblast precursors via the increased mitochondrial membrane potential.

关键词： puerarin osteoblasts autophagy apoptosis lymphoma B-cell

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Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-Le Lin Jun-Yang Lu Lai Xu Guan-Nan Zhang Jun-Feng Du Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction between PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation between PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;P<0.001]but not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC but not RCC,underscoring the importance of tumor location when using PIV as a colon cancer biomarker.

关键词： Colon cancer Left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis

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Circulating tumor DNA in liquid biopsy: Current diagnostic limitation

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World Journal of Gastroenterology 2024年第15期30卷 2175-2178页

作者： Shi-Cai Liu School of medical Information Wannan Medical CollegeWuhu 241002Anhui ProvinceChina

With the rapid development of science and technology,cell-free DNA(cfDNA)is rapidly becoming an important biomarker for tumor diagnosis,monitoring and prognosis,and this cfDNA-based liquid biopsy technology has great potential to become an important part of precision *** is the total amount of free DNA in the systemic circulation,including DNA fragments derived from tumor cells and all other somatic *** cells release fragments of DNA into the bloodstream,and this source of cfDNA is called circulating tumor DNA(ctDNA).cfDNA detection has become a major focus in the field of tumor research in recent years,which provides a new opportunity for non-invasive diagnosis and prognosis of *** this paper,we discuss the limitations of the study on the origin and dynamics analysis of ctDNA,and how to solve these problems in the *** the future faces major challenges,it also con-tains great potential.

关键词： Cell-free DNA Circulating tumor DNA Liquid biopsy Cancer Diagnosis Prognosis

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Antiviral treatment standards for hepatitis B:An urgent need for expansion

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World Journal of Gastroenterology 2024年第4期30卷 418-420页

作者： Zi-Hong Bao Zhi-Kun Dai Hao-Xian Tang Department of Infectious Diseases The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina medical college Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Cardiology The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The present letter to the editor is related to the review with the title“Past,present,and future of long-term treatment for hepatitis B virus.”Chronic hepatitis B(CHB)represents an important and pressing public health *** identification and effective antiviral therapy hold the potential to reduce liver-related mortality attributable to chronic infection with hepatitis B virus(HBV)***,the current global treatment rates for CHB remain conspicuously low,with the excessively stringent treatment criteria advocated by national CHB guidelines being a contributing factor to these low ***,recent strides in comprehending this malady and the emergence of novel antiviral agents prompt the imperative re-evaluation of treatment standards to extend the sphere of potential *** impending need arises for a novel paradigm for the classification of patients with CHB,the expansion of antiviral treatment eligibility for HBV-infected individuals,and even the streamlining of the diagnostic process for CHB to amplify cost-effectiveness and augment survival prospects.

关键词： Hepatitis B virus Chronic hepatitis B Antiviral treatment criteria Serum alanine aminotransferase Liver-related mortality Letter to the Editor

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