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World Journal of Cardiology 2021年第6期13卷 155-162页

作者： Shams Y-Hassan Rodney de Palma Coronary Artery Disease Area Heart and Vascular ThemeKarolinska Institutet and Karolinska University HospitalStockholm S-14186Sweden Buckinghamshire Healthcare NHS Trust Buckinghamshire HP112TTUnited Kingdom

A challenging technical scenario frequently encountered in a percutaneous coronary intervention of a coronary bifurcation lesion(CBL)is stent implantation of only the stenosed segment without compromising the other two normal segments in non-true bifurcation *** is precise stent implantation covering the side branch ostium without leaving excessive stent metal at the other two segments of a bifurcation lesion in complex true bifurcation *** aim of this study was to describe a novel stenting technique for both non-true and true CBLs by using a guide extension catheter(GuideLiner).With the assistance of a guide extension catheter mounted on both the main and the side-branch guidewires and with its intubation down to the bifurcation carina,a stent can be implanted in the side branch segment or distal main segment of the bifurcation lesion appropriately without compromising the other two segments of the coronary *** implantation is described in three bifurcation lesions in three cases and shown in detail with illustrative *** technique facilitates side-branch only stenting in side-branch mono-ostial(medina 0,0,1)CBL or only the distal main segment in distal mono-ostial(medina 0,1,0)CBL without compromising the other two remaining segments when using the onestent technique in non-true CBLs without leaving unnecessary excessive stent metal at the bifurcation site and when using a two-stent technique in complex true bifurcation lesions(tri-ostial or medina 1,1,1).Consequently,through optimizing stent deployment,the technique may have the potential to reduce the risk of subacute stent thrombosis and future in-stent *** most appropriate lesions suitable for the technique,and some other practical tips are also described.

关键词： Coronary bifurcation lesion GuideLiner stenting Percutaneous coronary intervention One-or two-stenting technique Novel descriptive,intelligible and ordered

MiSp: Full-length Gene Sequence, and Structural and Functional Characterization of Terminal Domains

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MiSp: Full-length Gene Sequence, and Structural and Function...

Biomarkers and Disease Trajectories Influencing Women’s Health: Results from the UK Biobank Cohort

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Gefei Chen Anna Rising Jan Johansson Qing Meng Donghua University karolinska institutet

Spider silk,as a kind of protein-based fiber,is known for its intriguing *** silk is used to make the auxiliary spiral of the orb-web and also for wrappingprey,has a high tensile strength and does not supercontract in *** far,only partialcDNA sequences have been obtained for minor ampullate spidroins(MiSps).Furthermore,poor understanding of spidroin-silk formation mechanism is supposed to be a big obstaclefor biomimetic native-like spider silk fibers *** are predominant byhighly repetitive sequences(Rp,0%),which give birth to outstanding strength andelasticity,and capped by non-repetitive N(NT,10 aa)and C terminal domains(CT,30aa).The terminal domains involve in stabilizing highly concentrated dope stored in silkgland and controlling the silk formation process,but the details are totally *** wedescribe the first MiSp full-length gene sequence from the spider species Araneusventricosus,and comparative analysis of the sequence reveals regulatory elements,as wellas unique spidroin gene and protein architecture including the presence of an unusuallylarge *** spliced full-length transcript of MiSp gene is 5440 bp in size and encodes1766 amino acid residues organized into conserved nonrepetitive NT and CT domains anda central predominantly repetitive region composed of four units that are iterated in a nonregular *** repeats are more conserved within *** MiSp than comparedto repeats from homologous proteins,and are interrupted by two nonrepetitivespacer regions,which have 100%identity even at the nucleotide *** find out thefunction and structural mechanism of the terminal domains,we measured the pH gradientin major ampullate gland(from 7.6 to 5.7),which is created by carbonic anhydrase(catalyses CO2+H2O HCO3-+H+).We determined NMR structures of minor ampullatespidroin NT and CT domains,the monomers of which are all 5α-***,the terminaldomains respond in opposite ways when pH i

关键词： Araneus ventricosus minor ampullate spidroin full-length gene protein structure and function spidroin-silk formation mechanism

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Phenomics 2022年第3期2卷 184-193页

作者： Haomin Yang Yudi Pawitan Fang Fang Kamila Czene Weimin Ye Department of Epidemiology and Health Statistics School of Public Health and Key Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityXue Yuan Road 1University TownFuzhou 350122China Department of Medical Epidemiology and Biostatistics Karolinska Institutet17177 StockholmSweden Institute of Environmental Medicine Karolinska Institutet17177 StockholmSweden

Women’s health is important for *** the known biological and sex-related factors influencing the risk of diseases among women,the network of the full spectrum of diseases in women is *** study aimed to systematically examine the women-specific temporal pattern(trajectory)of the disease network,including the role of baseline physical examination indexes,and blood and urine *** the UK Biobank study,502,650 participants entered the cohort from 2006 to 2010,and were followed up until 2019 to identify disease incidence via linkage to the patient *** those diseases with increased risk among women,conditional logistic regression models were used to estimate odds ratios(ORs),and the binomial test of direction was further used to build disease *** 301 diseases,82 diseases in women had ORs>1.2 and p<0.00017 when compared to men,involving mainly diseases in the endocrine,skeletal and digestive *** with the highest ORs included breast diseases,osteoporosis,hyperthyroidism,and deformity of the *** biomarker and disease trajectories suggested estradiol as a risk predictor for breast cancer,while a high percentage of reticulocyte,body mass index and waist circumference were associated with an increased risk of upper-limb *** addition,the risk of cholelithiasis was increased in women diagnosed with dyspepsia and diaphragmatic *** conclusion,women are at an increased risk of endocrine,skeletal and digestive *** biomarker and disease trajectories in women suggested key pathways to a range of adverse outcomes downstream,which may shed light on promising targets for early detection and prevention of these diseases.

关键词： Women health Disease trajectory Biomarkers Phenome wide association study

Expression and localization of prostaglandin receptors and stromal factors in human cervix—Variations in pregnant and non-pregnant states

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Open Journal of Molecular and Integrative Physiology 2013年第4期3卷 147-157页

作者： Chellakkan S. Blesson Nathalie Roos Olof Stephansson Britt Masironi Susann Reinert Ylva Vladic Stjernholm Gunvor Ekman-Ordeberg Lena Sahlin Division for Reproductive Endocrinology and the Pediatric Endocrinology Unit Department of Women’s and Children’s Health Karolinska University Hospital-Solna Karolinska Institutet Stockholm Sweden Division for Reproductive Endocrinology and the Pediatric Endocrinology Unit Department of Women’s and Children’s Health Karolinska University Hospital-Solna Karolinska Institutet Stockholm Sweden Division of Obstetrics and Gynecology Department of Women’s and Children’s Health Karolinska University Hospital-Solna Karolinska Institutet Stockholm Sweden Division of Obstetrics and Gynecology Department of Women’s and Children’s Health Karolinska University Hospital-Solna Karolinska Institutet Stockholm Sweden Division of Obstetrics and Gynecology Department of Women’s and Children’s Health Karolinska University Hospital-Solna Karolinska Institutet Stockholm Sweden Clinical Epidemiology Unit Department of Medicine Karolinska Institutet Stockholm Sweden

Prostaglandins (PGs) mediate cervical ripening leading to parturition. PGs are used successfully to induce cervical ripening. However, the cell type specific expression of PG receptor subtypes and various stromal factors important for cervical ripening in human cervix is not known. Our objective was to investigate the expression and localization of PG receptors EP1-4 and FP and localization of stromal factors CTGF (connective tissue growth factor), furin, calgranulin ?B, ALOX12 (arachidonate 12-lipooxy-genase) and ALOX15 in human cervical tissue from pregnant and non-pregnant women. Cervical biopsies were obtained from non-pregnant (NP), term pregnant (TP) and post-partum (PP) women. The mRNA expression was determined with real-time PCR, protein expression and localization with immunohistochemistry. Our results show that the EP2 mRNA level was higher in the PP group as compared to TP, whereas the EP4 mRNA level was lower in the TP group as compared to NP. Concomitantly stromal EP2 and epithelial EP3 immunoreactivity was higher in the TP as compared to the NP group, while the EP4 immunostaining in glands was lower in the TP as compared to the PP group. Immunostaining of endothelial CTGF, smooth muscle furin and ALOX12, were all lower in the TP group as compared to NP, for CTGF also the PP group was lower than NP. Endothelial calgranulin B immunoreactivity was higher in the PP group than the NP group. PG receptors and stromal factors exhibit differential expression in the cervix from women in non-pregnant and pregnant states, implying their involvement in the process of cervical ripening.

关键词： Cervical Ripening Pregnancy Extracellular Matrix Prostaglandin Receptors

Beliefs and Experiences of Fear of Hypoglycemia and Use of Uncooked Cornstarch before Bedtime in Persons with Type 1-Diabetes

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Open Journal of Nursing 2018年第11期8卷 795-810页

作者： Therese Anderbro Erik Moberg Ulf Adamson Per-Eric Lins Unn-Britt Johansson Stockholm University Department of Psychology Stockholm Sweden karolinska institutet Department of Clinical Sciences Danderyd Hospital Stockholm Sweden karolinska institutet Department of Medicine Karolinska University Hospital Huddinge Stockholm Sweden Sophiahemmet University Stockholm Sweden karolinska institutet Department of Clinical Sciences and Education S&#246 dersjukhuset Stockholm Sweden

Introduction: Among persons living with type 1-diabetes hypoglycemia and fear of hypoglycemia remain limiting barriers for achieving optimal glucose control and a good quality of life. Fear of hypoglycemia has been found stable over time if not treated. Uncooked cornstarch has been found to reduce the risk of hypoglycemia but has not been studied in relation to fear of hypoglycemia. The aims of this study were to through clinical data, self-reported measures and clinical interviews explore subjects’ experience of using uncooked cornstarch before bedtime and their beliefs and experiences of fear of hypoglycemia. Methods: Mixed methods with both quantitative and qualitative data were used. Self-reported measures of hypoglycemia and fear of hypoglycemia were compared to subjects’ responses during a clinical interview. The interviews were analyzed with a functional behavior analytical approach. Results: A total of five subjects took part in the study. One subject perceived the uncooked cornstarch helpful in reducing hypoglycemia. Several subjects could recall frightening hypoglycemic episodes triggering their fear. Three out of the five subjects reported avoidance behaviors such as excessive self-monitoring of blood glucose or overeating related to fear of hypoglycemia. Conclusions: The uncooked cornstarch was found appetizing but was not perceived as having an effect on BG or hypoglycemia frequency. The clinical interviews confirmed previous research regarding experience of hypoglycemia and fear of hypoglycemia.

关键词： Adults Fear of Hypoglycemia Experiences Type 1 Diabetes Uncooked Cornstarch

Role of p11 in depression and antidepressant actions

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Role of p11 in depression and antidepressant actions

New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

中国神经科学学会第十届全国学术会议

作者： Per SVENNINGSSON Department of Clinical Neuroscience Karolinska Institutet

Studies of the multifunctional protein,p11,are shedding light on the molecular and cellular mechanisms underlying *** will be presented implicating p11 both in the amplification of serotonergic signaling and regulation of gene *** talk will also review studies demonstrating that the levels of p11 are regulated in depression and by antidepressant regimens and,conversely,that p11 regulates depression-like behaviors and/or responses to *** studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.

关键词： p11 depression serotonin

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Cellular & Molecular Immunology 2017年第12期14卷 951-953页

作者： Chiara Sorini Ilaria Cosorich Marika Falcone Immunology and Allergy Unit Department of MedicineKarolinska InstitutetStockholmSweden Experimental Diabetes Unit-DRI Division of ImmunologyTransplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly

The gut microbiota plays a key role in the pathogenesis of autoimmune diseases such as Type 1 Diabetes(T1D),but the mechanism underlying this modulation is yet to be *** paper highlights the crucial role of the microbiota-induced gut metabolic profile,rather than the presence of single bacterial strains,in T1D *** importantly,it provides the first evidence that dietary interventions can modulate the autoimmune pathogenesis of T1D by altering the gut metabolic environment.

关键词： Diabetes autoimmune pathogenesis

SCREENING FOR GLAUCOMA USING FREQUENCY DOUBLING TECHNOLOGY

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国际眼科杂志 2003年第1期3卷 48-49页

作者： L.Vancea B.Gothlin P.Wanger L.Martin Eye Clinic Sundsvall Hospital SwedenEye Clinic Sundsvall Hospital SwedenDepartment of Clinical Science Karolinska InstitutetDepartment of Clinical Science Karolinska Institutet

Introduction: Frequency doubling technology (FDT) provides a screening program for the detection of glaucomatous optic nerve damage. The examination time using this program is very short, less than one minute per eye. High-pass resolution perime-try (HRP) is known to be sensitive for early glaucoma damage and has been reported to detect change earlier, than convention-

关键词：双倍增频技术 FDT 青光眼筛检视神经损害

Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients

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World Journal of Gastroenterology 2006年第43期12卷 7012-7018页

作者： Yesuf Taha Yngve Raab Marie Carlson Anders Larsson Mikael Lrdal Lars Lf Magnus Thrn Departments of Medical Sciences University Hospital Uppsala Sweden Department of Medicine KarolinskaInstitutet Karolinska University Hospital Huddinge Sweden Departments of Medical Sciences University Hospital Uppsala Sweden Departments of Clinical Chemistry University Hospital Uppsala Sweden Department of Medicine KarolinskaInstitutet Karolinska University Hospital Huddinge Sweden Center for Clinical Research Central Hospital Vsters Sweden Department of Surgery Karolinska Institutet South Stockholm General Hospital Stockholm Sweden

AIM：. To study the effect of oral steroids upon clinical response and rectal mucosa secretion of eosinophil cationic protein （ECP）, myeloperoxidase （NPO）, basic fibroblast growth factor （bFGF）, vascular endothelial growth factor （VEGF） and albumin in patients with collagenous colitis （CC）. METHODS： A segmental perfusion technique was used to collect perfusates from rectum of CC patients once before and twice （one and four weeks） after the start of steroid treatment. Clinical data was monitored and ECP, MPO, bFGF, VEGF and albumin concentrations were analyzed by immunochemical methods in perfusates and in serum. RESULTS： Steroids reduced the number of bowel movements by more than five times within one week and all patients reported improved subjective wellbeing at wk 1 and 4. At the same time, the median concentrations of ECP, bFGF, VEGF and albumin in rectal perfusates decreased significantly. MPO values were above the detection limit in only 3 patients before treatment and in none during treatment. VEGF, bFGF, ECP and albumin concentrations correlated with each other with the exception of ECP and albumin. A decrease of serum ECP and VEGF concentrations was also seen even if the overtime reduction was not significant.CONCLUSION： Oral steroid treatment in CC patients induced a simultaneous reduction of bowel movements and rectal release of ECP, bFGF, VEGF and albumin, suggesting that these polypeptides and increased mucosal permeability are important components of the pathophysiology in collagenous colitis.

关键词： Collagenous colitis Inflammatory mediator Steroid treatment Eosinophil cationic protein Basicfibroblast growth factor Vascular endothelial growthfactor