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Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin

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World Journal of Gastroenterology 2005年第27期11卷 4241-4245页

作者： Chia-Yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-Po Lee Ming-Yen Hsieh Nei-Jen Hou Zu-Yau Un Ming-Yuh Hsieh Liang-Yen Wang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung TaiwanChina Department of Occupational Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Taiwan China

AIM： The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C （CHC） and response of both viruses to combination therapy with high-dose interferon-alfa （IFN） plus ribavirin remain uncertain and are being ***： Total 164 （97 males and 67 females, the mean age 48.1＋11.4 years, range： 20-73 years, 128 histologically proved） naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR *** of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay （COBAS AMPLICOR HCV Test, version 2.0）. HCV genotypes la,lb, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay （Quantiplex HCV RNA 3.0）. There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is ***： Sixty-one （37.2%） patients were positive for SENV-D DNA and had higher mean age than those who were negative （50.7＋ 10.6 years vs 46.6＋ 11.6 years,P = 0.026）. The rate of sustained viral response （SVR） for HCV and SENV-D were 67.3% （105/156） and 56.3% （27/48）, respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b （P〈0.001）, younger ages （P = 0.014）, lower pretreatment levels of HCV RNA （P = 0.019） and higher histological activity index （HAI） score for intralobular regeneration and focal necrosis （P= 0.037）. By multivariate analyses, HCV genotype non-lb, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR （odds ratio （OR）/95% confidence interval （CI）： 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively）. The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy （P = 0.04）.CONCLUSION： Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Resi

关键词： Chronic hepatitis C Combination therapy Interferon Ribavirin SENV-D

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Primary small cell carcinoma of kidney after renal transplantation:a case report and literature review

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Chinese Journal of Cancer Research 2013年第5期25卷 608-611页

作者： Hsiang-Ying Lee Wen-Jeng Wu Kun-Bow Tsai Jung-Tsung Shen Mei-Yu Jang Hsun-Shuan Wang Shu-Fang Chang Li-Jiun Tsai Department of Urology Department of PathologyKaohsiung Medical University Hospital Department of Urology Kaohsiung Municipal Hsiao-Kang Hospital Department of Urology College of MedicineKaohsiung Medical University

Extrapulmonary small cell carcinoma （EPSCC） is a rare neoplasm comprising 2.5％ to 5％ of small cell carcinomas （SCCs）.Bladder SCC is the most common site of genitourinary *** renal SCC is extremely *** report a case of primary SCC of the kidney which is rarely reported in the urinary tract and presents an aggressive clinical picture.A 59-year-old female visited a urologic clinic with complaint of persistent left flank soreness 10 years after undergoing renal *** computed tomography showed a left renal pelvis *** the patient received left nephroureterectomy with bladder cuff resection,her pathology results showed *** surgery,she received adjuvant systemic chemotherapy,and her recovery has been uneventful as of 8 *** renal SCC presents with an advanced tumor stage and a short median survival period,therefore early intervention and close follow-up are recommended.

关键词： Kidney small cell carcinoma (SCC) extrapulmonary renal pelvis carcinoma

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Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model

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World Journal of Gastroenterology 2009年第39期15卷 4907-4914页

作者： Chao-Hung Kuo Huang-Ming Hu Pei-Yun Tsai I-Chen Wu Sheau-Fang Yang Lin-Li Chang Jaw-Yuan Wang Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Nursing Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China Department of Pathology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Microbiology Kaohsiung Medical University Kaohsiung 807 Taiwan China Department of Surgery Kaohsiung Medical University Hosoital Kaohsiung 807 Taiwan China

AIM： To evaluate the optimal intervention point of a selective cyclooxygenase-2 （COX-2） inhibitor, Celecoxib, for inhibiting Helicobacter pylori （H pylori-associated gastric carcinogenesis in Mongolian gerbils （MGs）.METHODS： One hundred and twelve MGs were divided into six groups （A-F）. One hundred gerbils were inoculated with H pylor/（groups A-E）. Twelve gerbils were inoculated with vehicle broth only （group F）. After 4 wk, they were given N＇-methyl-N＇ -nitro-N-nitroso-guanidine （MNNG）（50 μg/mL） in the drinking water for 20 wk. in groups B-E, the animals were given the stock Celecoxib （10 mg/kg per day） diet from the 21st, 31st, 21st and 41st week respectively. The periods of administering Celecoxib were 30, 20, 20, and 15 wk respectively. On the 51st week, the animals were sacrificed for histological examination. Local PCNA expression was examined by the immunohistochemistry method. The expression of COX-2 protein was assessed by Western Blot. Analysis used the 2 test. The difference was regarded as significant when P value was less than 0.05. RESULTS： Seventeen percent （17/100） of H pyloriinfected MGs developed gastric cancer. All of these lesions were well-differentiated adenocarcinoma. The incidence rates of adenocarcinoma in groups A-F were 40%, 0%, 0%, 20%, 25%, and 0% respectively. The inflammatory scores were higher in group B than in other groups. There was no inflammatory response noted in group F. Celecoxib treatment resulted in a significant reduction in the proliferation of H pyloriinfected mucosal cells （groups B, C and D）（P 〈 0.01）. The expression of COX-2 protein was significantly attenuated in the groups which were Celecoxib-treated for more than 20 wk （groups B, C, D）. The groups treated with Celecoxib had a significantly lower rate of advanced gastric cancer （34% vs 75%, P 〈 0.001） There were no sudden deaths in any of the groups. CONCLUSION： Short-term treatment with Celecoxib has an anti-carcinogenic effect, and resulted in less severe inflam

关键词： Cyclooxygenase-2 Chemoprevention He/icobacterpylori Mongolian gerbil

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Predictive model for *** mortality after breast cancer surgery in Taiwan residents

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Chinese Journal of Cancer 2017年第4期36卷 184-192页

作者： Su-Hsin Huang Joon-Khim Loh Jinn-Tsong Tsai Ming-Feng Houg Hon-Yi Shi Department of Nursing Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Medical University Kaohsiung Taiwan China Department of Healthcare Administration and Medical Informatics Kaohsiung Medical University 100.Shih.Chun 1st Road Kaohsiung Taiwan China Divison of Neurosurgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Surgery Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Taiwan China. Department of Computer Science National Pingtung University Pingtung Taiwan China Division of General & Gastroenterological Surgery Department of Surgery Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Taiwan China Cancer Center Kaohsiung Medical University Hospital and Institute of Clinical Medicine Kaohsiung Medical University Kaohsiung Taiwan China Department of Business Management National Sun Yat-sen University Kaohsiung Taiwan China

Background:Few studies of breast cancer surgery outcomes have used longitudinal data for more than 2 *** study aimed to validate the use of the artificial neural network(ANN)model to predict the 5?year mortality of breast cancer patients after surgery and compare predictive accuracy between the ANN model,multiple logistic regression(MLR)model,and Cox regression ***:This study compared the MLR,Cox,and ANN models based on clinical data of 3632 breast cancer patients who underwent surgery between 1996 and *** estimation dataset was used to train the model,and a validation dataset was used to evaluate model *** sensitivity analysis was also used to assess the relative signifi?cance of input variables in the prediction ***:The ANN model significantly outperformed the MLR and Cox models in predicting 5?year mortality,with higher overall performance *** results indicated that the 5?year postoperative mortality of breast cancer patients was significantly associated with age,Charlson comorbidity index(CCI),chemotherapy,radiotherapy,hormone therapy,and breast cancer surgery volumes of hospital and surgeon(all Phospital,age,and ***:Compared with the conventional MLR and Cox models,the ANN model was more accurate in predict?ing 5?year mortality of breast cancer patients who underwent *** mortality predictors identified in this study can also be used to educate candidates for breast cancer surgery with respect to the course of recovery and health outcomes.

关键词： Breast cancer surgery Artificial neural networks Multiple logistic regression Cox regression 5-year mortality

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Leptin in hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第46期16卷 5801-5809页

作者： Shen-Nien Wang King Teh Lee Chen-Guo Ker Division of Hepatobiliary Surgery Department of SurgeryKaohsiung Medical University Hospital Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical University Cancer Center Department of SurgeryKaohsiung Medical University Hospital Department of Surgery Kaohsiung Municipal Hsiao-Kang Hospital Graduate Institute of Medicine College of MedicineKaohsiung Medical University

The risk factors for hepatocellular carcinoma (HCC) development have been established,and include chronic hepatitis B and C,heavy alcohol consumption,and *** fact,5%-30% of patients with HCC still lack a readily identifiable risk *** has been reported that the majority of "cryptogenic" HCC may be attributed to nonalcoholic fatty liver disease,the hepatic presentation of the metabolic syndrome (MS).Obesity is associated with the development of the ***,adipose tissue has been considered as an endocrine organ because of its capacity to secrete a variety of cytokines,which are collectively known as the ***,the product of the obese gene,is mainly produced by adipose *** leptin was first characterized in 1994,accumulated literature has demonstrated the involvement of this adipokine in several areas of human *** binding to its receptor,leptin initiates a cascade of signaling events and subsequent cellular *** addition to being the regulatory mediator of energy homeostasis,several in vitro studies have demonstrated the fibrogenic role of leptin in the ***,the deregulated expression of leptin and its receptor have been demonstrated to be associated with a variety of metabolic disorders as well as human *** importantly,direct evidence supporting the inhibitory and/or activating role of leptin in the process of carcinogenesis and progression of human HCC has been accumulating *** review aims to provide important insights into the potential mechanisms of leptin in the development of ***,further investigations will shed light on a new therapeutic target in HCC.

关键词： Adipokine Hepatocellular carcinoma Leptin Liver cirrhosis Metabolic syndrome Obesity Steatohepatitis

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Superior mesenteric artery syndrome in a diabetic patient with acute weight loss

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World Journal of Gastroenterology 2009年第47期15卷 6004-6006页

作者： Meng-Chieh Wu I-Chen Wu Jeng-Yih Wu Deng-Chyang Wu Wen-Ming Wang Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan China Department of Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan China Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung 813 Taiwan China

Superior mesenteric artery(SMA)syndrome is an un- common disease resulting compression of the third portion of the duodenum from the superior mesenteric *** disease shares many common manifestations with diabetic gastroparesis,including postprandial fullness,nausea,vomiting,and ***,it is often overlooked in diabetic ***,we report a 41-year-old man with poorly controlled diabetic mellitus who developed SMA syndrome due to rapid weight loss. The diagnosis was confirmed by computed tomography and an upper gastrointestinal *** condition improved after parenteral nutrient,strict sugar control, and gradual weight gain.

关键词： Diabetes mellitus Superior mesenteric artery syndrome Gastroparesis

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Detection of genotypic clarithromycin-resistant Helicobacter pylori by string tests

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World Journal of Gastroenterology 2014年第12期20卷 3343-3349页

作者： Jeng-Yih Wu Sophie S W Wang Yi-Chern Lee Yoshio Yamaoka David Y Graham Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital Department of Medicine Faculty of MedicineCollege of MedicineKaohsiung Medical University Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Department of Medicine Veterans Affairs Medical Center and Baylor College of Medicine Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang HospitalKaohsiung Medical University

AIM: To evaluate the utility of the string test to detect genotypic clarithromycin-resistant Helicobacter pylori (H. pylori) by polymerase chain reaction (PCR)-restriction fragment length polymorphism.

关键词： Helicobacter pylori String test Clarithromycin resistance Polymerase chain reaction-restriction fragment length polymorphism

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Diagnosis of Helicobacter pylori infection: Current options and developments

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World Journal of Gastroenterology 2015年第40期21卷 11221-11235页

作者： Yao-Kuang Wang Fu-Chen Kuo Chung-Jung Liu Meng-Chieh Wu Hsiang-Yao Shih Sophie SW Wang Jeng-Yih Wu Chao-Hung Kuo Yao-kang Huang Deng-Chyang Wu Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital School of Medicine College of MedicineE-Da HospitalI-Shou University Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital Cancer for Stem Cell Research Kaohsiung Medical University Center for Infectious Disease and Cancer Research Kaohsiung Medical University Division of Gastroenterology Department of Internal MedicineTen Chan Hospital

Accurate diagnosis of Helicobacter pylori(H. pylori) infection is a crucial part in the effective management of many gastroduodenal diseases. Several invasive and non-invasive diagnostic tests are available for the detection of H. pylori and each test has its usefulness and limitations in different clinical situations. Although none can be considered as a single gold standard in clinical practice,several techniques have been developed to give the more reliable results. Invasive tests are performed via endoscopic biopsy specimens and these tests include histology,culture,rapid urease test as well as molecular methods. Developments of endoscopic equipment also contribute to the real-time diagnosis of H. pylori during endoscopy. Urea breathingtest and stool antigen test are most widely used noninvasive tests,whereas serology is useful in screening and epidemiological studies. Molecular methods have been used in variable specimens other than gastric mucosa. More than detection of H. pylori infection,several tests are introduced into the evaluation of virulence factors and antibiotic sensitivity of H. pylori,as well as screening precancerous lesions and gastric cancer. The aim of this article is to review the current options and novel developments of diagnostic tests and their applications in different clinical conditions or for specific purposes.

关键词： Helicobacter pylori Diagnosis Invasive Noninvasive

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Conservative pulp treatment for Oehlers type Ⅲ dens invaginatus: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2823-2830页

作者： Hui-Na Lee Yuk-Kwan Chen Cheng-Hui Chen Chun-Yin Huang Ying-Hui Su Ying-Wei Huang Fu-Hsiung Chuang Division of Conservative Dentistry Dental DepartmentKaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung 80756Taiwan Dental Department Kaohsiung Municipal CiJin HospitalKaohsiung 80756Taiwan Division of Oral Pathology and Radiology Dental DepartmentKaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung 80756Taiwan School of Dentistry Kaohsiung Medical UniversityKaohsiung 80756Taiwan Oral and Maxillofacial Radiology Center Kaohsiung Medical UniversityKaohsiung 80756Taiwan Department of Nuclear Medicine E-DA HospitalKaohsiung 80756Taiwan Dental Department Kaohsiung Municipal Hsiao Kang HospitalKaohsiung 80756Taiwan

BACKGROUND Diverse presentations of dens invaginatus (DI) and root canal treatment with an immature open apex often pose challenges to dentists. Adequate treatment planning for DI is the main reason for successful approach, i.e., we should consider the shape and depth of the concave folding, the condition of the original pulp, and the growth stage of the root formation. CASE SUMMARY A 9-year-old girl complained of severe pain of the right maxillary incisor (tooth 12) when chewing for two weeks. Following clinical and radiographic examinations, Oehlers type III DI of tooth 12, with an immature open apical foramen and a symptomatic periapical pathosis, was diagnosed. Cone-beam computed tomography verified the specific spatial and stereoscopic data regarding the communication between the main root canal and pseudo root canal of the involved tooth. After removing the source of infection, a mineral trioxide aggregate was selected to fill and seal the pseudo root canal;additionally, pulp capping of the main canal was performed through the interconnections between the root canals in the middle segment to preserve pulp vitality and enable continual root formation and eventual root apex closure. CONCLUSION We propose to conduct main root canal pulp capping for DI with communication between the main and pseudo root canals.

关键词： Conservative treatment Dens invaginatus Open apex Cone-beam computed tomography Case report

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CYP2C19 polymorphism influences Helicobacter pylori eradication

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World Journal of Gastroenterology 2014年第43期20卷 16029-16036页

作者： Chao-Hung Kuo Chien-Yu Lu Hsiang-Yao Shih Chung-Jung Liu Meng-Chieh Wu Huang-Ming Hu Wen-Hung Hsu Fang-Jung Yu Deng-Chyang Wu Fu-Chen Kuo Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Department of Medicine Faculty of MedicineCollege of Medicine and Center for Stem Cell ResearchKaohsiung Medical University Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Graduate Institute of Public Health Kaohsiung Medical University School of Medicine College of MedicineE-Da HospitalI-Shou University

The known factors that have contributed to the decline of Helicobacter pylori (H. pylori) eradication rate include antibiotic resistance, poor compliance, high gastric acidity, high bacterial load, and cytochrome P450 2C19 (CYP2C19) polymorphism. Proton pump inhibitor (PPI) is important in the eradication regimen. The principal enzyme implicated in the metabolism of PPIs is CYP2C19. The effects of PPI depend on metabolic enzyme, cytochrome P450 enzymes, and CYP2C19 with genetic differences in the activity of this enzyme (the homozygous EM, heterozygous EM (HetEM), and poor metabolizer). The frequency of the CYP2C19 polymorphism is highly varied among different ethnic populations. The CYP2C19 genotype is a cardinal factor of H. pylori eradication in patients taking omeprazole- based or lansoprazole-based triple therapies. In contrast, the CYP2C19 polymorphism has no significant effect on the rabeprazole-based or esomeprazole-based triple therapies. The efficacy of levofloxacin-based rescue triple therapy might be also affected by the CYP2C19 polymorphism, but CYP2C19 genotypes did not show obvious impact on other levofloxacin-based rescue therapies. Choice of different PPIs and/or increasing doses of PPIs should be individualized based on the pharmacogenetics background of each patient and pharmacological profile of each drug. Other possible factors influencing gastric acid secretion (e.g., IL-1β- 511 polymorphism) would be also under consideration.

关键词： Helicobacter pylori CYP2C19 Polymorphism Eradication Rabeprazole Omeprazole Lansoprazole Pantoprazole Esomeprazole

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