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A case of tiny foreign body hidden in the neck for 27 years

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Clinical Research Communications 2023年第3期6卷 7-9页

作者： Ming Huang Na Wang Zhi-Hua Hu Yu-Fei Zheng Shuang-Lin Qin Hubei Provincial Key Research Base for Humanities and Social Sciences Rural Education and Cultural Development Center Hubei University of Science and TechnologyXianning 437100China Xianning Medical College Hubei University of Science and TechnologyXianning 437100China Thyroid and Breast Surgery Xianning Central HospitalXianning 437100China

Neck trauma has the characteristics of diversity,complexity,and *** injuries generally require debridement and suturing or symptomatic *** severe cases,acute laryngeal obstruction,subcutaneous emphysema,severe deformation and collapse of laryngeal and tracheal cartilage,or damage to adjacent organs may *** not diagnosed in a timely manner or mishandled,it can endanger the patient’s life or leave *** foreign body residue is caused by head and neck trauma,a reasonable judgment should be made based on the patient’s condition and corresponding measures should be *** localization of foreign bodies before and during surgery,as well as appropriate surgical methods,are key to ensuring successful *** article reports a case of a small foreign body in the neck admitted to Xianning Central hospital at the end of January 2023.

关键词： neck trauma foreign body metal nodule

Clinico-Epidemiological Characteristics and Survival Outcomes of COVID-19 Infection in Kassala, Eastern Sudan

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Advances in Infectious Diseases 2023年第1期13卷 96-108页

作者： Abdualmoniem O. Musa Mushal Allam Elhadi A. Ahmed Nouh S. Mohamed Mohamed H. Ahmed Abubakr Omer Tajeldin M. Abdallah Nadir Abuzeid Department of Microbiology Faculty of Medical Laboratory Sciences University of Kassala Kassala Sudan Department of Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Madani Sudan General Administration of Medical Laboratories Ministry of Health Kassala Sudan Department of Genetics and Genomics College of Medicine and Health Sciences United Arab Emirates University Al Ain United Arab Emirates Department of Molecular Biology Faculty of Medical Laboratory Sciences Nile University Khartoum Sudan Department of Medicine and HIV Metabolic Clinic Milton Keynes University Hospital NHS Foundation Trust Milton Keynes UK School of Medical Sciences Örebro University Örebro Sweden Faculty of Medicine University of Khartoum Khartoum Sudan Department of Internal Medicine Faculty of Medicine University of Kassala Kassala Sudan Department of Microbiology Faculty of Medical Laboratory Sciences Omdurman Islamic University Omdurman Sudan

Introduction: Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) represents a major health problem worldwide. Thus, early detection and appropriate management of the virus will influence the outcome of the disease. This study aimed to investigate the epidemiological characteristics and survival outcomes of patients with COVID-19 infection in Kassala, Eastern Sudan. Methods: A cross-sectional hospital-study was conducted among patients visiting Kassala teaching hospital with suspicion of COVID-19 infection. A structured questionnaire was used to gather clinical and socio-demo- graphic information from COVID-19 patients. Nasopharyngeal specimens and blood samples were collected and tested to confirm the diagnosis of COVID-19 infection using RT-PCR. Results: A total of 371 patients were enrolled in the study from September 2020 to January 2021, with mean age ± SD was 42.9 ± 19.9. The prevalence of COVID-19 infection was estimated at 61.7%. The majority were males 159 (69.4%), of university-level education, 96 (49.7%), and urban residents, 175 (9.7%). The most common symptoms were fever 215 (93.9%), cough 188 (82.1%), headache 179 (78.2%), and shortness of breath 154 (67.2%). Overall all mortality was reported as 16%. Older age group with the age ≥ 70, P P = 0.020, diabetes mellitus P = 0.029 were significantly associated with high case fatality. Conclusion: This study demonstrated that older age, male gender, laboratory tests (leukocytosis, lymphopenia, low Hemoglobin and high CRP) and various comorbid conditions significantly increase the disease severity and mortality. Therefore, attention should be paid to preventive measures to reduce the considerable impacts of the disease.

关键词： COVID-19 Infection Epidemiology Outcome Sudan

计算机辅助联合吲哚菁绿分子荧光影像技术在肝脏肿瘤诊断和手术导航中的应用指南（2019版）（英文）

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南方医科大学学报 2019年第10期39卷 1127-1140页

作者：无方驰华 LU Qiping LAU Wanyee 中华医学会数字医学分会中国研究型医院学会数字智能化专业委员会中国医师协会肝癌专业委员会中国医师协会临床精准医学专业委员会中国图学学会医学图像与设备专业委员会中国生物物理学会分子影像学专业委员会南方医科大学珠江医院肝胆一科广东省数字医学临床工程技术研究中心 Department of General Surgery General Hospital of Central Theater Command Faculty of Medicine The Chinese University of Hong Kong

计算机辅助联合吲哚菁绿分子荧光影像技术可以从三维的形态解剖和细胞功能水平进行术前规划和术中侦测,从而导航肝癌解剖性、功能性、根治性的肝切除术,临床应用证明其有重要的诊疗价值,此项技术现已在全国得到了广泛推广和应用。为规... 详细信息

计算机辅助联合吲哚菁绿分子荧光影像技术可以从三维的形态解剖和细胞功能水平进行术前规划和术中侦测,从而导航肝癌解剖性、功能性、根治性的肝切除术,临床应用证明其有重要的诊疗价值,此项技术现已在全国得到了广泛推广和应用。为规范计算机辅助联合吲哚菁绿分子荧光影像技术在肝脏肿瘤精准诊疗中的应用,本指南在以下几个方面进行了研究:(1)三维可视化技术应用流程;(2)ICG分子荧光成像的机制及应用流程;(3)三维可视化和虚拟现实技术的临床应用;(4)ICG分子荧光影像技术的临床应用。ICG分子荧光成像技术能从分子、细胞水平层面实现肿瘤边界界定、肝段和肝叶切除切线的确定;微小病灶或转移灶的侦测;术中根据肝脏肿瘤的荧光信号特点,结合术中快速冰冻病理学检查,可初步判定肝脏占位性病变的分化程度;肝切除后对肝断面进行残留肿瘤病灶和胆漏的检测。计算机辅助联合ICG分子荧光影像技术在肝脏肿瘤诊断和手术导航中的应用,为肝脏肿瘤的外科治疗提供了一种新的数字智能化外科诊疗技术,该项技术亦将不断改进和完善,为肝脏肿瘤的精准诊疗展现出良好的应用前景。

关键词：吲哚菁绿荧光影像三维可视化肝脏肿瘤导航手术

酶促反应动力学教学刍议:米氏方程衍生公式与图像

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化学教育（中英文） 2021年第8期42卷 105-110页

作者：王志鹏车子良马新雨 Farica Zhuang 蒋振雄尹晟王鹏 Department of Chemistry Texas A&M UniversityCollege StationTexas 77840USA Division of Genetics Department of MedicineBrigham and Women’s HospitalDepartment of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBostonMA 02115USA Department of Mathematics Harvard UniversityMA 02138USA Citadel Securities LLC:131 South Dearborn St.Chicago Illinois 60603USA Department of Computer Science Duke UniversityDurhamNC 27708USA Department of Biology Texas A&M UniversityTexas 77840USA Duke Center for Genomic and Computational Biology Duke UniversityDurbamNC 27708USA Nutrition/Metabolism Laboratory Department of SurgeryBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02138USA 中山大学附属第一医院烧伤外科广州510080

许多国内外高校的本科教学缺乏对米氏方程的深入推衍,这对学生了解酶促反应的动态过程及在实际科研工作中的应用是极为不利的。从酶促反应方程出发对米氏方程进行推导,继之采用双倒数法、单倒数法、直接隐函数法、间接隐函数法以及积分... 详细信息

许多国内外高校的本科教学缺乏对米氏方程的深入推衍,这对学生了解酶促反应的动态过程及在实际科研工作中的应用是极为不利的。从酶促反应方程出发对米氏方程进行推导,继之采用双倒数法、单倒数法、直接隐函数法、间接隐函数法以及积分法对米氏方程进行线性化,得到适用于不同情况的衍生方程。从数学和酶学角度出发指出了不同方程的优势和缺点,并针对其缺陷提出了若干解决方案以及在实际应用过程中的注意事项。希对高校中有志于科研事业的相关专业的教师学生有所助益。

关键词：米氏方程米氏常数酶动力学线性化

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刍议组蛋白去乙酰化酶的结构分类与功能调控

生命的化学 2020年第12期40卷 2151-2161页

作者：王志鹏张璇蒋振雄车子良马新雨 Division of Genetics Department of MedicineBrigham and Women's HospitalDepartment of Biological Chemistry and Molecular PharmacologyHarvard Medical SchoolBoston 02115USA Department of Chemistry Texas A&M UniversityCollege Station 77B40USA 清华大学化学系北京100084 清华大学生命学院北京100084 Department of Plant and Pathology and Microbiology Texas A&M UniversityCollege Station 77840USA Department of Biology Texas A&M UniversityCollege Station 77840USA

赖氨酸乙酰化是一类典型的组蛋白翻译后修饰,受到组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)的共同精细调控。尽管HDAC一直是学科研究的前沿问题,但在国内科研综述或教学中缺乏相关内容的阐述。本文从HDAC的发现历史和去除乙酰化... 详细信息

赖氨酸乙酰化是一类典型的组蛋白翻译后修饰,受到组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)的共同精细调控。尽管HDAC一直是学科研究的前沿问题,但在国内科研综述或教学中缺乏相关内容的阐述。本文从HDAC的发现历史和去除乙酰化的机制入手,在现有对HDAC分类的基础上,依次概述了4类HDAC的基本结构特征和生物功能。此外,本文还分析了针对不同HDAC的抑制剂及其在医学药学中的应用,旨在为相关的靶点研究及教学工作提供参考。

关键词：赖氨酸乙酰化去乙酰化酶组蛋白去乙酰化酶抑制剂