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Chinese Journal of Polymer Science 2013年第11期31卷 1563-1578页

作者： Jin-hua Leng Heng Liu 何波兵 Bin Yang Xian Chen Qing-quan Qin Polymer Physics and Chemistry College of ChemistrySichuan University Chengdu Product Quality Supervision and Inspection Institute kaixian chenjia middle school

Although addition of β-nucleating agent directly into homo-polypropylene （PPH） is a useful method to improve ,β-crystal content and toughen PPH, polypropylene random copolymer （PPR） makes this method powerless due to its random structure and low crystallinity. In this study, the β-nucleated PPR with high β-crystal content was prepared by a novel high effective β-nucleating system which consists of β-nucleation agent （TMB-5） and modified zeolite 13X （M13X）. It was found that M13X and TMB-5 had a synergistic influence on improving β-crystal content and toughening PPR. The content of β-crystal in PPR/M13X/TMB-5 was significantly larger than the sum of that in PPR/M13X and PPR/TMB-5. Besides, fracture behavior, phase morphology and relaxation of matrix chain segments were also investigated. The results showed that M13X and TMB-5 improved the mobility of amorphous chain segments at low temperature and contributed to much energy dissipation. This work provides a powerful method to modify PPR.

关键词： Polypropylene random copolymer Zeolite fl-nucleating agent Crystallization Toughness.

Primary pulmonary amebic abscess in a patient with pulmonary adenocarcinoma:a case report

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Infectious Diseases of Poverty 2018年第1期7卷 344-348页

作者： Yuan-Yuan Liu Yue Ying Chong Chen Yue-Kai Hu Fei-Fei Yang Ling-Yun Shao Xun-Jia Cheng Yu-Xian Huang Department of Infectious Diseases Huashan HospitalFudan University12Middle Wulumuqi RoadShanghai 200040China Department of Infectious Diseases Chongqing Kaixian People’s Hospital8Ankang RoadChongqing 405499China Department of Medical Microbiology and Parasitology School of Basic Medical SciencesFudan University130 Dongan RoadShanghai 200032China

Background:Primary pulmonary amoeba is very rare and here we report a case of a 68-year-old man presenting with primary pulmonary amoeba after undergoing chemotherapy for lung *** presentation:In October 2016,the man aged 68 was admitted to our hospital because of repeated cough for 8 months and hemoptysis for 1 *** was diagnosed lung adenocarcinoma and underwent surgery in 2012 without receiving *** March 2016,the patients suffered recurrence of cancer and was treated with *** 2 months of chemotherapy,the patient had consistent cough with white sputum,and chest CT showed a local lung *** physicians suspected that the patient had pulmonary infectious diseases,and he was treated with empirical antibacterial ***,his symptom wasn’t relieved and later the percutaneous lung biopsy found trophozites of Entamoeba *** administration of metronidazole,the symptoms of the patient were markedly relieved and the lesions were ***:In such cases where patients with pulmonary nodules were in immunodeficiency state and had adequate but ineffective anti-bacterial treatment,Entamoeba histolytica infection could be one of the rare *** lung biopsy should be recommended and specific dying for parasites should be done when necessary.

关键词： Amebiasis Pulmonary amebic abscess Pulmonary adenocarcinoma

Rh(Ⅲ)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks

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Chinese Chemical Letters 2024年第8期35卷 270-277页

作者： Shulei Hu Yu Zhang Xiong Xie Luhan Li kaixian Chen Hong Liu Jiang Wang Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratoty Shanghai 200031China school of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and ***,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and *** report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular ***-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.

关键词： C-H functionalization Rh(Ⅲ)-catalyzed Alkenylation Cyclic peptides Macrolactamization

Force Compensation Control for Electro-Hydraulic Servo System with Pump-Valve Compound Drive via QFT-DTOC

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 228-246页

作者： kaixian Ba Yuan Wang Xiaolong He Chunyu Wang Bin Yu Yaliang Liu Xiangdong Kong Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Qinhuangdao 066004China school of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China National Engineering Research Center for Local Joint of Advanced Manufacturing Technology and Equipment Yanshan UniversityQinhuangdao 066004China

Each joint of a hydraulic-driven legged robot adopts a highly integrated hydraulic drive unit(HDU),which features a high power-weight ***,most HDUs are throttling-valve-controlled cylinder systems,which exhibit high energy *** contrast,pump control systems offer a high ***,their response ability is *** fully utilize the advantages of pump and valve control systems,in this study,a new type of pump-valve compound drive system(PCDS)is designed,which can not only effectively reduce the energy loss,but can also ensure the response speed and response accuracy of the HDUs in robot joints to satisfy the performance requirements of ***,considering the force control requirements of energy conservation,high precision,and fast response of the robot joint HDU,a nonlinear mathematical model of the PCDS force control system is first *** addition,pressure-flow nonlinearity,friction nonlinearity,load complexity and variability,and other factors affecting the system are considered,and a novel force control method based on quantitative feedback theory(QFT)and a disturbance torque observer(DTO)is designed,which is denoted as QFT-DTOC *** method improves the control accuracy and robustness of the force control system,reduces the effect of the disturbance torque on the control performance of the servo motor,and improves the overall force control performance of the ***,experimental verification is performed using the PCDS performance test *** experimental results and quantitative data show that the QFT-DTOC proposed herein can significantly improve the force control performance of the *** relevant force control method can be used as a bottom-control method for the hydraulic servo system to provide a foundation for implementing the top-level trajectory planning of the robot.

关键词： Legged robot Pump-valve compound drive system(PCDS) Force compensation control Quantitative feedback theory(QFT) Disturbance torque observer(DTO)

Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression,activity,and stability

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Journal of Pharmaceutical Analysis 2024年第1期14卷 69-85页

作者： Chen Hong Yifan Zhang Lili Yang Haoyang Xu Kang Cheng Zhi Lv kaixian Chen Yiming Li Huali Wu Department of TCM Chemistry School of PharmacyShanghai University of Traditional Chinese MedicineShanghai200000China Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200000China International Education College Shanghai University of Traditional Chinese MedicineShanghai200000China Shanghai Inoherb Cosmetics Co. Ltd.Shanghai200000China

Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim.,a traditional herb widely used in *** previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain ***,as an extension to our previous investigation,we provide comprehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and *** results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glycogen synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin ***,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and ***,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis *** data conclude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and cosmetic industries.

关键词： Epimedin B Melanosome Tyrosinase Melanogenesis

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong Rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu Xiaohong Liu Zhenghao Li kaixian Chen Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

ⅢA-ⅡB multicomponent perovskite rare earth ferrites with promising electromagnetic wave absorption properties

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Journal of Rare Earths 2024年第6期42卷 1118-1127,I0005页

作者： Yanyan He Tao Chen Yanyu Pan Minzhong Huang kaixian Wang Liyan Xue Yazhu Li Fengzhi Tan Fan Yang Tongkuan Xu Heng Chen school of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalian116034China Xiamen Institute of Rare EarthMaterials Haixi InstitutesChinese Academy of SciencesXiamen36021China Fujian Institute of Research on the Structure of Matter Chinese Academyof SciencesFuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Xiamen Key-Laboratoryof Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou3410ooChina

Perovskite-type rare-earth ferrites(REFeO_(3))are promising materials for absorbing electromagnetic(EM)wave ***,insufficient dielectric loss and poor impedance matching are key factors that limit the broader implementation of REFeO_(3).Herein,a series of multicomponent perovskite-type ferrites with strong EM wave absorption capabilities was *** the synergistic effect of chemical constitution regulation and entropy regulation,optimization of the dielectric loss and impedance matching is achieved by strengthening the structural defect mechanism,thus further adjusting the EM wave absorption *** with(LaGdSmNdBa)FeO_(3)(HE-1)and(LaGdPrSmNdBa)FeO_(3)(HE-2),(LaGdBa)FeO_(3)(ME-1)and(LaGdSmBa)FeO_(3)(ME-2)exhibit favorable performance,with optimal minimum reflection loss(RL_(min))of-56.35 dB(at 11.12 GHz)and-63.25 dB(at 7.22 GHz)and effective absorption bandwidth(EAB)of 4.46 and 4.72 GHz,*** multicomponent design provides a new strategy for the development of EM wave absorption materials.

关键词： Rare earths Multicomponent design Rare earth ferrites Entropy regulation Electromagnetic wave absorption

High-entropy rare earth stannate ceramics:Acid corrosion resistant radiative cooling materials with high atmospheric transparency window emissivity and high near-infrared solar reflectivity

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Journal of Advanced Ceramics 2024年第5期13卷 630-640页

作者： Tao Chen Yanyan He Yanyu Pan kaixian Wang Minzhong Huang Liyan Xue Yazhu Li Fan Yang Yanchun Zhou Heng Chen Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China school of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In response to the development of the concepts of“carbon neutrality”and“carbon peak”,it is critical to developing materials with high near-infrared(NIR)solar reflectivity and high emissivity in the atmospheric transparency window(ATW;8–13μm)to advance zero energy consumption radiative cooling *** regulate emission and reflection properties,a series of high-entropy rare earth stannate ceramics(HE-RE_(2)Sn_(2)O_(7):(Y_(0.2)La_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Sn_(2)O_(7),(Y_(0.2)La_(0.2)Sm_(0.2)Eu_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7),and(Y_(0.2)La_(0.2)Gd_(0.2)Yb_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7))with severe lattice distortion were prepared using a solid phase reaction followed by a pressureless sintering method for the first *** distortion is accomplished by introducing rare earth elements with different cation radii and *** as-synthesized HE-RE_(2)Sn_(2)O_(7)ceramics possess high ATW emissivity(91.38%–95.41%),high NIR solar reflectivity(92.74%–97.62%),low thermal conductivity(1.080–1.619 W·m^(−1)·K^(−1)),and excellent chemical *** the one hand,the lattice distortion intensifies the asymmetry of the structural unit to cause a notable alteration in the electric dipole moment,ultimately enlarging the ATW *** the other hand,by selecting difficult excitation elements,HE-RE_(2)Sn_(2)O_(7),which has a wide band gap(Eg),exhibits high NIR solar ***,the multi-component design can effectively enhance radiative cooling ability of HE-RE_(2)Sn_(2)O_(7)and provide a novel strategy for developing radiative cooling materials.

关键词： radiative cooling materials high-entropy ceramics(HECs) rare earth stannate(RE_(2)Sn_(2)O_(7)) high atmospheric transparency window emissivity high near-infrared(NIR)solar reflectivity

A novel(Sm0.2Eu0.2Gd0.2Ho0.2Yb0.2)CrO3 high-entropy ceramic nanofiber as a negative temperature coefficient thermistor

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Journal of Rare Earths 2024年第10期 1937-1942页

作者： Weijun Zhao Meng Zhang Liyan Xue kaixian Wang Fan Yang Jiuping Zhong Heng Chen school of Materials Sun Yat-sen University Xiamen Institute of Rare Earth Materials Haixi InstituteChinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of Sciences Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China Advanced Energy Science and Technology Guangdong Laboratory Sichuan Jcc Rare Earth Metals New Material Co. Ltd.

The electrical properties of high-entropy ceramics（HECs） have been extensively studied in recent years due to their unique structural characteristics and fascinating functional properties induced by entropy *** high-entropy(Sm0.2Eu0.2Gd0.2Ho0.2Yb0.2)CrO3（HE-RECrO3） nanofibers were prepared by electro *** work demonstrates that HE-RECrO3nanofibe rs were successfully synthesized at a low temperature（800℃）,which is approximately 400 ℃ lower than the temperatures at which chromate ceramics were synthesized via the sol-gel method and the solid-state reaction *** resistivity of HE-RECrO3nanofibers decreases exponentially with increasing temperature from 25 to600℃.The logarithm of the resistivity is linearly related to the inverse of the temperature,confirming the negative temperature coefficient property of *** B25/50value of the HERECrO3nanofibers reaches 4072 *** conclusion,HE-RECrO3nanofibers are expected to be potential candidates for negative-temperature-coefficient（NTC） thermistors.

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Harvesting Environment Mechanical Energy by Direct Current Triboelectric Nanogenerators

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Nano-Micro Letters 2023年第8期15卷 381-404页

作者： Chuncai Shan kaixian Li Yuntao Cheng Chenguo Hu school of Physics Chongqing UniversityChongqing 400044People’s Republic of China school of Energy and Engineering Chongqing UniversityChongqing 400044People’s Republic of China

As hundreds of millions of distributed devices appear in every corner of our lives for information collection and transmission in big data era,the biggest challenge is the energy supply for these devices and the signal transmission of *** nanogenerator(TENG)as a new energy technology meets the increasing demand of today’s distributed energy supply due to its ability to convert the ambient mechanical energy into electric ***,TENG can also be used as a sensing *** current triboelectric nanogenerator(DC-TENG)can directly supply power to electronic devices without additional *** has been one of the most important developments of TENG in recent ***,we review recent progress in the novel structure designs,working mechanism and corresponding method to improve the output performance for DC-TENGs from the aspect of mechanical rectifier,tribovoltaic effect,phase control,mechanical delay switch and *** basic theory of each mode,key merits and potential development are discussed in *** last,we provide a guideline for future challenges of DC-TENGs,and a strategy for improving the output performance for commercial applications.

关键词： Triboelectric nanogenerators Direct current Working mechanism