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The influence of corneal ablation patterns on prediction error after cataract surgery in post-myopic-LASIK eyes

Eye and Vision 2024年第4期10卷 23-31页

作者： Yunqian Yao jing Zhao Jifeng Yu Wenwen He Ling Wei Xingtao Zhou Yi Lu Xiangjia Zhu Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan University83 Fenyang RoadShanghai 200031China National Health Center key laboratory of myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghaiChina Shanghai key laboratory of Visual Impairment and Restoration ShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina Department of Ophthalmology Beijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijingChina State key laboratory of Medical Neurobiology Fudan UniversityShanghaiChina

Purpose:To evaluate the influence of corneal ablation patterns on the prediction error after cataract surgery in postmyopic-LASIK ***:Eighty-three post-myopic-LASIK eyes of 83 patients that underwent uneventful cataract surgery were retrospectively *** postoperative spherical equivalence(SE)was calculated for the implanted lens using the Haigis-L and Barrett True-K *** error at one month postsurgery was calculated as actual SE minus predicted *** each eye,area and decentration of the ablation zone was measured using the tangential curvature *** associations between prediction errors and corneal ablation patterns were ***:The mean prediction error was-0.83±1.00 D with the Haigis-L formula and-1.00±0.99 D with the Barrett True-K *** error was positively correlated with keratometry(K)value and negatively correlated with ablation zone area using either formula,and negatively correlated with decentration of the ablation zone using the Barrett True-K formula(all Pcataract surgery in post-myopic-LASIK eyes.

关键词： cataract surgery Laser in situ keratomileusis Intraocular lens power Keratometry Ablation zone decentration Ablation zone size

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Application of total keratometry in ten intraocular lens power calculation formulas in highly myopic eyes

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Eye and Vision 2024年第2期10卷 22-30页

作者： Ling Wei Kaiwen Cheng Wenwen He Xiangjia Zhu Yi Lu Department of Ophthalmology and Eye Institute Eye and ENT Hospital of Fudan UniversityShanghai 200031China key laboratory of myopia(Fudan University)key laboratory of myopiaShanghai key laboratory of Visual Impairment and Restoration National Health CommissionChinese Academy of Medical ScienceShanghai 200031China State key laboratory of Medical Neurobiology Fudan UniversityShanghai 200031China

Background:The accuracy of using total keratometry(TK)value in recent IOL power calculation formulas in highly myopic eyes remained ***:Highly myopic patients who underwent uneventful cataract surgery were prospectively enrolled in this prospective comparative *** one month postoperatively,standard deviation(SD)of the prediction errors(PEs),mean and median absolute error(MedAE)of 103 highly myopic eyes were back-calculated and compared among ten formulas,including XGboost,RBF 3.0,Kane,Barrett Universal II,Emmetropia Verifying Optical 2.0,Cooke K6,Haigis,SRK/T,and Wang-Koch modifications of Haigis and SRK/T formulas,using either TK or standard keratometry(K)***:In highly myopic eyes,despite good agreement between TK and K(P>0.05),larger differences between the two were associated with smaller central corneal thickness(P0.05),which both presented smaller MedAEs than others(all P0.05),and statistically larger percentages than the other eight formulas(P<0.05).Conclusions:Highly myopic eyes with thinner corneas tend to have larger differences between TK and *** XGboost enhancement calculator and RBF 3.0 formula using TK showed the most promising outcomes in highly myopic eyes.

关键词： High myopia Total keratometry cataract surgery IOL power calculation

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A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin Yuan Lei Luo Bao You-Jia Zhang Ke-Yin Liu Yu-Hong Chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China key laboratory of myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State key laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

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A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 684-690页

作者： Xiu-Kun Cui Ke-Ke Zhu Zheng Zhou Si-Min Wan Yi Dong Xuan-Ce Wang Jing Li Jing Zhang Hong-Mei Mu Lei Qin Yan-Zhong Hu Henan Intemational Union laboratory of Antibody Medicine Department of Cell biology and Genetics Henan University School of Medicine Kaifeng 475004 Henan Province China kaifeng key lab of cataract and myopia Institute of Eye Diseases Kaifeng Centre Hospital Kaifeng 475000 Henan Province China Department of Cardiovascular Medicine Kaifeng Centre Hospital Kaifeng 475000 Henan Province China

AIM：To investigate the genetic mutations that are associated the hereditary autosomal dominant cataract in a Chinese ***：A Chinese family consisting of 20 cataract patients（including 9 male and 11 female） and 2 unaffected individuals from 5 generations were diagnosed to be a typical autosomal dominant cataract pedigree. Genomic DNA samples were extracted from the peripheral blood cells of the participants in this pedigree. Exon sequence was used for genetic mutation screening. In silico analysis was used to study the structure characteristics of connexin 46（CX46） mutant. Immunoblotting was conduceted for testing the expression of ***：To determine the involved genetic mutations, 11 well-known cataract-associated genes（cryaa, cryab, crybb1, crybb2, crygc, crygd, Gja3, Gja8, Hsf4, Mip and Pitx3） were chosen for genetic mutation test by using exon sequencing. A novel cytosine insertion at position 1195 of CX46 c DNA（c.1194_1195ins C） was found in the samples of 5 tested cataract patients but not in the unaffected 2 individuals nor in normal controls, which resulted in 30 amino acids more extension in CX46Cterminus（cx46fs400） compared with the wild-type CX46. In silico protein structure analysis indicated that the mutant showed distinctive hydrophobicity and protein secondary structure compared with the wild-type CX46. The immunoblot results revealed that CX46 protein, which expressed in the aging cataract lens tissues, was absence in the proband lens. In contrast, CX50, alpha A-crystallin and alphaB-crystallin expressed equally in both proband and aging cataract tissues. Those results revealed that the cx46fs400 mutation could impair CX46 protein expression. CONCLUSION：The insertion of cytosine at position 1195 of CX46 cD NA is a novel mutation site that is associated with the autosomal dominant cataracts in this Chinese family. The C-terminal frameshift mutation is involved in regulating CX46 protein expression.

关键词： connexin 46 cataract congenital ocular lens autosome dominant heredity genetic mutation

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Lens thickness and associated ocular biometric factors among cataract patients in Shanghai

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Eye and Vision 2021年第1期8卷 214-222页

作者： Jiaqi Meng Ling Wei Wenwen He Jiao Qi Yi Lu Xiangjia Zhu Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan University83 Fenyang RoadXuhui DistrictShanghai 200031China key laboratory of myopia Ministry of HealthShanghaiChina key laboratory of Visual Impairment and Restoration ShanghaiChina key NHC key laboratory of myopia(Fudan University) ShanghaiChina laboratory of myopia Chinese Academy of Medical SciencesShanghaiChina

Background:To evaluate the distribution of lens thickness(LT)and its associations with other ocular biometric factors among cataract patients in ***:Twenty-four thousand thirteen eyes from 24,013 cataract patients were retrospectively *** biometric factors including LT,central corneal thickness(CCT),anterior chamber depth(ACD),white-to-white(WTW)distance,anterior corneal curvature,and axial length(AL)were obtained using the *** associations between LT and general or ocular factors were ***:The mean age was 62.5±13.6 years and 56.1%were *** mean LT was 4.51±0.46 *** LT was greater in older patients(Pcataractous population,we found that the thicker lens may be associated with older age,male gender,thicker CCT,shallower ACD,larger WTW,and flatter anterior corneal *** AL increased,the change of LT was nonlinear,with the thickest lens seen in the 20-22mm AL group.

关键词： Lens thickness cataract Ocular biometry Axial length

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Decentration and tilt of plate-haptic multifocal intraocular lenses in myopic eyes

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Eye and Vision 2020年第1期7卷 162-170页

作者： Jiaqi Meng Wenwen He Xianfang Rong Ao Miao Yi Lu Xiangjia Zhu Eye Institute Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai 200031China key laboratory of myopia Ministry of HealthShanghaiChina key laboratory of Visual Impairment and Restoration ShanghaiChina key NHC key laboratory of myopia(Fudan University) ShanghaiChina laboratory of myopia Chinese Academy of Medical SciencesShanghaiChina

Background:To investigate the decentration and tilt of plate-haptic multifocal intraocular lenses(MfIOLs)in myopic ***:Myopic(axial length[AXL]>24.5 mm)and non-myopic(21.0 mmcataract eyes were enrolled in this prospective study and randomly assigned to receive implantation of Zeiss AT LISA tri 839MP lenses(Group A)or Tecnis ZMB00 lenses(Group B).In total,122 eyes of 122 patients were available for *** and tilt of MfIOLs,high-order aberrations(HOAs),and modulation transfer functions(MTFs)were evaluated using the OPD-Scan III aberrometer 3 months *** symptoms were assessed with a Quality of Vision ***:Near and distance visual acuities,tilt and horizontal decentration did not differ between the two groups,***,myopic eyes of Group B showed greater vertical decentration than those of Group A(−0.17±0.14 mm vs.-0.03±0.09 mm,respectively),particularly when the MfIOLs were placed horizontally or *** decentration of myopic eyes was greater in Group B than in Group A(0.41±0.15 mm vs.0.16±0.10 mm,respectively).In Group B,AXL was negatively correlated with vertical decentration and positively correlated with overall *** such correlations were found in Group *** total HOAs,coma,trefoil and spherical aberrations were lower in Group A than in Group B for a 6.0 mm pupil among myopic ***,Group A had better MTFs and fewer subjective symptoms than Group B among myopic ***:Plate-haptic design of MfIOLs may be a suggested option for myopic cataract eyes due to the less inferior decentration and better visual quality postoperatively.

关键词： Decentration Tilt Multifocal intraocular lens High myopia cataract surgery

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Five‑year outcomes of EVO implantable collamer lens implantation for the correction of high myopia and super high myopia

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Eye and Vision 2021年第1期8卷 404-411页

作者： Xun Chen Xuanqi Wang Yilin Xu Mingrui Cheng Tian Han LingLing Niu Xiaoying Wang Xingtao Zhou Fudan University Eye Ear Nose and Throat Hospital No.19 BaoQing RoadXuHui DistrictShanghai 200031China National Health Commission key lab of myopia(Fudan University) ShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina

Background:To evaluate the long-term safety,efficacy,predictability,and stability of implantable collamer lens with a central hole(EVO ICL)implantation for correcting high myopia(HM)and super high myopia(SHM).Methods:This prospective study evaluated 83 eyes of 46 patients who were divided into groups based on their spherical equivalent refractive error(SE):HM group(−12 D≤SE<−6 D)and SHM group(SE<−12 D).They were followed up for 5 years after ICL implantation;assessments of uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),manifest refractive error,axial length,intraocular pressure,corneal endothelial cell density,and vault were conducted,and a questionnaire was ***:At 5 years postoperatively,the safety indices of the HM and SHM groups were 1.03±0.10 and 1.32±0.39,and the efficacy indices were 0.83±0.25 and 0.86±0.32,*** the HM group,60.47%and 79.07%of the eyes were within±0.50 D and±1.00 D of the attempted correction,while it was achieved for 22.50%and 47.50%of the eyes in the SHM group,*** SE of the HM group decreased from−9.72±1.41 D preoperatively to 0.04±0.39 D 1 month postoperatively and−0.67±0.57 D 5 years postoperatively,while in the SHM group,it decreased from−15.78±3.06 D preoperatively to−0.69±0.97 D 1 month postoperatively and−1.74±1.19 D 5 years ***:EVO ICL implantation is safe,effective,and predictable for correcting HM and *** improved more after surgery for SHM,but the growth of axial length still needs attention.

关键词： Posterior chamber phakic intraocular lens implantation High myopia Super high myopia EVO ICL

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Ocular Dimensions of the Chinese Adolescents with Keratoconus

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中国激光医学杂志 2018年第2期 149-150页

作者： JIAN Wei-jun SHEN Yang CHEN Ying-jun TIAN Mi ZHOU Xing-tao The Eye and ENT Hospital of Fudan University The key lab of myopia Ministry of Health

Objective:The purpose of this study is to investigate the ocular dimensions in Chinese adolescents with keratoconus(KC).Methods:One hundred and six KC eyes of 53(42 boys and11 girls)KC adolescents(age 15.5±1.7 years,range 11 to18)were involved in this retrospective *** eye with more severe KC(Severe Group)of each patient was compared to their less affected eye(Mild Group).Optical axial length(OAL)was measured by optical coherence biometry(IOL-master).Central corneal thickness,anterior chamber depth(ACD),flat keratometry value,steep keratometry value,and maximum keratometry value were assessed with an anterior segment analyzer(Pentacam HR).Anterior segment length(ASL)was manually measured from the 25 scheimp flug images captured by the Pentacam HR with the mean value *** posterior segment length(PSL)was calculated with the formula"PSL=OALASL".Results:The mean ACD,OAL,ASL,and PSL values of the Severe Group were(3.51±0.32)mm,(24.76±1.24)mm,(4.01±0.30)mm and(20.76±1.15)*** those of the Mild Group were(3.36±0.29)mm,(24.97±1.40)mm,(3.94±0.35)mm and(21.03±1.31)*** Severe Group has significantly higher ACD(P<0.001)value but lower OAL(P<0.05)and PSL(P<0.001)values when compared to those of the Mild ***:For adolescent KC,the more severe keratoconic eyes may be characterized by deeper ACD but shorter OAL and PSL,when compared to the less affected ones.

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The binocular intraocular lens power difference in eyes with different axial lengths

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 924-931页

作者： Ming-Hui Deng Xiao-Gang Wang Song Chen Xue-Feng Shi Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin key lab of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China Department of cataract Linfen Yaodu Eye HospitalLinfen 042000Shanxi ProvinceChina Department of cataract Shanxi Eye Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030002Shanxi ProvinceChina

AIM:To investigate the binocular intraocular lens(IOL)power difference in eyes with short,normal,and long axial lengths(AL)using Lenstar LS 900 optical ***:A total of 716(1432 eyes)participants were *** groups were categorized into short(group A:AL25 mm).The central corneal thickness(CCT),anterior chamber depth(ACD),lens thickness(LT),AL,anterior corneal keratometry,whiteto-white(WTW),pupil diameter(PD),as well as IOL power calculated using embedded Barrett formula were ***-Altman plots were used to test the agreement of the binocular ***:In group A,the CCT of the right eye was significantly thinner than that of the left eye(P=0.044)with a difference of-2±8μm[95%limits of agreement(LoA),-17.8 to 13.2μm].For group B,the PD and IOL power in the right eye were significantly lower than those of the left eye(P=0.001,<0.001)with a difference of-0.05±0.32 mm(95%LoA,-0.68 to 0.58 mm)and-0.18±1.01 D(95%LoA,-2.2 to 1.8 D).The AL of right eye was longer than that of the left eye(P=0.002)with a difference of 0.04±0.25 mm(95%Lo A,-0.45 to 0.52 mm).No significant difference was observed for all the binocular parameters in group *** percentage of participants with binocular IOL power difference within±0.5 D were 62%(31/50),68.3%(339/496),and 38.8%(66/170)in groups A,B,and C,***:The binocular parameters related to IOL power are in good agreement,but the binocular IOL power difference of more than half of participants with long AL is more than 0.50 D.

关键词： axial length intraocular lens power binocular difference

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Preoperative Characteristics of Ocular Biometry in Children with Unilateral Congenital cataracts

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Phenomics 2022年第2期2卷 136-144页

作者： Jiahui Chen Yating Tang Yongxiang Jiang Yi Lu Department of Ophthalmology and Vision Science Eye Ear Nose and Throat Hospital of Fudan University83 Fenyang Rd.Shanghai 200031China NHC key laboratory of myopia(Fudan University) Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China key laboratory of Visual Impairment and Restoration of Shanghai Shanghai 200031China

The ocular biometry characteristics are clinically significant for children with unilateral congenital cataracts,but there is a lack of data analysis concerning the preoperative *** axial length(AL),mean keratometry(Km),cor-neal astigmatism(CA),and the anterior chamber depth(ACD)from both eyes before cataract surgery were obtained from 205 patients(410 eyes,3-15 years of age)with unilateral congenital *** the congenital cataract eyes,shorter AL(22.44±1.52 mm vs.22.57±1.04 mm,p=0.036)and higher CA(-1.89±0.91 D vs.-1.24±0.67 D,pcataract eye)that less than *** preoperative ocular biometry of shorter AL,larger Km,higher CA,and shallower ACD should be considered in females with unilateral congenital *** age and the binocular axial differences had a statistically significant correlation(r=-0.192,p=0.006).Therefore,changes in the binocular axial differences associated with aging may enhance the guidelines for intraocular lens selection and the management of congenital cataracts.

关键词： Unilateral congenital cataract Ocular biometry Binocular axial difference Astigmatism

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