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Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

World Journal of Gastroenterology 2009年第34期15卷 4290-4297页

作者： Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata Division of Gastroenterology KKR Sapporo Medical Center Internal Medicine Tsuruoka Kyoritsu Hospital Internal Medicine Oizumi Medical Clinic Department of Cancer Control and Statistics Osaka Medical Center for Cancer and Cardiovascular Diseases Yamagata Prefectural medical center for Cancer and Lifestyle-Related Disease Internal Medicine Yamagata Prefectural Central Hospital Yamagata Prefectural Shonai Public Health center Department of Gastroenterology Faculty of MedicineYamagata University

AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,*** study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori ***:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 *** sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),*** follow-up tended to be associated with better prevention of gastric cancer,although not to a significant *** significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer.

关键词： Helicobacter pylori Peptic ulcer Gastric cancer Eradication therapy Cancer prevention

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Activation of c-Yes in hepatocellular carcinoma: A preliminary study

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World Journal of Gastroenterology 2006年第35期12卷 5743-5745页

作者： Han Feng Tsutomu Masaki Takako Nonomura Asahiro Morishita Gong Jian Seiji Nakai Akihiro Deguchi Naohito Uchida Takashi Himoto Hisakazu Iwama Hisashi Usuki Hisao Wakabayashi Kunihiko Izuishi Hitoshi Yoshiji Kazutaka Kurokohchi Shigeki Kuriyama Third Departmentof Internal Medicine Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Information Technology center Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Department of Gastroenterological Surgery Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Third Department of Internal Medicine Nara Medical University 840 Shijo-cho Kashihara Nara 634-8522 Japan Department of Gastroenterology KKR Takamatsu Hospital 4-18 Tenjinmae Takamatsu Kagawa 760-0018 Japan

Hepatocellular carcinoma （HCC） is thought to develop through a multistep process. A long history of viral hepatitis or prolonged exposure to environmental toxins predisposes liver cells to mutations of the genes critical in the control of hepatocyte growth. In fact, both activation of cellular oncogenes and inactivation of tumorsuppressor genes are involved in the development of HCC. Activation of oncogenes by hepatitis virus integration has been shown in the woodchuck animal model, although the significance of this finding in human hepatocarcinogenesis is still under investigation. Tyrosine kinases, though a minor class of cellular protein, represent a major class of oncogenes. These tyrosine kinases are classified into two major groups.

关键词： Hepatocellular carcinoma Tyrosine kinase c-Yes Oncogene

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Preliminary Study on the Effectiveness of Different Durations of Hot Towel Application to the Back during Bed Bathing

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Open Journal of Nursing 2017年第12期7卷 1375-1386页

作者： Inaho Shishido Yuka Yamaguchi Rie Miyata Sakiko Kutomi Rika Yano kkr medical center Sapporo Japan The University of Tokyo Hospital Tokyo Japan Elderly Support Section Fukagawa City Fukagawa Japan Toranomon Hospital Tokyo Japan Faculty of Health Sciences Hokkaido University Sapporo Japan

The purpose of this study was to determine the most effective duration of hot towel application during bed bathing, based on temporal changes in skin surface temperature, towel temperature, and subjective comfort. As a secondary objective, differences in skin surface temperature and subjective comfort for hot towel application on the back and dry towel wiping alone were evaluated. For the first objective, hot towels were applied on the lower back of 20 healthy adults, for different duration (10, 15, and 20 s), with a 10-s duration found to be the most effective. For the second objective, we compared bed bathing with hot towel application to dry wiping alone, n 21 healthy adult participants. A 10-s hot towel application increased the surface temperature of the skin (+0.5℃) and provided a perceived sensation of warmth and comfort. In contrast, dry wiping significantly decreased the surface skin temperature (-0.8℃). In conclusion, hot towel application increased skin surface temperature and improved subjective warmth and comfort during bed bathing.

关键词： Bed Bath Hot Towel Application Skin Surface Temperature

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Association between Subjective Evaluation of Skin Toxicities and Quality of Life in Patients with Lung Cancer Undergoing Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Treatment: A Pilot Study for Developing Skin Toxicity Assessment

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Open Journal of Nursing 2019年第12期9卷 1226-1239页

作者： Kengo Hirayama Ya Su Yasuyuki Ikezawa Megumi Chiba Kenichiro Ito Michiko Yuki Faculty of Health Sciences Hokkaido UniversitySapporoJapan Graduate School of Health Sciences Hokkaido UniversitySapporoJapan Department of Respiratory Medicine Oji General HospitalTomakomaiJapan kkr Sapporo medical center SapporoJapan

Purposes: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert satisfactory therapeutic effects in lung cancer patients. However, the resultant skin toxicity can deteriorate patients’ quality of life (QoL). Differences exist in skin toxicity evaluation between patients and clinicians. We aimed to clarify the association between the subjective evaluation of skin toxicities and QoL in lung cancer patients and to establish a document of scale development in the subjective evaluation of skin toxicity. Methods: We used self-administered questionnaires to evaluate 12 lung cancer patients receiving EGFR-TKI treatment. Indices of QoL were generated using the Functional Assessment of Cancer Therapy-Lung and Hospital Anxiety and Depression Scale, and a subjective evaluation questionnaire concerning skin toxicity was completed. The data were collected immediately before treatment initiation and at 4 weeks post treatment. Results: In the subjective evaluation of skin toxicity, four patients (33.3%) were classified as ≥Grade 2 (painful group), experiencing painful pruritus at the emergence site of the skin rash or xerosis. In this group, the QoL scores of physical and emotional aspects declined after treatment. Conversely, patients in the painless group (Grade 0 - 1) demonstrated an improved emotional QoL following treatment (p = 0.028). Conclusions: Lung cancer patients suffering from painful skin toxicity tended to show a decline in the physical and emotional aspects of QoL following EGFR-TKI treatment. The skin toxicity questionnaire was useful from the point of view of a subjective evaluation and could be a powerful assessment tool in future clinical settings with further modification.

关键词： Lung Cancer EGFR-Tyrosine Kinase Inhibitors Skin Toxicity Quality of Life

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Method for Converting Cone-Beam CT Values into Hounsfield Units for Radiation Treatment Planning

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International Journal of medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 361-375页

作者： Tadanori Abe Kunihiko Tateoka Yuichi Saito Takuya Nakazawa Masaki Yano Kensei Nakata Masanori Someya Masakazu Hori Koichi Sakata Depertment of Radiation Oncology and medical Physics Graduate School of Medicine Sapporo Medical University Sapporo Japan Department of Radiology KKR Sapporo Medical Center Sapporo Japan Preparatory Office for Proton Therapy center Radiation Therapy Research Institute Social Medical Corporation Teishinkai Sapporo Japan Department of Radiology National Hospital Organization Hokkaido Cancer Center Sapporo Japan Department of Radiology Kushiro City General Hospital Kushiro Japan Department of Radiation Oncology School of Medicine Sapporo Medical University Sapporo Japan

Cone-beam CT (CBCT) images acquired during radiation treatment can be used to recalculate the dose distribution as well as to confirm the treatment location. However, it is difficult to obtain the electron densities (EDs) necessary for dose calculation from CBCT images because of the effects of scatter contamination during CBCT image acquisition. This paper presents a mathematical method for converting the pixel values of CBCT images (CBCT values) into Hounsfield units (HUs) of radiation treatment simulation CT (simCT) images for use in radiation treatment planning. CBCT values are converted into HUs by matching the histograms of the CBCT values with the histograms of the HUs for each slice via linear scaling of the CBCT values. For prostate cancer and head-and-neck cancer patients, the EDs obtained from converted CBCT values (mCBCT values) show good agreement with the EDs obtained from HUs, within approximately 3.0%, and the dose calculated on the basis of CBCT images shows good agreement with the dose calculated on the basis of the simCT images, within approximately 2.0%. Because the CBCT values are converted for each slice, this conversion method can account for variation in the CBCT values associated with differences in body size, body shape, and inner tissue structures, as well as in longitudinally displaced positions from the isocenter, unlike conventional methods that use electron density phantoms. This method improves on conventional CBCT-ED conversion and shows considerable potential for improving the accuracy of radiation treatment planning using CBCT images.

关键词： Cone-Beam Computed Tomography Hounsfield Unit Electron Density Ra-diation Treatment Planning

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Relationship of Plasma IL-6 to the Metabolic Measures associated with Insulin Resistance due to Adiposity

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South China Journal of Cardiology 2004年第1期5卷 5-10页

作者： RyoyuTakeda YoshihiroTakayama YujiIto TakaharuMasunaga TakahiroZenda SatoshiAsaka HisanoriOiwake KimihideShinozaki YoshiyuTakeda IsamuMiyamori 吴平生 DepartraentofInternalMedicine KKR-HokutikuHospitalKanazawaJapan DepartmentofMedicine KanazawaUniversityKanazawaJapan FukuimedicalUniversity FukuiJapan NangFangHospital GuangzhouPRChina

Objectives To elucidate the re-lationship of plasma interleukin -6 (IL-6) to themetabolic measures associated with insulin resistance(IR) due to adiposity. Methods For a cross-sectionalstudy, eighty normotensive men with and without obe-sity were enrolled consecutively in our health exami-nation center. Fasting blood glucose (FBG), fastingplasma immunoreactive insulin (FIRI), HOMA -R(Homeostasis Model Assessment Insulin ResistanceIndex), plasma lipids (cholesterol, triglyceride, highdensity lipoprotein cholesterol), cortisol, dehy-droepiandrosterone-sulfate (DHEA - S), interleukin -6and C-reactive protein(CRP) were measured. ResultsPlasma levels of FIRI, triglyceride (TG), DHEA-S,CRP and HOMA -R were significantly higher inobese group with BMI over 25 than non-obese group,whereas HDL -C was significantly lower in obesegroup. BMI was positively correlated with FIRI, TG,hsCRP and HOMA-R, whereas negatively with HDL-C. BMI was positively correlated with plasma DHEA-S levels but not with cortisol. Plasma levels of IL-6were positively correlated with FIRI, TG, CRP andHOMA-R but in a multiple regression analysis withIL-6, only HOMA-R and TG remained explainablevariables. Conclusions Each of commonly used mea-sures of inflammatory reaction, CRP and IL-6, showeda significantly positive correlation with either FIRI orHOMA-R, suggesting associations between subclinicalinflammation and obesity as the risk of type 2 dia-betes mellitus.

关键词： Insulin resistance HOMA-R Interleukin-6(IL-6) CRP

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Submucosal hematoma is a highly suggestive finding for amyloid light-chain amyloidosis:Two case reports

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 434-437页

作者： Shinji Yoshii Katsuhiro Mabe Katsuhiko Nosho Hiroyuki Yamamoto Hiroshi Yasui Hiroyuki Okuda Akira Suzuki Masahiro Fujita Toshihiro Sato Department of Gastroenterology Keiyukai Sapporo HospitalSapporo 003-0027Japan Third Department of Internal Medicine Hokkaido University Graduate School of MedicineSapporo 060-8648Japan First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 060-8556Japan Department of medical Oncology Keiyukai Sapporo HospitalSapporo 003-0027Japan Department of Pathology KKR Sapporo Medical CenterSapporo 062-0931Japan Keiyukai Institute of Clinical Pathology Sapporo 003-0027Japan

The clinical and endoscopic features of amyloid lightchain(AL) amyloidosis are diverse and mimic various other ***,few reports on submucosal hematomas of the gastrointestinal(GI) tract are available in the ***,we report two cases of AL amyloidosis presenting as submucosal hematomas in the absence of clinical disease elsewhere in the *** 2 cases were referred to our hospital because of *** endoscopic findings in both cases were similar in submucosal hematoma ***,the clinical courses *** the first case,there was no evidence of systemic amyloidosis and the disease was conservatively *** the second case,the disease progressed to systemic amyloidosis and the patient died within a short *** conclude that the endoscopic detection of a submucosal hematoma in the setting of GI bleeding should raise suspicion of AL *** to a hematologist should be done immediately for treatment while the involvement is limited to the GI tract.

关键词： Amyloid light-chain amyloidosis Submucosal hematoma Gastrointestinal bleeding Colonoscopy

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Co-,Fe-,Ni-doped and co-doped rutile GeO_(2):insights from ab-initio calculations

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Communications in Theoretical Physics 2022年第4期74卷 113-126页

作者： R Essajai E Salmani M Bghour A Labrag F Goumrhar M Fahoume H Ez-Zahraouy Materials and Subatomic Physics Laboratory Faculty of SciencesIbn Tofail UniversityKenitraMorocco Group of Semiconductors and Environmental Sensor Technologies-Energy Research center Faculty of ScienceMohammed V UniversityB.P.1014RabatMorocco Laboratory of Condensed Matter and Interdisciplinary Sciences Department of PhysicsFaculty of SciencesMohammed V UniversityP.O.Box 1014RabatMorocco Equipe des Matériaux Supraconducteursàhaute température critique Department of PhysicsIbn Zohr UniversityFaculty of SciencesBP:8106AgadirMorocco Faculty of Applied Sciences Route Nationale N°10 citéAzrouAit MelloulIbn Zohr UniversityAit MelloulIbn Zohr UniversityMorocco Higher School of Education and Training of El Jadida(ESEF) Chouaib Doukkali UniversityEl Jadida 24000Morocco Laboratory of Physics of High Energy Modeling&Simulations(LPHE-MS)Faculty of SciencesMohammed V University of RabatIbn BatoutaB.P.1014 RabatMorocco Laboratoire des Sciences de l’Ingénieur pour l’Energie Ecole Nationale des Sciences Appliquées d’El Jadida(ENSA-J)BP 1166EL Jadida Plateau24002Morocco

Rutile germanium oxide(rutile GeO_(2)),a semiconductor,can act as a half-metallic compound and is a promising material for spintronic and optoelectronic *** were performed using the Korringa–Kohn–Rostoker(kkr)approach and the coherent potential approximation(CPA),which were further combined with two approximations,the local density approximation(LDA)and the self-interaction corrected LDA approximation(LDA-SIC),to study the electronic structure of bulk rutile GeO_(2) doped and co-doped with three transition-metal impurities:Fe,Co,and *** doping value was set to 10%,while the co-doping level was set to 5%for each *** main findings of this work are:(1)a direct ultrawide bandgap of4.80 eV is observed and the rutile GeO_(2) exhibits an N-type semiconducting property.(2)Doped and co-doped GeO_(2) acquire a magnetic behavior and exhibit half-metallicity.(3)The mechanism responsible for these properties is also studied.(4)The critical temperature can reach 334 K when GeO_(2) is doped with Fe,while it rises to 398 K when it is co-doped with Fe and Co.(5)The spin polarization can be improved by *** can be inferred that rutile GeO_(2) doped or codoped with(Co,Fe)transition metals can be considered to be potential candidates for spintronic and optoelectronic applications.

关键词： LDA approximation spintronic Curie temperature spin polarization LDA-SIC approximation rutile germanium oxide

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