检索结果-南通市图书馆

Single-cell omics: experimental workflow, data analyses and applications

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Autonomous attitude coordinated control for spacecraft formation with input constraint,model uncertainties, and external disturbances

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2014年第3期27卷 602-612页

作者： Zheng Zhong Song Shenmin center for Control theory and Guidance Technology Harbin Institute of Technology

To synchronize the attitude of a spacecraft formation flying system, three novel autonomous control schemes are proposed to deal with the issue in this paper. The first one is an ideal autonomous attitude coordinated controller, which is applied to address the case with certain models and no disturbance. The second one is a robust adaptive attitude coordinated controller, which aims to tackle the case with external disturbances and model uncertainties. The last one is a filtered robust adaptive attitude coordinated controller, which is used to overcome the case with input con- straint, model uncertainties, and external disturbances. The above three controllers do not need any external tracking signal and only require angular velocity and relative orientation between a spacecraft and its neighbors. Besides, the relative information is represented in the body frame of each spacecraft. The controllers are proved to be able to result in asymptotical stability almost everywhere. Numerical simulation results show that the proposed three approaches are effective for attitude coordination in a spacecraft formation flying system.

关键词： Attitude coordinatedcontrol Backstepping Command filter Robust adaptive control Spacecraft formation flying

Robust Chattering-Free Finite Time Attitude Tracking Control with Input Saturation

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2019年第6期32卷 1597-1629页

作者： CHEN Haitao SONG Shenmin center for Control theory and Guidance Technology Harbin Institute of Technology

This paper addresses the attitude tracking control problem of a rigid spacecraft in the presence of the modeling uncertainty,external disturbance,and saturated control input by designing two robust att计ude tracking *** basic controller is formulated using an integral sliding mode surface which is continuous and provides an asymptotic convergence rate for the closed-loop *** this case,only the external disturbance with the prior information is ***,to provide a finite time convergence rate and further improve the robustness of the control system under the unknown system uncertainty containing both the modeling uncertainty and external disturbance,a novel integral terminal sliding mode surface(ITSMS)is designed and associated w计h the continuous adaptive control ***,a command filter is utilized to deal with the immeasurability problem within the proposed ITSMS and an auxiliary system to counteract the input saturation *** simulations are presented to verify the effectiveness of the proposed controllers.

关键词： Chattering-free continuous adaptive control finite time convergence input saturation integral terminal sliding mode surface

Stabilization of linear time-varying systems with state and input constraints using convex optimization

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2016年第3期27卷 649-655页

作者： Feng Tan Mingzhe Hou Guangren Duan center for Control theory and Guidance Technology Harbin Institute of Technology

The stabilization problem of linear time-varying systems with both state and input constraints is considered. Sufficient conditions for the existence of the solution to this problem are derived and a gain-switched（gain-scheduled） state feedback control scheme is built to stabilize the constrained timevarying system. The design problem is transformed to a series of convex feasibility problems which can be solved efficiently. A design example is given to illustrate the effect of the proposed algorithm.

关键词： linear time-varying stabilization state constraints convex optimization

Reduced-order Kalman filtering for state constrained linear systems

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2013年第4期24卷 674-682页

作者： Chaoyang Jiang Yongan Zhang center for Control theory and Guidance Technology Harbin Institute of Technology

This paper aims at solving the state filtering problem for linear systems with state constraints. Three classes of typical state constraints, i.e., linear equality, quadratic equality and inequality, are discussed. By using the linear relationships among different state variables, a reduced-order Kalman filter is derived for the system with linear equality constraints. Afterwards, such a solution is applied to the cases of the quadratic equality constraint and inequality constraints and the two constrained state filtering problems are transformed into two relative constrained optimization problems. Then they are solved by the Lagrangian multiplier and linear matrix inequality techniques, respectively. Finally, two simple tracking examples are provided to illustrate the effectiveness of the reduced-order filters.

关键词： state constraint state filtering reduced-order Kalman filter linear matrix inequality (LMI).

Parametric output regulation using observer-based PI controllers with applications in flexible spacecraft attitude control

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2021年第7期64卷 148-164页

作者： Guangren DUAN Tianyi ZHAO center for Control theory and Guidance Technology Harbin Institute of Technology

A parametric multiobjective design approach based on a proportional-integral(PI) controller and a full-state observer is proposed for output regulation in a multivariable linear system. First, a complete parametric form of the observer-based PI control law is established, which yields a closed-loop system with the desired eigenstructure and ensures that the regulated output asymptotically tracks a given constant signal in the presence of constant but unknown disturbances. All design degrees of freedom are preserved and characterized using a set of parameter vectors. Second, a separation principle of eigenvalue sensitivities is proven, and based on this result, the parameters of the closed-loop system are comprehensively optimized to reduce the eigenvalue sensitivity and the control gain, and also to enhance the tolerance to time-varying disturbances. Finally, the proposed method is applied to attitude control of a flexible spacecraft. Moreover,numerical simulations based on practical engineering parameters are performed to verify the superiority of the proposed method over traditional proportional-integral-derivative(PID) control methods.

关键词： parametric control system design multiobjectivedesign observer-based control separation principle PI regulator constant signaltracking disturbance decoupling and attenuation

Adaptive finite-time backstepping control for attitude tracking of spacecraft based on rotation matrix

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2014年第2期27卷 375-382页

作者： Guo Yong Song Shenmin center for Control theory and Guidance Technology Harbin Institute of Technology

This paper investigates two finite-time controllers for attitude control of spacecraft based on rotation matrix by an adaptive backstepping method. Rotation matrix can overcome the draw- backs of unwinding which makes a spacecraft perform a large-angle maneuver when a small-angle maneuver in the opposite rotational direction is sufficient to achieve the objective, With the use of adaptive control, the first robust finite-time controller is continuous without a chattering phenom- enon. The second robust finite-time controller can compensate external disturbances with unknown bounds. Theoretical analysis shows that both controllers can make a spacecraft following a time-varying reference attitude signal in finite time and guarantee the stability of the overall closed-loop system. Numerical simulations are presented to demonstrate the effectiveness of the proposed control schemes.

关键词： Adaptive control Attitude control Backstepping Finite-time control Robustness

Fully actuated system approach to attitude control of flexible spacecraft with nonlinear time-varying inertia

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第11期65卷 148-162页

作者： Tianyi ZHAO Guang-Ren DUAN center for Control theory and Guidance Technology Harbin Institute of Technology

A high-order fully actuated(HOFA) system approach is proposed for the attitude control problem of a flexible spacecraft with nonlinear and time-varying inertia. Different from most existing results,the proposed method guarantees a linear time-invariant closed-loop system with arbitrarily assignable eigenvalues. Firstly, the HOFA model for the attitude system is derived from the original dynamic equations of the system by using state transformation and variable elimination. Then, by using the full-actuation characteristics of the obtained HOFA system, the nonlinearity in the system is completely canceled and a linear time-invariant system with arbitrarily assignable eigenvalues is derived. Finally, the control laws are designed for both problems of attitude stabilization and attitude maneuvering, and simulations are carried out based on practical engineering parameters, which demonstrate the effects of the proposed method.

关键词： high-order fully actuated system flexible spacecraft time-varying nonlinear systems attitude stabilization attitude maneuvering

同方期刊数据库