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Dermatoscopy in the Diagnosis of Vulvar Basal Cell Carcinoma:A Case Report

International Journal of dermatology and Venereology 2022年第2期5卷 107-109页

作者： Diego Adolfo de los Cobos Davaios Rodrigo Cepeda-Valdes Luis Fernando Favela-Fernandez Claudia Villarreal-Carrillo julio Cesar salas-Alanis Debra Mexico GuadalupeNuevo León 67150Mexico julio salas dermatology GuadalupeNuevo León 67150Mexico Facultad de Medicina Universidad Autónoma de Nuevo LeónMonterreyNuevo León 67150México.

Introduction: Basal cell carcinoma (BCC) is the most common human malignancy commonly in white people, but in less than 1% of cases it may appear on unexposed areas, like the perineal and anal regions. Vulvar BCC is often diagnosed late because it grows slowly and tends to be asymptomatic, with no specific physical findings. Here, we present a rare Latin patient with a 10-year history of vulvar BCC with dermatoscopic and histopathologic findings.Case report: A 65-year-old Latin woman presented with a nodule on her left labium majus, which she first noted 10 years ago, and that had grown slowly but constantly. She also reported a 20-year history of pruritus and occasional pain. Physical examination showed a 3.5 cm × 3.0 cm erythematous lesion with a central rough without inguinal lymphadenopathy. Contact dermatoscopy (Dermalite DL3 Gen.) showed one blurred cluster of arborising vessels in a pinkish background with white homogeneous areas and lines radial converging. An incisional biopsy was realized, and histopathology diagnosed BCC.Discussion: Vulvar BCC is a rare malignancy that affects mainly Caucasian women over 70 years of age. The most common etiology for BCC is ultraviolet radiation, but as the vulva is unexposed its cause is unclear. Mutations in tumor suppressor and regulatory genes such as p53 are present in 50% of cases. Gorlin syndrome, chronic radiation, chronic arsenic exposure, xeroderma pigmentosum, and immunosuppression have been considered as risk factors.Conclusion: Vulvar BCC characteristics are the same as other cutaneous forms, featuring blue ovoid nests and arborizing telangiectasia, confused with inflammatory diseases, such as eczema, psoriasis, and chronic infection (especially if it is accompanied by pruritus), this makes diagnosis complex, with a delay of 5 to 6 years on average, with an average size of 2.1 cm. Diagnosis is enhanced with dermatoscopy, as the preferred treatment for most BCC cases is wide surgical excision.

关键词： basal cell carcinoma cancer case report latino tumors woman

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Reassessment of Prejanopterus curvirostris, a Basal Pterodactyloid Pterosaur from the Early Cretaceous of Spain

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Acta Geologica Sinica(English Edition) 2012年第6期86卷 1389-1401页

作者： Xabier PEREDA-SUBERBIOLA Fabien KNOLL José Ignacio RUIZ-OMEACA julio COMPANY Fidel TORCIDA FERNNDEZ-BALDOR Universidad del País Vasco/Euskal Herriko Unibertsitatea Facultad de Cienciay TecnologíaDpto.Estratigrafíay Paleontología Departamento de Paleobiología Museo Nacional de Ciencias Naturales-CSIC Museo del Jurásico de Asturias (MUJA) Departamento de Geología Universidad de Oviedo Departamento de Ingeniería del Terreno Universidad Politécnica de Valencia Colectivo Arqueológico-Paleontológico de salas (C.A.S.) Museo de Dinosaurios

Prejanopterus curvirostra, from the Early Cretaceous of La Rioja province, was the first pterosaur genus and species described from Spain. The material comprises disarticulated cranial and postcranial remains from several individuals. The fossil-bearing bed is assigned to the lacustrine Leza Formation （eastern Cameros Basin, NW margin of the Iberian Range）. This unit is regarded as either Berriasian-Valanginian or Barremian-Aptian. Prejanopterus curvirostris （specific name emended） was originally diagnosed on the basis of several characters of which the most significant was a lateral curvature of the rostrum. Re-examination of the holotype （rostrum） and paratype （partial rostrum with teeth） indicates that there is no genuine sideways bend of the preserved premaxilla-maxilla segments, but a slight dorsal curvature. Prejanopterus is characterized by a unique combination of characters： an emended diagnosis is provided. In contrast with previous estimates, the wing span of Prejanopterus was probably not much （if ever） in excess of 2 m. A phylogenetic analysis suggests that Prejanopterus is a basal pterodactyloid positioned between Pterodactylus and Cycnorhamphus- Gallodactylus. Prejanopterus represents the first evidence of Pterodactylidae in the Early Cretaceous of the Iberian Peninsula.

关键词： Pterosauria Prejanopterus Leza Formation Early Cretaceous La Rioja Spain

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