检索结果-南通市图书馆

Chinese Medical Sciences Journal 1999年第2期 49-53页

作者： $$$$ Jiang Zhuming, MD Liu Yuewu, MD, PhD , Ma Yongxian, MD , Bai Manxi,MD, PhD , Qiang Boqing, PhD  ,Robert Smith, MD Wlley Souba, MD , ScD and Douglas Wilmore, MD Department of Surgery, Peking Department of Surgery Peking Union Medical College Hospital Beijing 100730 Molecular Biology Laboratory of Chinese Academy of Medical Sciences Beijing 100730 joslin diabetic center Department of Surgery Massachusetts General Hospital and Brigham and Women's Hospital Harvard Medical School

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒ...

ＩＮＴＲＯＤＵＣＴＩＯＮＡｌｔｅｒａｔｉｏｎｓｉｎｉｎｔｅｓｔｉｎａｌｓｔｒｕｃｔｕｒｅａｎｄｆｕｎｃｔｉｏｎｏｃｕｒｆｏｌｏｗｉｎｇｍａｊｏｒｏｐｅｒａｔｉｏｎ，ｒａｄｉｏｔｈｅｒａｐｙａｎｄｌｏｎｇｔｅｒｍｐａｒｅｎｔｅｒａｌｎｕｔｒｉｔｉｏｎ（...

关键词：

Generation and improvement of insulin-producing cells from differentiating embryonic stem cells for diabetes therapy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Generation and improvement of insulin-producing cells from d...

diabetic and Prediabetic Profile of Patients in a Family Health Care Unit of Salvador, Northeastern Brazil

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Arun Sharma Sai Kiang Lim joslin Diabetes center Harvard Medical School BostonUSA Institute of Medical Biology A*STAR Singapore

Most type 1 diabetic patients rely on daily insulin injections,yet still developing cardiovascular complications. Transplantation of human pancreas or isolated islets may cure the ***,shortage of cadaveric pancreata and requirement of life-long immune suppression are 2 major obstacles in transplantation therapy of insulin-dependent *** of functional insulin-producing cells from stem cells and immunoisolation by encapsulation may circumvent the *** had generated a dozen of unlimited and glucose-responsive insulin-producing cell lines(*** and ERoSHK) from mouse embryonic stem and progenitor *** of these cells in immune deficient diabetic mice could correct *** allo-transplantation studies were carried out in immune-competent,streptozotocin-induced diabetic ***-producing(MEPI-1) cells derived from mouse embryonic progenitor cells were immunoisolated by encapsulation with alginate and peritoneally transplanted into diabetic *** glucose and insulin levels,and glucose tolerance tests were *** were washed out to determine cell functions and *** was reversed within a few days after transplantation,followed by a period of stable normoglycemic or moderate hypoglycemic levels for 2.5 months before *** reappeared immediately upon washing out of capsules.A second transplantation in relapsed mice corrected hyperglycemia as in the first *** from washed-out capsules remained the capability of glucose-stimulated insulin *** spite of fibrotic overgrowth on the capsules,the permeability of capsules seemed not *** transplantation,the number of viable cells in capsules was increased initially and then decreased to less than the transplanted cell number after 75 *** examinations showed the presence of proliferating cells and a necrotic core in the encapsulated cell clusters beyond 40 *** chang

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 66-71页

作者： João Zallio Coelho Pedro Julião Zallio Coelho Sanchela Raiane Pereira de Oliveira Alex Farias Soares Jacqueline Novais Santana Paulo Ricardo Bacelar Macedo Juliana Silveira de Freitas Danilo Guimarães Nogueira Andrade Mirella Hansen de Almeida Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Physician Joslin Diabetes Center Harvard University Boston USA Visiting Scientist Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes Mellitus is one of the most prevalent diseases in the world. In Brazil, 8.7% of the population between 20 and 79 years of age has diabetes, estimating 11.6 million diabetics. It is commonly associated with other co-morbidities such as hypertension, dyslipidemia and obesity, which put these patients into a high cardiovascular risk profile. This study was performed using the medical records of enrolled population attending a Family Health Unit of Alto do Coqueirinho, Salvador, Northeastern Brazil, consisting of one doctor, one nurse, one dentist, one nursing technician and six community health workers. Medical records and data provided by the system of the Primary Care Information (SIAB), showed total of 2495 patients. Considering the prevalence morbidities in this population, hypertension was present in 9.8% of patients and Type 2 Diabetes in only 3.6%. Since the prevalence of morbidities is the key indicator to the development of public health policies, it seems important a better knowledge on the prevalence rates of diabetes, prediabetes and its co-morbidities of this population. Future plans and projects for health professionals will be based on a consistent medical record.

关键词： Diabetes Prediabetes Comorbidities Family Health Unit

全身用药药物对糖尿病性视网膜病变发生和进展的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

糖尿病天地(临床) 2010年第10期04卷 472-480页

作者：保罗庄稼英 joslin糖尿病中心Beetham眼科研究所

糖尿病性视网膜病变(diabetic retinopathy,DR)仍然是全球首要的致盲性眼病。糖尿病患者通常需要各种药物治疗糖尿病合并症。旨在控制血糖和其合并症的全身用药药物(systemic medications),可能对DR的发生和进展产生有利或有害的影响。... 详细信息

糖尿病性视网膜病变(diabetic retinopathy,DR)仍然是全球首要的致盲性眼病。糖尿病患者通常需要各种药物治疗糖尿病合并症。旨在控制血糖和其合并症的全身用药药物(systemic medications),可能对DR的发生和进展产生有利或有害的影响。此外,积累的数据建议,主要针对DR的眼部并发症的全身用药,可能是一个有效果的治疗方法。本文回顾了目前糖尿病患者治疗全身性疾病的常用药物以及其对眼部的影响,此类药物直接用于控制高血糖、高血脂、高血压、心脏病、贫血、炎症和癌症。现有的临床证据证明,在预防或延缓DR发病早期,血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体拮抗剂(ARB)最有效。在一个更有限的范围内,有证据证明贝特类治疗糖尿病性黄斑水肿(diabetic macular edema,DME)有效。其他大量的替代药物有相当大的效果或潜在的风险。因此,在提供确切的治疗护理建议前,这些化合物必须经过进一步严格的研究,以确定实际的临床疗效和不良影响。

关键词：糖尿病患者全身用药糖尿病性视网膜病变药物糖尿病性黄斑水肿血管并发症噻唑烷二酮 DR 糖尿病代谢病糖尿病视网膜病变二甲双胍

来源：博看期刊

非散瞳数字图像替代以前证实无或轻度糖尿病性视网膜病变患者每年1次的视网膜检查

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2006年第2期 20-20页

作者： Cavallerano J.D Aiello L.P Cavallerano A.A. L.M. Aiello 王永强 Beetha m Eye Institute Joslin Diabetes Center One Joslin Place Boston MA 02215 Uni ted States Dr.

PURPOSE: To prospectively evaluate the joslin Vision Network (JVN) for follow-up annual retinal examination for level of diabetic retinopathy (DR). DESIGN: Prospective cohort study. METHODS: Fifty-two patients with no or mild nonproliferative DR (Early Treatment diabetic Retinopathy Study [ETDRS] level ≤ 35) and no diabetic macular edema (DME) at dilated retinal examination 11 or more months earlier were imaged. Patients then had dilated retinal examination and color 35- mm seven standard field stereoscopic photography (ETDRS photographs) and completed a satisfaction survey. Level of DR determined from JVN images, clinical examination, and ETDRS photographs was compared. RESULTS: Two (1.9% ) eyes had JVN images ungradable for level of DR. In the 102 gradable eyes (98.1% ), JVN diagnosis exactly matched clinical examination for level of DR in 82 eyes (77.9% ) and was within one level of DR in all eyes (100% ). Three eyes (2.9% ) had JVN images ungradable for DME; one of these eyes had DME by clinical examination. JVN diagnosis matched clinical examination for DME in all eyes (101) gradable by JVN. Fifty patients (96.1% ) reported JVN imaging improved their understanding of eye disease, 100% were satisfied with JVN, and forty-eight (92.3% ) would consider replacing dilated examination by their eye doctor with JVN imaging. CONCLUSIONS: JVN digital imaging closely matched clinical examination for level of DR and DME, would have resulted in no patients receiving less stringent follow-up, and was well accepted by patients. JVN digital imaging may be a suitable alternative for annual dilated retinal examination for determining level of DR or DME and appropriate follow-up comprehensive ophthalmic examination.

关键词：视网膜 DR 糖尿病性视网膜病变散瞳患者数字图像

高血糖对血管细胞内信息传导的影响——糖尿病血管并发症发病机制的探讨

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华内分泌代谢杂志 1996年第4期12卷 222-225页

作者：夏朴 GeorgeL.King 北京协和医院内分泌科 100730 国哈佛医学院joslin糖尿病中心

作者观察了高血糖对大、小血管细胞内信息传导约影响。结果表明血管细胞暴露在高糖环境下,细胞内二酰基甘油(DAG)合成明显增加,DAG含量升高,进而激活了蛋白激酶C(PKC)。因此,高血糖可以使细胞内DAG-PKC传导通路处于活化状态,从而影响血... 详细信息

作者观察了高血糖对大、小血管细胞内信息传导约影响。结果表明血管细胞暴露在高糖环境下,细胞内二酰基甘油(DAG)合成明显增加,DAG含量升高,进而激活了蛋白激酶C(PKC)。因此,高血糖可以使细胞内DAG-PKC传导通路处于活化状态,从而影响血管的一系列生理功能。这可能是糖尿病血管并发症发生的一个重要机制。

关键词：高血糖并发症糖尿病血管疾病病理学

维普期刊数据库

Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

在线全文

学校读者我要写书评

暂无评论

四川生理科学杂志 2021年第11期43卷 1988-1988页

作者： Charles C Wykoff Retina Consultants of Texas Retina Consultants of America Blanton Eye Institute Houston Methodist Hospital Houston TX USA Genentech South San Francisco CA USA Roche Products (Ireland) Dublin Ireland Retina Vitreous Associates of Florida St Petersburg FL USA Morsani College of Medicine University of South Florida Tampa FL USA Tel Aviv Medical center and Tel Aviv University Tel Aviv Israel Royal Liverpool University Hospital Liverpool UK Department of Ophthalmology Kagoshima University Kagoshima Japan Organización Médica de Investigación Buenos Aires Argentina Roche Products Welwyn Garden City UK joslin Diabetes center Beetham Eye Institute Harvard Department of Ophthalmology Boston MA USA Palmetto Retina center Retina Consultants of America Columbia SC USA Université de Paris AP-HP Lariboisière Saint Louis Paris France Fondation Adolphe de Rothschild Hospitals Paris France

Background:To reduce treatment burden and optimise patient outcomes in diabetic macular oedema,we present 1-year results from two phase 3 trials of faricimab,a novel angiopoietin-2 and vascular endothelial growth factor-A bispecific ***:YOSEMITE and RHINE were randomised,double-masked,non-inferiority trials across 353 sites *** with vision loss due to centre-involving diabetic macular oedema were randomly assigned(1:1:1)to intravitreal faricimab 6.0 mg every 8 weeks,faricimab 6.0 mg per personalised treatment interval(PTI),or aflibercept 2.0 mg every 8 weeks up to week *** dosing intervals were extended,maintained,or reduced(every 4 weeks up to every 16 weeks)based on disease activity at active dosing *** primary endpoint was mean change in best-corrected visual acuity at 1 year.

关键词： edema random durability