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How a Cancer Registry Was Set Up in Senegal: An Example to Follow for a Developing Country

Journal of Cancer Therapy 2023年第9期14卷 382-389页

作者： Salif Baldé Sokhna Diop Niang Oumar Ba Mamadou Diop joliot curie institute Aristide Le Dantec Hospital Dakar Senegal Departmentof Internal Medicine Dalal Jamm Hospital Dakar Senegal Department of Internal Medicine Idrissa Pouye Hospital Dakar Senegal

Objectives: Senegal, with the support of WHO, had begun the establishment of a National Cancer Registry in 2009, although it had been at a standstill since 1969;the objective of this work was to test the reliability of data collection tools and feasibility stages necessary for the validation of media before the establishment of a national cancer registry. Methodology: We conducted a non-exhaustive preliminary study over a period of three months from the first of January to 31 March 2010 at four major hospitals in Dakar at the time. Results: Two hundred and eighty-nine cases had been identified: 44% of men (n = 127) and 56% of women (n = 162) with a sex ratio of 0.8. The ages ranged from 20 to 90 years with an average of 50 years. The main diagnostic mode was essentially histological, with 76% of cases (n = 219). The most frequent locations were: ORL (ENT meaning Ear, Nose and Throat) with 25% of cases, liver 7% and bronchopulmonary 4.5% of cases. In men, liver cancer was the most common location and women for cervical cancer with 16%. Squamous cell carcinoma was the most common histological type with 68% of cases followed by adenocarcinoma with 22% of cases. Thirty-eight percent of patients were classified as stage III and IV. A quarter of our patients had received palliative treatment. In contrast, 15 (15%) had received chemotherapy and 4% had received radiotherapy. Data collection was satisfactory. Conclusion: Cancer is a reality in Senegal but it remains underdiagnosed. The materials made it possible to make the cancer registry effective throughout the country.

关键词： Registry Cancer Senegal

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Establishment of Local Diagnostic Reference levels in Conventional Radiography: A Pilot Study in Dakar, Senegal

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World Journal of Nuclear Science and Technology 2022年第1期12卷 28-42页

作者： Adji Yaram Diop Magatte Diagne Ndeye Arame Boye Faye Mamadou Moustapha Dieng Cheikh Anta Diop University of Dakar Dakar Senegal aristide le dantec hospital Joliot Curie Institute of Cancer Dakar Senegal Nuclear Radiation Protection and Safety Authority Dakar Senegal

Diagnostic Reference levels (DRLs) are indicators that allow assessing the quality of equipment and procedures from the point of view of the doses delivered to patients and subsequently initiate corrective actions if necessary. The purpose of this study is to encourage health professionals to investigate patient radiation doses and to determine whether those doses comply with the principles of radiation protection in medical fields so as to improve practices by reducing patient exposure without reducing clinical effectiveness. To perform this work, we have investigated patient doses for different radiological examinations from six (6) medical centers in Dakar, including the following nine routine types: chest (PA), abdomen (AP), pelvis (AP), cervical spine (AP), lumbar spine (AP, Lat), hip (AP), thoracic spine (AP, Lat). Three types of data were collected, i.e., X-ray tube machine data, patient data and output measurements. The data were analyzed statistically and the median, minimum, maximum, and third quartile values were calculated and displayed throughout boxplots graphs for all exams and medical centers. The two sigma range (95% confidence interval) was also checked. Comparison of third quartiles of Entrance Surface Dose (ESD) and Dose Area Product (DAP) by type of examination with recommended international DRLs was performed. The third quartile of ESD for pelvis (AP) and thoracic spine (AP) was up to 16% and 38% higher, respectively than their corresponding DRLs in the European Commission Report RP 180 Part 2. For all exams, except thoracic spine (lat), the third quartiles of the dose area product were higher than the corresponding DRLs in the above report. The source of dose variability between medical centers was related to many parameters such as poor radiographic techniques, lack of modern X-ray machines and adequately documented radiation protection practices. The results show the need to develop protocols for dose measurement as well as to carry

关键词： Entrance Surface Dose Diagnostic Radiology Dose Area Product Optimization X-Rays

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Profile of Plasma Galectin-3 Concentrations, Inflammatory Cytokines levels and Lymphocytes Status in Breast Cancer under Chemotherapy

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Open Journal of Immunology 2022年第1期12卷 1-14页

作者： Doudou Georges Massar Niang Sidy Ka Jacobus Hendricks Doudou Diouf Folly Mawulolo Gaba Adame Diouf Maimouna Diop Moustapha Mbow Babacar Faye Rokhaya Ndiaye Diallo Maguette Deme Sylla Niang Ahmadou Deme Babacar Mbengue Alioune Dieye Unit of Immunology FMPOS Cheikh Anta Diop University Dakar Senegal Unit of Immunology Aristide Le Dantec Hospital Dakar Senegal joliot curie institute Aristide Le Dantec Hospital Dakar Senegal Department of Physiology University of Limpopo Limpopo South Africa Unit of Human Genetics FMPOS Cheikh Anta Diop University Dakar Senegal

We investigated relationship between galectin-3 (Gal-3) levels and T lymphocytes apoptosis and the activation rates in breast cancer during chemotherapy. We used plasma samples from 112 women classified into two groups: 70 women with breast cancer (BC) and submitted to neoadjuvant chemotherapy (3 cycles) and 42 healthy women used as controls. In the group of BC, blood samples were taken before each cycle of chemotherapy and Gal-3 levels was evaluated by ELISA sandwich. Flow cytometry was used to study T cells apoptosis and activation. Before treatment, median value of Gal-3 was 6.31 ng/ml (range 1.07 - 50.74) in BC and 0.84 ng/ml (range 0.00 - 4.82) in HC. Gal-3 levels were highest in plasmas from BC (p p p = 0.010). In addition, we found a dynamic relationship between gal-3 levels, tumor size and T lymphocytes apoptosis rates during treatment depending to the cure efficiency. We suggest gal-3 plasma concentrations could be used as predictive biomarker for chemotherapy efficiency in breast cancer patients.

关键词： Galectin-3 T Lymphocyte B Lymphocyte Breast Neoplasms

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Curative 3D Conformal Radiotherapy of Non-Operated Prostate Adenocarcinoma at Pointe-a-Pitre University hospital (Guadeloupe): About 29 Cases

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Journal of Cancer Therapy 2021年第5期12卷 279-288页

作者： Ibrahima Thiam Kanta Ka Awa Sadikh Badiane Mouhamadou Bachir Bâ El Hadj Amadou Sall Boucar Ndong Papa Ahmet Fall Mamadou Moustapha Dieng Papa Macoumba Gaye joliot curie institute of aristide le dantec hospital Dakar Senegal Radiotherapy Department of the University hospital Center of Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University Dakar Senegal Urology Department of the University hospital Center of Dalal Jamm Guédiawaye Senegal

Context: Technological advances have improved the toxicities of radiotherapy. We are evaluating the 3D technique in prostate cancer. Materials and Methods: Retrospective study from January 2015 to December 2015 with 29 files. Survival was calculated by Kaplan-Meier method. Results: We collected 29 patient records over the study period. The median age was 75 years with the following extremes: 54 years and 83 years. The median PSA level was 12 ng/ml with a range of 3.05 to 79 ng/ml. Gleason score analysis showed 6 patients (20.69%) with a score of 6 (3 + 3), 23 patients (79.31%) with a score of 7 including 12 patients (41.38%) with grade 3 and 11 patients (37.93%) with grade 4. The median dose delivered was 74 Gy, with a mean dose of 73.79 Gy and extremes of 70 Gy for the minimum and 76 Gy for the maximum. Hormone therapy was combined with radiotherapy in 17 patients (58.62%). Seven patients (24.14%) had grade 1 acute bladder toxicity and one patient (3.45%) had grade 2 acute toxicity. Late bladder toxicity was grade 1 in 5 patients (17.24%), grade 2 in 3 patients (10.34%) and grade 3 in 1 patient (3.45%). Late rectal toxicity, grade 2 in 3 patients (10.34%), grade 3 in 1 patient, was noted. Overall survival at 2 years was 100% and 89.65% at 5 years. Relapse-free survival at 2 years was 82.76% and 62.07% at 5 years. There were 3 deaths (10.34%) of which only one was related to prostate cancer. le="font-family:Verdan

关键词： Prostate Cancer 3D Conformal Radiotherapy Survival

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Peripheral Blood Cytokines levels in Senegalese Women with Cervical Cancer during Chemotherapy

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Open Journal of Immunology 2022年第4期12卷 86-97页

作者： Diop Maimouna Folly Mawulolo Gaba Doudou Georges Massar Niang Doudou Diouf Sidy Ka Moustapha Mbow Rokhaya Ndiaye Diallo Maguette Sylla Niang Mbacké Sembene Ahmadou Dem Babacar Mbengue Alioune Dieye Immunology Unit FMPOS University Cheikh Anta Diop Dakar Senegal joliot curie institute Aristide Le Dantec Hospital Dakar Senegal Unit of Human Genetics FMPOS University Cheikh Anta Diop Dakar Senegal Department of biology FST University Cheikh Anta Diop Dakar Senegal

Cervical cancer is the leading cause of cancer deaths of women in developing world. Several studies demonstrated evidences of inflammatory cytokines implication in cancer progression including in initiation, promotion and invasion by affecting the immune surveillance. Our aim was to measure blood circulating pro- and anti-inflammatory cytokines levels, their profiles according to treatment issue and relation with prognostic factors in cervical cancer during chemotherapy. Blood samples were collected from a cohort of 35 cervical cancer women and 42 women healthy controls (HC) with no history of malignancy. For each CP, three samples were taken at three-week intervals. The first one (S1) was taken before initiation of the chemotherapy protocol. S2 and S3 were samples collected respectively at day 21 and day 42. Cytokines levels were evaluated by ELISA. Mean age of patients was 54.1 year (35 - 77 yo). In groups, no relation was observed between age and cytokines levels. Before chemotherapy, high levels of IL-6, IL-4 and IFN-γ were observed in CP compared to HC (p 0.001) and at the same period, IL-10 and TNF-α levels were significantly low in CP (p 0.05) and negatively correlated (r = —0.79;p = 0.017). In this CP group, IL-4 levels were positively correlated between S1 and S2 (r = 0.72;p = 0.002) and between S1 and S3 (r = 0.74;p = 0.019). Similar correlations were observed for TNF-α levels: S1/S2 (r = 0.54;p = 0.027), S2/S3 (r = 0.82;p = 0.009) and S1/S3 (r = 0.66;p = 0.036) with a significant increase of TNF-α in blood during treatment. Depending on chemotherapy’s efficacy, CP patients were separated into 1) non responders (NR), 2) partial responders (PR) and 3) good responders (GR). Compared to PR and GR groups, NR patients showed: a) higher serum levels of IL-6, IL-10 and IFN-γ during the follow-up and b) lower serum levels of IL-4 and TNF-α. In addition, serum levels of IL-4 were significantly higher in GR patients however TNF-α was the predominant cytokines in PR

关键词： Cervical Cancer Chemotherapy Cytokines Biomarkers

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Management of Phylloid Sarcomas: A Retrospective Study of 12 Cases

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Advances in Breast Cancer Research 2021年第2期10卷 25-33页

作者： Kanta Ka Abdoul Halim Bague Ibrahim Mounkeila Mamadou Lassana Foba N. Zongo Davide Soldato Filippo Dall’Olio Mamadou Moustapha Dieng Papa Macoumba Gaye Daniele Presti Radiotherapy Department Centre Hospitalier National Universitaire Dalal Jamm de Guédiawaye Guédiawaye Senegal School of Cancer Sciences Paris Sud Orsay French Unité D’oncologie Chirurgicale CHU Yalgado Ouedraogo Ouagadougou Burkina Faso Servie d’Oncologie Institut joliot curie Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal Department of Plastic Surgery Aristide Le Dantec University Hospital Dakar Senegal University Cheikh Anta Diop of Dakar Dakar Senegal Medical Oncology Service ICS Maugeri IRCCS SpA University of Pavia Pavia Italy

Background: Phylloid sarcomas are rare. There is not enough data to codify the management. Objectives: The objective was to study the clinical and therapeutic aspects and the fate of patients after a follow-up of at least 4 years. Thus contributing to the limited body of knowledge on these tumors. Methods: a retrospective analysis of the files from 2013 to 2017 was carried out and patients were followed up until 2021at Hassan II Hospital. Epidemiological, clinical and therapeutic aspects were studied. Survival was calculated using the Kaplan-Meier method. Results:le="font-family:Verdana;"> We collected 12 charts of patients treated for phyllodeal sarcoma from 2013 to 2017. The median age was 43 years. The circumstance of discovery was marked by the presence of nodule in all patients. The coupled echo-mammography examination classified the nodules, ACR 4 in 7 patients and ACR 3 in 3 and ACR 5 in 2 patients. Histological examination revealed a phylloid sarcoma in 11 patients and a borderline phylloid tumor in 1 patient. All patients had radical surgery with positive margins in 2 patients, 16.66%. One patient had revision surgery. Histological examination of the surgical specimens showed phylloid sarcoma on all specimens. All patients had adjuvant radiotherapy with doses of 50 Gy in 25 fractions of 2 Gy and a boost of 10 Gy was done in one patient. The median spread of radiotherapy was 37 days. Grade 1 and 2 skin toxicities were noted in 5 and 3 patients respectively. The median time from surgery to radiotherapy was 2.95 months. 3 patients relapsed after 13.6 months of follow-up. The recurrence-free survival at 1 and 3 years was 83% and

关键词： Phylloid Sarcoma Radiotherapy Survival

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