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Anticancer activity of crude acetone and water extracts of Tulbaghia violacea on human oral cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 456-462页

作者： Samkeliso Takaidza Arumugam Madan Kumar Cornelius Cano Ssemakalu Nagabishek Sirpu Natesh Gayathri Karanam Michael Pillay Department of Biotechnology Vaal University of Technology Cancer Biology Lab Molecular and Nanomedicine Research Unit Sathyabama Institute of Science and Technology

Objective: To evaluate the anticancer activity of crude acetone and water leaf extracts of Tulbaghia violacea on a human oral cancer cell line(KB).Methods: The antioxidant activity of the leaf extracts was evaluated by using the DPPH assay while the anti-proliferative activity was assessed by using the MTT *** morphological characteristics of apoptotic cells were examined by using the dual acridine orange/ethidium bromide *** cytometry was used to evaluate the induction of multi-caspase activity and changes in the cell ***: The acetone and water extracts exhibited antioxidant activity in a concentration dependent *** extracts inhibited the growth of the KB cell line with IC_(50) values of 0.2 mg/mL and 1 mg/mL, respectively for acetone and *** changes such as cell shrinkage, rounding and formation of membrane blebs were observed in the treated *** acridine orange/ethidium bromide staining, the number of apoptotic cells increased as the concentration of the extracts *** activation of multi-caspase activity in KB cells treated with Tulbaghia violacea extracts was concentration dependent, leading to cell death by apoptosis and cell cycle arrest at the G_2/M ***: The acetone and water extracts of Tulbaghia violacea appear to have anti-cancer activity against human oral cancer cells and need to be investigated further.

关键词： Anticancer activity Antioxidant Apoptosis Caspase Cell cycle Tulbaghia

MoS_(2) nanoflowers and PEDOT:PSS nanocomposite enabling wearable dual-mode pressure sensors

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Science China(Technological Sciences) 2024年第6期67卷 1737-1747页

作者： WANG FengMing YANG WeiJia MA Ke SHEN GengZhe SU DaoJian LI BaiJun WANG ShuangPeng QIN BoLong ZHANG Chi XIN Yue CAO XiaoBing HE Xin School of Applied Physics and Materials Wuyi UniversityJiangmen529020China Biomaterials R&D Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai519003China joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacao999078China

A versatile sensing platform employing inorganic MoS_(2) nanoflowers and organic poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)has been investigated to develop the resistive and capacitive force-sensitive *** microstructure of the sensing layer heightens the sensitivity and response time of the dual-mode pressure sensors by augmenting electron pathways and inner stress in response to mechanical ***,the capacitive and resistive sensors exhibit sensitivities of 0.37 and 0.12 kPa^(-1),respectively,while demonstrating a remarkable response time of approximately 100 ***,it is noteworthy that the PEDOT:PSS layer exhibits excellent adhesion to polydimethylsiloxane(PDMS)substrates,which contributes to the development of highly robust force-sensitive sensors capable of enduring more than 10000loading/unloading *** combination of MoS_(2)/PEDOT:PSS layers in these dual-mode sensors has shown promising results in detecting human joint movements and subtle physiological ***,the sensors have achieved a remarkable precision rate of 98%in identifying target *** outcomes underscore the significant potential of these sensors for integration into applications such as electronic skin and human-machine interaction.

关键词： MoS_(2)/PEDOT:PSS nanocomposite force-sensitive sensor multi-scaled microstructure physiological signals monitoring object grasping recognition

A wide-linear-range and low-hysteresis resistive strain sensor made of double-threaded conductive yarn for human movement detection

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Journal of Materials Science & Technology 2024年第5期172卷 202-212页

作者： Fei Huang Jiyong Hu Xiong Yan Shanghai Frontier Science research Center for Modern Textiles Donghua UniversityShanghai 201620China

Yarn-based flexible strain sensors with advantages in wearability and integrability have attracted wide ***,it is still a big challenge to achieve yarn-based strain sensors with a wide linear strain range,low hysteresis,and durability synchronously that can be used for full range detection of human body ***,a new structure,double-threaded conductive yarn with rhythmic strain distribu-tion,is reported to markedly widen the linear strain range of microcrack-based stretchable strain sensors.A new method of winding and thermally adhering hot-melt filaments on the surface of the elastic fiber is used to achieve double-threaded yarn(DTY)with rhythmic strain *** proposed strategy,the integration of heterogeneous materials,is reported to significantly reduce the mechanical hysteresis of composite *** strain distribution of the DTY during stretching causes multi-level micro-cracks in different regions of the carbon nanotube(CNT)conductive layer deposited on the surface of the ***,the sensing performance of DTY-based strain sensor can be adjusted by designing the structural *** final prepared flexible strain sensor has the advantages of a wide linear strain range(100%),great sensitivity(GF=12.43),low hysteresis,rapid response(158 ms),high repeatability(>2000 cycles at 50%strain),and hydrophobicity,*** sensor can monitor human motion repeatedly and stably well,and shows great advantages in flexible wearable devices.

关键词： Double-threaded yarn Strain redistribution Hysteresis Human motion monitoring

Digital Earth from vision to practice:making sense of citizen-generated content

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International Journal of Digital Earth 2012年第5期5卷 398-416页

作者： M.Craglia F.Ostermann L.Spinsanti Digital earth and reference data unit european commission joint research centreispraitaly

The vision of Digital Earth(DE)put recently forward under the auspices of the International Society for DE extends the paradigm of spatial data infrastructures by advocating an interactive and dynamic framework based on near-to-real time information from sensors and *** paper contributes to developing that vision and reports the results of a two-year research project exploring the extent to which it is possible to extract information useful for policy and science from the large volumes of messages and photos being posted daily through social *** the noted concerns about the quality of such data in relation to that provided by authoritative sources,the research has developed a semi-automatic workflow to assess the fitness for purpose of data extracted from Twitter and Flickr,and compared them to that coming from official sources,using forest fires as a case *** findings indicate that we were able to detect accurately six of eight major fires in France in the summer of 2011,with another four detected by the social networks but not reported by our official source,the European Forest Fire Information *** findings and the lessons learned in handling the very large volumes of unstructured data in multiple languages discussed in this study provide useful insights into the value of social network data for policy and science,and contribute to advancing the vision of DE.

关键词： Digital Earth social networks volunteered geographic information data quality

Portable fluorogenic probe for monitoring of volatile amine vapour and food spoilage

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Chinese Chemical Letters 2024年第3期35卷 257-261页

作者： Jian-Hao Zhao Wen-Xing Xu Bin Li Wei Xu Wu-Kun Zhang Ming-Shuai Yuan Hui-Zi Li Qing-Guo He Xiang Ma Jian-Gong Cheng Yan-Yan Fu State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of the Chinese Academy of SciencesBeijing 100039China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist joint research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

There are urgent needs of volatile amine gas sensors with high-performance in food quality control,disease monitoring and environmental ***-film fluorescent probe is suitable for amine vapour sensing due to its high sensitivity,high selectivity,and no polluting ***,a novel fluorescent probe based on indacenodithiophene structure withπconjugated system was designed and *** experimental results show that the films prepared by this material exhibit rapid and distinct fluorescence quenching after being exposed to saturated vapours of primary amine,secondary amine and tertiary amine represented by n-propylamine,diethylamine and trimethylamine,*** quenching of fluorescence is 84%,87%and 96%,respectively,within 10 *** detection mechanism of probe for primary amine is based on specific chemical reaction,while the detection mechanism for secondary amine and tertiary amine is intramolecular charge *** experiments show that the detection limit of the fluorescent probe for trimethylamine,an important marker of food spoilage,could reach 4.610 ***-site detection based on spoilage of small yellow croaker suggests the material possesses the potential for food freshness *** simple fluorogenic probe is an original approach to simplify real-time visual monitoring of volatile amine vapour.

关键词： Fluorescent probe Volatile amine Gas sensing Trimethylamine Food spoilage

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

Oxygen‑Coordinated Single Mn Sites for Efficient Electrocatalytic Nitrate Reduction to Ammonia

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Nano-Micro Letters 2024年第1期16卷 147-159页

作者： Shengbo Zhang Yuankang Zha Yixing Ye Ke Li Yue Lin Lirong Zheng Guozhong Wang Yunxia Zhang Huajie Yin Tongfei Shi Haimin Zhang Laboratory of Materials Physics Centre for Environmental and Energy NanomaterialsAnhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China Key Laboratory of Agricultural sensors Ministry of AgricultureSchool of Information and ComputerAnhui Agricultural UniversityHefei 230026People’s Republic of China Hefei National research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026People’s Republic of China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing 100049People’s Republic of China

Electrocatalytic nitrate reduction reaction has attracted increasing attention due to its goal of low carbon emission and environmental ***,we report an efficient NitRR catalyst composed of single Mn sites with atomically dispersed oxygen(O)coordination on bacterial cellulose-converted graphitic carbon(Mn-O-C).Evidence of the atomically dispersed Mn-(O-C_(2))_(4)moieties embedding in the exposed basal plane of carbon surface is confirmed by X-ray absorption *** a result,the as-synthesized Mn-O-C catalyst exhibits superior NitRR activity with an NH_(3)yield rate(RNH_(3))of 1476.9±62.6μg h^(−1)cm^(−2)at−0.7 V(*** hydrogen electrode,RHE)and a faradaic efficiency(FE)of 89.0±3.8%at−0.5 V(***)under ambient ***,when evaluated with a practical flow cell,Mn-O-C shows a high RNH_(3)of 3706.7±552.0μg h^(−1)cm^(−2)at a current density of 100 mA cm−2,2.5 times of that in the H *** in situ FT-IR and Raman spectroscopic studies combined with theoretical calculations indicate that the Mn-(O-C_(2))_(4)sites not only effectively inhibit the competitive hydrogen evolution reaction,but also greatly promote the adsorption and activation of nitrate(NO_(3)^(−)),thus boosting both the FE and selectivity of NH_(3)over Mn-(O-C_(2))_(4)sites.

关键词： Atomically dispersed Oxygen coordination Nitrate reduction reaction In situ spectroscopic studies Hydrogen evolution reaction

Self-biased magnetoelectric responses in magnetostrictive/piezoelectric composites with different high-permeability alloys

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Chinese Physics B 2014年第11期23卷 527-531页

作者：鲁彩江李平文玉梅杨爱超杨超王德才何伟张吉涛 research Center of sensors and Instruments College of Optoelectronic EngineeringChongqing University

We comparatively investigate the influence of various high-permeability alloys on the hysteretic and remanent res- onant magnetoelectric （ME） response in a composite of magnetostrictive nickel （Ni） and piezoelectric Pb（Zrl_x, Tix）O3 （PZT）. In order to implement this comparative research, Co-based amorphous alloy （CoSiB）, Fe-based nanocrystalline alloy （FeCuNbSiB） and Fe-based amorphous alloy （FeSiB） are used according to different magnetostriction （2s） and saturation magnetization （μtoMs） characteristics. The bending and longitudinal resonant ME voltage coefficients （αME,b and αME,1） are observed comparatively for CoSiB/Ni/PZT, FeCuNbSiB/Ni/PZT, and FeSiB/Ni/PZT composites. The experimental data indicate that the FeSiB/Ni/PZT composite has the largest remanent self-biased aME,b and aME,1 due to the largest magnetic grading of λs and μ0Ms in the FeSiB/Ni layer. When the number of FeSiB foils is four, the maximum remanent aME,b and aME,I at zero bias magnetic field are 57.8 V/cm·Oe and 107.6 V/cm·Oe, respectively. It is recommended that the high-permeability alloy is supposed to have larger λs and μ0Ms for obtaining a larger remanent self-biased ME responses in ME composite with high-permeability alloy.

关键词： magnetoelectric effect composite materials high-permeability alloy

miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

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Cancer Communications 2022年第12期42卷 1412-1416页

作者： Iris Garrido-Cano Anna Adam-Artigues Ana Lameirinhas Juan F.Blandez Vicente Candela-Noguera Federico Rojo Sandra Zazo Juan Madoz-Gúrpide Ana Lluch Begoña Bermejo Felix Sancenón Juan Miguel Cejalvo Ramón Martínez-Mañez Pilar Eroles Biomedical research Institute INCLIVA Valencia 46010Spain Bioengineering Biomaterials and Nanomedicine Networking Biomedical Research Centre(CIBER-BBN)Madrid 28029Spain Interuniversity research Institute for Molecular Recognition and Technological Development(IDM) Polytechnic University of ValenciaUniversity of ValenciaValencia 46010Spain joint unit CIPF-UPV of Mechanisms of Diseases and nanomedicine ValenciaPolytechnic University of ValenciaPrince Felipe Research CenterValencia 46012Spain joint research unit in nanomedicine and sensors Polytechnic University of ValenciaMedical Research Institute Hospital La FeValencia 46026Spain Biomedical research Networking Center in Oncology(CIBERONC) Madrid 28029Spain Department of Pathology Fundación Jiménez Díaz University Hospital Health Research InstituteMadrid 28040Spain Department of Clinical Oncology University Clinical Hospital of ValenciaValencia 46010Spain Department of Medicine University of ValenciaValencia 46010Spain Department of Physiology University of ValenciaValencia 46010Spain

Dear Editor,Breast cancer(BC)is the most commonly diagnosed cancer and the fifth cause of cancer-related death worldwide[1].Despite the advances in BC targeted therapies,cytotoxic chemotherapy is still widely used[2].However,around 20%-30%of BC patients develop metastasis after treatment as a consequence of drug resistance[3].In this context,microRNAs have emerged as potential therapeutic targets to overcome therapy resistance[4].Therefore,we aimed to elucidate the molecular mechanisms underlying resistance to doxorubicin,one of the most effective chemotherapeutic agents used in *** are detailed in Supplementary Materials.

关键词： doxorubicin ABCG2 chemotherapy