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Molecular landscapes of human hippocampal immature neurons across lifespan

四川生理科学杂志 2022年第6期44卷 944-944页

作者： Yi Zhou department of Neuroscience and Mahoney Institute for Neurosciences Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of Neuroregeneration Nantong University Nantong China Institute for Regenerative Medicine University of Pennsylvania Philadelphia PA USA department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA The Epigenetics Institute Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Division of Neurosurgery Children’s Hospital of Philadelphia Philadelphia PA USA department of Neurosurgery Perelman School of Medicine University of Pennsylvania Philadelphia PA USA biochemistry and Molecular biophysics Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuroscience Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA department of Pathology and Laboratory Medicine Children’s Hospital of Philadelphia Philadelphia PA USA Division of Neurology Children’s Hospital of Philadelphia Philadelphia PA USA The Epilepsy NeuroGenetics Initiative (ENGIN) Children’s Hospital of Philadelphia Philadelphia PA USA department of Biomedical and Health Informatics (DBHi) Children’s Hospital of Philadelphia Philadelphia PA USA department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Lieber Institute for Brain Development The Solomon H. Snyder Department of Neuroscience Department of Neurology and Department of Psychiatry School of Medicine Johns Hopkins University Baltimore MD USA department of Pathology Johns Hopkins University School of Medic

Immature dentate granule cells(imGCs)arising from adult hippocampal neurogenesis contribute to plasticity and unique brain functions in rodents1,2 and are dysregulated in multiple human neurological *** is known about... 详细信息

关键词： plasticity Molecular 1,2

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This research was supported by ***6 Integrated Project“Molecular Imaging”LSHG-CT-2003-503259 and ***7 Collaborative Project“FMT-XCT”.*** support from the Marie Curie Program EST-MolecImag Early Stage Training MEST-CT-2004-007643.

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 365-374页

作者： MAHSA RANJI SHOKO NIOKA HE N.XU BAOHUA WU LIN Z.LI DWIGHT L.JAGGARD BRITTON CHANCE Biophotonics Laboratory department of Electrical Engineering and Computer Science university of Wisconsin-Milwaukee MilwaukeeWI 53211USA department of Electrical and Systems Engineering university of pennsylvania PhiladelphiaPA 19104USA department of biochemistry and biophysics university of pennsylvania PhiladelphiaPA 19104USA department of Radiology university of pennsylvania PhiladelphiaPA 19104USA

We have imaged mitochondrial oxidation-reduction states by taking a ratio of mitochondrial fluorophores:NADH(reduced nicotinamide adenine dinucleotide)to Fp(oxidized flavoprotein).Although NADH has been investigated for tissue metabolic state in cancer and in oxygen deprived tissues,it alone is not an adequate measure of mitochondrial metabolic state since the NADH signal is altered by dependence on the number of mitochondria and by blood *** redox ratio,NADH/(Fp+NADH),gives a more accurate measure of steady-state tissue metabolism since it is less dependent on mitochondrial number and it compensates effectively for hemodynamic *** ratio provides important diagnostic information in living *** this study,the emitted fluorescence of mouse colon in situ is passed through an emission filter wheel and imaged on a CCD *** ratio images of the healthy and hypoxic mouse intestines clearly showed significant ***,the corrected redox ratio indicated an increase from an average value of 0.51±0.10 in the healthy state to 0.92±0.03 in dead tissue due to severe ischemia(N=5).We show that the CCD imaging system is capable of displaying the metabolic differences in normal and ischemic tissues as well as quantifying the redox ratio in vivo as a marker of these changes.

关键词： Optical diagnosis NADH flavoprotein in vivo ischemia fluorescence.

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睡眠剥夺中感觉运动皮层和视觉皮层神经活动及警觉水平的改变（英文）

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生物化学与生物物理进展 2020年第2期47卷 139-156页

作者：张岱左真涛饶衡毅范勇中国科学院自动化研究所模式识别国家重点实验室北京100190 中国科学院大学北京100049 中国科学院生物物理研究所脑与认知科学统计重点实验室北京100101 中国科学院大学中丹学院北京100049 中国科学院脑科学与智能技术卓越创新中心上海200031 department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA department of Radiology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

在睡眠剥夺(sleep deprivation,SD)过程中,人类大脑的神经活动和警觉水平如何受到影响,尤其是感觉运动和视觉系统,目前仍是研究的热点.静息状态功能磁共振成像(resting state functional magnetic resonance imaging,rf MRI)作为一种反... 详细信息

在睡眠剥夺(sleep deprivation,SD)过程中,人类大脑的神经活动和警觉水平如何受到影响,尤其是感觉运动和视觉系统,目前仍是研究的热点.静息状态功能磁共振成像(resting state functional magnetic resonance imaging,rf MRI)作为一种反映人脑自发活动的非侵入式成像技术,在睡眠剥夺的研究中得到了广泛应用.本研究采用9次重复rf MRI和心理运动警觉任务(psychomotor vigilance task,PVT),以探索23名志愿者在整个36 h的睡眠剥夺过程中神经活动和警觉水平的变化.采用基于PVT的平均反应时间(mean reaction time,MRT)和失效率(lapses ratio,LR)评估警觉水平的变化;采用基于rf MRI的区域同质性(region homogeneity,Re Ho)和低频波动幅度(amplitude of low frequency fluctuation,ALFF)评估大脑神经活动变化.结果表明,感觉运动网络(sensorimotor network,SMN)和视觉区域(visual network,VN)是受到睡眠剥夺影响最严重的区域.我们采用组独立成分分析(group independent component analysis,GICA)将视觉相关区域划分为视觉Ⅰ区、视觉Ⅱ区、视觉关联区,并从解剖自动标记(anatomical automatic labeling,AAL)模板中提取运动感觉相关区域,包括中央前/中央后回、中央旁小叶和辅助运动区.研究发现,睡眠剥夺后16~30 h脑神经活动及警惕性下降.采用2×3重复测量方差分析,探讨睡眠压力、昼夜节律及其交互作用对感觉运动相关和视觉相关脑区神经活动的影响.观察到睡眠压力与交互作用对感觉运动相关区域和视觉相关区域有显著影响.采用皮尔逊相关系数评估警觉水平变化与感觉运动相关和视觉相关脑区神经活动变化的关系.睡眠剥夺期间所有感觉运动相关区域的神经活动变化与警觉变化均存在显著的相关关系.研究结果证实,睡眠剥夺从第一天24:00开始改变SMN和VN的警戒水平和神经活动,睡眠压力和昼夜节律在睡眠剥夺期间调节SMN和VN的神经活动.此外,昼夜节律的效应受到睡眠压力的显著调节.感觉运动相关区域和视觉相关区域的增强导致他们远程连接的减弱,这可能是睡眠剥夺期间响应时间变慢的原因.

关键词：静息态功能磁共振成像睡眠剥夺感觉运动皮层视觉皮层大脑神经活动

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

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四川生理科学杂志 2020年第4期42卷 480-480页

作者： Carol C L Chen department of Human Genetics McGill University Montreal QC H3A 0C7 Canada Canadian Centre for Computational Genomics McGill University Montreal QC H3A 0E9 Canada Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Boston MA 02215 USA department of Pathology Montreal Children’s Hospital McGill University Health Centre Montreal QC H4A 3J1 Canada UCL Queen Square Institute of Neurology London WC1N 3BG UK department of Pediatrics McGill University and The Research Institute of the McGill University Health Centre Montreal QC H4A 3J1 Canada Samantha Dickson Brain Cancer Unit University College London Cancer Institute London United Kingdom Second department of Paediatrics Semmelweis University Budapest 1094 Hungary department of Neurosurgery University of Debrecen Debrecen 4032 Hungary department of Paediatric Haematology and Oncology Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic department of Pathology and Molecular Medicine Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic Children’s Cancer Center The Royal Children’s Hospital Murdoch Children’s research Institute department of Pediatrics University of Melbourne Parkville VIC 3052 Australia Kids Cancer Centre Sydney Children’s Hospital Randwick NSW 2031 Australia department of Pathology Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada department of Pediatric Oncology Dana-Farber Boston Children’s Cancer and Blood Disorders Center Boston MA 02215 USA School of Computer Science McGill University Montreal QC H3A 2A7 Canada and Murdoch Children’s research Institute Parkville VIC 3052 Australia department of biochemistry McGill University Montreal QC H3A 1A3 Canada department of Pediatric Neurosurgery Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada department of biochemistry and

Histone H3.3 glycine 34 to arginine/valine(G34R/V)mutations drive deadly gliomas and show exquisite regional and temporal specificity,suggesting a developmental context permissive to their *** we show that 50%of G34R/V tumors(n=95)bear activating PDGFRA mutations that display strong selection pressure at *** considered gliomas,G34R/V tumors actually arise in GSX2/DLX-expressing interneuron progenitors,where G34R/V mutations impair neuronal *** lineage of origin may facilitate PDGFRA co-option through a chromatin loop connecting PDGFRA to GSX2 regulatory elements,promoting PDGFRA overexpression and *** the single-cell level,G34R/V tumors harbor dual neuronal/astroglial identity and lack oligodendroglial programs,actively repressed by GSX2/DLX-mediated cell fate specification.G34R/V may become dispensable for tumor maintenance,whereas mutant-PDGFRA is potently ***,our results open novel research avenues in deadly tumors.G34R/V gliomas are neuronal malignancies where interneuron progenitors are stalled in differentiation by G34R/V mutations and malignant gliogenesis is promoted by co-option of a potentially targetable pathway,PDGFRA signaling.

关键词： PDGFRA specificity connecting

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