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人绒毛膜促性腺激素可能提高排卵机能障碍妇女接受枸橼酸氯米芬促排卵行宫腔内人工受精的妊娠率

世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 20-20页

作者： Vlahos N.F. Coker L. Lawler C. 朱国栋 johns hopkins medical i nstitutions 600 N. Wolfe Street/Phipps 249 Baltimore MD 21287 United States Dr.

Objective: To investigate factors that may affect pregnancy outcome following ovarian stimulation with clomiphene citrate (CC) combined with intrauterine inse mination (iUi). Design: Retrospective cohort study. Setting: University teaching hospital. Patient(s): Three hundred and twenty women who underwent 691 ovarian stimulation cycles with CC for iUi. intervention(s): Ovarian stimulation with CC followed by a single iUi either 24 hours after a spontaneous serum LH surge (>2 5 miU/mL) or 36 hours after intramuscular human chorionic gonadotropin (hCG) adm inistration (10,000 iU) when the largest follicle had reached a diameter of 17 m m. Main Outcome Measure(s): Clinical pregnancies. Result(s): Women with ovulator y dysfunction who received hCG had significantly higher pregnancy rates (24.6%) compared with women with other types of infertility. There were no differences in pregnancy rates between the LH surge group and the hCG group (14.3%vs 12.4% ). A spontaneous LH surge was noted in a variety of follicular sizes (14 to 35 m m). There was no correlation for age, body mass index, follicular diameter, numb er of mature follicles, other sperm characteristics, and pregnancy outcome in ei ther group. Conclusion(s): After ovarian stimulation with CC, iUi is equally eff ective 24 hours after a spontaneous LH surge or 36 hours after administration of hCG. Spontaneous LH surges were observed at a variety of follicular sizes with comparable pregnancy rates. in women with ovulatory dysfunction, hCG administrat ion before insemination may be beneficial.

关键词：枸橼酸氯米芬人工受精促排卵机能障碍卵泡数目黄体生成素大学教学医院妊娠结局肌内注射回顾性队列研究

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