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Car-following strategy of intelligent connected vehicle using extended disturbance observer adjusted by reinforcement learning

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 365-373页

作者： Ruidong Yan Penghui Li Hongbo Gao Jin Huang Chengbo Wang school of Traffic and Transportation The Beijing Jiaotong UniversityBeijingChina Department of Automation School of Information Science and TechnologyUniversity of Science and Technology of ChinaHefeiChina school of Vehicle and Mobility The Tsinghua UniversityBeijingChina Liverpool Logistics Offshore and Marine Research Institute(LOOM)Liverpool John Moores UniversityLiverpoolUK

Disturbance observer-based control method has achieved good results in the carfollowing scenario of intelligent and connected vehicle(ICV).However,the gain of conventional extended disturbance observer(EDO)-based control method is usually set manually rather than adjusted adaptively according to real time traffic conditions,thus declining the car-following *** solve this problem,a car-following strategy of ICV using EDO adjusted by reinforcement learning is *** from the conventional method,the gain of proposed strategy can be adjusted by reinforcement learning to improve its estimation *** the“equivalent disturbance”can be compensated by EDO to a great extent,the disturbance rejection ability of the carfollowing method will be improved *** Lyapunov approach and numerical simulations are carried out to verify the effectiveness of the proposed method.

关键词： adaptive system autonomous vehicle intelligent control

Twenty-nine million intrinsic Q-factor monolithic microresonators on thin-film lithium niobate

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Photonics Research 2024年第8期12卷 I0001-I0006页

作者： XINRUI ZHU YAOWEN HU SHENGYUAN LU HANA KWARNER XUDONG LI YUNXIANG SONG LETÍCIA MAGALHÃES AMIRHASSAN SHAMS-ANSARI ANDREA CORDARO NEIL SINCLAIR MARKO LONČAR john A.Paulson school for Engineering and Applied Sciences Harvard UniversityCambridgeMassachusetts 02138USA State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China DRS Daylight Solutions San DiegoCalifornia 92127USA

The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated *** has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry ***,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this ***,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/*** present spectral analysis and the statistical distribution of Q factors across different resonator *** work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.

关键词： resonator lithium film

Nanotechnology-based delivery systems to overcome drug resistance in cancer

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Medical Review 2024年第1期4卷 5-30页

作者： Harsh Patel Jiaxin Li Letao Bo Riddhi Mehta Charles R.Ashby Shanzhi Wang Wei Cai Zhe-Sheng Chen College of Pharmacy and Health Sciences St.John’s UniversityNew YorkNYUSA school of Pharmaceutical Sciences Hunan University of MedicineHuaihuaHunan ProvinceChina St.john’s College of Liberal Arts and Sciences St.John’s UniversityNew YorkNYUSA school of Pharmaceutical Sciences Hunan University of MedicineNo.492 Jinxi South RoadHuaihua41800Hunan ProvinceChina College of Pharmacy and Health Sciences St.John’s UniversityNo.8000 Utopia ParkwayQueensNew YorkNY 11439USA

Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional *** resistance(MDR)in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic *** have been successes in the development of cancer nanomedicine to overcome MDR;however,relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of *** is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer ***,we discuss the advances,types of nanomedicines,and the challenges regarding the translation of in vitro to in vivo results and their relevance to effective therapies.

关键词： nanotechnology multidrug resistance drug delivery systems nanoformulations enhanced permeability and retention effect

Missed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecystectomy

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Surgical Science 2024年第7期15卷 451-464页

作者： Dylan S. Goto Larissa Fujii-Lau Linda L. Wong Department of Surgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecystectomy has been recommended for patients with acute cholecystitis and gallstone pancreatitis. However, patients with pancreaticobiliary malignancy may present acutely with similar symptoms. We hypothesize that the diagnoses of these malignancies may potentially be delayed as an unintended consequence of expedited cholecystectomies. This study reviews a cohort of patients who underwent pancreaticoduodenectomy (PD) to identify those who underwent a separate cholecystectomy before their PD. Methods: We retrospectively reviewed 162 PDs performed between 2012 and 2022. Data collected included: demographics, disease etiology and the presence of cholelithiasis. We identified patients who had a previous cholecystectomy and the time elapsed before PD as well as procedures done during the interval. We reported detailed case summaries on those patients who had a cholecystectomy within 1 year of PD. Results: In the entire cohort, mean age was 65 years, 54% were males, and 83% had a malignant reason for PD. Thirty-one patients had cholelithiasis with 23 (14%) patients having had previous cholecystectomy. Six patients had cholecystectomy within 1 year of PD. They had the following malignancies: ampullary—3, pancreas—1, cholangiocarcinoma—1 and neuroendocrine—1. Four of these patients had expedited cholecystectomy on their index hospital admission and were later found to have a periampullary malignancy with further work up. Conclusions: Pancreaticobiliary malignancies can be difficult to diagnose, and surgeons should not overlook these potential diagnoses when considering expedited cholecystectomy. Future studies in large cohorts are needed to identify high risk candidates who should undergo more detailed testing to exclude malignancy before proceeding with cholecystectomy.

关键词： Cholecystectomy Periampullary Malignancy Pancreas Malignancy Pancreaticoduodenectomy

Spatio-Temporal Service Analysis in Multi-Layer Non-Terrestrial Networks

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Journal of Communications and Information Networks 2024年第1期9卷 43-55页

作者： Qian Chen Weixiao Meng Shuai Han Cheng Li school of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China school of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical and Computer Engineering Memorial UniversitySt.John’sNL A1B 3X5Canada

In the advent of the 6G era, non-terrestrial networks (NTN) with expansive coverage are being increasingly recognized as a vital supplement to cellular networks for facilitating seamless communication. The intricate interplay between network performance and service quality necessitates a thorough investigation into the modeling and analysis of services for efficient construction of *** studies on service analysis, predominantly focused on terrestrial networks,fall short in addressing the unique challenges posed by NTN,particularly those related to platform distribution and antenna gain modeling. This deficiency in research,coupled with the varying preferences of users for different network types, forms the basis of this study. This paper explores the spatio-temporal characteristics of services within a multi-layered NTN *** this context,the spatial distribution of the platforms is modeled using a binomial point process, and the antennas are characterized by a sectorized beam pattern. We derive the closed-form expressions for the association probability,the number of accessed users, and the arrival rate of services with certain delay requirements towards different types of NTN. Simulation results are provided to evaluate the influence of various parameters on the association probability, the number of accessed users, and the total arrival rate of services. The number of satellites can be determined to achieve the optimal system utility,balancing the accessed services, offloading effects, and launching costs. This initial investigation lays the groundwork for further theoretical progress in the service analysis and platform deployment of NTN.

关键词： association strategy non-terrestrial networks service analysis stochastic geometry system utility

A cross-sectional study of breastfed infants referred for tongue tie assessment and frenotomy in one Canadian health region

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Pediatric Investigation 2024年第1期8卷 53-60页

作者： Tiffany A.Lee Jessica Bishop Anne Drover William K.Midodzi Laurie K.Twells school of Pharmacy Memorial University of Newfoundland(MUN)St.John’sCanada Faculty of Medicine Memorial University of Newfoundland(MUN)St.John’sCanada

Importance:Tongue tie(TT)is a condition that can cause infant feeding difficulties due to restricted tongue *** TT presents as a significant barrier to breastfeeding,a frenotomy may be *** accepted diagnostic criteria for TT are lacking and wide prevalence estimates are *** referral processes and a Frenotomy Assessment Tool were implemented in one Canadian health region to connect breastfeeding dyads with a provider for TT evaluation and ***:To determine the proportion of babies with TT as well as the frequency of ***:This cross-sectional study included infants who initiated breastfeeding at birth and were referred for TT evaluation over a 14-month *** were collected retrospectively by chart review and analyzed using *** associated with frenotomy were examined using logistic ***:Two hundred and forty-one babies were ***-two percent(n=222)were diagnosed with TT and 66.0%(n=159)underwent *** the multivariate model,nipple pain/trauma,inability to latch,inability to elevate tongue,and dimpling of tongue on extension were associated with frenotomy(P<0.05).Most referrals in our region resulted in a diagnosis of TT;however,the number of referrals was lower than expected,and of these two-thirds underwent ***:TT is a relatively common finding among breastfed *** research should examine whether a simplified assessment tool containing the four items associated with frenotomy in our multivariate model can identify breastfed infants with TT who require frenotomy.

关键词： Breastfeeding Nutrition Community health services Pediatrics

A Self-Adapting and Efficient Dandelion Algorithm and Its Application to Feature Selection for Credit Card Fraud Detection

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 377-390页

作者： Honghao Zhu MengChu Zhou Yu Xie Aiiad Albeshri IEEE school of Computer and Information Engineering Bengbu UniversityBengbu 233030China school of Information and Electronic Engineering Zhejiang Gongshang UniversityHangzhou 310018China Helen and john C.Hartmann the Department of Electrical and Computer EngineeringNew Jersey Institute of TechnologyNewark NJ 07102 USA College of Information Engineering Shanghai Maritime UniversityShanghai 201306China Department of Computer Science King Abdulaziz UniversityJeddah 21481Saudi Arabia

A dandelion algorithm(DA) is a recently developed intelligent optimization algorithm for function optimization problems. Many of its parameters need to be set by experience in DA,which might not be appropriate for all optimization problems. A self-adapting and efficient dandelion algorithm is proposed in this work to lower the number of DA's parameters and simplify DA's structure. Only the normal sowing operator is retained;while the other operators are discarded. An adaptive seeding radius strategy is designed for the core dandelion. The results show that the proposed algorithm achieves better performance on the standard test functions with less time consumption than its competitive peers. In addition, the proposed algorithm is applied to feature selection for credit card fraud detection(CCFD), and the results indicate that it can obtain higher classification and detection performance than the-state-of-the-art methods.

关键词： Credit card fraud detection(CCFD) dandelion algorithm(DA) feature selection normal sowing operator

Dostarlimab in the treatment of mismatch repair deficient recurrent or advanced endometrial cancer

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Cancer Pathogenesis and Therapy 2024年第3期2卷 135-141页

作者： Siddhant Shukla Harsh Patel Shuzhen Chen Rainie Sun Liuya Wei Zhe-Sheng Chen Institute for Biotechnology St.John's UniversityNew YorkNew York 11439United States Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityNew YorkNew York 11439United States school of Pharmacy Weifang Medical UniversityWeifangShandong 261053China Stuyvesant high school New YorkNew York 10282United States

Dostarlimab,a programmed death receptor-1(PD-1)-blocking IgG4 humanized monoclonal antibody,gained accelerated approval from the US Food and Drug Administration(FDA)in April 2021,and received a full approval in February *** was approved for treating adult patients with mismatch repair deficient(dMMR)recurrent or advanced endometrial cancer(EC)that progressed during or after prior treatment who have no other suitable treatment ***,we review the structure-based mechanism of action of dostarlimab and the results of a clinical study(GARNET;NCT02715284)to comprehensively clarify the efficacy and toxicity of the *** efficacy and safety of dostarlimab as monotherapy was assessed in a non-randomized,multicenter,open-label,multi-cohort trial that included 209 patients with dMMR recurrent or advanced solid tumors after receiving systemic *** received 500 mg of dostarlimab intravenously every three weeks until they were given four ***,patients received 1000 mg dostarlimab intravenously every six weeks until disease progression or unacceptable *** overall response rate,as determined by shrinkage in tumor size,was 41.6%(95%confidence interval[CI];34.9,48.6),with 34.7 months as the median response *** conclusion,dostarlimab is an immunotherapy-based drug that has shown promising results in adult patients with recurrent or advanced dMMR ***,its efficacy in other cancer subtypes,the development of resistance to monotherapy,and efficacy and safety in combination with other immunotherapeutic drugs have not yet been studied.

关键词： Dostarlimab PD-1 Immunotherapy Endometrial cancer Check-point inhibitor

Mapping Network-Coordinated Stacked Gated Recurrent Units for Turbulence Prediction

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1331-1341页

作者： Zhiming Zhang Shangce Gao MengChu Zhou Mengtao Yan Shuyang Cao Faculty of Engineering University of ToyamaToyama 930-8555Japan Helen and john C.Hartmann Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewark NJ 07102 USA Gaoling school of Artificial Intelligence Renmin University of ChinaBeijing 100872China College of Civil Engineering Tongji UniversityShanghai 200092China IEEE

Accurately predicting fluid forces acting on the sur-face of a structure is crucial in engineering ***,this task becomes particularly challenging in turbulent flow,due to the complex and irregular changes in the flow *** this study,we propose a novel deep learning method,named mapping net-work-coordinated stacked gated recurrent units(MSU),for pre-dicting pressure on a circular cylinder from velocity ***-cally,our coordinated learning strategy is designed to extract the most critical velocity point for prediction,a process that has not been explored *** our experiments,MSU extracts one point from a velocity field containing 121 points and utilizes this point to accurately predict 100 pressure points on the *** method significantly reduces the workload of data measure-ment in practical engineering *** experimental results demonstrate that MSU predictions are highly similar to the real turbulent data in both spatio-temporal and individual ***,the comparison results show that MSU predicts more precise results,even outperforming models that use all velocity field *** with state-of-the-art methods,MSU has an average improvement of more than 45%in various indicators such as root mean square error(RMSE).Through comprehensive and authoritative physical verification,we estab-lished that MSU’s prediction results closely align with pressure field data obtained in real turbulence *** confirmation underscores the considerable potential of MSU for practical applications in real engineering *** code is available at https://***/zhangzm0128/MSU.

关键词： Convolutional neural network deep learning recurrent neural network turbulence prediction wind load predic-tion.