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ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

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Nano-Micro Letters 2024年第8期16卷 341-361页

作者： Xi Zhou Quan Zhou Zhaozhi He Yi Xiao Yan Liu Zhuohang Huang Yaoji Sun Jiawei Wang Zhengdong Zhao Xiaozhou Liu Bin Zhou Lei Ren Yu Sun Zhiwei Chen Xingcai Zhang The Higher Educational Key Laboratory for Biomedical engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005People’s Republic of China john a.paulson school of engineering and applied sciences Harvard UniversityCambridgeMA 02138USA department of Otorhinolaryngology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China NO.1 Middle school Affiliated to Central China Normal University Wuhan 430223People’s Republic of China

Reactive oxygen species(ROS)plays important roles in living *** ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound *** Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill ***,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) ***,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au *** two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound *** innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关键词： Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing

Design of optimum solid oxide membrane electrolysis cells for metals production

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Progress in Natural Science:Materials International 2015年第6期25卷 591-594页

作者： Xiaofei Guan Uday B.Pal Division of Materials Science and engineering Boston University department of Mechanical engineering Boston University john a.paulson school of engineering and applied sciences Harvard University

Oxide to metal conversion is one of the most energy-intensive steps in the value chain for metals *** oxide membrane(SOM)electrolysis process provides a general route for directly reducing various metal oxides to their respective metals,alloys,or *** of its lower energy use and ability to use inert anode resulting in zero carbon emission,SOM electrolysis process emerges as a promising technology that can replace the state-of-the-art metals production *** this paper,a careful study of the SOM electrolysis process using equivalent DC circuit modeling is performed and correlated to the experimental results.A discussion on relative importance of each resistive element in the circuit and on possible ways of lowering the rate-limiting resistive elements provides a generic guideline for designing optimum SOM electrolysis cells.

关键词： Electrolysis Solid oxide Membranes Metals production Environmentally benign

Bayesian force fields from active learning for simulation of inter-dimensional transformation of stanene

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npj Computational Materials 2021年第1期7卷 361-370页

作者： Yu Xie Jonathan Vandermause Lixin Sun Andrea Cepellotti Boris Kozinsky john a.paulson school of engineering and applied sciences Harvard UniversityCambridgeMAUSA Robert Bosch LLC Research and Technology CenterCambridgeMAUSA

We present a way to dramatically accelerate Gaussian process models for interatomic force fields based on many-body kernels by mapping both forces and uncertainties onto functions of low-dimensional *** allows for automated active learning of models combining near-quantum accuracy,built-in uncertainty,and constant cost of evaluation that is comparable to classical analytical models,capable of simulating millions of *** this approach,we perform large-scale molecular dynamics simulations of the stability of the stanene *** discover an unusual phase transformation mechanism of 2D stanene,where ripples lead to nucleation of bilayer defects,densification into a disordered multilayer structure,followed by formation of bulk liquid at high temperature or nucleation and growth of the 3D bcc crystal at low *** presented method opens possibilities for rapid development of fast accurate uncertainty-aware models for simulating long-time large-scale dynamics of complex materials.

关键词： transformation dimensional fields

Transition towards higher penetration of renewables: an overview of interlinked technical, environmental and socio-economic challenges

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Journal of Modern Power Systems and Clean Energy 2019年第1期7卷 1-8页

作者： Xinyu CHEN Michael B.MCELROY Qiuwei WU Yinbiao SHU Yusheng XUE john a.paulson school of engineering and applied sciences Harvard University department of Electrical engineering Technical University of Denmark State Grid Corporation of China State Grid Electric Power Research Institute

Investment for renewables has been growing rapidly since the beginning of the new century, and the momentum is expected to sustain in order to mitigate the impact of anthropogenic climate *** towards higher renewable penetration in the power industry will not only confront technical challenges, but also face socio-economic *** connected between environment and energy systems are also tightened under elevated penetration of *** paper will provide an overview of some important challenges related to technical, environmental and socio-economic aspects at elevated renewable *** integrated analytical framework for interlinked technical, environmental and socio-economic systems will be presented at the end.

关键词： Wind power Solar power Integrated energy systems Missing money problem Low carbon policies

The Soft X-ray Imager(SXI)on the SMILE Mission

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Earth and Planetary physics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang school of physics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China University of applied sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of applied sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STM engineering N-5165 LaksevagNorway john Hopkins University applied physics Laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space physics Boston UniversityBostonMA 02215USA department of Theoretical physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)*** is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of sciences(CAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Imaging micropore optics large area CCD

CoolVox:Advanced 3D convolutional neural network models for predicting solar radiation on building facades

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Building Simulation 2022年第5期15卷 755-768页

作者： Jung Min Han Eun Seuk Choi Ali Malkawi Harvard University Graduate school of Design CambridgeUSA Harvard Center for Green Buildings and Cities CambridgeUSA Harvard john a.paulson school of engineering and applied sciences CambridgeUSA

Data-driven models have become increasingly prominent in the building,architecture,and construction *** area ideally suited to exploit this powerful new technology is building performance ***-based models have traditionally been used to estimate the energy flow,air movement,and heat balance of ***,physics-based models require many assumptions,significant computational power,and a considerable amount of time to output *** neural networks(ANNs)with prefabricated or simulated data are likely to be a more feasible option for environmental analysis conducted by designers during the early design *** ANNs require fewer inputs and shorter computation times and offer superior performance and potential for data augmentation,they have received increased attention for predicting the surface solar radiation on ***,ANNs can provide innovative and quick design solutions,enabling designers to receive instantaneous feedback on the effects of a proposed change to a building's *** research introduces deep learning methods as a means of simulating the annual radiation intensities and exposure level of buildings without the need for physics-based *** propose the CoolVox model to demonstrate the feasibility of using 3D convolutional neural networks to predict the surface radiation on building *** CoolVox model accurately predicted the radiation intensities of building facades under different boundary conditions and performed better than ARINet(with average mean square errors of 0.01 and 0.036,respectively)in predicting the radiation intensity both with(validation error=0.0165)and without(validation error=0.0066)the presence of boundary buildings.

关键词： artificial neural networks 3D convolutional neural networks solar radiation simulation building performance simulation

Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

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Nano-Micro Letters 2021年第12期13卷 1-13页

作者： Won Young Kim Miae Won Seyoung Koo Xingcai Zhang Jong Seung Kim department of Chemistry Korea UniversitySeoul 02841Korea john a.paulson school of engineering and applied sciences Harvard UniversityCambridgeMA 02138USA school of engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory *** current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and ***-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is *** TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory ***,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse *** vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise *** behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.

关键词： Theranostics Anti-inflammation Mitochondria Hydrogen polysulfides

Dirac-like cone-based electromagnetic zero-index metamaterials

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Light(Science & Applications) 2021年第11期10卷 2048-2066页

作者： Yang Li C.T.Chan Eric Mazur State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision InstrumentTsinghua UniversityBeijingChina department of physics Hong Kong University of Science and TechnologyKowloonHong KongChina john a.paulson school of engineering and applied sciences Harvard UniversityCambridgeMAUSA

Metamaterials with a Dirac-like cone dispersion at the center of the Brillouin zone behave like an isotropic and impedance-matched zero refractive index material at the Dirac-point *** metamaterials can be realized in the form of either bulk metamaterials with efficient coupling to free-space light or on-chip metamaterials that are efficiently coupled to integrated photonic *** materials enable the interactions of a spatially uniform electromagnetic mode with matter over a large area in arbitrary *** unique optical property paves the way for many applications,including arbitrarily shaped high-transmission waveguides,nonlinear enhancement,and phase mismatch-free nonlinear signal generation,and collective emission of many *** review summarizes the Dirac-like cone-based zero-index metamaterials’fundamental physics,design,experimental realizations,and potential applications.

关键词： index collective realization

Chip-Based High-Dimensional Optical Neural Network

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Nano-Micro Letters 2022年第12期14卷 570-578页

作者： Xinyu Wang Peng Xie Bohan Chen Xingcai Zhang school of Future Technology University of Chinese Academy of SciencesBeijing 100049China department of engineering Science University of OxfordParks RoadOxford OX13PJUK school of engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA john a.paulson school of engineering and applied sciences Harvard UniversityCambridgeMA 02138USA

Parallel multi-thread processing in advanced intelligent processors is the core to realize high-speed and high-capacity signal processing *** neural network(ONN)has the native advantages of high parallelization,large bandwidth,and low power consumption to meet the demand of big ***,we demonstrate the dual-layer ONN with Mach-Zehnder interferometer(MZI)network and nonlinear layer,while the nonlinear activation function is achieved by optical-electronic signal *** frequency components from the microcomb source carrying digit datasets are simultaneously imposed and intelligently recognized through the *** successfully achieve the digit classification of different frequency components by demultiplexing the output signal and testing power *** parallelization feasibility with wavelength division multiplexing is demonstrated in our high-dimensional *** work provides a high-performance architecture for future parallel high-capacity optical analog computing.

关键词： Integrated optics Optical neural network High-dimension Mach-Zehnder interferometer Nonlinear activation function Parallel high-capacity analog computing