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Root canal morphology and configuration of 123 maxillary second molars by means of micro-Ct

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International Journal of Oral Science 2017年第1期9卷 33-37页

作者： thomas Gerhard Wolf Frank Paqué Anja-Christin Woop Brita Willershausen Benjamín Briseno-Marroquín Department of Operative Dentistry Johannes Gutenberg University Medical CenterMainzGermany Division of Endodontology Department of Preventive DentistryPeriodontology and CariologyUniversity of ZurichZurichSwitzerland

the aim of this study was to investigate the root canal configuration, accessory canals and number of main foramina of 123 maxillary second molars by means of micro-computed tomography. the teeth were scanned and reproduced with 3D software imaging. the root canal configuration and number of main foramina were evaluated by means of a four-digit system. the morphological complexity of human maxillary second molars is depicted by the number of accessory and connecting canals. the most frequently observed root canal configurations in the mesiobuccal root were 2-2-2/2 （19.5%）, 2-2-1/1 （14.6%） and 2-1-1/1 （13.0%）. A 1-1-1/1 configuration was observed in 93.5% and in 96.7% in the distobuccal and palatal roots, respectively. the MB1 mot canal had one accessory canal （18.7%）, and 8.9% of the MB2 root canal had one or two accessory canals. the distobuccal （11.3%） and palatal （14.6%） root canals had at least one accessory canal, and connecting canals were observed in 16.3% of mesiobuccal roots. the MB1, MB2, distobuccal and palatal root canals had one main foramen in 99.2%, 43.1%, 98.4% and 99.2% of samples, respectively. In the mesiobuccal root, one accessory foramen was detected in 14.6%, two were detected in 7.3%, and three were detected in 5.7%. the distobuccal root showed one or two accessory foramina in 9.1% of samples. the root canal configuration of maxillary second molars is quite heterogeneous; the mesiobuccal root has predominantly two root canal entrances （58.4%, 1 in 41.1%） with one main foramen （54.4%）. two main foramina were observed in 43.0%. Morphological variations, connecting and accessory canals were observed in all apical thirds.

关键词： accessory and connecting canals apical foramina maxillary second molar micro-Ct morphology root canal configuration

Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?

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World Journal of Gastroenterology 2007年第26期13卷 3605-3609页

作者： Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede thomas Borschitz Stefan Biesterfeld Martin Holtmann thomas Wehler Andreas teufel Kerstin Herzer thomas Fischer Martin R Berger theodor Junginger Peter R Galle Carl C Schimanski Department of General and Abdominal Surgery Johannes Gutenberg University of Mainz MainzGermany First Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Institute of Pathology Johannes Gutenberg University of MainzMainzGermany third Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Unit of toxicology and chemotherapy German Cancer Research CenterGermany

AIM: to define the (co-)expression pattern of target receptor-tyrosine-kinases (RtK) in human gastric adenocarcinoma. MEtHODS: the (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by Rt-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RtK localisation. RESULtS: the majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RtKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα ***-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RtK-inhibitors within a combination therapy.

关键词：胃癌病理组织治疗临床

three-dimensional analysis of the physiological foramen geometry of maxillary and mandibular molars by means of micro-Ct

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International Journal of Oral Science 2017年第3期9卷 151-157页

作者： thomas Gerhard Wolf Frank Paqué Michael Sven Patyna Brita Willershausen Benjamín Briseno-Marroquín Department of Operative Dentistry University Medical Center of the Johannes Gutenberg University Mainz Department of Endodontology Division of Preventive DentistryPeriodontologyand CariologyCenter of Dental MedicineUniversity of Zürich

the aim of this study was to investigate the physiological foramen diameter, shape and distance between physiological and anatomical apex of maxillary and mandibular first and second molars. Accurate knowledge of the physiological foramina morphology; thus, inherent mechanical shaping technical hindrances, is decisive when taking the corresponding root canal final preparation decision. the morphological dimensions of a total of 1 727 physiological foramina were investigated by means of micro-computed tomography. Mean narrow and wide （to a high number, oval） diameters of the physiological foramen were 0.24, 0.22 and 0.33 mm and 0.33, 0.31 and 0.42 mm in mesiobuccal （MB）, distobuccal （DB） and palatal （P） roots in maxillary first molars; 0.24, 0.22 and 0.33 mm and 0.41, 0.33 and 0.44 in MB, DB, and P roots in maxillary second molars. Mandibular first molars showed mean narrow and wide diameters of 0.24 and 0.30 mm and of 0.39 and 0.46 mm in mesial （M） and distal （D） roots; second mandibular molars showed 0.25 and 0.31 mm and 0.47 mm in M and D roots. the mean distance between the physiological foramina and anatomical apex was 0.82, 0.81 and 1.02 mm and 0.54, 0.43 and 0.63 mm in MB, DB and P roots of the maxillary first and second molars, respectively. A mean distance of 0.95 mm （M） and 1.05 mm （D） in the first and 0.78 mm （M） and 0.81 mm （D） in the second mandibular molars was observed. Based on the results obtained, assumable recommendations for final preparation size of the physiological foramen were calculated. However, when taking into consideration, the resulting standard deviations of marginal errors must be cautiously considered when taking a final decision in clinical endodontic treatment.

关键词： apical constriction final apical file maxillary and mandibular molars morphology micro-computed tomography physiological foramen

What are the pathways between poverty and malaria in sub-Saharan Africa?A systematic review of mediation studies

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Infectious Diseases of Poverty 2023年第3期12卷 13-30页

作者： Solomon t.Wafula theresa Habermann Mara Anna Franke Jürgen May Dewi Ismajani Puradiredja Eva Lorenz Johanna Brinkel Department of Infectious Disease Epidemiology Bernhard Nocht Institute for Tropical MedicineHamburgGermany Department of Disease Control and Environmental Health School of Public HealthMakerere UniversityKampalaUganda Charité Global Health Charité Universitätsmedizin BerlinBerlinGermany German Center for Infection Research(DZIF) Partner Site Hamburg-Borstel-Lubeck-RiemsHamburgGermany Department of tropical Medicine University Medical Center Hamburg-Eppendorf(UKE)HamburgGermany Institute of Medical Biostatistics Epidemiology and InformaticsUniversity Centre of the Johannes Gutenberg UniversityMainzGermany

Background Malaria remains a major burden in sub-Saharan Africa(SSA).While an association between poverty and malaria has been demonstrated,a clearer understanding of explicit mechanisms through which socioeconomic position(SEP)influences malaria risk is needed to guide the design of more comprehensive interventions for malaria risk *** systematic review provides an overview of the current evidence on the mediators of socioeconomic disparities in malaria in *** We searched PubMed and Web of Science for randomised controlled trials,cohort,case-control and cross-sectional studies published in English between January 1,2000 to May 31,*** studies were identified following reviews of reference lists of the studies *** included studies that either(1)conducted a formal mediation analysis of risk factors on the causal pathway between SEP and malaria infections or(2)adjusted for these potential mediators as confounders on the association between SEP and malaria using standard regression *** least two independent reviewers appraised the studies,conducted data extraction,and assessed risk of bias.A systematic overview is presented for the included *** We identified 41 articles from 20 countries in SSA for inclusion in the final *** these,30 studies used cross-sectional design,and 26 found socioeconomic inequalities in malaria *** formal mediation analyses showed limited evidence of mediation of food security,housing quality,and previous antimalarial ***,education,insecticide-treated nets,and nutrition were highlighted in the remaining studies as being protective against malaria independent of SEP,suggesting potential for ***,methodological limitations included the use of cross-sectional data,insufficient confounder adjustment,heterogeneity in measuring both SEP and malaria,and generally low or moderate-quality *** studies considered exposure mediator interactions or considered iden

关键词： Malaria Mediation Socioeconomic disparity Sub-Saharan Africa

StCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.t.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng t.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.t.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong t.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou t.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.t.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li t.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.t.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu t.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo t.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin t.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui university Hefei 230039China Beihang university Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal university Wuhan 430079China Central South university Changsha 410083China China university of Geosciences Wuhan 430074China China university of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan university Shanghai 200433China Goethe university Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal university Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal university Shijiazhuang 050024China Hebei university Baoding 071002China Hefei university of technology Hefei 230601China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan university Huangshan 245000China Hubei university of Automotive technology Shiyan 442002China Hunan Normal university Changsha 410081China Hunan university of Science and technology Xiangtan 411201China Hunan university Changsha 410082China Indiana university BloomingtonIndiana 47405USA Inner Mongolia university Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin university Changch

the superτ-charm facility(StCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the StCF,describes conceptual designs of the StCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCF detector conceptual design

tailoring molecular island shapes:influence of microscopic interaction on mesostructure

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Nano Research 2020年第3期13卷 843-852页

作者： Simon Aeschlimann Lu Lyu Benjamin Stadtmuller Martin Aeschlimann Angelika Kuhnle Institute of Physical Chemistry Johannes Gutenberg University MainzDuesbergweg 10-14Mainz55099Germany Graduate School Materials Science in mainz Staudingerweg 9Mainz55128Germany Department of Physics and Research Center OPtIMAS University of KaiserslauternErwin-Schrödinger-Straße 46Kaiserslautern67663Germany Graduate School Materials Science in mainz Erwin-Schrodinger-Straße 46Kaiserslautern67663Germany Physical Chemistry I Faculty of ChemistryBielefeld UniversityUniversitätsstraße 25Bielefeld33615Germany

Controlling the structure formation of molecules on surfaces is fundamental for creating molecular nanostructures with tailored properties and functionalities and relies on tuning the subtle balance between intermolecular and molecule-surface *** far,however,reliable rules of design are largely lacking,preventing the controlled fabrication of self-assembled functional structures on *** addition,while so far many studies focused on varying the molecular building blocks,the impact of systematically adjusting the underlying substrate has been less frequently ***,we elucidate the potential of tailoring the mesoscopic island shape by tuning the interactions at the molecular *** a model system,we have selected the molecule dimolybdenum tetraacetate on three prototypical surfaces,Cu(111),Au(111)and CaF2(111).While providing the same hexagonal geometry,compared to Cu(111),the lattice constants of Au(111)and CaF2(111)differ by a factor of 1.1 and 1.5,*** high-resolution scanning probe microscopy images reveal molecular-level information on the resulting islands and elucidate the molecular-level design principles for the observed mesoscopic island *** study demonstrates the capability to tailor the mesoscopic island shape by exclusively tuning the substrate lattice constant,in spite of the very different electronic structure of the substrates *** work provides insights for developing general design strategies for controlling molecular mesostructures on surfaces.

关键词： scanning tunneling microscopy(StM) self-assembly island shape mesostmcture scanning probe microscopy(SPM) twodimensionBl structures

A Novel Full-Euler Low Mach Number IMEX Splitting

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Communications in Computational Physics 2020年第1期27卷 292-320页

作者： Jonas Zeifang Jochen Schutz Klaus Kaiser Andrea Beck Maria Lukacova-Medvid’ova Sebastian Noelle IAG Universiẗat StuttgartPfaffenwaldring 21DE-70569 StuttgartGermany Faculty of Sciences Hasselt UniversityAgoralaan Gebouw DBE-3590 DiepenbeekBelgium IGPM RWTH Aachen UniversityTemplergraben 55DE-52062 AachenGermany Institut f̈ur Mathematik Johannes Gutenberg-Universiẗat MainzStaudingerweg 9DE-55128 MainzGermany

In this paper,we introduce an extension of a splitting method for singularly perturbed equations,the socalled RS-IMEX splitting[Kaiser et al.,Journal of Scientific Computing,70(3),1390–1407],to deal with the fully compressible Euler *** straightforward application of the splitting yields sub-equations that are,due to the occurrence of complex eigenvalues,not hyperbolic.A modification,slightly changing the convective flux,is introduced that overcomes this *** is shown that the splitting gives rise to a discretization that respects the low-Mach number limit of the Euler equations;numerical results using finite volume and discontinuous Galerkin schemes show the potential of the discretization.

关键词： Euler equations low-Mach IMEX Runge-Kutta RS-IMEX

Affiliation of Dihydrolipoyl Dehydrogenase Allozymes in Mycorrhizae of European Forest trees and Characterization of the Enzyme of the Matt Bolete (<i>Xerocomus pruinatus</i>) and the Bay Bolete (<i>X. badius</i>)

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Open Journal of Ecology 2018年第6期8卷 356-377页

作者： Uwe Schirkonyer Gunter M.Rothe johannes gutenberg-university MainzGermany

Mycorrhizal roots of the deciduous trees European beech (Fagus sylvatica (L.)) and Sessile oak (Quercus petraea (MattuschkaLiebl.)) and the conifers Norway spruce (Picea abies (L.) H. Karst.) and European larch (Larix decidua (Mill.)) associated with the ectomycorrhizal fungi matt bolete (Xerocomus pruinatus (Fries 1835)) or bay bolete (X. badius (Fries 1818)) were analysed with respect to the occurrence of dihydrolipoyl dehydrogenase (EC 1.***.1.4) allozymes. In root tissues of the two deciduous trees, two gene loci could be visualized after cellulose acetate electrophoresis while three loci were expressed in root tissues of the two coniferous species. the two fungal species and further ectomycorrhizal fungi expressed exclusively one dihydrolipoyl dehydrogenase gene. In Xerocomus pruinatus and X. badius, the dihydrolipoyl dehydrogenase gene consists of 1460 bp and 1370 bp, respectively, including five introns each consisting of 52 bp. their DNA sequences correspond to 70 to 90% to other fungal dihydrolipoyl dehydrogenase genes. One monomer of the dimeric dihydrolipoyl dehydrogenase enzyme consists of 486 (X. pruinatus) or 454 (X. badius) amino acids which sum up to a molecular mass of 55 kDa (X. pruinatus), respectively 52 kDa (X. badius). the number of positively charged amino acid residues makes 79 (X. pruinatus) and 68 (X. badius) and the number of negatively charged amino acid residues was calculated to make 46 (X. pruinatus) and 48 (X. badius);isoelectric points make 9.99 (X. pruinatus) and 9.68 (X. badius). Calculated three dimensional structures reveal a short NADH binding site being part of a larger FAD-binding site and a binding/dimerization domain.

关键词： Amino Acid Sequence cDNA Ectomycorrhizae Fagus sylvatica Gene Sequence Larix decidua mRNA Dihydrolipoyl Dehydrogenase Picea abies Quercus petraea Xerocomus pruinatus Xerocomus badius

Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus

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World Journal of Gastroenterology 2006年第23期12卷 3746-3750页

作者： Ines Gockel Kathrin Dirksen Claudia M Messow theodor Junginger Department of General and Abdominal Surgery Johannes Gutenberg-UniversityMainzGermany Institute of Biostatistics and Documentation Johannes Gutenberg-UniversityMainzGermany

瞄准：C 反应的蛋白质(CRP ) 是尖锐阶段的反应物和瘤的恶意的潜力的已知的指示物。这研究的目的是作为起作用的仙子的一个参数调查外科手术前的 CRP 的意义在有有鳞的房间癌和食道的腺癌的病人的路线和长期的预后。方法：浆液 CRP 在从... 详细信息

瞄准：C 反应的蛋白质(CRP ) 是尖锐阶段的反应物和瘤的恶意的潜力的已知的指示物。这研究的目的是作为起作用的仙子的一个参数调查外科手术前的 CRP 的意义在有有鳞的房间癌和食道的腺癌的病人的路线和长期的预后。方法：浆液 CRP 在从 1989 年 12 月为癌症经历 oesophagectomy 到 2004 年 3 月的 371 个病人中的 291 个外科手术前地被决定。中部的耐心的年龄是 59 (28-79 ) 年， 82.5% 病人是男性。有鳞的房间癌在 151 被诊断(51.9%) 并且在 122 个病人的腺癌。transhiatal oesophagectomy 在 151 被做(51.9%) 病人并且 134 (46.0%) 病人们经历了腹胸的过程。结果：(43.6%) 在 127，外科手术前的浆液 CRP 集中在正常以内的病人变化(< 5 mg/dL ) ，提高的 CRP 层次在 164 被测量(56.4%) 病人。瘤扩展(P < 0.0005 ) 并且淋巴节点的数字由变形传播影响了(P = 0.015 ) 显著地与提高的 CRP 层次在这个组被增加。在起作用的仙子之中参数两输血的数字(P = 0.006 ) 并且一般复杂并发症率(P = 0.002 ) 在有提高的外科手术前的 CRP 层次的病人是更高的。13.6 的长期的幸存率(0-109.8 ) 瞬间在有与 18.9 相比的提高的 CRP 层次的组是更差的(0-155.4 ) 在有正常 CRP 的组的瞬间铺平(木头等级测试：P = 0.107 ) 。有向后的变量选择的 Multivariate 分析与食道的癌在病人作为长期的预后的一个独立预示的因素识别了外科手术前的 CRP，与 1.182 的危险比率(95% 信心间隔：1.030-1.356 ) 。结论：外科手术前的浆液 CRP 水平是在有有鳞的房间癌和食道的腺癌的病人的一个容易坚定的独立预示的标记。

关键词： C-反应蛋白手术治疗牙周炎鳞状细胞癌食管