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Neural Regeneration Research 2022年第3期17卷 557-558页

作者： Hao Ding Sergiu Groppa Muthuraman Muthuraman Movement Disorders and Neurostimulation Biomedical Statistics and Multimodal Signal ProcessingDepartment of NeurologyJohannes Gutenberg UniversityMainzGermany

Parkinson's disease(PD) is one of the most common neurodegenerative diseases,affecting individuals especially over 60 years of *** the next three decades,more than 12 million people will suffer from PD worldwide(Rocca,2018).The characteristic symptoms of PD begin as a movement disorder including bradykinesia,resting tremor,rigidity,and postural instability.

关键词： stimulation diseases rigidity

Proteome alterations in aqueous humour of primary open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 176-179页

作者： Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch Department of Ophthalmology University Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Experimental and Translational Ophthalmology Department of OphthalmologyUniversity Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Royal Eye Hospital School of MedicineUniversity of ManchesterManchester M202ULUnited Kingdom

AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably ***: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as ***: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins.

关键词： primary open angle glaucoma aqueous humor proteomics Wnt signaling pathway

In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy

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World Journal of Gastroenterology 2007年第15期13卷 2160-2165页

作者： Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich Medical Clinic johannes gutenberg-universit(a|¨)t MainzGermany Department of Pathology johannes gutenberg-universit(a|¨)t MainzGermany

AIM： To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents. METHODS： A novel rigid confocal probe （diameter 7 mm） was designed with optical features similar to the flexible endomicroscopy system for use in humans using a 488 nm single line laser for fluorophore excitation, Light emission was detected at 505 to 750 nm. The field of view was 475 μm × 475 μm. Optical slice thickness was 7 μm with a lateral resolution of 0.7 μm. Subsurface serial images at different depths （surface to 250 μm） were generated in real time at 1024 × 1024 pixels （0.8 frames/s） by placing the probe onto the tissue in gentle, stable contact. Tissue specimens were sampled for histopathological correlation.RESULTS： The esophagus, stomach, small and large intestine and meso, liver, pancreas and gall bladder were visualised in vivo at high resolution in n = 48 mice. Real time microscopic imaging with the confocal minimicroscopy probe was easy to achieve. The different staining protocols （fluorescein, acriflavine, FITC-labelled dextran and L. esculentum lectin） each highlighted specific aspects of the tissue, and in vivo imaging correlated excellently with conventional histology. In vivo blood flow monitoring added a functional quality to morphologic imaging.CONCLUSION： Confocal microscopy is feasible in vivo allowing the visualisation of the complete GI tract at high resolution even of subsurface tissue structures. The new confocal probe design evaluated in this study is compatible with laparoscopy and significantly expands the field of possible applications to intra-abdominal organs. It allows immediate testing of new in vivo staining and application options and therefore permits rapid transfer from animal studies to clinical use in patients.

关键词： Confocal microscopy in vivo imaging Endomicroscopy Fluorescence

Comparison of wormlion behavior under man-made and natural shelters:urban wormlions more strongly prefer shaded,fine-sand microhabitats,construct larger pits and respond faster to prey

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Current Zoology 2020年第1期66卷 91-98页

作者： Yehonatan SAMOCHA Inon SCHARF School of Zoology Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Organismic and Molecular Evolution Johannes Gutenberg University MainzMainzGermany

Urban habitats differ from their natural surroundings in various aspects,such as a higher temperature and a distinct species *** is therefore not surprising that animal behavior too differs between these habitat *** studied the foraging and habitat selection behavior of a pit-building predator,a wormlion,originating from either an urban or a more natural *** occur in nature under structures that provide shelter from sunlight and rain,such as caves,and are also common in cities,occurring under artificial *** construct pittraps to hunt arthropods,and the pits constructed by urban wormlions were larger than those constructed by wormlions from *** wormlions responded faster to prey falling into their pit,probably leading to a higher capture *** suggest that these 2 findings indicate the higher investment of urban wormlions in foraging,resulting from the higher abundance of potential prey in the *** wormlions were choosier regarding their preferred *** both fine sand and shaded microhabitats were preferred by wormlions,urban wormlions demonstrated a greater preference for such *** suggest that relocation is more likely to lead wormlions in cities to find microhabitats of a higher quality compared with wormlions inhabiting *** is probably due to the larger areas in the city available for *** from the caves possessed more lipids,suggesting that they employ a conservative growth strategy,intended to contend with the uncertainty of prey arrival,in contrast to the city,where potential prey are more abundant.

关键词： antiions habitat selection habitat structure optimal foraging trap-building predators

Evidence for the effect of brief exposure to food,but not learning interference,on maze solving in desert ants

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Integrative Zoology 2022年第5期17卷 704-714页

作者： Tomer GILAD Arik DORFMAN Aziz SUBACH Romain LIBBRECHT Susanne FOITZIK Inon SCHARF School of Zoology The George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Organismic and Molecular Evolution Johannes Gutenberg University MainzMainzGermany

Theories of forgetting highlight 2 active mechanisms through which animals forget prior knowledge by recipro-cal disruption of *** to“proactive interference,”information learned previously interferes with the acquisition of new information,whereas“retroactive interference”suggests that newly gathered information interferes with already existing *** goal was to examine the possible effect of both mechanisms in the desert ant Cataglyphis niger,which does not use pheromone recruitment,when learning spatial information while searching for food in a *** experiment indicated that neither proactive nor retroactive interference took place in this system although this awaits conﬁrmation with individual-level learning ***,the ants’persistence or readiness to search for food grew with successive runs in the *** persistence led to more ant workers arriving at the food when retested a day later,even if the maze was shifted between *** support thisﬁnding in a second experiment,where ant workers reached the food reward at the maze end in higher numbers after encountering food in the maze entry compared to a treatment,in which food was present only at the maze *** result suggests that spatial learning and search persistence are 2 parallel behavioral mechanisms,both assisting foraging *** suggest that their relative contribution should depend on habitat complexity.

关键词： binary-tree maze desert ants forgetting memory motivation

Biosynthesis of Monoterpenoid Indole AlkaloidAjmaline Catalyzed by Novel Reductases

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Chemical Research in Chinese universities 2006年第2期22卷 267-269页

作者： Gerald von Schumann Joachim Stckigt Department of Pharmaceutical Biology Institute of Pharmacy Johannes Gutenberg University Staudinger Weg 5 D-55099 Mainz Germany

Introduction One of the major root alkaloids of the Indian medicinal plant Rauvolfia serpenlina Benth. ex Kurz is named ajmaline. The enzymatic biosynthesis of this alkaloid has been studied for a long time by our group As a result, a biosynthetic pathway has been established, in which about 10 enzymes participate, several of them belonging to the group of NADPH-dependent reductases. Started with the biosynthetic precursors tryptamine and secologanin,

关键词： Biosynthesis Alkaloid Reductase Ajmaline

GekkoFS—A Temporary Burst Buffer File System for HPC Applications

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Journal of Computer Science & Technology 2020年第1期35卷 72-91页

作者： Marc-AndréVef Nafiseh Moti Tim Süβ Markus Tacke Tommaso Tocci Ramon Nou Alberto Miranda Toni Cortes AndréBrinkmann Zentrum für Datenverarbeitung Johannes Gutenberg University MainzMainz 55128Germany Barcelona Supercomputing Center Barcelona 08034Spain Computer Architecture Department Universitat Politècnica de CatalunyaBarcelona 08034Spain

Many scientific fields increasingly use high-performance computing(HPC)to process and analyze massive amounts of experimental data while storage systems in today's HPC environments have to cope with new access *** patterns include many metadata operations,small I/O requests,or randomized file I/O,while general-purpose parallel file systems have been optimized for sequential shared access to large *** buffer file systems create a separate file system that applications can use to store temporary *** aggregate node-local storage available within the compute nodes or use dedicated SSD clusters and offer a peak bandwidth higher than that of the backend parallel file system without interfering with ***,burst buffer file systems typically offer many features that a scientific application,running in isolation for a limited amount of time,does not *** present GekkoFS,a temporary,highly-scalable file system which has been specifically optimized for the aforementioned use *** provides relaxed POSIX semantics which only offers features which are actually required by most(not all)*** is,therefore,able to provide scalable I/O performance and reaches millions of metadata operations already for a small number of nodes,significantly outperforming the capabilities of common parallel file systems.

关键词： distributed file system high-performance computing(HPC) burst buffer POSIX(portable operating system interface)

TLR3-independent activation of mast cells by cytomegalovirus contributes to control of pulmonary infection

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Cellular & Molecular Immunology 2017年第6期14卷 479-481页

作者： Niels AW Lemmermann Matthias J Reddehase Institute for Virology and Research Center forImmunotherapy (FZI) University Medical Centerof the Johannes Gutenberg University MainzGermany.

Interstitial pneumonia is a life-threatening clinical manifestation of human cytomegalovirus （hCMV） infection. In particular, it can be deadly in patients with hematopoietic malignancies who undergo hematopoietic cell transplantation （HCT） in whom a ＇window of risk＇, which is defined by transient immunodeficiency, occurs between hematoablative therapeutic treatment and immunological reconsfi- tution.

关键词： activation cytomegalovirus pulmonary

Multidisciplinary management of gastric and gastroesophageal cancers

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World Journal of Gastroenterology 2008年第24期14卷 3773-3780页

作者： Markus Moehler Orestis Lyros Ines Gockel Peter R Galle Hauke Lang First Department of Internal Medicine of johannes gutenberg university of mainz Institute of Surgery of johannes gutenberg university of mainz

Carcinomas of the stomach and gastroesophageal junction are among the five top leading cancer types worldwide. In spite of radical surgical R0 resections being the basis of cure of gastric cancer, surgery alone provides long-term survival in only 30% of patients with advanced International Union Against Cancer （UICC） stages in Western countries because of the high risk of recurrence and metachronous metastases. However, recent large phase-Ⅲ studies improved the diagnostic and therapeutic options in gastric cancers, indicating a more multidisciplinary management of the disease. Multimodal strategies combining different neoadjuvant and/or adjuvant protocols have clearly improved the gastric cancer prognosis when combined with surgery with curative intention. In particular, the perioperative （neoadjuvant, adjuvant） chemotherapy is now a well-established new standard of care for advanced tumors. Adjuvant therapy alone should be carefully discussed after surgical resection, mainly in individual patients with large lymph node positive tumors when neoadjuvant therapy could not be done. The palliative treatment options have also been remarkably improved with new chemotherapeutic agents and will further be enhanced with targeted therapies such as different monoclonal antibodies. This article reviews the most relevant literature on the multidisciplinary management of gastric and gastroesophageal cancer, and discusses future strategies toimprove Iocoregional failures.

关键词： Gastric cancer Chemotherapy Chemoradiation Adjuvant Neoadjuvant

Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?

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World Journal of Gastroenterology 2007年第26期13卷 3605-3609页

作者： Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski Department of General and Abdominal Surgery Johannes Gutenberg University of Mainz MainzGermany First Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Institute of Pathology Johannes Gutenberg University of MainzMainzGermany Third Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Unit of toxicology and chemotherapy German Cancer Research CenterGermany

AIM： To define the （co-）expression pattern of target receptor-tyrosine-kinases （RTK） in human gastric adenocarcinoma. METHODS： The （co-）expression pattern of VEGFR1-3, PDGFR（α/β and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition, IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS： The majority of samples revealed a VEGFR1 （98%）, VEGFR2 （80%）, VEGFR3 （67%）, PDGFRα （82%） and PDGFRβ （82%） expression, whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells, accompanied by an additional nuclear staining for VEGFR3, EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes, which also depicted a PDGFRα expression. CONCLUSION： Our results reveal a high rate ofreceptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy.

关键词： VEGFR EGFR PDGFR Cancer Adeno-carcinoma Gastric Stomach