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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

DOCK8 deficiency with mediastinal lymph node tuberculosis

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World Journal of Pediatrics 2020年第2期16卷 213-214页

作者： Lin-Qian Zhang Xiao-Bing Li Yun-Guang Bao jinhua hospital of Zhejiang University Jinhua 321300China

A 12-year-old girl presented with a history of unexplained persistent fever,accompanied by paroxysmal dry cough,skin *** patient had a past medical history of recurrent fever,pneumonia(at least four times per year),eczema,accompanied by diarrhea,repeated skin Staphylococcus aureus infection since 6 months of *** examination revealed broad nasal bridge and scoliosis,and chest computed tomography(CT)showed pneumonia,partial bronchiectasis of the right lung,and multiple mediastinal lymph node enlargement with confluence(Fig.1).Laboratory studies demonstrated significantly increased blood eosinophils and serum level of total *** biopsy of the rashes on the buttocks suggested eosinophil infiltration.

关键词： diarrhea tuberculosis fever

Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child

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World Journal of Pediatrics 2014年第1期10卷 86-88页

作者： Dong-Lai Hu Xiao-Dong Guo Zhi-Nan Sun Yan-Min Zhao Department of Pediatric Surgery Jinhua Hospital of Zhejiang UniversityJinhua Municipal Central HospitalJinhua 321000China

Background:XELOX(oxaliplatin 130mg/m^(2)iv,capecitabine 1000mg/m^(2)bid oral d1–14,q3w)chemotherapy has never been used in *** this report,we present a case of a 12-year-old girl with colon adenocarcinoma,treated with surgery and XELOX ***:On admission,the girl complained of abdominal pain and intestinal *** examination revealed a distended abdomen with tenderness on the left upper *** enema revealed a stenotic lesion at the distal end of the transverse colon,and abdominal computed tomography showed acute obstruction and a colonic *** was performed after the failure of conservative ***:The mass was originated from the transverse *** sections of the specimens revealed an *** colectomy was performed and regional lymph nodes were *** examination confirmed that the mass was a poorly differentiated adenocarcinoma,and XELOX chemotherapy was *** evidence of recurrent or metastatic tumor was found after 18 ***:Although complete resection is the most effective treatment,XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma.

关键词： chemotherapy colon adenocarcinoma XELOX regimen

Mesenteric phlebosclerosis with amyloidosis in association with the long-term use of medicinal liquor: A case report

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World Journal of Clinical Cases 2020年第4期8卷 798-805页

作者： Yi-Bing Hu Min-Li Hu Jin Ding Qun-Ying Wang Xiao-Yun Yang Department of Gastroenterology and Hepatology Jinhua Municipal Central Hospital Jinhua Hospital of Zhejiang University

BACKGROUND Mesenteric phlebosclerosis(MP)is a rare disease of the *** clinical manifestations of this disease are nonspecific and it may easily be *** report a case of MP with amyloidosis in the colonic vessel walls in a patient with hypertension who had been consuming Chinese medicinal liquor for 10 *** also review the relevant literature and summarize the characteristics of MP in patients in China's *** SUMMARY A 64-year-old man was referred to our department from his primary hospital because of abdominal pain,diarrhea,and fever for almost 10 *** tomography showed colon wall thickening,with threadlike calcifications in the mesenteric vein in the transverse *** revealed purple-blue mucosa with multiple ulcers in the ascending and transverse *** showed thickening and calcification of the vein walls,perivascular and mucosal collagen degeneration,and *** patient had been consuming Chinese medicinal liquor,mainly that made from gardenia fruit,for 10 *** on these results,a diagnosis of MP with amyloidosis was *** conservative treatment,the patient’s discomfort subsided and he was followed *** use of Chinese herbal medicine was suspected to play a role in the pathogenesis of *** The clinical manifestations of MP are *** of its typical imaging findings,including multiple calcifications on computed tomography and purple-blue mucosal discoloration on colonoscopy,is vital.

关键词： Mesenteric phlebosclerosis Amyloidosis Medicinal liquor Case report

Clinical applications of metagenomics next-generation sequencing in infectious diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 471-484页

作者： Ying LIU Yongjun MA Department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to human *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unbiased and comprehensive approach for detecting all RNA and DNA in a *** the development of sequencing and bioinformatics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host background and low-biomass samples;and(3)lack of standardized instructions for mass data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review briefly introduces the history of next-generation sequencing,mainstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cerebrospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microbiome

Segmental small bowel necrosis associated with antiphospholipid syndrome:A case report

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World Journal of Gastroenterology 2015年第13期21卷 4096-4100页

作者： Qun-Ying Wang Xiao-Hua Ye Jin Ding Xiao-Kang Wu Department of Gastroenterology and Hepatology Jinhua Municipal Central Hospital jinhua hospital of Zhejiang University Department of Hepato-Biliary-Pancreatic Surgery Jinhua Municipal Central Hospital

Antiphospholipid syndrome is a multi-system disease characterized by the formation of thromboembolic complications and/or pregnancy morbidity, and with persistently increased titers of antiphospholipid antibodies. We report the case of a 50-year-old, previously healthy man who presented with fever and new-onset, dull abdominal pain. A contrast-enhanced computed tomography scan showed segmental small bowel obstruction, for which an emergency laparotomy was performed. Histopathologic examination of resected tissues revealed multiple intestinal and mesenteric thromboses of small vessels. Laboratory tests for serum antiphospholipid(anticardiolipin Ig M) and anti-β2-glycoprotein I antibodies were positive. Despite proactive implementation of anticoagulation, steroid, and antibiotic therapies, the patient's condition rapidly deteriorated, and he died 22 d after admission. This case highlights that antiphospholipid syndrome should be suspected in patients with unexplainable ischemic bowel and intestinal necrosis presenting with insidious clinical features that may be secondary to the disease, as early diagnosis is critical to implement timely treatments in order to ameliorate the disease course.

关键词： Anticardiolipin antibodies Antiphospholipid syndro

Dexmedetomidine Promotes Angiogenesis and Vasculogenic Mimicry in Human Hepatocellular Carcinoma through α^(2)-AR/HIF-1α/VEGFA Pathway

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Biomedical and Environmental Sciences 2022年第10期35卷 931-942页

作者： FANG Tao LIN Li YE Zhi Jian FANG Lian SHI Shuai YU Ke Da MIAO Hui Hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Anesthesiology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina IVF centre The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000ZhejiangChina

Objective Dexmedetomidine(DEX),the most specificα^(2)-adrenergic receptor agonist widely used for its sedative and analgesic properties,has been reported to upregulate HIF-1αexpression to protect hypoxic and ischemic ***,it is largely unclear whether DEX can also upregulate Hypoxiainducible factor-1 alpha(HIF-1α)expression and its downstream vascular endothelial growth factor-A(VEGFA)in cancer tissues with oxygen-deficient tumor *** We used SMMC-7721 cells,MHCC97-H cells,and a mouse model of orthotopic hepatic carcinoma to explore the effect of DEX on angiogenesis and vasculogenic mimicry(VM)and its *** normoxic(20%O^(2))and hypoxic(1%O^(2))conditions,DEX was used to intervene cells,and yohimbine was used to rescue *** The results showed that DEX promoted angiogenesis and VM in human liver cancer cells within a certain dose range,and the addition of yohimbine inhibited this *** could activate HIF-1α/VEGFA pathway,which was further verified by silencing HIF-1α.Consistently,in vivo results also showed that DEX can up-regulate HIF-1α/VEGFA expression,and enhance the number of VM channels and microvessel density(MVD).Conclusion We believe that HIF-1α/VEGFA might be an important signaling pathway by which DEX promotes angiogenesis and VM formation in human hepatocellular carcinoma,whereasα^(2)-adrenergic receptor mediation might be the critical mechanisms.

关键词： Hepatocellular carcinoma Dexmedetomidine Yohimbine α^(2)-adrenergic receptor HIF-1a VEGFA Vascular mimicry Angiogenesis

Rectal tubular adenoma with submucosal pseudoinvasion misdiagnosed as adenocarcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1418-1424页

作者： Dan Chen Ding-Fu Zhong Hong-Ying Zhang Ying Nie Dong Liu Department of Gastroenterology Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua People's HospitalJinhua 321000Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Gastroenterology Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua People's HospitalJinhua 321000Zhejiang ProvinceChina

BACKGROUND Differential diagnosis of colorectal intramucosal tumors from invasive adenocarcinoma is important in clinical practice due to the different risks of lymph node metastasis and different treatment *** phenomenon of a colorectal adenoma with part of the gland entering the submucosa is known as pseudoinvasion of the adenoma,which is a major challenge for pathological *** is essential to raise awareness of colorectal adenoma with submucosal pseudoinvasion clinically to avoid *** SUMMARY We describe a case of rectal adenoma with submucosal pseudoinvasion in a 48-year-old *** patient was admitted to jinhua People's hospital due to a change in stool habit for 5 *** performed colonoscopy,and the results suggested a submucosal bulge approximately 1.0 cm×1.0 cm in size in the rectum 8 cm from the anal verge,with red surface *** colonoscopy was also performed and a homogeneous hypoechoic mass about 0.52 cm×0.72 cm in size was seen at the lesion,protruding into the lumen with clear borders and invading the *** surgery was then performed and the pathological specimen showed a tubular adenoma with high-grade intraepithelial neoplasia(intramucosal carcinoma)involving the adenolymphatic *** addition,we performed a literature review of rectal tubular adenoma with submucosal pseudoinvasion to obtain a deeper understanding of this *** The aim of this study was to improve awareness of this lesion for clinicians and pathologists to reduce misdiagnosis.

关键词： Colorectal adenoma Submucosal pseudoinvasion Ultrasound endoscopy Pathological diagnosis Treatment Case report

Smoking, alcohol consumption, and the risk of extrahepatic cholangiocarcinoma:A meta-analysis

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World Journal of Gastroenterology 2013年第46期19卷 8780-8788页

作者： Xiao-Hua Ye Jia-Ping Huai Jin Ding Yan-Ping Chen Xue-Cheng Sun Department of Gastroenterology and Hepatology Jinhua Municipal Central Hospital jinhua hospital of Zhejiang University Department of Critical Care Medicine Jinhua Municipal Central Hospital Department of Gastroenterology and Hepatology First Affiliated Hospital of Wenzhou Medical University

AIM:To assess the association between smoking and alcohol consumption and extrahepatic cholangiocarcinoma(ECC)through a meta-analysis of clinical observational ***:A literature search was conducted using Embase and MEDLINE databases from inception to 31May 2013 without language limitations,and by manually searching the references of retrieved *** and cohort studies that investigated the association between smoking or alcohol consumption and ECC were *** quality of these studies was assessed using the Newcastle-Ottawa quality assessment *** relative risks and corresponding95%CI were calculated using a random-effects *** bias was assessed by Begg’s funnel plot and Egger’s ***:A total of 12 eligible articles(11 case-control studies and one cohort study)were included in this *** studies reported the association between smoking and *** analysis indicated that smokers had an increased risk of ECC development as compared with non-smokers(summary RR=1.23;95%CI:1.01-1.50).This correlation was present in population-based studies(n=5;summary RR=1.47;95%CI:1.06-2.05)but not in hospital-based studies(n=6;summary RR=1.10;95%CI:0.88-1.37)and in non-Asian regions(n=7;summary RR=1.39;95%CI:1.03-1.87)but not in Asia(n=4;summary RR=1.08;95%CI:0.85-1.38).Seven studies reported an association between consuming alcohol and *** analysis indicated that alcohol drinkers had a similar risk of ECC development as did individuals who did not drink alcohol(summary RR=1.09;95%CI:0.87-1.37).There was moderate heterogeneity among the studies and no evidence of publication ***:Smoking is associated with an increased risk of ECC,but alcohol consumption is *** population-based studies,particularly cohort studies,are warranted to enable definitive conclusions.

关键词： Extrahepatic cholangiocarcinoma Smoking Alcohol consumption Meta-analysis Relative risk

Effect of Ginkgo Leaf Extract on Vascular Endothelial Function in Patients with Early Stage Diabetic Nephropathy

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Chinese Journal of Integrative Medicine 2009年第1期15卷 26-29页

作者：李旭升郑伟英楼时先陆小文叶赏和 Medical College Jinhua College of Profession and Technology The Affiliated hospital of jinhua College of Profession and Technology Medical College Jinhua College of Profession and TechnologyJinhua

Objective:To explore the effect of ginkgo leaf extract(GLE) on vascular endothelial function(VEF) in patients with early stage diabetic nephropathy(DN).Methods:Sixty-four patients were randomized equally by a randomzing digital table into two groups,the treated group and the control *** were all treated for 8 weeks with conventional therapy for diabetes,but GLE tablets were given to the treated group additionally. Changes in VEF were estimated before and after treatment by ultrasonic examination of t...

关键词： ginkgo leaf extract diabetic nephropathy endothelial function von Willebrand factor