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Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis

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World Journal of Gastrointestinal Oncology 2020年第1期12卷 54-65页

作者： Yao-Yao Bian Li-Li Yang Yan Yan Min Zhao Yan-Qi Chen Ya-Qi Zhou Zi-Xin Wang Wen-Lin Li Li Zeng School of Nursing Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina jingwen library Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Guang′anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Postoperative peritoneal adhesion(PPA),characterized by abdominal pain,female infertility,and even bowel obstruction after surgery,has always been a major *** occurrence and formation of adhesion are from complex biological ***,the molecular mechanisms underlying the basis of microarray data profile,followed by peritoneal adhesion formation,are largely *** To reveal the underlying pathogenesis of PPA at the molecular *** The gene expression profile was retrieved from the Gene Expression Omnibus database for our *** identified a panel of key genes and related pathways involved in adhesion formation using bioinformatics analysis *** performed quantitative PCR and western blotting in vivo to validate the results *** In total,446 expressed genes were altered in peritoneal *** found that several hub genes(e.g.,tumor necrosis factor,interleukin 1 beta,interleukin 6,CX-C motif chemokine ligand 1,C-X-C motif chemokine ligand 2)were marked as significant *** analysis suggested that these genes were enriched in the Toll-like receptor signaling *** to the Kyoto Encyclopedia of Genes and Genomes pathway and published studies,TLR4,myeloid differentiation primary response protein 88(MyD88),and nuclear factor kappa B(NF-κB)played essential roles in Toll-like signaling ***,we obtained a regulatory evidence chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion involved in the pathogenesis of postoperative *** results of the microarray analysis were verified by the animal *** findings may extend our understanding of the molecular mechanisms of *** The regulatory evidence chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion may play key roles in the pathogenesis of *** studies are required to validate our findings.

关键词： Postoperative peritoneal adhesion Candidate biomarkers Molecular pathogenesis Bioinformatics analysis

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Research on Mechanisms of Chinese Medicines in Prevention and Treatment of Postoperative Adhesion

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Chinese Journal of Integrative Medicine 2023年第6期29卷 556-565页

作者： Ya-li Wang WANG Ya-li ZHANG Hui-xiang CHEN Yan-qi YANG Li-li LI Zheng-jun ZHAO Min LI Wen-lin BIAN Yao-yao ZENG Li School of First Clinical Medicine Nanjing University of Chinese MedicineNanjing(210023)China jingwen library Nanjing University of Chinese MedicineNanjing(210023)China College of Health Economics Management Nanjing University of Chinese MedicineNanjing(210023)China School of Chinese Medicine School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210023)China College of Acupuncture and Massage College of Regimen and RehabilitationNanjing University of Chinese MedicineNanjing(210023)China Faculty of Chinese Medicine Macao University of Science and TechnologyTaipaMacao(999078)China Jiangsu Provincial Engineering Center of Traditional Chinese Medicine External Medication Researching and Industrializing Nanjing University of Chinese MedicineNanjing(210023)China

Postoperative adhesion(PA)is currently one of the most unpleasant complications following surgical *** have developed several new strategies to alleviate the formation of PA to a great extent,but so far,no single measure or treatment can meet the expectations and requirements of clinical patients needing complete PA *** medicine(CM)has been widely used for thousands of years based on its remarkable efficacy and indispensable advantages CM treatments are gradually being accepted by modern ***,this review summarizes the formating process of PA and the efficacy and action mechanism of CM treatments,including their pharmacological effects,therapeutic mechanisms and advantages in PA *** aim to improve the understanding of clinicians and researchers on CM prevention in the development of PA and promote the in-depth development and industrialization process of related drugs.

关键词： postoperative adhesion Chinese medicine prevention treatment review

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Identification of key genes involved in post-traumatic stress disorder:Evidence from bioinformatics analysis

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World Journal of Psychiatry 2020年第12期10卷 286-298页

作者： Yao-Yao Bian Li-Li Yang Bin Zhang Wen Li Zheng-Jun Li Wen-Lin Li Li Zeng School of Nursing Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of First Clinical Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina jingwen library Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Digestive Department Ningbo Hospital of Traditional Chinese MedicineNingbo 315200Zhejiang ProvinceChina School of Preclinical Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Management School University of St AndrewsSt Andrews KY169AJUnited Kingdom College of Health Economics Management Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Post-traumatic stress disorder(PTSD)is a serious stress-related *** To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics *** Gene expression profiles were obtained from the Gene Expression Omnibus *** differentially expressed genes(DEGs)were identified by using *** functional annotation and pathway enrichment were then *** gene-pathway network was constructed with Cytoscape *** real-time polymerase chain reaction(qRT-PCR)analysis was applied for validation,and text mining by Coremine Medical was used to confirm the connections among genes and *** We identified 973 DEGs including 358 upregulated genes and 615 downregulated genes in PTSD.A group of centrality hub genes and significantly enriched pathways(MAPK,Ras,and ErbB signaling pathways)were identified by using gene functional assignment and enrichment *** genes(KRAS,EGFR,NFKB1,FGF12,PRKCA,and RAF1)were selected to validate using *** results of text mining further confirmed the correlation among hub genes and the enriched *** indicated that these altered genes displayed functional roles in PTSD via these pathways,which might serve as key signatures in the pathogenesis of *** The current study identified a panel of candidate genes and important pathways,which might help us deepen our understanding of the underlying mechanism of PTSD at the molecular ***,further studies are warranted to discover the critical regulatory mechanism of these genes via relevant pathways in PTSD.

关键词： Post-traumatic stress disorder Differentially expressed genes Key pathway Gene-pathway co-expression Bioinformatics analysis Microarray

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