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A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox:A case of jing Liqueur

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Chinese Herbal Medicines 2021年第3期13卷 430-438页

作者： jing Zhou Feng-jie Liu Xin-xin Li Ping Li Hua Yang Yuan-cai Liu Yan-he Chen Chao-dan Wei Hui-jun Li State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Hubei Provincial Key Laboratory for Quality and Safety of Traditional Chinese Medicine Health Food Jing Brand Co.Ltd.Daye 435100China jing brand research institute Jing Brand Co.Ltd.Daye 435100China

Objective:The quality evaluation of herbal products remains a big *** markers are the core concept of the authentication of herbal ***,the discovery of traceable markers is labor-intensive and *** aim of this study is to develop a convenient approach to rapidly screen the traceable markers for herbal product ***:Commercial jing Liqueur and its 22 species of herbal ingredients were analyzed using HPLCQTOF-MS and GC–MS to characterize nonvolatile and volatile *** acquired data were imported into MZmine 2 software for mass detection,chromatogram building,deconvolution and *** aligned data were exported into a csv file and then traceable markers were selected using the built-in filter function in ***,the traceable markers were identified by searching against online databases or publications,some of which were confirmed by reference ***:A total of 288 chemical features transferred from herbal materials to jing Liqueur product were rapidly screened *** them,52 markers detected by HPLC-QTOF-MS were annotated,while nine volatile markers detected by GC–MS were ***,30 of these markers were confirmed by comparing with reference standards.A chemical fingerprint consisting of traceable markers was finally generated to ensure the authentication and quality consistency of jing ***:A strategy for rapid discovery of traceable markers in herbal products using MZmine 2 software was developed.

关键词： GC–MS herbal products HPLC-QTOF-MS jing Liqueur MZmine 2 traceable markers

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Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus

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Chinese Medicine and Culture 2021年第4期4卷 201-210页

作者： Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao Department of Pharmaceutical Sciences Daniel K.Inouye College of PharmacyUniversity of Hawai’i at HiloHawaii 96720USA Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food Jing Brand Research InstituteJing Brand Co.Ltd.Daye 435100HubeiChina

Huang Qi(黄芪Astragalus membranaceus)is a well-known and widely used herb in traditional Chinese medicine(TCM)tonic *** has been used for many ailments over the last 2000 ***,saponins,and polysaccharides have been shown to be the main compounds responsible for the biological and pharmacological activities,especially the immunomodulatory properties,of such tonic *** review summarizes the published data on Astragalus extracts and fractions and the natural compounds responsible for the immunomodulatory activity with special reference to the modulation of nuclear factor-kappa B and related pathways(e.g.,Nrf2).In addition,this review highlights the importance of Astragalus membranaceus in TCM for treating patients with diseases related to immunocompromised conditions,such as cancer and diabetes.

关键词： Huang Qi(黄芪Astragalus membranaceus) immunomodulatory nuclear factor-kappa B phytochemicals

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang jing Liu Stem Cell Clinical research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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X-ray photoelectron spectroscopic analysis of effect of EB on electronic state of Ti species in TiCl_4/MgCl_2/EB Ziegler-Natta catalysts

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Chinese Science Bulletin 2006年第11期51卷 1393-1395页

作者： SONG Yang GAO Mingzhi ZHAO Xi MAO Bingquan College of Science Beijing University of Chemical Technology Bei- jing 100029 China Polyolefin Engineering and research Center Beijing Research Institute of Chemical Industry Beijing 100029 China

X-ray photoelectron spectroscopy (XPS) analysis was performed on TiCl4/MgCl2/EB (ethyl benzoate) catalysts, TiCl4/MgCl2 internal donor free catalysts and TiCl4·EB complex to elucidate the effect of EB on electronic state of Ti species in TiCl4/MgCl2/ EB catalysts. Combined with FTIR analysis, the way that EB influenced electronic state of Ti species was postulated. XPS results showed that the binding en- ergy of Ti2p3/2 in TiCl4/MgCl2/EB catalysts was lower than that in TiCl4/MgCl2 internal donor free catalysts indicating that EB influenced electronic state of Ti atoms by providing electrons to Ti atoms in TiCl4/ MgCl2/EB catalysts.

关键词： Ziegler-Natta催化剂内给体苯甲酸乙酯 XPS 光谱分析

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Influence of Friction Interface Contact on Ultrasonic Motor Efficiency Under Static Conditions

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Transactions of Nanjing University of Aeronautics and Astronautics 2015年第2期32卷 163-173页

作者：张毅锋张武肖爱武朱萌潘云华张小亚 Xi'an Chuang Lian Ultrasonic Technology Co Ltd School of Marine Science and Tchnology Northwest Polytechnical University Xi jing Electronic Corp Xi'an Modern Control Technology research institute

The friction interface matching plays a deterministic role in the motor efficiency,and the microcosmic contact status of friction interface should be investigated to improve the ultrasonic motor *** main purpose is to improve the effective output power of ultrasonic ***,one studies the contact condition of the friction interface of the ultrasonic motor,analyzes the micro condition of contact interface through finite element analysis,optimizes unreasonable structures,and compares the two different-structure ultrasonic motors through *** results reflect the necessity of *** optimization,the stator and rotor deform after pre-pressure and the contact interface of them full contact *** reaching heat balance the effective output of the motor is 37%,and the average effective output efficiency is 2.384 times higher than that of the *** can be seen that the total consumption of the ultrasonic motor system decreases ***,when using in certain system the consumption taken from the system will decreases largely,especially in the system with a strict consumption control.

关键词： ultrasonic motor friction interface contact area efficiency

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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A channel estimation algorithm for optical orthogonal frequency division multiplexing systems

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Optoelectronics Letters 2013年第3期9卷 217-220页

作者： WANG Dong YOU Nian-yu WANG Wei-dong ZHANG Ying-hai Laboratory of Information and Electronics Technology Beijing University of Posts and Telecommunications Bei-jing 100876 China research institute of Photonics Dalian Polytechnic University Dalian 116034 China

A simple channel estimation (CE) scheme, which is pilot-aided with just a little number of pilots inserted in the first half part of the subcarriers, is proposed and simulated for resisting the fiber dispersion in optical orthogonal frequency division multiplexing (OFDM) systems. The simulation results verify that the receiver sensitivity is improved by 2-3 dBm for bit error rate (BER) of 10~(-3) with the proposed CE algorithm than that with other kinds of CE algorithms based on linear square principle. The good constellation performance for a 40 Gbit/s transmission system can be also obtained by the proposed scheme.

关键词：正交频分复用系统信道估计算法接收灵敏度 OFDM 仿真结果传输系统子载波飞行员

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Triboelectric nanogenerator enhanced multilayered antibacterial nanofiber air filters for efficient removal of ultrafine particulate matter

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Nano research 2018年第8期11卷 4090-4101页

作者： Guang Qin Gu Chang Bao Han jing jing Tian Tao Jiang Chuan He Cun Xin Lu Yu Bai Jin Hui Nie Zhou Li Zhong Lin Wang Beijing institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100049 China School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA 30332-0245 USA Guang Oin Gu Chang Bao Han and Jing Jing Tian contributed equally to this work.

We developed a high-efficiency rotating triboelectric nanogenerator （R-TENG）- enhanced *** antibacterial polyimide （PI） nanofiber air filters for removing ultrafine particulate matter （PM） from ambient atmosphere. Compared to single- layered PI nanofiber filters, the multilayered nanofiber filter can completely remove all of the particles with diameters larger than 0.54 ffm and shows enhanced removal efficiency for smaller PM particles. After connecting with a R-TENG, the removal efficiency of the filer for ultrafine partides is further enhanced. The highest removal efficiency for ultrafine particulate matter is 94.1% at the diameter of 53.3 nm and the average removal efficiency reached 89.9%. Despite an increase in the layer number, the thickness of each individual layer of the film decreased, and hence, the total pressure drop of the filter decreased instead of increasing. Moreover, the nanofiber film exhibited high antibacterial activity because of the addition of a small amount of silver nanoparticles. This technology with zero ozone release and low pressure drop is appropriate for cleaning air, haze treatment, and bacterial control.

关键词： triboelectricnanogenerator antibacterial property electrospinnin Ag-polyimide nanofiber air filter,ultrafine particle

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GR5 acts in the G protein pathway to regulate grain size in rice

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Plant Communications 2024年第1期5卷 181-195页

作者： Yueying Wang Yang Lv Haiping Yu Peng Hu Yi Wen Junge Wang Yiqing Tan Hao Wu Lixin Zhu Kaixiong Wu Bingze Chai Jialong Liu Dali Zeng Guangheng Zhang Li Zhu Zhenyu Gao Guojun Dong Deyong Ren Lan Shen Qiang Zhang Qing Li Longbiao Guo Guosheng Xiong Qian Qian Jiang Hu State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Hainan Yazhou Bay Seed Laboratory Sanya 572024HainanChina National Nanfan research institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China Nanjing Agricultural University Nan Jing 210000JiangsuChina

Grain size is an important determinant of grain yield in *** dozens of grain size genes have been reported,the molecular mechanisms that control grain size remain to be fully ***,we report the cloning and characterization of GR5(GRAIN ROUND 5),which is allelic to SMOS1/SHB/RLA1/NGR5 and en-codes an AP2 transcription ***5 acts as a transcriptional activator and determines grain size by influencing cell proliferation and *** demonstrated that GR5 physically interacts withfive Gg subunit proteins(RGG1,RGG2,DEP1,GS3,and GGC2)and acts downstream of the G protein *** downstream target genes of GR5 in grain development(DEP2,DEP3,DRW1,and CyCD5;2)were re-vealed and their core T/CGCAC motif identified by yeast one-hybrid,EMSA,and ChIP–PCR *** results revealed that GR5 interacts with Gg subunits and cooperatively determines grain size by regu-lating the expression of downstream target *** provide new insight into the genetic reg-ulatory network of the G protein signaling pathway in the control of grain size and provide a potential target for high-yield rice breeding.

关键词： grain size G proteinγsubunit GR5 AP2 transcription factor rice(Oryza sativa L.)

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Raman Spectrum of Epitaxial Graphene Grown on Ion Beam Illuminated 6H-SiC （0001）

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Chinese Physics Letters 2014年第11期31卷 126-129页

作者：周智胡颖单欣岩陆兴华 Beijing National Laboratory for Condensed-Matter Physics and Institute of Physics Chinese Academy of Sciences Be{jing 100190 Collaborative Innovation Center of Quantum Matter Beijing 100190

Patterning SiC substrates with focused ion beam for growth of confined graphene nanostructures is interesting for fabrication of graphene devices. However, by imposing an ion beam, the morphology of illuminated SiC substrate surface is inevitably damaged, which imposes significant effects on the subsequent growth of graphene. By using confocal Raman spectroscopy, we investigate the effects of ion beam illumination on the quality of graphene layers that are grown on 6H-SiC （0001） substrates with two different growth methods. With the first method, the 6H-SiC （0001） substrate is flash annealed in ultra-high vacuum. Prominent defects in graphene grown on illuminated areas are revealed by the emergence of Raman D peak. Significant changes in D peak intensity are observed with Ga＋ ion fluence as low as 10^5 μm^-2. To eliminate the damage from the ion beam illumination, hydrogen etching is employed in the second growth method, with which prominent improvement in the quality of crystalline graphene is revealed by its Raman features. The defect density is significantly reduced as inferred from the disappearance of D peak. The Raman shift of G peak and 2D peak indicates strain-released graphene layers as grown in such a method. Such results provide essential information for patterning graphene nano-devices.

关键词： Graphene Ion beams Silicon carbide Raman spectroscopy Field-effect transistors

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