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World Journal of Emergency Medicine 2024年第1期15卷 52-55页

作者： Miao Bian Zhihao Wang Yanling Chen Yue Sun Hongsen Ji Yutao Wang Li Pang Department of Respiratory Qianwei Hospital of Jilin ProvinceChangchun 130012China Department of Geriatrics Jilin Provincial Geriatric Medicine Clinical Research Centerthe First Hospital of Jilin UniversityChangchun 130021China Department of Emergency the First Hospital of Jilin UniversityChangchun 130021China The First Operating Room the First Hospital of Jilin UniversityChangchun 130021China

Sepsis is a lethal condition characterized by multiple organ dysfunction due to disrupted host responses to severe infections.[1]Aff ected patients often have a Sequential Organ Failure Assessment(SOFA)score≥2.[2]Patients with a SOFA score<2 and at least one of the following were considered as“suspected sepsis”:(1)quick SOFA(qSOFA)score≥2;(2)SOFA score=1;or(3)National Early Warning Score(NEWS)4-6.[3]Compared with studies on fluid resuscitation in sepsis patients,there are few studies on fluid management in patients with suspected ***,we conducted a retrospective cohort study to evaluate the relationship between fluid management and disease progression in suspected sepsis patients.

关键词： patients sepsis admitted

Cut-off value of glycated hemoglobin A1c for detecting diabetic retinopathy in the Chinese population

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World Journal of Diabetes 2024年第7期15卷 1531-1536页

作者： Yan Wen Qing Wang Department of Endocrinology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and ***,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in jilin,China,remains *** To determine the best cut-off of HbA1c for diagnosing DR among the *** This cross-sectional study included 1933 participants from the Yanbian area of jilin Province,*** investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the *** best cut-off value for HbA1c was established via the receiver operating characteristic *** factors associated with HbA1c-associated risk factors were determined via linear *** The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation *** prevalence of DR was 3.27% in the total ***1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation *** both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off *** optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,***,body mass index,and FBG were determined as the risk factors impacting HbA1c *** HbA1c may serve as a useful diagnostic indicator for *** HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.

关键词： Diabetic retinopathy Glycated hemoglobin A1c Cut-off value Age Body mass index Fasting blood glucose

Cloning, Characterization and Transformation of Methyltransferase 2a Gene (Zmet2a) in Maize (Zea mays L.)

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1767-1779页

作者： Xin Qi Yu Wang Xing Zhang Xiaoshuang Wei Xinyang Liu Zhennan Wang Zhenhui Wang Fenglou Ling Faculty of Agronomy Jilin Agricultural UniversityChangchun130118China Rice Research Center Jilin Agricultural UniversityChangchun130118China

DNA methylation is an important epigenetic regulatory mechanism,it regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s)to *** this study,a novel methyltransferase 2a gene(Zmet2a)was cloned in maize and identiﬁed by polymerase chain reaction-base(PCR-base)using a bioinformatics *** Zmet2a cDNA sequence is 2739 bp long and translates to 912 amino acid *** Zmet2a protein revealed that it contains BAH and CHROMO structural domains,is a non-transmembrane protein that is hydrophilically unstable,and has no signal peptide ***,we veriﬁed the biological roles of Zmet2a using transgenic Arabidopsis overexpressing Zmet2a and Zmet2a-knockout *** Zmet2a Arabidopsis thaliana showed highly signiﬁcant advancement inﬂowering time,and Zmet2a-knockout maize showed advancement inﬂowering time,with signiﬁcant changes in several ***,these report the role of Zmet2a in the regulation ofﬂowering time,which will lay a foundation for revealing the biological function and epigenetic regulation mechanism of Zmet2a in the growth,development andﬂowering of maize.

关键词： DNA methylation methyltransferase Zea mays L ﬂowering time functional analysis

Design and experiment of high-speed straw cleaning unit with double air springs

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 89-97页

作者： Xiaomeng Xia Honggang Li Shuyan Liu Ruiqiang Ran Yongjian Cong Yuhan Jin Dongyan Huang School of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China jilin Agricultural Machinery Research Institute Changchun 130022China

No-tillage planters need to be equipped with row cleaners to remove post-harvest plant residue from the *** two-disc row cleaners cannot effectively remove the plant residue at high speed because the working depth is unstable,which leads to poor seeding quality of the seeder.A straw cleaning unit with double air springs was designed to achieve better straw cleaning performance at high *** analysis of the mechanical characteristics of the double air spring system showed that it enabled separate adjustment of force and stiffness.A dynamic model of the straw cleaning unit was established,and the effectiveness of the double air spring system with adjustable stiffness in stabilizing the working depth of the row cleaners was *** experiments were conducted to evaluate the straw cleaning performance and consistency of downforce against the ground of the straw cleaning unit with double air springs at different high *** results showed that the stiffness of the double air spring system for better straw cleaning performance of the straw cleaning unit was different at different working speed,and the required stiffness increased as the working speed increased;When the working speed was 8-12 km/h,the coefficient of variation of cleaned strip width was 6.9%-12.1%,the straw cleaning rate was 81.6%-92.2%and the root mean square error of downforce was 19.93-28.63 N;the coefficient of variation of cleaned strip width was moderately positively correlated with the root mean square error of downforce,and the cleaned strip width consistency was better when the root mean square error of downforce was lower than 25.00 N.

关键词： conservation tillage row cleaners straw cleaning unit double air spring system

Theoretical investigation of excited dipole bound states of alkali-containing diatomic anions

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Chinese Physics B 2024年第5期33卷 389-393页

作者：连艺肖利丹边丽丽徐海峰闫冰 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

Information about electronic excited states of molecular anions plays an important role in investigating electron attachment and detachment *** we present a high-level theoretical study of the electronic structures of 12 alkali-metal-containing diatomic anions MX-(MX = LiH,LiF,LiCl,NaF,NaCl,NaBr,RbCl,KCl,KBr,RbI,KI and CsI).The equation-of-motion electron-attachment coupled-cluster singles and doubles(EOM-EA-CCSD) method is used to calculate the electron binding energies(EBEs) of 10 electronic excited states of each of the 12 molecule *** addition of different s-/p-/d-type diffusion functions in the basis set,we have identified possible excited dipole bound states(DBSs) of each *** the investigation of EBEs on the 12 MXs with dipole moment(DM) up to 12.1 D,we evaluate the dependence of the number of anionic excited DBSs on molecular *** results indicate that there are at least two or three DBSs of anions with a molecular DM larger than 7 D and a molecule with DM > 10 D can sustain a π-DBS of the *** study has some implications for the excited DBS electronic states of alkali-metal-containing diatomic molecules.

关键词： anions dipole bound states alkali-metal-containing diatomic molecules

Tunable spectral continuous shift of high-order harmonic generation in atoms by a plasmon-assisted shaping pulse

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Chinese Physics B 2024年第3期33卷 433-440页

作者：王源李玉龙乔月高娜郭福明陈洲赫兰海杨玉军赵曦王俊 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy Jilin UniversityChangchun 130012China Beijing Institute of Space Launch Technology Beijing 100076China School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710062China

We delve into the phenomenon of high-order harmonic generation within a helium atom under the influence of a plasmon-assisted shaping *** findings reveal an intriguing manipulation of the frequency peak position in the harmonic emission by adjusting the absolute phase parameter within the frequency domain of the shaping *** phenomenon holds potential significance for experimental setups necessitating precisely tuned single ***,we observe a modulated shift in the created harmonic photon energy,spanning an impressive range of 1.2 *** frequency peak shift is rooted in the asymmetry exhibited by the rising and falling edges of the laser pulse,directly influencing the position of the peak frequency *** study quantifies the dependence of this tuning range and the asymmetry of the laser pulse,offering valuable insights into the underlying mechanisms driving this ***,our investigation uncovers the emergence of semi-integer order harmonics as the phase parameter is *** attribute this discovery to the intricate interference between harmonics generated by the primary and secondary return *** observation introduces an innovative approach for generating semi-integer order harmonics,thus expanding our understanding of high-order harmonic ***,our work contributes to the broader comprehension of complex phenomena in laser-matter interactions and provides a foundation for harnessing these effects in various applications,particularly those involving precise spectral control and the generation of unique harmonic patterns.

关键词： high-order harmonic semi-integer-order spectra shift inhomogeneous field

Electronic structure tuning of layered double hydroxides for electrochemical sensing and its biomedical applications

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Science China Chemistry 2024年第11期67卷 3614-3630页

作者： Kun Wang Zhiying Cao Qihang Ding Jiyoung Yoo Nem Singh Heemin Kang Lin Wang Lin Xu Jong Seung Kim School and Hospital of Stomatology Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University State Key Laboratory on Integrated Optoelectronics Collage of Electronic Science and Engineering Jilin University Department of Chemistry Korea University Department of Materials Science and Engineering Korea University

Modifying the electrodes of electrochemical sensors is critical to enhance sensitivity, selectivity, and stability, ultimately improving both their effectiveness and performance. In this paper, recent advancements in electrochemical sensors are reviewed,focusing on the utilization of layered double hydroxides(LDHs). The first section explores the advantageous and disadvantageous aspects of electrochemical sensing. Benefits include rapid response, ease of operation, and cost-effectiveness,while drawbacks concern the potential instability of prolonged use, susceptibility to interference, and the risk of biomolecule inactivation. Following this, the second section delves into the synthesis, constituents, and structure of LDHs. Moreover, after introducing the chemical mechanisms and functions of LDHs in electrochemical sensors, we concentrate on diverse modifying materials of LDHs and their different performances. Finally, the applications of LDHs in electrochemical sensing across different fields are discussed. This review aims to facilitate the continued advancement for applying LDHs in electrochemical sensors, as well as inspire the evolution of electrochemical sensing technology.

关键词： layered double hydroxides electrochemical sensor biological field modified electrode

Kinetically and thermodynamically expediting elementary steps via high-valence Cr-incorporated of nickel selenide for water electrolysis

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Nano Research 2024年第3期17卷 1199-1208页

作者： Huafeng Fan Dongxu Jiao Jinchang Fan Dewen Wang Bilal Zaman Wei Zhang Lei Zhang Weitao Zheng Xiaoqiang Cui State Key Laboratory of Automotive Simulation and Control School of Materials Science and EngineeringKey Laboratory of Automobile Materials of MOEJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsElectron Microscopy CenterJilin UniversityChangchun 130012China College of Chemistry Jilin UniversityChangchun 130012China

Designing high-performance electrocatalysts toward hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is essential to reduce the activation barrier and optimize free adsorption energy of reactive ***,we report that incorporating high-valence Cr into NiSe_(2)(Cr_(x)Ni_(1-x)Se_(2))kinetically and thermodynamically expedites elementary steps of both HER and *** as-prepared Cr_(0.05)Ni_(0.95)Se_(2) catalyst displays excellent HER and OER activities,with low overpotentials of 89 and 272 mV at the current density of 10 mA·cm^(-2)(j10),respectively,and remains stable during operation for 30 h.A low cell voltage of only 1.59 V is required to drive j10 in alkaline *** situ Raman spectroscopy reveals that Cr incorporation facilitates the formation of NiOOH active species during the OER ***,theoretical explorations demonstrate that high-valence Cr incorporation efficiently accelerates water dissociation kinetics and improves H*adsorption during HER process,lowering the activation barrier of OER and optimizing the adsorption energy of oxygen-based intermediate,thus kinetically and thermodynamically enhancing the intrinsic performance of NiSe_(2) for over water *** strategy provides a new horizon to design transition metal based electrocatalysts in the clean energy field.

关键词： nickel selenide electrocatalytic water splitting high-valence Cr density functional theory(DFT)calculation

Compressive property and energy absorption characteristic of interconnected porous Mg-Zn-Y alloys with adjusting Y addition

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Journal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： J.A.Liu S.J.Liu B.Wang W.B.Sun X.J.Liu Z.W.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for Bionics-jilin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys with different phase compositions were prepared by various Y additions(x=0.4,3,and 6 wt.%)to adjust the compressive properties and energy absorption *** characterization methods were then applied to identify the microstructure of the porous Mg-Zn-Y and describe the details of the second *** tests were performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),W-phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).When the Y content ranges between 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy absorption capacity increases from 7.33 MJ/m^(3)to 10.97 MJ/m^(3)at RT,which is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-Zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs