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Epidemiological Characteristics of Visceral Leishmaniasis—Shanxi province,China,1950–2019

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China CDC weekly 2022年第28期4卷 614-617,I0004页

作者： Yingze Zhao Ping Tie Yongfei Bai Liping Wang Yuhua Zheng Jiaojiao Zhang Xiao Qi Canjun Zheng Xiao-nong Zhou National Institute for Viral disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Shanxi Provincial center for disease control and Prevention Taiyuan CityShanxi ProvinceChina Chinese center for disease control and Prevention BeijingChina Beijing center for disease control and Prevention BeijingChina National Institute of Parasitic diseases of Chinese center for disease control and Prevention ShanghaiChina.

Summary What is already known about this topic?Visceral leishmaniasis(VL)is the most serious form of *** recent years,reported cases of VL have been gradually increasing in Shanxi province,*** is added by this report?The report describes the epidemiology of VL from 1950 to 2019 in Shanxi province and the recent trend of VL *** are the implications for public health practice?Measures to prevent and control VL,such as health education,improving clinical diagnostics,strengthening epidemiological investigation capacity for VL cases,monitoring surveillance,and use of other evidence-based preventive measures,should be undertaken in Shanxi province.

关键词： Shanxi strengthening education

Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui Li Peizheng Zhan Hongju Duan Wenbo Luo Benfu Li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial center for disease control and Prevention Lanzhou CityGansu ProvinceChina The center for disease control and Prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps center for disease control and Prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial center for disease control and Prevention Chengdu CitySichuan ProvinceChina Qinhai Institute for Endemic disease control and Prevention Xining CityQinghai ProvinceChina Ningxia center for disease control and Prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region center for Comprehensive disease control and Prevention Hohhot CityInner Mongolia AutonomousChina Yunnan Institute of Parasitic diseases Puer CityYunnan ProvinceChina Shaanxi Provincial center for disease control and Prevention Xi'an CityShaanxi ProvinceChina Henan Provincial center for disease control and Prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial center for disease control and Prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 370 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

An Index–Contact Paired Data Analysis on Sexual Contact Tracing Outcomes of HIV-Infected Individuals—Yunnan province,China,2022–2024

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China CDC weekly 2024年第48期6卷 1271-1277,I0002-I0003页

作者： Wenjun Yan Junli Huo Xiaojing An Qiongli Duan Yu Han Nengmei Huang Ting Tan Zhimin Yang Jing Han Mengjie Han Yuhua Shi Jian Li National center for AIDS/STD control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Yunnan center for disease control and Prevention Kunming CityYunnan ProvinceChina center for disease control and Prevention in Honghe Hani and Yi Autonomous Prefecture MengziYunnan ProvinceChina Kunming Medical University Kunming CityYunnan ProvinceChina

What is already known about this topic?A substantial proportion of people living with human immunodeficiency virus(PLWH)remain unaware of their infection *** tracing serves as an effective public health tool for identifying human immunodeficiency virus(HIV)infections and supports progress toward achieving the 95-95-95-95 *** is added by this report?

关键词： identifying tracing comes

Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning

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Neural Regeneration Research 2024年第6期19卷 1284-1290页

作者： Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong Clinical Research center of Neurological disease The Second Affiliated Hospital of Soochow UniversityInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric DiseasesSoochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology and Clinical Research center of Neurological disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural *** brain physiology,highly dynamic microglial processes are facilitated to sense the surrounding environment and *** the brain switches its functional states,microglia are recruited to specific sites to exert their immune functions,including the release of cytokines and phagocytosis of cellular *** crosstalk of microglia between neurons,neural stem cells,endothelial cells,oligodendrocytes,and astrocytes contributes to their functions in synapse pruning,neurogenesis,vascularization,myelination,and blood-brain barrier *** this review,we highlight the neuron-derived“find-me,”“eat-me,”and“don't eat-me”molecular signals that drive microglia in response to changes in neuronal activity for synapse refinement during brain *** review reveals the molecular mechanism of neuron-microglia interaction in synaptic pruning and presents novel ideas for the synaptic pruning of microglia in disease,thereby providing important clues for discovery of target drugs and development of nervous system disease treatment methods targeting synaptic dysfunction.

关键词： complement immune signals microglia molecular signal synapse elimination synapse formation synapse refinement synaptic pruning

Comparison of 1 Versus 2 Doses of Quadrivalent Influenza Vaccine in 3-8-Year-Old Children with Different Immunological States—jiangsu province,China,2021

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China CDC weekly 2024年第19期6卷 424-430,I0002-I0004页

作者： Qian Liu Pengfei Jin Jingxin Li Xiaoqin Chen Chenhao Wang Qingbin Lu Wei Jiang Shixuan Zhang Lairun Jin Hongxin Pan Xue Guo Fengcai Zhu School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina jiangsu Provincial Medical Innovation center National Health Commission Key Laboratory of Enteric Pathogenic MicrobiologyJiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina Donghai County center for disease control and Prevention Donghai CityJiangsu ProvinceChina Changchun Institute of Biological Products Co. Ltd.Changchun CityJilin ProvinceChina Department of Laboratorial Science and Technology&Vaccine Research center School of Public HealthPeking UniversityBeijingChina Key Laboratory of Epidemiology of Major diseases(Peking University) Ministry of EducationBeijingChina

Summary What is already known about this topic?The quadrivalent influenza vaccine(QIV)provides protection against a broader range of influenza strains by including strains of influenza A/H1N1,A/H3N2,B/Yamagata,and B/*** is added by this report?This study aimed to assess the immunogenicity and safety of administering a single dose compared to two doses of QIV in children,taking into consideration their previous influenza vaccination history.

关键词： ent doses jiangsu

Epidemiological Data of Work-Related Musculoskeletal Disorders—China,2018–2020

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China CDC weekly 2021年第18期3卷 383-389页

作者： Ning Jia Huadong Zhang Ruijie Ling Yimin Liu Gang Li Zaoliang Ren Yan Yin Hua Shao Hengdong Zhang Bing Qiu Meibian Zhang Dayu Wang Qiang Zeng Rugang Wang Jianchao Chen Danying Zhang Liangying Mei Yongquan Liu Jixiang Liu Chengyun Zhang Tianlai Li Qing Xu Ying Qu Xueyan Zhang Xin Sun Zhongxu Wang National Institute of Occupational Health and Poison control Chinese Center for Disease Control and PreventionBeijingChina Chongqing center for disease control and Prevention ChongqingChina Hubei Provincial Hospital of Integrated Chinese&Western Medicine WuhanHubeiChina Guangzhou Twelfth People’s Hospital Affiliated to Guangzhou Medical University GuangzhouGuangdongChina Liaoning Provincial Health Service center ShenyangLiaoningChina Guizhou province Occupational disease Prevention and control Hospital GuiyangGuizhouChina Shanghai center for disease control and Prevention ShanghaiChina Shandong Academy of Occupational Health and Occupational Medicine JinanShandongChina jiangsu Provincial center for disease control and Prevention NanjingJiangsuChina Civil Aviation Medical center Civil Aviation Administration of ChinaBeijingChina Zhejiang Provincial center for disease control and Prevention HangzhouZhejiangChina Tianjin Occupational disease Prevention and control Hospital TianjinChina Tianjin center for disease control and Prevention TianjinChina Beijing center for disease control and Prevention BeijingChina Fujian province Occupational disease and Chemical Poisoning Prevention and control center FuzhouFujianChina Guangdong province Hospital for Occupational disease Prevention and Treatment GuangzhouGuangdongChina Hubei Provincial center for disease control and Prevention WuhanHubeiChina Institute of Occupational Medicine of Jiangxi NanchangJiangxiChina Ningxia Hui Autonomous Region center for disease control and Prevention YinchuanNingxiaChina Sichuan Provincial center for disease control and Prevention ChengduSichuanChina Shaanxi Provincial center for disease control and Prevention Xi’anShaanxiChina.

Summary What is already known about this topic?In recent decades,work-related musculoskeletal disorders(WMSDs)have become increasingly prominent and have become an important issue that is of universal concern and an urgent need to be solved in all countries of the *** is added by this report?The top three industries or occupational groups with the highest standardized prevalence rate of WMSDs were flight attendants,medical staff,and vegetable greenhouses in that *** workers were 1.5 times more likely to suffer from WMSDs than men workers.

关键词： WMS likely workers

disease and Economic Burden of Kashin-Beck disease—China,2021

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China CDC weekly 2024年第2期6卷 40-44页

作者： Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Kashin-Beck Disease ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Heilongjiang Provincial Key Laboratory of Trace Elements and Human HealthKey Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceInstitute of Endemic Fluorosis ControlCenter for Endemic Disease ControlChinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina

What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage *** is an endemic disease that is highly prevalent among the Chinese population and poses a significant health *** is added by this report?This is the first national report on the economic burden of KBD in *** to the data from 2021,KBD has caused significant disease and economic *** most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the *** strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas.

关键词： prevention degeneration burden

Pulmonary Heart disease Associated Mortality—China,2014–2021

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China CDC weekly 2023年第35期5卷 779-784页

作者： Yangyang Xu Zhe Liu Jinlei Qi Lijun Wang Maigeng Zhou Peng Yin National center for Chronic and Noncommunicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the latter half of the previous century,pulmonary heart disease(PHD)emerged as a significant public health issue in ***,the current mortality rate is *** the Multiple Cause of Death database,the present study aims to investigate the current state and progression of PHD-associated death in ***:Data from the China National Mortality Surveillance System were used to analyze progression in mortality rates attributable to PHD from 2014 to *** standardize population structure for each year during the investigation period,demographic information from the 2020 census was employed as the reference *** mortality rates(ASMR)were determined based on sex,urban-rural area,and *** identify trends in ASMR,a joinpoint regression analysis was ***:The ASMR of PHD exhibited a marked decrease,falling from 61.68 per 100,000 in 2014 to 28.53 per 100,000 in *** downward trend was observable in both genders,all regions,and both urban and rural *** greatest ASMR values were documented in the western *** observations revealed a higher ASMR in rural areas versus urban ones and in males versus *** deaths predominantly occurred among older individuals,particularly those aged 80 and *** obstructive pulmonary disease(COPD)emerged as the principal underlying cause of death PHD-associated mortalities,accounting for between 87.41%and 93.42%of cases throughout the period 2014–***:There was a declining trend in PHD mortality in China from 2014 to 2021,with COPD accounting for a significant proportion of these *** the high prevalence of COPD and the escalating population aging in China,PHD remains a significant health concern that warrants further attention.

关键词： latter downward urban