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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu key laboratory of molecular medicine Nanjing UniversityNanjingJiangsu ProvinceChina State key laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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Ferulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance

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Journal of Environmental Sciences 2025年第5期151卷 616-626页

作者： Hanyu Wang Shenye Feng Enzhuang Pan Xiaomeng Ji Mengyuan Zhou Shuai Zhang Baoshi Xu Huimiao Feng Jilei Yin Zibo Dong jiangsu key laboratory of Marine Bioresources and Environment Co-Innovation Center of Jiangsu Marine Bio-industry TechnologyJiangsu Marine Pharmaceutical Resources Development Engineering Research CenterJiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningCollege of PharmacyJiangsu Ocean UniversityLianyungang 222005China Department of Traditional Chinese medicine Jiangsu Union Technical Institute Lianyungang Branch institute of Traditional Chinese MedicineLianyungang 222006China

Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in *** acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective function on the immunological damage caused by AVM is still *** this study,carp were chronically exposed to(1/1096 hr LC_(50))AVM for 30 day(s),with a dietary supplement of FA(400 mg/kg)to assess its effects on carp *** experimental groups(n=10)included:control,AVM-exposed(2.404μg/L),FA+AVM co-treated,and FA ***-term AVM exposure altered spleen tissue,reducing serum complement C3(p<0.01)and immunoglobulin M levels(p<0.001),and increasing proinflammatory tnf-α(p<0.001),il-6(p<0.001),il-1β(p<0.001),and inos mRNA levels,whilst down-regulating the anti-inflammatory tgf-β(p<0.05).Additionally,it disrupted the balance of oxidative stress indicators such asMDA(p<0.001),T-AOC,GSH,and CAT,leading to spleen tissue apoptosis(42.4%).However,the addition of FA reversed these conditions,elevated the anti-inflammatory factor,and improved spleen immune function following chronic exposure to AVMin ***,the ability to restore oxidative homeostasis in carp by adjusting the Nrf2/NQO-1 axis protected the health of spleen *** discovery also supports the development of fish feed for aquaculture.

关键词： Avermectin Ferulic acid Oxidative stress Inflammation response

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Bistable switch molecule DPACdCl_(4) showing four physical channels and high phase transition temperature

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Chinese Chemical Letters 2025年第1期36卷 591-596页

作者： Ying-Yu Zhang Jia-Qi Luo Yan Han Wan-Ying Zhang Yi Zhang Hai-Feng Lu Da-Wei Fu Institute for Science and Applications of molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhua 321004China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and applications of Molecular FerroelectricsSoutheast UniversityNanjing 211189China

Multiple switchable physical channels within one material or device,encompassing optical,electrical,thermal,and mechanical pathways,can enable multifunctionality in mechanical-thermal-opto-electronic *** integrated encryption and enhanced performance in storage and sensing presents a formidable challenge in the synthesis and functionality of new *** an effort to overcome the complexities associated with these multiple physical functions,this study investigates the large-size crystal of DPACdCl_(4)(DPA=diisopropylammonium),revealing significant features in rare multi-channel *** compound demonstrates the ability to switch between"OFF/0"and"ON/1"states in the mechanical-thermal-opto-electronic ***,DPACd Cl_(4)possesses four switchable physical channels,characterized by a higher phase transition temperature of 440.7 K and a competitive piezo-electric coefficient of 46 pC/***,solid-state NMR analysis indicates that thermally activated molecular vibrations significantly contribute to its multifunctional switching capabilities.

关键词： Organic-inorganic hybrid Phase transition Crystal Perovskite Piezoelectricity

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State key laboratory of Pharmaceutical Biotechnology and Institute of Translational medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu key laboratory for molecular medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第1期68卷 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben Hua State key laboratory of Radiation medicine and Protection School of Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The efficient separation of fission products,such as TcO_(4)^(-)and I^(-),holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis(bromomethyl)benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups(Cl@QPN),exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/(mg min)for ReO_(4)^(-)(a nonradioactive surrogate of TcO_(4)^(-))and 0.677 g/(mg min)for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO_(4)^(-)and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for^(99)TcO_(4)^(-).Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO_(4)^(-),respectively.

关键词： quaternized polymer networks adsorption pertechnetate iodide liquid radioactive streams

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A wearable sensor device based on screen-printed chip with biofuel cell-driven electrochromic display for noninvasive monitoring of glucose concentration

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Chinese Chemical Letters 2025年第2期36卷 441-445页

作者： Kezuo Di Jie Wei Lijun Ding Zhiying Shao Junling Sha Xilong Zhou Huadong Heng Xujing Feng Kun Wang School of Chemistry and Chemical Engineering Jiangsu University key laboratory for Theory and Technology of Intelligent Agricultural Machinery and Equipment Jiangsu University

Wearable flexible sensor devices have the characteristics of lightweight and ***,power supply and detection components limit the portability of wearable flexible sensor ***,conventional liquid electrolytes are unsuitable for the integration of sensing *** address these constraints,wearable biofuel cells and flexible electrochromic displays have been introduced,which can improve integration with other devices,safety,and color-coded display ***,electrode chips prepared through screen printing technology can further improve *** this work,a wearable sensor device with screen-printed chips was constructed and used for non-invasive detection of *** gel electrolytes doped with PDA-CNTs were prepared,and the mechanical strength and moisture retention were significantly improved compared with traditional gel *** in interstitial fluid was non-invasive extracted to the skin surface using reverse *** a biofuel for wearable biofuel cells,glucose drives self-powered sensor and electrochromic display to produce color change,allowing for visually measurement of glucose levels in body *** detection results can be visualized by reading the RGB value with a cell phone.

关键词： Biofuel cell Electrochromic display Screen-printed chip Visualization Wearable flexible sensor device

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Xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex

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Chinese Journal of Integrative medicine 2025年第1期31卷 28-38页

作者： LI Cheng-gang XU Lu-shan SUN Liang XU Yu-hao CAO Xiang ZHAO Chen-chen XIA Sheng-nan ZHANG Qing-xiu XU Yun Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China State key laboratory of Pharmaceutical Biotechnology and Institute of Translational medicine for Brain Critical Diseases Nanjing UniversityNanjing210008China jiangsu key laboratory for molecular medicine Medical School of Nanjing UniversityNanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(MCAO).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that MCAO combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(P<0.05 or P<0.01).XSG inhibited microglial activation and the expressions of pro-inflammatory cytokines including tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(P<0.05 or P<0.01).Furthermore,XSG decreased the expression of indoleamine 2,3-dioxygenase1(IDO1)and increased the concentration of 5-hydroxytryptamine in PSD mice(P<0.05 or P<0.01).Conclusion XSG could reverse

关键词： post-stroke depression Xiangshao Granules indoleamine 2,3-dioxygenase 1 Chinese medicine

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Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

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Chinese Journal of Natural medicines 2025年第1期23卷 31-42页

作者： Qimeng Yang Zhipeng Hu Hongyu Jiang Jialing Wang Han Han Wei Shi Hai Qian Centre of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University jiangsu key laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical University

Peptide-based therapies have attracted considerable interest in the treatment of cancer, diabetes, bacterial infections, and neurodegenerative diseases due to their promising therapeutic properties and enhanced safety profiles. This review provides a comprehensive overview of the major trends in peptide drug discovery and development, emphasizing preclinical strategies aimed at improving peptide stability, specificity, and pharmacokinetic properties. It assesses the current applications and challenges of peptide-based drugs in these diseases, illustrating the pharmaceutical areas where peptide-based drugs demonstrate significant potential. Furthermore, this review analyzes the obstacles that must be overcome in the future,aiming to provide valuable insights and references for the continued advancement of peptidebased drugs.

关键词： Antimicrobial peptides Diabetes Neurodegenerative diseases Oncology Peptide-based drugs

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A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy

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Chinese Chemical Letters 2025年第1期36卷 397-402页

作者： Cheng-Zhe Gao Hao-Ran Jia Tian-Yu Wang Xiao-Yu Zhu Xiaofeng Han Fu-Gen Wu State key laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 211189China

Vascular disrupting agents(VDAs)can destroy tumor vasculature and lead to tumor ischemia and hypoxia,resulting in tumor ***,VDAs are easy to induce the upregulation of genes that are associated with cancer cell drug resistance and angiogenesis in tumor ***-activated chemotherapy will be an ideal supplement to VDAs therapy since it can help to fully utilize the ischemia and hypoxia induced by VDAs to realize a synergistic antitumor therapeutic ***,we design a liposome whose surface is modified with a tumor-homing peptide Cys-Arg-Glu-Lys-Ala(CREKA,which can specifically target tumor vessels and stroma)and whose aqueous cavity and lipid bilayer are loaded by a hypoxia-activatable drug banoxantrone dihydrochloride(AQ4N)and a VDA combretastatin A4(CA4),***4 can selectively target vascular endothelial cells and destroy the tumor blood vessels,which will cause the rapid inhibition of blood flow in tumor and enhance the hypoxia in the tumor *** a consequence,AQ4N can exert its boosted cytotoxicity under the enhanced hypoxic *** as-prepared liposome with a uniform particle size exhibits good stability and high cancer cell killing efficacy in *** addition,in vivo experiments confirm the excellent tumortargeting/accumulation,tumor vasculature-damaging,and tumor inhibition effects of the *** work develops a liposomal which can achieve safe and effective tumor suppression without external stimulus excitation by only single injection,and is expected to benefit the future development of effective antitumor liposomal drugs.

关键词： Tumor-homing peptide Liposome Vascular disrupting agents Chemotherapy Hypoxia-activated

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu Zhu Yongsheng Fu key laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094JiangsuChina jiangsu Pylon Battery Co.Ltd Yangzhou 211400JiangsuChina

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene (PP) *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance(145.88 MPa) of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm^(-2)with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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