检索结果-南通市图书馆

Influence of preheating treatments on cyanide content， nutritional composition， physicochemical properties， color and oxidative stability of flaxseed meal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国油脂 2024年

作者： ZHOU Junzhuo CHU Pengfei DONG Guimei PEI Xuechen HUANG Jiaqian ZHENG Rui YIN Fawen ZHOU Dayong SKL of marine Food Processing & Safety Control， National Engineering Research center of Seafood， Collaborative innovation center of Seafood Deep Processing， Liaoning Province Key Laboratory for marine Food Science and Technology， School of Food Science and Technology， Dalian Polytechnic University

This study aimed to investigate the effects of different preheating treatments （steaming， roasting and microwave） of flaxseed on cyanide content， nutritional composition， physicochemical properties， color and oxidative stability of flaxseed meal. The three preheating methods of flaxseed all significantly decreased the hydrocyanic acid （HCN） contents. By contrast， microwave was the most effective detoxification method. After 5 min of microwave treatment， the HCN content in flaxseed was reduced from 94.65 ± 1.68 mg/kg to 7.80 ± 0.57 mg/kg. In addition， the three preheating methods all significantly increased the polyphenol content， thiobarbituric acid reactive substances （TBARS）， peroxide value （POV）， and a*value， and slightly decreased polyunsaturated fatty acid （PUFA） contents， but significantly decreased total amino acid contents as well as L*， W*and b*values. Interestingly， the three preheating methods all improved the oxidative stability and color stability of flaxseed upon accelerated storage under 40 °C. Compared with steaming （120 ℃ for 20 min） and roasting （100 ℃ for 40 min）， microwave （560 W for 4 min） is recommended for decreasing cyanide content， as well as enhancing the flaxseed' stability and qualitative attributes.

关键词：

Mitochondrial diseases and mtDNA editing

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 303-310页

作者： Min Song Lingqun Ye Yongjin Yan Xuechun Li Xinglong Han Shijun Hu Miao Yu Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Collaborative Innovation Center of HematologyState Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215000China Hai'an People's Hospital NantongJiangsu 226600China

Mitochondrial diseases are a heterogeneous group of inherited disorders character-ized by mitochondrial dysfunction,and these diseases are often severe or even ***-chondrial diseases are often caused by mitochondrial DNA ***,there is no curative treatment for patients with pathogenic mitochondrial DNA *** the rapid development of traditional gene editing technologies,such as zinc finger nucleases and tran-scription activator-like effector nucleases methods,there has been a search for a mitochon-drial gene editing technology that can edit mutated mitochondrial DNA;however,there are still some problems hindering the application of these *** discovery of the DddA-derived cytosine base editor has provided hope for mitochondrial gene *** this paper,we will review the progress in the research on several mitochondrial gene editing technologies with the hope that this review will be useful for further research on mitochondrial gene editing technologies to optimize the treatment of mitochondrial diseases in the future.

关键词： Gene editing Mitochondrialdisease MitochondrialDNA mutation Transcription activator-like effectornucleases Zinc finger nucleases

Combining QTL Mapping and Multi-Omics Identify Candidate Genes for Nutritional Quality Traits during Grain Filling Stage in Maize

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2024年第7期93卷 1441-1453页

作者： Pengcheng Li Tianze Zhu Yunyun Wang Shuangyi Yin Xinjie Zhu Minggang Ji Wenye Rui Houmiao Wang Zefeng Yang Chenwu Xu jiangsu Key Laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics of the Ministry of EducationJiangsu Key Laboratory of Crop Genomics and Molecular BreedingAgricultural College of Yangzhou UniversityYangzhou225009China jiangsu Co-innovation center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou225009China

The nutritional composition and overall quality of maize kernels are largely determined by the key chemical com-ponents:protein,oil,and ***,the genetic basis underlying these nutritional quality traits during grainﬁlling remains poorly *** this study,the concentrations of protein,oil,and starch were studied in 204 recombinant inbred lines resulting from a cross between DH1M and T877 at four different stages *** the traits exhibited considerable phenotypic *** the grain-ﬁlling stage,the levels of protein and starch content generally increased,whereas oil content decreased,with signiﬁcant changes observed between 30 and 40 days after *** trait locus(QTL)mapping was conducted and a total of 32 QTLs,comprising 14,12,and 6 QTLs for grain protein,oil,and starch content were detected,*** QTLs were consistently detectable across different time *** integrating QTL analysis,glo-bal gene expression proﬁling,and comparative genomics,we identiﬁed 157,86,and 54 differentially expressed genes harboring nonsynonymous substitutions between the parental lines for grain protein,oil,and starch con-tent,*** gene function annotation prioritized 15 candidate genes potentially involved in reg-ulating grain quality traits,including those encoding transcription factors(NAC,MADS-box,bZIP,and MYB),cell wall invertase,cellulose-synthase-like protein,cell division cycle protein,trehalase,auxin-responsive factor,and phloem protein *** study offers signiﬁcant insights into the genetic architecture of maize kernel nutritional quality and identiﬁes promising QTLs and candidate genes,which are crucial for the genetic enhance-ment of these traits in maize breeding programs.

关键词： Maize protein oil starch QTL mapping candidate genes

Alloyed Pt-Sn nanoparticles on hierarchical nitrogen-doped carbon nanocages for advanced glycerol electrooxidation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 4055-4061页

作者： Jietao Jiang Liqi Zhou Fengfei Xu Guanghai Chen Xiaoyu Liu Zhen Shen Lijun Yang Qiang Wu Xizhang Wang Zheng Hu Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Provincial Laboratory for NanotechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Glycerol is an alternative sustainable fuel for fuel cells,and efficient electrocatalyst is crucial for glycerol oxidation reaction(GOR).The promising Pt catalysts are subject to the inadequate capability of C-C bond cleavage and the susceptibility to ***,Pt-Sn alloyed nanoparticles are immobilized on hierarchical nitrogen-doped carbon nanocages(hNCNCs)by convenient ethylene glycol reduction and subsequent thermal *** optimal Pt_(3)Sn/hNCNC catalyst exhibits excellent GOR performance with a high mass activity(5.9 A·mg_(Pt)^(-1)),which is 2.7 and 5.4 times higher than that of Pt/hNCNC and commercial Pt/C,*** an enhancement can be mainly ascribed to the increased anti-poisoning and C-C bond cleavage capability due to the Pt_(3)Sn alloying effect and Sn-enriched surface,the high dispersion of Pt_(3)Sn active species due to N-participation,as well as the high accessibility of Pt_(3)Sn active species due to the three-dimensional(3D)hierarchical architecture of *** study provides an effective GOR electrocatalyst and convenient approach for catalyst preparation.

关键词： Pt_(3)Sn alloy hierarchical nitrogen-doped carbon nanocages glycerol electrooxidation anti-poisoning C-C bond cleavage

Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 107-119页

作者： Shuren Zhang Dongfan Song Wenhao Yu Ji Li Xiaoyu Wang Yachao Li Zihan Zhao Qi Xue Jing Zhao Jie P.Li Zijian Guo State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University Department of Urology Afflliated Drum Tower HospitalMedical SchoolNanjing University Nanchuang (jiangsu)Institute of Chemistry and Health

Mounting evidence suggests that strategies combining DNA-damaging agents and stimulator of interferon genes(STING) agonists are promising cancer therapeutic regimens because they can amplify STING activation and remodel the immunosuppressive tumor microenvironment. However, a single molecular entity comprising both agents has not yet been developed. Herein, we designed two PtIV-MSA-2 conjugates(Ⅰand Ⅱ) containing the DNA-damaging chemotherapeutic drug cisplatin and the innate immuneactivating STING agonist MSA-2; these conjugates showed great potential as multispecific small-molecule drugs against pancreatic cancer. Mechanistic studies revealed that conjugate Ⅰ upregulated the expression of transcripts associated with innate immunity and metabolism in cancer cells, significantly differing from cisplatin and MSA-2. An analysis of the tumor microenvironment demonstrated that conjugate I could enhance the infiltration of natural killer(NK) cells into tumors and promote the activation of T cells, NK cells and dendritic cells in tumor tissues. These findings indicated that conjugate I, which was created by incorporating a Pt chemotherapeutic drug and STING agonist into one molecule, is a promising and potent anticancer drug candidate, opening new avenues for small-molecule-based cancer metalloimmunotherapy.

关键词： platinum drug STING agonist single-molecule multitarget metalloimmunology

Effect of various aromatic compounds with different functional groups on enzymatic hydrolysis of microcrystalline cellulose and alkaline pretreated wheat straw

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of bioresources and Bioproducts 2024年第2期9卷 211-221页

作者： Yufeng Yuan Xinyu Guo Bo Jiang Wenjuan Wu Tingwei Zhang Michael Sweeney Mehraj Ahmad Yongcan Jin jiangsu Co-innovation center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Pulp and Paper Science and TechnologyNanjing Forestry UniversityNanjing 210037China School of Chemistry and Chemical Engineering Queen’s University BelfastBelfast BT71NNNorthern Ireland United Kingdom Department of Food Science and Engineering College of Light Industry and Food EngineeringNanjing Forestry UniversityNanjing 210037China

Low molecular aromatic compounds are detrimental to the enzymatic hydrolysis of ***,the specific role of their functional groups remains ***,a series of nine aromatic compounds as additives were tested to understand their effect on the hydrolysis yield of microcrystalline cellulose(MCC)and alkaline pretreated wheat *** on the results,the inhibition of aldehyde groups on MCC was greater than that of carboxyl groups,whereas for the alkaline pretreated wheat straw case,the inhibitory effect of aldehyde groups was lower than that of carboxyl *** methoxyl groups of aromatic compounds reduced the inhibitory ef-fect on enzymatic hydrolysis of both *** inhibition of aromatic compounds on MCC hydrolysis was detected in comparison with the alkaline pretreated wheat straw,indicating that the substrate lignin can offset the inhibition to a certain *** all aromatic com-pounds,syringaldehyde with one aldehyde group and two methoxyl groups improved the glucan conversion of the alkaline pretreated wheat straw.

关键词： Aromatic compound Functional group Enzymatic hydrolysis Alkaline pretreated wheat straw Microcrystalline cellulose

Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 120-123页

作者： Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu jiangsu Collaborative innovation center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingJiangsu 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjingJiangsu 210023China College of Pharmacy Nanjing University of Chinese MedicineNanjingJiangsu 210023China School of Medicine Xiamen UniversityXiamenFujian 361102China

Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.

关键词： herbal Gypenosides immunosuppression

Function investigation of p11.5 in ASFV infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第3期39卷 469-477页

作者： Dan Yin Bin Shi Renhao Geng Yingnan Liu Lang Gong Hongxia Shao Kun Qian Hongjun Chen Aijian Qin Ministry of Education Key Laboratory for Avian Preventive Medicine Yangzhou UniversityJiangsu 225009China jiangsu Co-innovation center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Jiangsu 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Jiangsu 225009China Shanghai Veterinary Research Institute CAASShanghai200241China South China Agricultural University Guangzhou 510642China

Virus replication relies on complex interactions between viral *** the case of African swine fever virus(ASFV),only a few such interactions have been identified so *** this study,we demonstrate that ASFV protein p72 interacts with p11.5 using co-immunoprecipitation and liquid chromatography-mass spectrometry(LC-MS).It was found that protein p72 interacts specifically with p11.5 at sites amino acids(aa)1–216 of p72 and aa 1–68 of *** assess the importance of p11.5 in ASFV infection,we developed a recombinant virus(ASFVGZΔA137R)by deleting the A137R gene from the ASFVGZ *** with ASFVGZ,the infectious progeny virus titers of ASFVGZΔA137R were reduced by approximately 1.0 *** addition,we demonstrated that the growth defect was partially attributable to a higher genome copies-to-infectious virus titer ratios produced in ASFVGZΔA137R-infected MA104 cells than in those infected with *** finding suggests that MA104 cells infected with ASFVGZΔA137R may generate larger quantities of noninfectious ***,we found that p11.5 did not affect virus-cell binding or ***,we show for the first time the interaction between ASFV p72 and *** results effectively provide the relevant information of the p11.5 *** results extend our understanding of complex interactions between viral proteins,paving the way for further studies of the potential mechanisms and pathogenesis of ASFV infection.

关键词： African swine fever virus p72 protein p11.5 protein Protein interactions

Natural high-porous diatomaceous-earth based self-floating aerogel for efficient solar steam power generation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第2期9卷 378-389页

作者： Aitang Zhang Kai Wang Md Julker Nine Mengyu Cao Hanwen Zong Zhiqiang Liu Hanwen Guo Jingquan Liu Dusan Losic College of Materials Science and Engineering Institute for Graphene Applied Technology InnovationCollaborative Innovation Center for Marine Biomass Fibers Materials and Textiles of Shandong ProvinceQingdao UniversityQingdao266071China The University of Adelaide School of Chemical Engineering and Advanced MaterialsARC Graphene Research HubNorth Engineering BuildingN206 AdelaideSA 5005Australia

The application of solar steam generation in seawater desalination is an effective way to solve the shortage of fresh water *** present,many kinds of photothermal conversion materials have been developed and used as evaporators in seawater ***,some evaporators need additional thermal insulation or water supply devices to achieve efficient photothermal *** addition,their complex,time consuming and no scalable preparation process,high cost of raw materials and poor salt resistance hinder the practical application of these *** to its distinctive nanoporous structure,diatomite as fossilized single-cells algae diatoms is a promising natural silica-based material for seawater *** are taken from sea and that makes true sense to use them in the ***,we report the first example of synthesis robust three-dimensional(3D)natural-diatomite composite by assembling polyaniline nanoparticles covered diatomite into the polyvinyl alcohol pre-treated melamine foam frameworks and demonstrate its application as new evaporator for seawater *** porous framework does not only improve the sunlight scattering efficiency,but also offer large network of channels for water *** inherent mechanism behind salt desalination process involves the absorption of water molecules on the surface of the internal silica micro-nano pores,and evaporation under the heat induced by the polyaniline absorbed ***,the metal ions are segregated by many available pores and channels to achieve the self-desalting *** developed evaporator possesses the superiority of multi-stage pore structure,strong hydrophilicity,low thermal conductivity,excellent light absorption,fast water transportation and salt-resistant crystallization as well as good *** evaporation rate without an additional device is found to be 1.689 kg m^(-2)h^(-1)under 1-Sun irradiation,and the energy conversion efficiency is as

关键词： Diatomite Micro/nanopores Polyaniline Three-dimensional composite Solar steam generation