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Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

Food Science and Human Wellness 2024年第2期13卷 709-720页

作者： Bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research center for Functional Food Jiangnan UniversityWuxi 214122China

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： Blautia producta D4 Colitis Intestinal mechanical barrier TLR4/NF-κB pathway Intestinal microbiot

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Metal Chlorides Supported Solid Catalysts for F-C Acylations of Arenes

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Transactions of Tianjin University 2015年第5期21卷 400-405页

作者：李阳刘云龙穆曼曼陈立功 School of Chemical Engineering and Technology Tianjin University Collaborative innovation center of Chemical Science and Engineering (Tianjin)

A series of metal chlorides supported solid catalysts were prepared by simple wet impregnation method. Their catalytic performances for Friedel-Crafts acylation of toluene with benzoyl chloride were evaluated and the excellent results were obtained over FeC13/SiO2. These catalysts were characterized by BET, NH3-TPD and FT-IR of pyridine adsorption to clarify the structure-activity relationship. It was found that FeC13/SiO2 has larger pore size and pore volume than other catalysts, which increased the accessibility of the catalyst. In addition, FeC13/SiO2 ex- hibited higher molar ratio of Lewis acid sites and Brtpnsted acid sites, which might be another reason for the in- crease of toluene conversion. Furthermore, the reaction parameters, including temperature, time and molar ratio, were optimized. Under the optimized conditions, 91.2% conversion and 82.0% selectivity were obtained. Mean- while, the generality of the catalyst was demonstrated by the acylations of alkyl substituted aromatics. Finally, the catalyst was reused for four runs with slight loss in catalytic activity, which attributed to the drain of the active component.

关键词： acylation heterogeneous catalyst silica gel ferric chloride

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New design concept for stableα-silicon nitride based on the initial oxidation evolution at the atomic and molecular levels

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Journal of Materials Science & Technology 2022年第27期122卷 156-164页

作者： Chunyu Guo Enhui Wang Zhi Fang Yapeng Zheng Tao Yang Zhijun He Xinmei Hou Beijing Advanced innovation center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Technology BeijingBeijing 100083China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China

As the dominated composition of Si_(3)N_(4)ceramics,α-silicon nitride(α-Si_(3)N_(4))can satisfy the strength and fracture toughness demand in the ***,α-Si_(3)N_(4)is oxygen-sensitive at high temperatures,which limits its high-temperature *** improve the oxidation resistance ofα-Si_(3)N_(4)ceramics,it is necessary to shed light on the oxidation ***,the initial oxidation ofα-Si_(3)N_(4)was systematically studied at the atomic and molecular *** density functional theory(DFT)calculation denotes that the(001)surface ofα-Si_(3)N_(4)has the best stability at both room temperature and high ***,the oxidation process of theα-Si_(3)N_(4)(001)surface consists of O adsorption and N desorption,and the consequent formation of nitrogen-vacancy(VN)is the key step for further ***,the molecular dynamics(MD)simulation indicates that the oxidation rate ofα-Si_(3)N_(4)(100)surface is slower than that ofα-Si_(3)N_(4)(001)surface due to the lower N concentration at the outermost ***,the oxidation resistance ofα-Si_(3)N_(4)can be improved by regulating the(100)surface as the dominant exposure *** addition,reducing the concentration of N on the final exposed surface ofα-Si_(3)N_(4)by mean of constructing the homojunction of the Si-terminal(100)surface and other N-containing surfaces(such as(001)surface)should be also a feasible approach.

关键词： α-Si_(3)N_(4) Surface oxidation Nitrogen vacancy DFT MD

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Numerical modeling and prediction of future response of permafrost to different climate change scenarios on the Qinghai-Tibet Plateau

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International Journal of Digital Earth 2016年第5期9卷 442-456页

作者： Wenjie Zhang Zhoupeng Ren Ling Yao Chenghu Zhou Yunqiang Zhu State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina jiangsu center for Collaborative innovation in Geographical Information Resource Development and Application NanjingChina

Projecting the future distribution of permafrost under different climate change scenarios is essential,especially for the Qinghai–Tibet Plateau(QTP).The altitude-response model is used to estimate future permafrost changes on the QTP for the four RCPs(RCP2.6,RCP4.5,RCP6.0,and RCP8.5).The simulation results show the following:(1)from now until 2070,the permafrost will experience different degrees of significant degradation under the four RCP *** will affect 25.68%,40.54%,45.95%,and 62.84%of the current permafrost area,respectively.(2)The permafrost changes occur at different rates during the periods 2030–2050 and 2050–2070 for the four different RCPs.(1)In RCP2.6,the permafrost area decreases a little during the period 2030–2050 but shows a small increase from 2050 to 2070.(2)In RCP4.5,the rate of permafrost loss during the period 2030–2050(about 12.73%)is higher than between 2050 and 2070(about 8.33%).(3)In RCP6.0,the permafrost loss rate for the period 2030–2050(about 16.52%)is similar to that for 2050–2070(about 16.67%).(4)In RCP8.5,there is a significant discrepancy in the rate of permafrost decrease for the periods 2030–2050 and 2050–2070:the rate is only about 3.70%for the first period but about 29.49%during the second.

关键词： future permafrost changes Qinghai-Tibet Plateau altitude-response model temperature data VLRT RCPs

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Synthesis of CA_(6)/AlON composite with enhanced slag resistance

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 756-765页

作者： Yunsong Liu Enhui Wang Linchao Xu Tao Yang Zhijun He Tongxiang Liang Xinmei Hou Beijing Advanced innovation center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Tech-nology BeijingBeijing 10083China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Different amounts of AlON have been introduced in calcium hexaaluminate(CA_(6)) using two approaches, that is, one-step and twostep methods, to improve the slag resistance of CA_(6). A one-step method can directly sinter the mixtures combining Al_(2)O_(3), CaCO_(3), and Al in flowing nitrogen, in which AlON clusters are always formed because of the poor wettability of Al by Al_(2)O_(3), leading to the high porosity of CA_(6)/AlON composite. In a two-step method, CA_(6)and AlON are prepared separately and then mixed and sintered in flowing nitrogen. Compared with the sample prepared by the one-step method, CA_(6)and AlON in composite by the two-step method are more uniformly distributed,and the optimized amount of AlON added is 10wt%. The slag corrosion and penetration test shows that the CA_(6)/AlON composite using the two-step method exhibits superior slag corrosion protection. The promoted effect of AlON on slag penetration and corrosion resistance is also discussed.

关键词： CA_(6)/AlON composite two-step method wettability slag resistance

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A NIR to NIR rechargeable long persistent luminescence phosphor Ca_(2)Ga_(2)GeO_(7):Yb^(3+),Tb^(3+)

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Journal of Rare Earths 2021年第12期39卷 1520-1526,I0003页

作者： Junhe Zhou Zhangwen Long Jianbei Qiu Dacheng Zhou Jun'an Lai Xuhui Xu Songhan Hu Xizheng Li Qi Wang Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093China Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China Key Lab.of Advanced Materials of Yunnan Province Kunming 650093China

Near infrared to near infrared(NIR-NIR)photo-stimulated persistent luminescence(PSPL)has shown excellent potential in high-resolution bioimaging for deep ***,the PSPL in NIR-Ⅱregion(900-1700 nm)is still *** this work,Ca_(2)Ga_(2)GeO_(7):Yb^(3+),Tb^(3+)(CGGYT)phosphor with unique lowdimensional crystal structure was synthesized by high-temperature solid-state *** to the carriers transferring from deep traps to shallow ones induced by low energy light,the 978 nm PSPL originating from ^(2)F_(5/2) to ^(2)F_(7/2) transition of Yb^(3+)induced by multimode stimulating(980 nm or WLED)is successfully realized after pre-excited by UV *** NIR PSPL of the specimen can be repeatedly stimulated after placed in dark for 12 ***,the results indicate that codoping with Tb^(3+)can significantly enhance the NIR-ⅡPSPL owing to the quantum cutting persistent energy transfer(QC PET)from Tb^(3+)to Yb^(3+).Our study points to a new direction for the future development of multimode PSPL materials for bioimaging or multimode optical storage applications.

关键词： Rechargeable long persistent luminescence Near infrared emission Yb^(3+) Trap Energy transfer Rare earths

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Nonlinear interval analysis of rotor response with joints under uncertainties

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Chinese Journal of Aeronautics 2020年第1期33卷 205-218页

作者： Yanhong MA Yongfeng WANG Cun WANG Jie HONG School of Energy and Power Engineering Beihang UniversityBeijing 100083China Collaborative innovation center of Advanced Aero-Engine Beijing 100083China

The dynamic influence of joints in aero-engine rotor systems is investigated in this ***,the tangential stiffness and loss factor are obtained from an isolated lap joint setup with dynamic excitation ***,the influence of the normal contact pressure and the excitation level are examined,which revel the uncertainty in ***,the updated Thin Layer Elements(TLEs)method with fitted parameters based on the experiments is established to simulate the dynamic properties of joints on the *** response of the rotor subjected to unbalance excitation is calculated,and the results illustrate the effectiveness of the proposed ***,using the Chebyshev inclusion function and a direct iteration algorithm,a nonlinear interval analysis method is established to consider the uncertainty of parameters in *** accuracy is proved by comparison with results obtained using the Monte-Carlo *** with the updated TLEs,the nonlinear Chebyshev method is successfully applied on a finite model of a *** study shows that substantial attention should be paid to the dynamical design for the joint in rotor systems,the dynamic properties of joints under complex loading and the corresponding interval analysis method need to be intensively studied.

关键词： Aero-engine Bolted joints Nonlinear interval analysis method Rotor dynamics Uncertainties Updated Thin Layer Elements(TLE)method

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Robust ultrathin and transparent AZO/Ag-SnOx/AZO on polyimide substrate for flexible thin film heater with temperature over 400℃

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Journal of Materials Science & Technology 2020年第13期47卷 156-162页

作者： Zhaozhao Wang Jia Li Junjun Xu Jinhua Huang Ye Yang Ruiqin Tan Guofei Chen Xingzhong Fang Yue Zhao Weijie Song School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Faculty of Information and Computer Science Ningbo UniversityNingbo 315211China jiangsu Collaborative innovation center of Photovoltaic Science and Engineering Changzhou 213164China

We developed flexible and transparent thin film heaters(TFHs)with a structure of AZO/AgSnOx/AZO/polyimide(PI)which exhibited superior stability under operational *** and robust doped silver(Ag)films were produced by introducing a small amount of SnOx during the sputtering *** AZO/Ag-SnOx/AZO stacks showed the best figure of merit value of 139.9,which was higher than that of ITO counterpart(25.5)with the same *** addition,it exhibited excellent durability,which showed unaffected optical and electrical properties under the heat treatment of 500℃for 30 min in air,highly-accelerated tempe ratu re and humidity stress test(HAST)at 121℃and 97%RH for 36 h,10,000 times of scratching and 1500 times of inner and outer bending ***,the TFHs based on AZO/Ag-SnOx/AZO/PI achieved a high temperature of 438.8℃with response time in several seconds,which outperformed most previous *** robust high-temperature TFHs in this research hold promising commercial applications in flexible and high temperature occasions.

关键词： Ultrathin Ag films SnOx Doping Durability High temperature thin film heater

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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： Qian-Yun Guo Jia-Qi Yang Xun-Xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

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An algorithm for Monte Carlo simulation of bremsstrahlung emission by electrons

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Nuclear Science and Techniques 2017年第5期28卷 86-94页

作者： Muhammad Abdul Wasaye Hui Wang Peng He Key Laboratory of Neutronics and Radiation Safety Institute of Nuclear Energy Safety Technology Chinese Academy of Sciences Hefei 230031 China Collaborative innovation center of Radiation Medicine of jiangsu Higher Education Institutions Suzhou 215006 China School of Nuclear Science and Technology University of Science and Technology of China Hefei 230027 China

An algorithm for Monte Carlo simulation of bremsstrahlung emission by electrons based on the framework of Super MC is presented in this paper with efficient and accurate methods to sample the angular distribution and energy of bremsstrahlung photons. The photon energy is sampled according to scaled energy-loss differential cross sections tabulated by Seltzer and Berger. A novel hybrid model for photon angular distribution by low-and high-energy incident electrons is developed. The model uses Tsai's full form of angular distribution function with atomic form factors for high-energy incident electrons. For electrons o\500 ke V, a simple efficient and accurate analytical distribution function is developed, using adjustable parameters determined from the fitting of numerical values of the shape functions tabulated by Kissel et al. The efficiency of sampling photon energy is 80%. Our angular sampling algorithm for high-energy electron bremsstrahlung based on Tsai distribution function is very efficient(sampling efficiency*70%) in the useful photon energy range.

关键词： Bremsstrahlung Monte Carlo SuperMC Differential cross section Angular distribution

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