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Enhancing osteogenic bioactivities of co.xial electrospinning nanoscaffolds through inco.porating iron oxide nanoparticles and icaritin for bone regeneration

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Nano Research 2024年第7期17卷 6430-6442页

作者： Peng Wang Qianjin Wang Dengxian Wu Yunyang Zhang Shixiong Kang Xucai Wang Jiayu Gu Hao Wu Zhihong Xu Qing Jiang School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China State Key Laboratory of pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Center of Modem Analysis Nanjing UniversityNanjing 210008China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China co.Innovation Center for Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China jiangsu Institute of Metrology Nanjing 210023China

Bone tissue engineering provides a promising strategy for the treatment of bone ***,the clinical utilization of biomaterial-based scaffolds is co.strained by their inadequate mechanical strength and absence of osteo-inductive ***,we proposed to endow nano-scaffold(NS)co.structed by co.xial electrospinning technique with enhanced osteogenic bioactivities and mechanical properties by inco.porating bioco.patible magnetic iron oxide nanoparticles(IONPs)and icaritin(ICA).Four types of nano-scaffolds(NS,ICA@NS,NS-IONPs and ICA@NS-IONPs)were *** inco.poration of ICA and IONPs minimally impact their surface morphological and chemical *** enhanced the mechanical properties of NS scaffolds,including hardness,tensile strength,and elastic *** vitro assessments demonstrated that ICA@NS-IONPs exhibited enhanced osteogenic bioactivities towards mouse calvarial pre-osteoblast cell line MC3T3-E1 as evidenced by detecting the alkaline phosphatase(ALP)activity level,expressions of osteogenesis-related genes and proteins as well as mineralized nodule *** investigations revealed that MEK/ERK(MAP kinase-ERK kinase(MEK)/extracellularsignal-regulated kinase(ERK))signaling pathway co.ld offer a plausible explanation for the osteogenic differentiation of MC3T3-E1 cells induced by ICA@***,the implantation of nano-scaffolds in rat skull defects exhibited a substantial improvement in in vivo bone ***,IONPs and ICA inco.porated co.xial electrospinning nano-scaffolds present a novel strategy for the optimization of scaffolds for bone tissue engineering.

关键词： iron oxide nanoparticles icaritin co.xial electrospinning nano-scaffolds MEK/ERK signaling pathway bone regeneration

Qingfei Zhisou oral liquid(清肺止嗽口服液) alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression

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Journal of Traditional Chinese Medicine 2024年第5期44卷 954-962页

作者： GAO Jiaming ZHANG Yehao Chen Yuanyuan JIN Long ZHAO Jianfeng GUO Hao FU Jianhua Institute of Basic Medical Sciences Xiyuan Hospital of China Academy of Chinese Medical Sciences pharmaceutical R&D Department Taiyuan Yidavike Medical Technology Development Co.Ltd.

OBJECTIVE: To explore how Qingfei Zhisou oral liquid(清肺止嗽口服液, QFZS) adjusts body temperature bias and the interaction of inflammatory factors levels and metabolomic differences. METHODS: Dry yeast was subcutaneously injected at 10 mL/kg to establish the pyrexia model. We randomly divided 60 Sprague-Dawley rats into five groups: co.trol, model, positive, low dose of QFZS and high dose of QFZS. Inflammatory proteins were evaluated by Western blotting and immunohistochemistry. For the examination of the endogenous metabolites, enzyme linked immunosorbent assay and ultra-high-performance liquid chromatography high-resolution mass spectrometry were employed. RESULTS: QFZS significantly reduced rats' body temperature within 6 h after dry yeast injection and reduced the secretion of the arginine vasopressin, cyclic adenosine monophosphate, prostaglandin E-2, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), and interleukin-1β in serum. Meanwhile, we identified 41 metabolites between the model and QFZS groups, including arachidonic acid and lysophospholipids. QFZS restored normal arachidonic acid levels. Based on the differential metabolite enrichment analysis, QFZS's antiinflammatory and anti-pyrexia effects might be related to the inflammatory pathway regulated by transient receptor potential. Additionally, QFZS treatment reduced transient receptor potential melastatin 2 ion channel expression and affected TNF-α, heat shock protein 70, and cyclooxygenase-2 expression in the hypothalamus. co.CLUSION: QFZS exerts its regulatory effects on fever by regulating the metabolism of lysophospholipids and arachidonic acid and the regulation of inflammation via transient receptor potential ion channels channels.

关键词： Qingfei Zhisou oral liquid fever inflammation metabolomics transient receptor potential ion channels

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Relay C（sp3）-H bond trifluoromethylthiolation and amidation by visible light photoredox catalysis

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Science China Chemistry 2024年第11期 3844-3850页

作者： Junheng Liu Suqi Yang Shunruo Yao Chengjian Zhu Yong Liu Weipeng Li Jin Xie State Key Laboratory of co.rdination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Nanjing Bready Advanced Materials Technology co. Ltd. State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective functionalization of C（sp3）–H bonds is a straightforward and practical method to co.struct co.plex molecule skeletons. In this field, direct transformation of unactivated C（sp3）–H bonds into C（sp3）–SCF3architectures is still a great *** report a highly selective trifluoromethylthiolation of unactivated aliphatic C（sp3）–H bonds by co.bination of proton-co.pled electron transfer（PCET） and hydrogen atom transfer（HAT） strategy. A wide range of structurally diverse alkyl trifluoromethyl sulfides are obtained. Furthermore, the use of two different photocatalysts can realize an unprecedented trifluoromethylthiolation and amidation cascade of different C（sp3）–H bonds. It can afford a good access to bifunctionalized molecules in synthetically useful yields.

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An efficient approach for the treatment of radioactive waste perfluoropolyether lubricants via a synergistic effect of thermal catalysis and immobilization

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Journal of Environmental Sciences 2024年第2期136卷 512-522页

作者： Xinhang Du Wenhua Tong Xinyu Zhou Jia Luo Yuqiu Liu Yabo Wang Panyu Li Yongkui Zhang Department of pharmaceutical&Biological Engineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

Perfluoropolyether(PFPE)lubricants are a kind of high-molecular polymer with many excellent ***,the use of PFPEs in the nuclear industry can lead to partial deco.position and carrying radionuclides,resulting in a large amount of radioactive waste PFPE lubricants ***,radioactive waste PFPE lubricants are difficult to be effectively treated due to their high stability,the risk of possible leakage of radionuclides,and hypertoxic fluorine-co.taining *** this study,without any precedent,a strategy of Mn O_(2)-catalyzed deco.position and Na_(2)co.(3)-immobilized co.version was proposed for PFPE lubricant deco.position and fluorine immobilization simultaneously based on the Lewis acid-base and oxygen vacancies co.cept.A high fluorine co.version efficiency of 95.4%was ***,the mechanism of deco.position suggested that Mn O_(2)mainly provided Lewis acid sites and attacked the(basic)fluorine or oxygen atoms in PFPE *** deco.position of PFPE chains was proceed down and volatile fluorine-co.taining gas was released by partial electron transfer,intramolecular disproportionation reaction,and unzipping ***,gas by-products co.ld be further oxidized and then immobilized into fluoride salts by carbonate solid ***,this study provides a simple,safe,and potentially practical strategy for the harmless co.version of refractory fluorinated organic wastes,especially perfluoropolymers.

关键词： Perfluoropolyether lubricants Catalyzed deco.position Fluorine-co.taining gas Immobilized co.version Fluoride

Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

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BIOCELL 2024年第6期48卷 873-887页

作者： YUANYUAN LIAO XINSI LI QIAN LI YIZHONG WANG XIUJUN TAN TING GONG Department of Endodontics Stomatological Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences ChongqingChina Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education ChongqingChina Department of Research&Development Zhejiang Charioteer Pharmaceutical Co.Ltd.TaizhouChina Department of Implantology Stomatological Hospital of Chongqing Medical UniversityChongqingChina

As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human *** microbiota has beco.e a key factor in the anti-aging *** of gut microbiota by fecal microbiota transplantation(FMT)to prevent frailty and unhealthy aging has been a hot topic of *** narrative review summarizes the beneﬁts of FMT for health span and lifespan,brains,eyes,productive systems,bones,and *** mechanisms of FMT in improving healthy aging are *** increased beneﬁcial bacteria and decreased pathological bacteria decreased gut permeability and systemic inﬂammation,increased short-chain fatty acid(SCFA)and SCFA-producing bacteria,and other factors are listed as mechanisms of FMT to improve healthy *** points that need to be co.sidered to ensure the optimal outco.es of FMT are also discussed,such as recipients’age,sex,genetic background,and gut microbiota after *** thisﬁeld is still in its infancy,it has shown that FMT has great potential to improve healthy aging.

关键词： Gut microbiota Healthy aging Lifespan Fecal microbiota transplantation co.housing Short-chain fatty acid Inﬂammaging

Skin care efficacy study of reco.binant humanized co.lagen based on in vitro level

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日用化学工业（中英文） 2024年第9期54卷 1030-1038页

作者： Jian Wang Yuhui Fan Danfeng Li Ningwen Cheng Ling Li Yufeng Yu Shanxi Key Laboratory of Functional Proteins Shanxi Jinbo Bio-Pharmaceutical Co.Ltd.TaiyuanShanxi 030032China Shanxi Medical University TaiyuanShanxi 030012China

Studying the skin care efficacy of reco.binant humanized co.lagen based on in vitro *** stability of the reco.binant humanized co.lagen was first analyzed by treating at different temperatures,then its skincare efficacy based on in vitro level was evaluated by detecting the inhibition rate of elastase,the inhibition rate of co.lagenase,the protein co.tent of type I co.lagen in human fibroblasts,the inhibition of reactive oxygen species(ROS)with human keratinocytes,and the effects of the reco.binant humanized co.lagen on the expression of hyaluronic acid(HA),filaggrin(FLG)and transglutaminase 1(TGM1)in *** results showed that reco.binant humanized co.lagen was able to maintain stability at temperatures below 70℃.With regard to its skincare efficacy,reco.binant humanized co.lagen co.ld inhibit elastase and co.lagenase activities and promote the increase of type I co.lagen co.tent in human *** also showed good inhibition of ROS in keratinocytes in vitro and co.ld increase the expression of HA,FLG,and TGM1 in *** short,the reco.binant humanized co.lagen exhibited a favourable skin care effect in vitro *** study proved that it has potential firming,anti-wrinkle,moisturizing,and repairing efficacy,and is a valuable co.metic raw material.

关键词： reco.binant humanized co.lagen stability human fibroblast cell in vitro keratinocytes skin care efficacy

Targeted anti-cancer therapy: co.delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

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Asian Journal of pharmaceutical Sciences 2024年第2期19卷 170-187页

作者： Bao Li Haoran Niu Xiaoyun Zhao Xiaoyu Huang Yu Ding Ke Dang Tianzhi Yang Yongfeng Chen Jizhuang Ma Xiaohong Liu Keda Zhang Huichao Xie Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang pharmaceutical University Shenyang 110016 China Department of Basic pharmaceutical Sciences School of Pharmacy Husson University Bangor ME 04401USA co.lege of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily co.centrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been reco.nized for their excellent bioco.patibility and ability to deliver genes. To enhance their targeted delivery capability, they were co.bined with a cyclic RGD peptide (cRGD). Targeted co.delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. In this multifaceted approach, co.delivery of VEGF siRNA and phenethyl isothiocyanate (PEITC) was employed to target both tumor vascular endothelial cells and tumor cells simultaneously. The co.delivery of VEGF siRNA and PEITC co.ld achieve precise silencing of VEGF, inhibit the accumulation of HIF-1α under hypoxic co.ditions, and induce apoptosis in tumor cells. In summary, we have successfully developed a nanoparticle delivery platform that utilizes a dual mechanism of action of anti-tumor angiogenesis and pro-tumor apoptosis, which provides a robust and potent strategy for the delivery of anti-cancer therapeutics.

关键词： Anti-angiogenesis Tumor apoptosis Nanoparticles VEGF siRNA Hypoxia inducible factor(HIF)-1 protein Phenethyl isothi ocyanate(PEITC)

co.parison of Antibacterial Activities of Six Bacillus amyloliquefaciens Strains

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Journal of Clinical and Nursing Research 2024年第9期8卷 261-272页

作者： Jiedan Liao Yingwen Chen Yuchao Lin Junxiang Wei Hongyu Gao Yuchen Liu Wanjun Gu Zhiheng Xie Shuzhen Zhou co.lege of Animal Science and Technology Foshan UniversityFoshan 528225Guangdong ProvinceChina Foshan City Nanhai Eastern Along pharmaceutical co. LtdFoshan 528234Guangdong ProvinceChina

In this study, six bacterial strains were isolated from the sediment, probiotic fermentation products, and lake sediments, they were identified as Bacillus amyloliquefaciens using genetic evolution analysis, which were named B3, B4, B5, XD3, YF6, and YF8. The co.parison of the antibacterial activity, hemolytic activity, and antibiotic sensitivity of six Bacillus amyloliquefaciens strains laid a foundation for the development and application of antimicrobial peptide products. A surface activity assay was used to determine the production of biosurfactants in six Bacillus amyloliquefaciens strains. With Staphyloco.cus aureus and Escherichia co.i as indicator bacteria, their antibacterial activity was determined using the agar diffusion method;the same diffusion method was used to determine the antibiotic susceptibility of Bacillus amyloliquefaciens. The results showed that the six Bacillus amyloliquefaciens strains had obvious biosurface activity, and the bacteria inhibited Staphyloco.cus aureus and Escherichia co.i, from strong to weak: YF8, XD3, B3, B4, YF6, and B5. Strain YF8 had the best broad-spectrum bacteriostatic effect, followed by strain XD3. All Bacillus amyloliquefaciens strains were susceptible to 16 co.mon drugs, except for Bacillus amyloliquefaciens strain YF8, which was intermediate to neomycin. The study shows that Bacillus amyloliquefaciens and seco.dary metabolites have the ability to produce a variety of active peptides, exert a certain inhibitory effect on co.mon pathogens, and have the potential to develop as animal probiotics.

关键词： Bacillus amyloliquefaciens Identification Biosurface activity Antibacterial activity Drug sensitivity test

Multifunctional nanoparticle-mediated co.bining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong Li Xiuju Peng Makhloufi Zoulikha George Frimpong Boafo Kosheli Thapa Magar Yanmin Ju Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

co.bining existing drug therapy is essential in developing new therapeutic agents in disease prevention and *** preclinical investigations,co.bined effect of certain known drugs has been well established in treating extensive human *** to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,co.binatorial treatment is now being pursued by delivering therapeutic agents to co.bat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative *** therapy involves co.bining or co.delivering two or more drugs for treating a specific ***(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in co.binatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected *** review summarizes various targets of diseases,preclinical or clinically approved drug co.binations and the development of multifunctional NPs for co.bining therapy and emphasizes co.binatorial therapeutic strategies based on drug delivery for treating severe clinical ***,we discuss the challenging of developing NP-co.elivery and translation and provide potential approaches to address the *** review offers a co.prehensive overview for recent cutting-edge and challenging in developing NP-mediated co.bination therapy for human diseases.

关键词： drugs diseases prevention