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Phase Ⅱb trial of in vivo electroporation mediated dualplasmid hepatitis B virus DNA vaccine in chronic hepatitis B patients under lamivudine therapy

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World Journal of Gastroenterology 2017年第2期23卷 306-317页

作者： Fu-Qiang Yang Gui-Rong Rao Gui-Qiang Wang Yue-Qi Li Yao Xie Zhan-Qing Zhang Cun-Liang Deng Qing Mao Jun Li Wei Zhao Mao-Rong Wang Tao Han Shi-Jun Chen Chen Pan De-Ming Tan Jia Shang Ming-Xiang Zhang Yue-Xin Zhang Ji-Ming Yang Guang-Ming Chen Liver Disease Research Center 458~(th) Hospital of PLA Department of Infectious Diseases Peking University First Hospital Beijing 302 Hospital Ninth Clinical Department Beijing Ditan Hospital Department of Liver Diseases Public Health Center Fudan University Department of Infectious Diseases Affiliated Hospital of Luzhou Medical College PLA Institute of Infectious Diseases Southwest Hospital Third Military Medical University jiangsu Province People’s Hospital Nanjing 2~(nd) Hospital Nanjing PLA 81 Hospital Tianjin 3~(rd) Center Hospital Jinan Infectious Disease Hospital Fuzhou Infectious Disease Hospital Xiangya Hospital Central South University Henan Provincial People’s Hospital The Sixth People’s Hospital of Shenyang The First Affiliated Hospital of Xinjiang Medical University Infectious Disease Hospital of Tianjin

AIM To assess the efficacy and safety of in vivo electroporation(EP)-mediated dual-plasmid hepatitis B virus(HBV) DNA vaccine vs placebo for sequential co.bination therapy with lamivudine(LAM) in patients with chronic hepatitis B. METHODS Two hundred and twenty-five patients were randomized to receive either LAM + vaccine(vaccine group, n = 109) or LAM + placebo(co.trol group, n = 116). LAM treatment lasted 72 wk. Patients received the DNA vaccine or placebo by intramuscular injection mediated by EP at weeks 12(start of treatment with vaccine or placebo, SOT), 16, 24, and 36(end of treatment with vaccine or placebo, EOT). RESULTS In the modified intent-to-treat population, morepatients had a decrease in HBV DNA > 2 log10 IU/m L in the vaccine group at week 12 after EOT co.pared with the co.trol group. A trend toward a difference in the number of patients with undetectable HBV DNA at week 28 after EOT was obtained. Adverse events were similar. In the dynamic per-protoco. set, which excluded adefovir(ADV) add-on cases at each time point instantly after ADV administration due to LAM antiviral failure, more patients had a decrease in HBV DNA > 2 log10 IU/mL in the vaccine group at week 12 and 28 after EOT co.pared with the co.trol group. More patients with undetectable HBV DNA at week 28 after EOT in the vaccine group were also observed. Among patients with a viral load co.ies/mL at week 12, more patients achieved HBeA g seroco.version in the vaccine group than among co.trols at week 36 after EOT, as well as less virological breakthrough and YMDD mutations. co.CLUSION The primary endpoint was not achieved using the HBV DNA vaccine. The HBV DNA vaccine co.ld only be beneficial in subjects that have achieved initial virological response under LAM chemotherapy.

关键词： Chronic hepatitis B DNA vaccine In vivo electroporation Lamivudine-resistant mutants Randomized placebo-co.trolled trial

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拉洛他赛的波谱解析及高效液相色谱法对其脂质体含量的测定

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北京大学学报（医学版） 2019年第3期51卷 467-476页

作者：李雪琦李建伟李秋红阎妍段嘉伦崔一诺苏展博罗倩许佳瑞杜亚菲王桂玲谢英吕万良天然药物与仿生药物国家重点实验室分子药剂学与新释药系统北京市重点实验室北京大学药学院北京100191 《中国药学(英文版)》 Asian Journal of pharmaceutical Sciences Precision Nanomedicine BioMed Research International 北京大学前沿交叉学科研究院北京100871 山西振东制药股份有限公司制剂所山西长治047100 山西大学中医药现代研究中心太原030006 中国药学会药剂专业委员会中国颗粒学会、生物颗粒专业委员会《北京大学学报(医学版)》《中国药学杂志》《中国新药杂志》

目的:拉洛他赛是国内外均未上市的新结构药物,未见质量研究相关报道。对拉洛他赛进行波谱解析以验证其分子式、相对分子质量和化学结构式,同时建立一种定量方法用于拉洛他赛脂质体制剂的含量测定。方法:利用质谱、红外吸收光谱、核磁共... 详细信息

目的:拉洛他赛是国内外均未上市的新结构药物,未见质量研究相关报道。对拉洛他赛进行波谱解析以验证其分子式、相对分子质量和化学结构式,同时建立一种定量方法用于拉洛他赛脂质体制剂的含量测定。方法:利用质谱、红外吸收光谱、核磁共振波谱测定方法,对拉洛他赛进行药物结构和光谱学解析;利用紫外-可见分光光度法对拉洛他赛进行全波长扫描,确定其吸收波长;利用高效液相色谱法,建立拉洛他赛定量方法并用于脂质体拉洛他赛包封率的测定。结果:揭示了拉洛他赛的四大光谱学特征并制订相应的标准图谱。确认了拉洛他赛的结构为三环二萜,分子式为C45H53NO14 ,相对分子质量为831.900 1。建立了拉洛他赛的高效液相色谱定量方法,其色谱柱为C18硅胶反相色谱柱(5 μm, 250 mm×4.6 mm),流动相为乙腈-水(体积比75 ∶ 25),检测波长为230 nm,该方法可用于测定脂质体制剂中拉洛他赛的包封率,稳定性、回收率和精密度高。此外,新制备了拉洛他赛脂质体,该脂质体粒径大约105 nm,均一性良好,药物包封率大于80%。结论:制订了拉洛他赛的质谱、红外吸收光谱、核磁共振波谱和紫外-可见光谱图谱,验证了拉洛他赛的分子式、相对分子质量和结构式,建立了拉洛他赛的高效液相色谱定量方法,该方法可用于拉洛他赛脂质体的质量控制。

关键词：拉洛他赛波谱解析高效液相色谱法

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Fungal diversity notes 929-1035:taxonomic and phylogenetic co.tributions on genera and species of fungi

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Fungal Diversity 2019年第2期95卷 1-273页

作者： Rungtiwa Phookamsak Kevin D.Hyde Rajesh Jeewon D.Jayarama Bhat E.B.Gareth Jones Sajeewa S.N.Maharachchikumbura Olivier Raspe Samantha C.Karunarathna Dhanushka N.Wanasinghe Sinang Hongsanan Mingkwan Doilom Danushka S.Tennakoon Alexandre R.Machado Andre L.Firmino Aniket Ghosh Anuruddha Karunarathna Armin Mesic Arun Kumar Dutta Benjarong Thongbai Bandarupalli Devadatha Chada Norphanphoun Chanokned Senwanna Deping Wei Dhandevi Pem Frank Kwekucher Ackah Gen-Nuo Wang Hong-Bo Jiang Hugo Madrid Hyang Burm Lee Ishani D.Goonasekara Ishara S.Manawasinghe Ivana Kusan Josep Cano Josepa Gene Junfu Li Kanad Das Krishnendu Acharya K.N.Anil Raj K.P.Deepna Latha K.W.Thilini Chethana Mao-Qiang He Margarita Duenas Margita Jadan Maria P.Martin Milan C.Samarakoon Monika C.Dayarathne Mubashar Raza Myung Soo Park M.Teresa Telleria Napalai Chaiwan Neven Matocec Nimali Ide Silva Olinto L.Pereira Paras Nath Singh Patinjareveettil Manimohan Priyanka Uniyal Qiu-Ju Shang Rajendra P.Bhatt Rekhani H.Perera Renato Lucio Mendes Alvarenga Sandra Nogal-Prata Sanjay K.Singh Santhiti Vadthanarat Seung-Yoon Oh Shi-Ke Huang Shiwali Rana Sirinapa Konta Soumitra Paloi Subashini C.Jayasiri Sun Jeong Jeon Tahir Mehmood Tatiana Baptista Gibertoni Thuong T.T.Nguyen Upendra Singh Vinodhini Thiyagaraja V.Venkateswara Sarma Wei Dong Xian-Dong Yu Yong-Zhong Lu Young Woon Lim Yun Chen Zdenko Tkalcec Zhi-Feng Zhang Zong-Long Luo Dinushani A.Daranagama Kasun M.Thambugala Saowaluck Tibpromma Erio Camporesi Timur S.Bulgakov Asha J.Dissanayake Indunil C.Senanayake Dong Qin Dai Li-Zhou Tang Sehroon Khan Huang Zhang Itthayakorn Promputtha Lei Cai Putarak Chomnunti Rui-Lin Zhao Saisamorn Lumyong Saranyaphat Boonmee Ting-Chi Wen Peter E.Mortimer Jianchu Xu Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Institute of Animal Science State Key Laboratory of AnimalNutritionChinese Academy of Agricultural SciencesBeijing 100193People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Rai 50150Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius No.128/1-J Co-Op Azad Housing SocietyCurcaGoa VelhaIndia Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Botanic Garden Meise Nieuwelaan 381860 MeiseBelgium Federation Wallonie-Bruxelles Service general de l’Enseignement universitaire et de la Recherche scientifiqueRue A.Lavallee 11080 BrusselsBelgium Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Science and OceanographyShenzhen University3688Nanhai AvenueNanshanShenzhen 518060People’s Republic of China Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004Taiwan Departamento de Mico.ogia Universidade Federal de PernambucoRecifePernambucoBrazil Instituto de Ciencias Agrarias Universidade Federal de UberlandiaMonte CarmeloMinas GeraisBrazil Department of Botany&Microbiology H.N.B.Garhwal UniversitySrinagarGarhwal 246174UttarakhandIndia Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Ruder Boskovic Institute Bijenicka cesta 5410000 ZagrebCroatia Molecular and Applied Myco.ogy and Plant Pathology Laboratory Department of BotanyUniversity of CalcuttaKolkataWest Bengal

This article is the ninth in the series of Fungal Diversity Notes,where 107 taxa distributed in three phyla,nine classes,31 orders and 57 families are described and *** described in the present study include 12 new genera,74 new species,three new co.binations,two reference specimens,a re-circumscription of the epitype,and 15 reco.ds of sexualasexual morph co.nections,new hosts and new geographical *** new genera co.prise Brunneofusispora,Brunneomurispora,Liua,Lonicerico.a,Neoeutypella,Paratrimmatostroma,Parazalerion,Proliferophorum,Pseudoastrosphaeriellopsis,Septomelanco.iella,Velebitea and ***-four new species are Agaricus memnonius,***,Aleurodiscus patagonicus,Amanita flavoalba,***,Amphisphaeria mangrovei,Baorangia major,Bartalinia kunmingensis,Brunneofusispora sinensis,Brunneomurispora lonicerae,Capronia camelliaeyunnanensis,Clavulina thindii,co.iochaeta simbalensis,co.larium thailandense,co.rinus trigonosporus,Liua muriformis,Cyphellophora filicis,Cytospora ulmico.a,Dacrymyces invisibilis,Dictyocheirospora metroxylonis,Distoseptispora thysanolaenae,Emericellopsis koreana,Galiico.a baoshanensis,Hygrocybe lucida,Hypoxylon teeravasati,Hyweljonesia indica,Keissleriella caraganae,Lactarius olivaceopallidus,Lactifluus midnapurensis,Lembosia brigadeirensis,Leptosphaeria urticae,Lonicerico.a hyaloseptispora,Lophiotrema mucilaginosis,Marasmiellus bico.oripes,Marasmius indojasminodorus,Micropeltis phetchaburiensis,Muco. orantomantidis,Murilentithecium lonicerae,Neobambusico.a brunnea,Neoeutypella baoshanensis,Neoroussoella heveae,Neosetophoma lonicerae,Ophiobolus malleolus,Parabambusico.a thysanolaenae,Paratrimmatostroma kunmingensis,Parazalerion indica,Penicillium dokdoense,Peroneutypa mangrovei,Phaeosphaeria cycadis,Phanerochaete australosanguinea,Plectosphaerella kunmingensis,Plenodomus artemisiae,***,Proliferophorum thailandicum,Pseudoastrosphaeriellopsis kaveriana,Pseudohelico.yces menglunicu

关键词： 86 new taxa Agarico.ycetes Asco.yco.a Basidiomyco.a Dacrymycetes Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Muco.omycetes Muco.omyco.a Pezizomycetes Sordariomycetes Taxonomy

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Biomarkers of aging

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Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker co.sortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu Aging Biomarker co.sortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a co.bination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,co.prising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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