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An instrument for methodological quality assessment of single-subject finite element analysis used in computational orthopaedics

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Medicine in Novel Technology and Devices 2021年第3期11卷 113-119页

作者： Duo Wai-Chi Wong Tony Lin-Wei Chen Yinghu Peng Wing-Kai Lam Yan Wang Ming Ni Wenxin Niu Ming Zhang Department of biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong KongChina The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina Guangdong Provincial Engineering Technology Research Center for Sports Assistive Devices Guangzhou Sport UniversityGuangzhouChina Department of Kinesiology Shenyang Sport UniversityShenyangChina Li Ning Sports Science Research Center Li Ning(China)Sports Goods CompanyBeijingChina Department of Orthopaedics Pudong New Area Peoples’Hospital Affiliated to Shanghai University of Medicine and Health SciencesShanghaiChina Department of Rehabilitation Medical College of Tongji UniversityShanghaiChina

The methodological quality of subject-specific finite element analysis papers depends on the rigor of the study design and detailed description of key elements,while assessment instruments are often confined to clinical trials or *** study aims to present an instrument for methodological quality assessment of singlesubject finite element analysis used in computational orthopaedics(MQSSFE).Based upon existing instruments and relevant review papers,a pilot version was developed consisting of 37 items with 6 domains,including study design and presentation of findings,subject recruitment,model reconstruction and configuration,boundary and loading conditions(simulation),model verification and validation,and model assumption and *** interviewed four experts in the field to assess the face validity and refined the *** instrument was tested for interrater reliability among two assessors on nine finite element study ***,the criterion validity was evaluated by comparing the similarity of the MQSSFE and the modified Down and Black *** intraclass correlation coefficient was 0.965,while the MQSSFE was significantly moderately correlated with the modified Down and Black instruments(r=0.61).We believed that MQSSFE was adequately appropriate,reliable,and valid for assessing the methodological quality for finite element studies used in computational *** instrument could facilitate quality assessment in the systematic reviews of finite element models and checklists for fidelity.

关键词： Finite element model Simulation Validation and verification Mesh convergence Uncertainty analysis

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A design of Software and Hardware System for Pre-hospital Emergency Treatment

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Chinese Journal of biomedical Engineering(English Edition) 2020年第3期29卷 1-9页

作者： Bingxu Ye Feng Chen Shaomin Ou Yang Xie Yaowen Chen The key Lab of Digital Signal and Image Processing of Guangdong Shantou Guangdong 515063China Shantou University Medical College Shantou Guangdong 515041China The Second Affiliated Hospital of Shantou University Medical College Shantou Guangdong 515041China

This paper aims to improve the pre-hospital first-aid knowledge and pre-hospital first-aid success rate and optimize the pre-hospital emergency *** paper mainly discusses a comprehensive pre-hospital emergency system,which consists of the hardware part and software *** hardware is based on the international cardiopulmonary resuscitation guidelines,and a cardiopulmonary resuscitation(CPR)training auxiliary equipment is developed,which can be applied in pre-hospital first aid training to help people perform accurate chest *** software part is based on the WeChat applet platform to set up a pre-hospital first-aid dispatching system that connects callers and CPR *** software system effectively improves the pre-hospital CPR first-aid system and increases the rescue success rate of cardiac arrest patients.

关键词： Chest compression CPR Auxiliary equipment WeChat applet

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Obesity communication among patients by health professionals: Findings from the Weight Care Project

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Health 2013年第8期5卷 100-109页

作者： S. Anne Moorhead Vivien E. Coates Alison M. Gallagher Geraldine Nolan Kathy Murphy Diane E. Hazlett Department of Health Promotion National University of Ireland Galway Galway Republic of Ireland Northern Ireland Centre for Food and Health School of Biomedical Sciences University of Ulster Coleraine Northern Ireland School of Communication University of Ulster Shore Road Newtownabbey Northern Ireland School of Nursing National University of Ireland Galway Galway Republic of Ireland School of Nursing University of Ulster Coleraine Northern Ireland/Western Health and Social Care Trust Londonderry Northern Ireland

Obesity is on the increase worldwide and is a major global public health problem. In an increasingly obesogenic environment, it’s important that health professionals are equipped to identify and address obesity issues within their clinical practice. As part of the Weight Care Project, the aim of this study was to explore the obesity-related communication issues for primary care and community-based health professionals. The study design was a quantitative survey, which was completed by 382 primary care and community-based health professionals across Northern Ireland and Republic of Ireland working with adults and children. key findings included that the majority of the health professionals (86%) recognized having a role in giving obesity advice, acknowledged that in clinical practice communication of obesity messages is both complex and challenging (81%), and reported difficulty in sensitively addressing obesity issues (27%). The health professionals surveyed stated that they communicate obesity messages to their patients using a range of different methods, mainly verbally to individuals, leaflets and factsheets. Numerous benefits of communicating obesity messages were reported;the main one was interacting with patients to build trust. Identified barriers to commu nication were: limited time in patient consultations, restricted access to appropriate information, and not sure where to access appropriate resources. Communication needed be reported by the health professionals included provision of greater resources, more information on obesity management and prevention, followed by health communication training, and clear and consistent messages. Significant differences were observed, including significantly much younger health professionals considered their role to provide obesity advice (P = 0.025). It is clear from this study that health professionals view as important the need to be given information on “what” and “how” to communicate with their patients on obesity.

关键词： Obesity Communication Health Professionals Patients

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鞭毛/纤毛内在驱动机制启发的一体式管状机器人驱动器

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Engineering 2023年第4期23卷 170-180,M0008页

作者：苗佳麒张铁山李根郭栋孙思琦谭蓉史家海申亚京 Shenzhen Research Institute of City University of Hong Kong Shenzhen 515100China Department of biomedical Engineering City University of Hong KongHong Kong 999077China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Cheng Kar-Shun Robotics Institute(CKSRI) Hong Kong University of Science and TechnologyHong Kong 999077China Synthetic Biology Translational Research Programmes Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119077Singapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119077Singapore

鞭毛和纤毛独特的运动模式(如鞭毛的平面/螺旋波形式推进和纤毛的二维/三维不对称搏动)在众多生物的生命活动中起到至关重要的作用,这也启发了诸多仿生设计,尤其对于微型机器人系统。然而,与自然界中微生物能够从统一化的9+2轴丝生物结... 详细信息

鞭毛和纤毛独特的运动模式(如鞭毛的平面/螺旋波形式推进和纤毛的二维/三维不对称搏动)在众多生物的生命活动中起到至关重要的作用,这也启发了诸多仿生设计,尤其对于微型机器人系统。然而,与自然界中微生物能够从统一化的9+2轴丝生物结构中进化出多种运动模式不同的是,当前的仿生学仍然没有有效的工程策略去实现这样的智慧。在此,我们通过研究鞭毛和纤毛的内部结构及其内在驱动机制,推导出了一个统一的物理模型来描述微管弯曲及其所构建的宏观鞭毛/纤毛运动。基于该模型,我们进而提出了基于三通道的管状驱动概念,并相应地通过杆嵌入铸造工艺制造了一个三通道的管状驱动器。通过编程不同通道的驱动模式,这一管状驱动器不仅可以再现自然界中多样的二维及三维鞭毛/纤毛运动,还可以延展出更多的非对称纤毛搏动模式以实现低雷诺数下的有效推进。该研究加深了我们对微生物推进机制的理解,为仿生系统的设计提供了新灵感,并有望在广泛的工程领域中寻找到重要的应用场景。

关键词： Biomimetic systems Soft actuators 9+2 structure Artificial cilia Low Reynolds number

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Additive manufacturing alumina components with lattice structures by digital light processing technique

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Journal of Materials Science & Technology 2019年第12期35卷 2751-2755页

作者： Qjngfeng Zeng Changhao Yang Dingyi Tang Jiayao Li Zhiqiang Feng Jiantao Liu Kang Guan Science and Technology on Thermostructural Composite Materials laboratory School of Materials Science and EngineeringNorthwestern Polytechnical University.Xi'an 710072China International Center for Materials Discovery School of Materials Science and EngineeringNorthwestern Polytechical UniversityXi'an 710072China MSEA International Institute for Materials Genome Gu'an065500China School of Mechanics and Engineering Southwest Jiaotong UniversityChengdu 610031China LMEE-UEVE Universiti Paris-SaclayEvry 91020France School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China

Digital light processing technique was applied to manufacture alumina ceramic parts with two types of lattice structure units, i.e. vertex interconnect structure and edge structure. The internal porosity of the unit is 40%. The printed parts were sintered and the grain size is about 1.1 μm. The bending strength of the vertex interconnect structure is much larger than that of the edge structure. Materials genome initiative(MGI) aims to digital design and intelligent manufacture for advanced components. This research shows us an example to achieve this goal.

关键词： Additive manufacturing Ceramics DLP Lattice structure

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Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria

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Chinese Chemical Letters 2023年第2期34卷 214-218页

作者： Zhiping Liu Fanny Demontrond Anne Imberty Andrew C.-H.Sue Sébastien Vidal Hongxia Zhao Tianjin key Lab for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Laboratoire de Chimie Organique 2-GlycochimieUMR 5246CNRSUniversitéClaude Bernard Lyon 1Universitéde LyonVilleurbanne 69622France CNRS Univ.Grenoble AlpesCERMAVGrenoble 38000France College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China CNRS Institut de Chimie des Substances NaturellesUniversitéParis-SaclayUPR 2301Gif-sur-Yvette 91198France

Macrocycle-based glycoclusters, on account of their promising anti-adhesive properties against bacteria,are potential therapeutic alternatives to classic antibiotics through the much less explored anti-adhesive strategy. In this study, a series of constitutionally-pure pentavalent glycoclusters was prepared by conjugating assorted azido-carbohydrates onto a penta-propargyl rim-differentiated pillar[5]arene(RD-P[5])scaffold through Cu(I)-catalyzed azide–alkyne cycloaddition “click” reactions. Their binding towards therapeutically relevant bacterial lectins, such as Lec A and Lec B from Pseudomonas aeruginosa and concanavalin A(Con A), were evaluated subsequently by isothermal titration calorimetric studies. Most of these isomerfree RD-P[5] pentavalent glycoclusters, except the fucosylated ones, display good affinities to ***, the dissociation constants observed are similar to those displayed by an analogous pentavalent glycocluster consisting of four P[5] constitutional isomers, in which the RD-P[5] component merely accounts for 7% in the mixture. Our results revealed that high constitutional purity is not essential for achieving effective multivalent interactions between P[5]-based glycoclusters and lectins, presumably as a result of the conformationally labile nature of the P[5] scaffold. This information provides valuable design principles for low-cost and facile syntheses of glycosylated P[5]s for biomedical applications.

关键词： Glycocluster Lectin Pillararene Multivalency Constitutional purity

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Direct laser-written aperiodic photonic volume elements for complex light shaping with high efficiency:inverse design and fabrication

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Advanced Photonics Nexus 2023年第3期2卷 53-61页

作者： Nicolas Barré Ravi Shivaraman Simon Moser Patrick Salter Michael Schmidt Martin J.Booth Alexander Jesacher Medical University of Innsbruck Institute of Biomedical PhysicsInnsbruckAustria Friedrich-Alexander-University Erlangen-Nürnberg Institute of Photonic TechnologiesErlangenGermany Friedrich-Alexander-University Erlangen-Nürnberg Erlangen Graduate School in Advanced Optical TechnologiesErlangenGermany University of Oxford Department of Engineering ScienceOxfordUnited Kingdom

Light plays a central role in many *** key to unlocking its versatility lies in shaping it into the most appropriate form for the task at *** tailored refractive index modifications,directly manufactured inside glass using a short pulsed laser,enable an almost arbitrary control of the light ***,the stringent requirements for quantitative knowledge of these modifications,as well as for fabrication precision,have so far prevented the fabrication of light-efficient aperiodic photonic volume elements(APVEs).Here,we present a powerful approach to the design and manufacturing of light-efficient *** optimize application-specific three-dimensional arrangements of hundreds of thousands of microscopic voxels and manufacture them using femtosecond direct laser writing inside millimeter-sized glass *** experimentally achieve unprecedented diffraction efficiencies up to 80%,which is enabled by precise voxel characterization and adaptive optics during *** demonstrate APVEs with various functionalities,including a spatial mode converter and combined intensity shaping and wavelength *** elements can be freely designed and are efficient,compact,and *** approach is not limited to borosilicate glass but is potentially extendable to other substrates,including birefringent and nonlinear materials,giving a preview of even broader functionalities,including polarization modulation and dynamic elements.

关键词： integrated photonics holography mode conversion inverse design

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Review on near-field detection technology in the biomedical field

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Advanced Photonics Nexus 2023年第4期2卷 15-30页

作者： Xitian Hu Li Zhou Xu Wu Yan Peng University of Shanghai for Science and Technology Terahertz Technology Innovation Research InstituteTerahertz Spectrum and Imaging Technology Cooperative Innovation CenterShanghai Key Lab of Modern Optical SystemShanghaiChina

We review the recent biomedical detection developments of scanning near-field optical microscopy(SNOM),focusing on scattering-type SNOM,atomic force microscope-based infrared spectroscopy,peak force infrared microscopy,and photo-induced force microscopy,which have the advantages of label-free,noninvasive,and specific spectral *** the high water content of biological samples and the strong absorption of water by infrared waves,we divide the relevant research on these techniques into two categories:one based on a nonliquid environment and the other based on a liquid *** the nonliquid environment,the chemical composition and structural information of biomedical samples can be obtained with nanometer *** the liquid environment,these techniques can be used to monitor the dynamic chemical reaction process and track the process of chemical composition and structural change of single molecules,which is conducive to exploring the development mechanism of physiological *** elaborate their experimental challenges,technical means,and actual cases for three microbiomedical samples(including biomacromolecules,cells,and tissues).We also discuss the prospects and challenges for their *** work lays a foundation for the rational design and efficient use of near-field optical microscopy to explore the characteristics of microscopic biology.

关键词： near-field scattering-type scanning near-field optical microscopy atomic force microscope-based infrared spectroscopy photo-induced force microscopy biomedical detection nanospectroscopy

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Rationale,design,and baseline characteristics of Chinese registry in early detection and risk stratification of coronary plaques(C-STRAT)study

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Chinese Medical Journal 2021年第7期134卷 870-872页

作者： Jun-Jie Yang Dong-Kai Shan Lei Xu Jun-Fu Liang Zhao-Qian Wang Mei Zhang Min Li Wen-Jie Yang Jian-Rong Xu Yong-Gao Zhang Li-Ming Xia Li-Hua Wang Hong-Jie Hu Zhi-Gang Yang Tao Li Qi Tian Xu-Dong Lyu Yun-Dai Chen Department of Cardiology the First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Beijing Huairou Hospital Beijing 101400China The First Affiliated Hospital of Dalian Medical University DalianLiaoning 116011China Department of Cardiology Qilu Hospital of Shandong UniversityJinanShandong 250012China 960 Hospital of PLA JinanShandong 250031China Department of Radiology Shanghai Jiao Tong University Medical School Affiliated Ruijin HospitalShanghai 200025China Department of Radiology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China The First Affiliated Hospital of Zhengzhou University ZhengzhouHenan 450052China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China The Second Affiliated Hospital of Zhejiang University College of Medicine HangzhouZhejiang 310009China Sir Run Run Shaw Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China Radiology Department the First Medical CenterChinese PLA General HospitalBeijing 100853China College of biomedical Engineering and Instrumental Science Zhejiang UniversityHangzhouZhejiang 310027China.

To the Editor:Coronary computed tomographic angiography(CCTA)has been considered as one of the most important noninvasive imaging modalities in diagnosing coronary artery disease(CAD).[1]Modern scanner of CCTA can provide precise coronary atherosclerotic plaque information,showing improved diagnostic accuracy and sensitivity for identifying obstructive CAD with a preferable temporal and spatial *** studies have demonstrated the prognosis value of CCTA for the prediction of future adverse CAD events.

关键词： coronary Rational scanner

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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