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红树植物内生真菌Penicillium sp.中新木质素的分离及结构鉴定

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天然产物研究与开发 2007年第1期19卷 4-6页

作者：李想孙光芝郑毅男林文翰 Isabel Sattler 吉林农业大学中药材学院北京大学天然药物与仿生药物国家重点实验室 Hans-Knll-Institute for Natural Product Research Beutenbergstraβe 11Jena D-07745Germany

应用各种层析手段,从红树植物内生真菌的发酵液中分离纯化了一个新的木质素类化合物,结合多种波谱方法确定其结构为4,4′-二(1-丙烯酸甲酯)-3′-甲氧基-二苯醚(1)。

关键词：红树植物内生真菌 Penicillium sp. 木质素

Biodiversity-ecosystem functioning research in Chinese subtropical forests

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Journal of Plant Ecology 2017年第1期10卷 1-3页

作者： Keping Ma Jin-Sheng He Helge Bruelheide Alexandra-Maria Klein Xiaojuan Liu Bernhard Schmid State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Department of Ecology College of Environmental SciencesPeking UniversityBeijing 100871China Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-WittenbergAm Kirchtor 106120 HalleGermany German Centre for Integrative Biodiversity Research(iDiv)Halle-jena-Leipzig DeutscherPlatz 5e04103 LeipzigGermany Chair of Nature Conservation and Landscape Ecology Faculty of Environment and Natural ResourcesUniversity of FreiburgTennenbacher Straße 479106 FreiburgGermany Department of Evolutionary Biology and Environmental Studies and Zürich-Basel Plant Science Center University of ZürichWinterthurerstrasse 190CH-8057 ZürichSwitzerland

Worldwide,forests provide habitat for a large diversity of plants,animals and *** the same time,forest ecosystems are essential providers of multiple ecosystem services important for human ***,the relationship between biodiversity and ecosystem functioning has only been little researched in forests and therefore its role for the functioning of forest ecosystems and their services is not yet *** results from comparable studies in other ecosystems are considered(*** et al.2006),it is conceivable that diverse forests would,for example,grow faster,produce more biomass,store more carbon and better maintain soil fertility and plant-insect interactions and functional stability than less diverse forests or monoculture tree *** hypothesis that biodiversity increases and stabilizes interactions and functions is the common theme of the papers in the present issue of the Journal of Plant Ecology.

关键词： forest fertility soil

红树植物内生真菌Penicillium sp.的化学成分

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天然产物研究与开发 2007年第5期19卷 804-806页

作者：李想姚燕华孙光芝林文翰 Isabel Sattler 吉林农业大学中药材学院北京大学天然药物与仿生药物国家重点实验室 Hans-Knll-Institute for Natural Product Research Beutenbergstra βe11D-07745jena Germany

应用各种层析手段,从红树植物内生真菌GT26158菌丝体的甲醇提取物中分离纯化了7个含氮化合物,结合多种波谱方法(ESI-MS,1D-NMR,2D-NMR),它们被鉴定为2′-deoxyuridine(1)、thymidine(2)、2′-deoxyad-enosine(3)、cyclo(tyrosyl-phenyla... 详细信息

关键词：红树植物内生真菌化学成分

南极大型动物粪土层和蛋卵中有机氯污染物分布特征及生态学意义

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中国科学（D辑） 2006年第12期36卷 1111-1121页

作者：张海生王自磐卢冰朱纯武光海 Walter Vetter 国家海洋局海底资源重点实验室国家海洋局第二海洋研究所杭州310012 宁波市微生物和环境工程重点实验室宁波315100 Friedrich-Schiller Universitt jena Institut Für Ernhrung und Umweltjenagermany07743

新近从南极菲尔德斯半岛和阿德雷岛的海鸟和海豹栖息地粪土层中检出持久性有机氯污染物(POPs)总含量范围：多氯联苯(PCBs)为0．21～3.85ng/g；有机氯农药滴滴涕(∑DDT)为0．09～2．01ng／g；六六六(∑HCH)为0．06～0．76ng/g,并以七氯... 详细信息

新近从南极菲尔德斯半岛和阿德雷岛的海鸟和海豹栖息地粪土层中检出持久性有机氯污染物(POPs)总含量范围：多氯联苯(PCBs)为0．21～3.85ng/g；有机氯农药滴滴涕(∑DDT)为0．09～2．01ng／g；六六六(∑HCH)为0．06～0．76ng/g,并以七氯、六氯联苯、P,P-DDE和α-HCH化合物为主体；在贼鸥和巨海燕、企鹅蛋卵中检出POPs含量各为12．5～294．2和2．0～10．2ng/g(湿重)；积蓄形式以PCB180,PCB153,P,P’-DDE和HCB和P,P’-DDE为主．研究表明,栖息地粪土层POPs含量变化与海鸟不同种群食性以及营巢占域的不同而相异；对不同种类海鸟卵样的POPs数据进行统计分析,结果显示不同鸟种POPs积累水平的差异取决于不同鸟种的生态习性,如活动范围、迁徒距离、觅食习性以及巢址选择等,最重要是海鸟生态食物链中的位置,其食谱的宽窄,同样表明海鸟体内POPs积累通过食物链逐渐加强的结果．其次还对阿德雷岛地区AD1,AD2短柱粪土地层进行210Pb测年,并进行POPs积累率及分子地层学记录的初步研究．

关键词：持久性有机氯污染物动物栖息地粪土层海鸟卵南极

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

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Bone Research 2022年第3期10卷 469-481页

作者： Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann Institute of Comparative Molecular Endocrinology(CME) Ulm UniversityHelmholtzstrasse 8/189081 UlmGermany Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Leibniz Institute on Aging–Fritz Lipmann Institute(FLI) Beutenbergstrasse 11D-07745 JenaGermany Praxisklinik für Orthopädie Unfall-und Neurochirurgie Prof.Bischoff/Dr.Spies/Dr.Mengele89231 Neu-UlmGermany Paracelsus Medizinische Privatuniverstät Institute of PharmacyStrubergasse 215020 SalzburgAustria Department of Endocrinology Ludwig Maximilians University MunichMunich 80336Germany Present address:Institute of Orthopedic Research and Biomechanics Ulm UniversityHelmholtzstrasse 1489081 UlmGermany Present address:UPMC Hillman Cancer Center Department of Pharmacology and Chemical BiologyUniversity of Pittsburgh5115 Center Avenue15232 PittsburghPAUSA Present address:TAmiRNA GmbH Leberstrasse 201110 ViennaAustria

Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.

关键词： Cdk5 healing expression

Proteomic Differences between Azole-Susceptible and -Resistant <i>Aspergillus fumigatus</i>Strains

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Advances in Microbiology 2018年第1期8卷 77-99页

作者： Edith Vermeulen Sebastien Carpentier Olaf Kniemeyer Machteld Sillen Johan Maertens Katrien Lagrou Department of Microbiology and Immunology University of Leuven Leuven Belgium Facility for Systems Biology Based Mass Spectrometry University of Leuven Leuven Belgium Leibniz Institute for Natural Product Research and Infection Biology—Hans Knoell Institute (HKI) Molecular and Applied Microbiology Jena Germany Department of Microbiology and Immunology and UZ Leuven Clinical Department of Hematology University of Leuven Leuven Belgium Department of Microbiology and Immunology and UZ Leuven Clinical Department of Laboratory Medicine and National Reference Center for Mycosis University of Leuven Leuven Belgium

Background: Azole-resistance is increasingly reported in Aspergillus fumigatus infections. It remains challenging to rapidly assess antifungal susceptibility to initiate the appropriate therapy. The aim of this study was to map the proteomic differences of azole-susceptible and -resistant strains. Methods: Proteomic studies were performed with ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS). Results: UPLC-MS/MS detected 7899 peptides, of which 1792 peptides had a significantly different abundance (p A. fumigatus resistance. Conclusions: UPLC-MS/MS provided proof-of-concept that the proteome of azole-resistant A. fumigatus is diverse enough to serve as a diagnostic tool.

关键词： Aspergillus fumigatus Triazole Resistance Proteomic Mass Spectrometry

Tissue-specific signatures of metabolites and proteins in asparagus roots and exudates

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Horticulture Research 2021年第1期8卷 1044-1057页

作者： Stefanie Doll Roxana Djalali Farahani-Kofoet Rita Zrenner Andrea Henze Katja Witzel Leibniz Institute of Plant Biochemistry Weinberg 306120 Halle/SaaleGermany Leibniz Institute of Vegetable and Ornamental Crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany University of Potsdam Institute of Nutritional ScienceArthur-Scheunert-Allee 114-11614558 NuthetalGermany Present address:German Centre for Integrative Biodiversity Research(iDiv)Halle-jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany

Comprehensive untargeted and targeted analysis of root exudate composition has advanced our understanding of rhizosphere ***,little is known about exudate spatial distribution and *** studied the specific metabolite signatures of asparagus root exudates,root outer(epidermis and exodermis),and root inner tissues(cortex and vasculature).The greatest differences were found between exudates and root *** total,263 non-redundant metabolites were identified as significantly differentially abundant between the three root fractions,with the majority being enriched in the root exudate and/or outer tissue and annotated as‘lipids and lipid-like molecules’or‘phenylpropanoids and polyketides’.Spatial distribution was verified for three selected compounds using MALDI-TOF mass spectrometry ***-specific proteome analysis related root tissue-specific metabolite distributions and rhizodeposition with underlying biosynthetic pathways and transport *** proteomes of root outer and inner tissues were spatially very distinct,in agreement with the fundamental differences between their functions and *** to KEGG pathway analysis,the outer tissue proteome was characterized by a high abundance of proteins related to‘lipid metabolism’,‘biosynthesis of other secondary metabolites’and‘transport and catabolism’,reflecting its main functions of providing a hydrophobic barrier,secreting secondary metabolites,and mediating water and nutrient *** more abundant in the inner tissue related to‘transcription’,‘translation’and‘folding,sorting and degradation’,in accord with the high activity of cortical and vasculature cell layers in growth-and development-related *** summary,asparagus root fractions accumulate specific *** expands our knowledge of tissue-specific plant cell function.

关键词： function outer signature

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单核细胞增多性李斯特菌性眼内炎

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 45-45页

作者： Augsten R. Krffer E. Dawczynski J. 宋虎平 Klinik fü ur Augenheilkunde Friedrich-Schiller-Univ. Jena Bachstr. 18 07740 Jena Germany Dr.

Purpose: Listeria monocytogenes is a rare cause of endogenous endophthalmitis. Controversy exists concerning clinical progress and prognosis in this bacterial infection. However, only a few reports about the clinical features have been pr eviously published in the literature. Case Report: The case of a 24-year-old w oman is reported. She developed an endogenous endophthalmitis within 3 weeks. Th e patient received a pars-plana vitrectomy showing Listeria monocytogenes in th e vitreous body. An intensive antibiotic therapy was initiated (local, subconjun ctival, intravitreal and systemic). Visual acuity was increased from hand motion to 0.5 by the end of the clinical attendance and to 1.0 three months later. The re were no hints concerning systemic manifestation of listeriosis or granuloma f ormation. Conclusion: Frequently, endogenous endophthalmitis has a very poor pro gnosis. However, the presented case report describes a very prosperous progress of endogenous endophthalmitis caused by an infection with Listeria monocytogenes .

关键词：单核细胞增多眼内炎李斯特菌玻璃体腔注射玻璃体切割术结膜下注射大剂量抗生素文献报道内源肉芽肿形成

Opposing intraspecific *** diversity effects on herbivory and growth in subtropical experimental tree assemblages

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Journal of Plant Ecology 2017年第1期10卷 242-251页

作者： Christoph Z.Hahn Pascal A.Niklaus Helge Bruelheide Stefan G.Michalski Miaomiao Shi Xuefei Yang Xueqin Zeng Markus Fischer Walter Durka Helmholtz Centre for Environmental Research—UFZ Department of Community Ecology(BZF)Theodor-Lieser-Straße 4D-06120 HalleGermany Department of Evolutionary Biology and Environmental Studies University of ZürichWinterthurerstrasse 190CH-8057 ZürichSwitzerland Institute of Biology Martin Luther University Halle-WittenbergAm Kirchtor 106108 HalleGermany German Centre for Integrative Biodiversity Research(iDiv)Halle-jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany South China Botanical Garden 723 Xingke RoadGuangzhou 510650China Key Laboratory of Biodiversity and Biogeography Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650204China Kadoorie Farm and Botanic Garden Lam Kam RoadTai PoNew TerritoriesHong Kong Institute of Plant Sciences University of BernAltenbergrain 21CH-3013 BernSwitzerland

Aims Positive plant diversity-ecosystem function relations are ultimately driven by variation in functional traits among individuals that form a *** date,research has largely focused on the role of species diversity for ecosystem ***,substantial intraspecific trait variation is common and a significant part of this variation caused by genetic differences among ***,we studied the relative importance of species diversity and seed family(SF)diversity within species for growth and herbivory in experimental subtropical tree *** In 2010,we set up a field experiment in subtropical China,using four species from the local species *** were raised from seeds,with seeds from the same mother tree forming an *** established 23 plots containing one or four species(species diversity treatment)and one or four SFs per species(SF diversity treatment).Tree growth(stem diameter,plant height and crown expansion)and herbivory(percentage leaf loss due to leaf chewers)were monitored annually from 2011 to *** findings Tree species richness promoted growth but had no effect on *** contrast,SF diversity reduced growth and increased herbivory but only so in species *** of the observed effects were time dependent,with the largest effect found in *** results suggest that biodiversity can affect plant performance directly via tree species-species interactions,or context dependent,via potential effects on inter-trophic *** important conclusions should be drawn from our ***,in future studies regarding biodiversity and ecosystem functioning(BEF)relationships,intraspecific genetic diversity should be given similar weight as species diversity as it has often been neglected and its effects are not well ***,we demonstrate opposite effects of biodiversity among and within species,stressing the importance to consider the effects of multiple levels of biodiversity simul

关键词： BEF-China species diversity genetic diversity growth herbivory