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Contribution of Major Hydrophilic and Lipophilic Antioxidants from Papaya Fruit to Total Antioxidant Capacity

Food and nutrition Sciences 2013年第8期4卷 93-100页

作者： Laura E. Gayosso-García Sancho Elhadi M. Yahia Gustavo A. González-Aguilar Coordinación de Tecnología de Alimentos de Origen Vegetal Centro de Investigación en Alimentación y Desarrollo Hermosillo México Facultad de Ciencias naturales Universidad Autónoma de Querétaro Querétaro México jefatura de nutrición humana Universidad Estatal de Sonora Hermosillo México

Several studies have shown that phenolic and carotenoid compounds protect against oxidative stress, reducing the risk of cardiovascular diseases and some types of cancers. The objective of this research was to determine the individual contribution of the main phenolic compounds from the papaya fruit skin and the individual contribution of main carotenoids from the pulp for total antioxidant capacity at four ripening stages;and the individual and combined radical scavenging ability used the essays DPPH (radical 2, 2-diphenyl-1-picryhydrazyl) and ABTS (radical 2, 20-azino-bis (3-ethylbenzothiazoline)-6 sulphonic acid). Phenolic acids standards for this study were ferulic (FA), caffeic (CA) and p-coumaric (pCA) acids and carotenoids studied were Lycopene, β-carotene and β-cryptoxanthin. The phenol that showed the best DPPH· and ABTS·+ radical scavenging ability was CA, with 89.47% and 92.98%, respectively. Lycopene contributed the greatest to the TAC (11.9-43.2). Lycopene also showed the best DPPH· and ABTS ·+ radical scavenging ability with 62.12% and 94.26%, respectively. Antiradical ability of phenolics and carotenoids depended on the structure of the compound and its concentration.

关键词： Carica Papaya Carotenoids Phenolics Radical Scavenging Activity TEAC DPPH

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Inhibition of Proliferation of Breast Cancer Cells MCF7 and MDA-MB-231 by Lipophilic Extracts of Papaya (<i>Carica papaya</i>L. var. Maradol) Fruit

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Food and nutrition Sciences 2014年第21期5卷 2097-2103页

作者： Laura E. Gayosso-García Sancho Elhadi M. Yahia Pablo García-Solís Gustavo A. González-Aguilar jefatura de nutrició n humana Universidad Estatal de Sonora Hermosillo M&#233 xico Facultad de Ciencias naturales Universidad Aut&#243 noma de Queré taro Quer&#233 taro M&#233 xico Facultad de Medicina Universidad Aut&#243 noma de Queré taro Quer&#233 taro M&#233 xico Coordinació n de Tecnologí a de Alimentos de Origen Vegetal Centro de Investigaci&#243 n en Alimentació n y desarrollo A.C. Hermosillo M&#233 xico

Several epidemiological studies have suggested that carotenoids have antineoplasic activities. The objective of this study was to determine the antiproliferative effect of rich carotenoid lipophilic extracts of papaya fruit pulp ( Carica papaya L., cv Maradol) in breast cancer cells, MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative), and in non-tumoral mammary epithelial cells MCF-12F. Antiproliferative effect was evaluated using the methylthiazolydiphenyl-tetrazolium bromide (MTT) assay and testing lipophilic extracts from different papaya fruit ripening stages (RS1, RS2, RS3, RS4), at different times (24, 48 and 72 h). Papaya lipophilic extracts do not inhibit cell proliferation of MCF-12F and MDA-MB-231 cells. However, MCF-7 cells showed a significant reduction in proliferation at 72 h with the RS4 papaya extract. Results suggested that lipophilic extracts had different action mechanisms on each type of cells and therefore, more studies were required to elucidate such mechanisms.

关键词： Carica papaya Antiproliferative Activity Breast Cancer Carotenoids

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