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Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection

World Journal of Orthopedics 2016年第8期7卷 467-474页

作者： Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel Department of Biomedical Engineering University of MemphisMemphisTN 38152United States Department of Microbiology and Immunology University of Arkansas Medical SciencesLittle RockAR 72205United States jamesport NY 11947United States Zimmer Biomet WarsawIN 46581United States

AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological ***: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded ***: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects.

关键词： Biofilm Implant Drug delivery coating Antibiotic Orthopaedic infection

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