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Network Modelling and Visualisation Analysis of the Undergraduate dental Curriculum System in China

Journal of Computer and Communications 2021年第6期9卷 38-51页

作者： Qian Ren Xiao Peng Xiaoyu Liu Qiao Zheng Ting He Die Hu Xuelian Jiang Linglin Zhang Education Affairs Office West China Hospital of Stomatology Sichuan University Chengdu China college of Computer Science Sichuan University Chengdu China State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral Diseases Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu China

Objectives: This study aims to present the characteristics of the undergraduate dental curriculum system using network modelling and visualisation analysis based on complex network theory, thus providing a theoretical foundation for the course development and curriculum reform. Methods: The correlation coefficient was used to quantify the intensity of the correlation between courses, and a visualisation complex network of the dental curriculum was built to explore the curriculum pattern from a dynamic perspective. Further, the statistical measurements of curriculum network were adopted to express the most relevant topological features. Subsequently, the minimum spanning tree and parallel coordinates plot were drawn to explore the curriculum community structure, quantify the key courses, and present different courses in time and space relationships. Results: The correlation analysis results show that the courses are closely related to each other. The main courses focus on pathology, pathophysiology, oral anatomy and physiology, closely connecting almost all medicine-related courses. The whole course network has an average degree value of 41.53, and a clustering coefficient of 0.78, indicating an obvious small-world characteristic. From the perspective of curriculum attributes, the number of public and theoretical courses was more than that of skills and practical courses. Moreover, the academic performance of skills and practical courses was lower than that of public and theoretical courses. Conclusion: The undergraduate dental courses have a progressive structure from basic professional knowledge to professional skills, which is reasonable for the dental education in China. However, some efforts towards curriculum reform based on this study are needed.

关键词： Complex Network dental Education Curriculum Data Visualisation Educational Data Mining

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An amelogenin-based peptide hydrogel promoted the odontogenic differentiation of human dental pulp cells

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Regenerative Biomaterials 2022年第1期9卷 511-521页

作者： Xinxin Li Zhaoxia Yu Shihui Jiang Xiaohua Dai Guanhua Wang Yue Wang Zhimou Yang Jie Gao Huiru Zou State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction Tianjin Stomatological HospitalThe Affiliated Stomatological Hospital of Nankai UniversityTianjin 300041China School of Medicine Nankai UniversityTianjin 300071China

Amelogenin can induce odontogenic differentiation of human dental pulp cells(HDPCs),which has great potential and advantages in dentine-pulp complex ***,the unstability of amelogenin limits its further *** study constructed amelogenin self-assembling peptide hydrogels(L-gel or D-gel)by heating-cooling technique,investigated the effects of these hydrogels on the odontogenic differentiation of HDPCs and explored the underneath *** critical aggregation concentration,conformation,morphology,mechanical property and biological stability of the hydrogels were characterized,*** effects of the hydrogels on the odontogenic differentiation of HDPCs were evaluated via alkaline phosphatase activity measurement,quantitative reverse transcription polymerase chain reaction,western blot,Alizarin red staining and scanning electron *** mechanism was explored via signaling pathway *** showed that both the L-gel and D-gel stimulated the odontogenic differentiation of HDPCs on both Day 7 and Day 14,while the D-gel showed the highest enhancement ***,the D-gel promoted calcium accumulation and mineralized matrix deposition on Day *** D-gel activated MAPK-ERK1/2 pathways in HDPCs and induced the odontogenic differentiation via ERK1/2 and transforming growth factor/smad ***,our study demonstrated that the amelogenin peptide hydrogel stimulated the odontogenic differentiation and enhanced mineralization,which held big potential in the dentine-pulp complex regeneration.

关键词： amelogenin peptide hydrogel odontogenic differentiation human dental pulp cells

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Evolution of People Living with HIV and AIDS in Medical Consultation at 17 ESOPE Sites in Mali

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Journal of Pharmacy and Pharmacology 2019年第9期7卷 504-509页

作者： S.Traore K.Kayentao B.Traore I.Coulibaly N.Telly S.Diop S.Doumbia M.Traore Department Surveillance Epidemiology Coordination Unit of the AIDS Control Sector Committee of the Ministry of Health and Public Health (CSLS/MSHP) BPE 594 Mali Department Parasitoly Center for International Excellence Studies USSTB Medical College (ICER-Mali)University Of ScienceTechnology of Bamako Faculty of medicine and Odontostomalogy Point G Mali Department of Public Health Teaching and Research Medical and Dental College of Stomatology (DERSP) University Of ScienceTechnology of Bamako Faculty of medicine and Odontostomalogy Point G Mali Director-General of the Center for Disease Support (CNAM) Djikoroni Para BP 251 Para Mali Director- General ofNational Institute of Public Health (INRSP) B.P. 1771 Bamako Mali

Despite the efforts made by the Malian government with technical and financial partners in the fight against HIV and AIDS, there are no data on the evolution of people with HIV in medical consultation in antiretroviral treatment sites. The objective of this work is to fill this gap by generating factual data describing the evolution of the number of people with HIV in medical consultation in Mali. To achieve this goal, we conducted a cross-sectional study using data from the Coordination Unit of the Sectoral Committee for AIDS Control of the Ministry of Health and Public Hygiene. Sampling was comprehensive including all people living with HIV. The data collected concerned those of the years 1999 to 2014 by the ESOPE software and analyzed with Stata version 12. A Total of 39,619 people were enrolled in the study. And 26,212 people living with HIV in the 17 ESOPE sites of Mali were female. Patients aged 25-34 and 35-44 years were strongly represented in consultation in the years 2007 and 2011, and those aged 15-24 were the least frequent. HIV1 was the most dominant with 97%. The majority of patients presented for initial consultation were clinical stages 2 and 3 in all years. Cases of lost sites seen in the more common in hospitals are 62.79% at the Hospital of Mopti and 57% at the University Hospital of Point G. The number of cases of people living with HIV in medical consultation has progressively augmented from 1999-2007. Then it dropped from 2008-2010. After this number has increased by 2011, it dropped again in 2012-2014. This study made it possible to note the evolution of the patients in medical consultation in ESOPE antiretroviral treatment sites according to the years and events (safe, subsidized by activities by the global fund). The activities of sensitization and communications, case research should be strengthened by involving the community.

关键词： Evolution HIV Sites of ESOPE Mali 1999 to 2014

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ChatGPT for shaping the future of dentistry: the potential of multi-modal large language model

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International Journal of Oral Science 2023年第3期15卷 377-389页

作者： Hanyao Huang Ou Zheng Dongdong Wang Jiayi Yin Zijin Wang Shengxuan Ding Heng Yin Chuan Xu Renjie Yang Qian Zheng Bing Shi State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengduChina Department of Civil Environmental&Construction EngineeringUniversity of Central FloridaOrlandoUSA college of Transportation Engineering University of Central FloridaOrlandoUSA School of Transportation and Logistics Southwest Jiaotong UniversityChengduChina C2SMART Center Tandon School of EngineeringNew York UniversityBrooklynUSA State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Eastern Clinic West China Hospital of StomatologySichuan UniversityChengduChina

The ChatGPT,a lite and conversational variant of Generative Pretrained Transformer 4(GPT-4)developed by OpenAI,is one of the milestone Large Language Models(LLMs)with billions of *** have stirred up much interest among researchers and practitioners in their impressive skills in natural language processing tasks,which profoundly impact various *** paper mainly discusses the future applications of LLMs in *** introduce two primary LLM deployment methods in dentistry,including automated dental diagnosis and cross-modal dental diagnosis,and examine their potential ***,equipped with a cross-modal encoder,a single LLM can manage multi-source data and conduct advanced natural language reasoning to perform complex clinical *** also present cases to demonstrate the potential of a fully automatic Multi-Modal LLM AI system for dentistry clinical *** LLMs offer significant potential benefits,the challenges,such as data privacy,data quality,and model bias,need further ***,LLMs have the potential to revolutionize dental diagnosis and treatment,which indicates a promising avenue for clinical application and research in dentistry.

关键词： modal equipped operations

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The Insight into the Development of Titanium dental Implant

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功能材料信息 2016年第4期13卷 54-54页

作者： Wang Xiao-Xiang He Fu-Ming college of Materials Science and Engineering Zhejiang University The Affiliated Stomatology Hospita Zhejiang University

dental implantation surgery has been clinically conducted widely in the domestic stomatology ***,the dental implants are almost all imported from the developed countries,such as Swissland,Us and *** allied with the domestic medical device company and dentists 8 years ago and developed a new kind of dental implant of *** 8 years of combined efforts,the

关键词：英语阅读理解生物材料

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The prosthodontic treatment for maxillofacial defects

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中国口腔颌面外科杂志 2008年第B5期6卷 54-54页

作者： Yi Min Zhao Department of Prosthodontics College of Stomatology the Fourth Military Medical University Xi'an 710032 China

The maxillofacial defects include the maxillofacial (mandibular) defects and the facial defects, which both conduce to the severe physiological and mental obstructions.

关键词：上颌面整形技术修复方法移植技术

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Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev J.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev J.Balewski D.R.Beavis N.K.Behera R.Bellwied M.J.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel J.Bieleik J.Bielcikova B.Biritz L.C.Bland W.Borowski J.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen J.H.Chen J.Y.Chen L.Chen J.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.J.M.Codrington R.Corliss J.G.Cramer H.J.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong J.L.Drachenberg J.E.Draper J.C.Dunlop L.G Efimov M.Elnim J.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi J.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han J.W.Harris J.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.J.Hofiman B.Huang H.Z.Huang T.J.Humanic L.Huo G.Igo P.Jacobs W.W.Jacobs C.Jena F.Jin J.Joseph E.G.Judd S.Kabana K.Kang J.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola J.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger J.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont J.M.Landgraf S.LaPointe J.Lauret A.Lebedev R.Lednicky J.H.Lee W.Leight M.J.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu J.Liu T.Ljubicic W.J.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of Jammu Jammu 180001India Joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State University East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

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COVID-19 is a natural infectious disease

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Journal of Biosafety and Biosecurity 2022年第1期4卷 38-42页

作者： Zhenjun Li Jiafu Jiang Yigang Tong Xiangdong Ruan Jianguo Xu State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingPR China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingPR China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijingPR China Academy of Forest Inventory and Planning State Forestry and Grassland AdministrationBeijing 100714PR China

Coronavirus disease 2019 is an infectious disease that has emerged naturally,not accidentally or ***,Severe acute respiratory syndrome coronavirus 2 is not a man-made or genetically modified *** genetic technology can only be used to produce infectious clones of a known ***,the RaTG13 genome sequence recovered from bats is the most closely related viral sequence to SARS-CoV-2;however,the corresponding RaTG13 virus is yet to be isolated or cultured in a ***,the so-called bat coronavirus RaTG13 could not have been used as a starting strain or“backbone”for genetic ***,it would be impossible to generate SARS-CoV-2 by inserting the furin cleavage site into the bat coron-avirus *** is critical for the prevention and control of SARS-CoV-2 to investigate the animal reservoirs of SARS-CoV-2,and this work is on *** the prospective of biosafety and biosecurity,outbreaks of infectious diseases can be classified into three types:natural,acci-dental,and deliberate.^(1,2) There is a large body of evidence that COVID-19 is caused by a natural *** has no characteristics of an accidental or deliberate infection.^(3)

关键词： acute respiratory infectious

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载血管内皮细胞生长因子微球促进牙髓再生和血管形成的实验研究

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中华口腔医学杂志 2018年第1期53卷 42-48页

作者：李祥伟孙宏晨刘晓华吉林大学口腔医学院牙体牙髓病科长春130021 吉林大学口腔医学院病理科长春130021 Department of Biomedical Sciences Baylor College of Dentistry Texas A&M University Dallas TX 75246 U S A

目的评价载血管内皮细胞生长因子（vascular endothelial growth factor,VEGF）微球促进牙髓再生和血管形成的作用,以期为应用组织工程技术探索牙髓治疗新方法奠定基础.方法应用前期制备的载VEGF微球进行体外释放实验和人脐静脉内皮... 详细信息

目的评价载血管内皮细胞生长因子（vascular endothelial growth factor,VEGF）微球促进牙髓再生和血管形成的作用,以期为应用组织工程技术探索牙髓治疗新方法奠定基础.方法应用前期制备的载VEGF微球进行体外释放实验和人脐静脉内皮细胞（human umbilical vein endothelial cell,HUVEC）迁移实验明确微球释放VEGF的特点;将牙髓干细胞（dental pulp stem cell,DPSC）与载VEGF微球共培养,观察细胞与微球的相容性;DPSC与载VEGF微球经根尖孔注入根管腔,植入裸鼠背部皮下,9周后进行组织学和免疫组织化学观察.以DPSC、载VEGF微球单独注入根管,空白根管作为空白对照组.结果 DPSC可在载VEGF微球上生长和增殖;DPSC和载VEGF微球体内形成牙髓样组织,长约9.0 mm,充满根管的根尖1/3和根中1/3,可达冠1/3,伴血管分布和成牙本质细胞样细胞分化.结论载VEGF微球和DPSC可在体内促进牙髓再生和血管形成.

关键词：牙髓血管内皮生长因子类牙髓再生牙髓干细胞

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Preventing Implant Bacterial Infections with Interconnected 3D Porous Structures (I3D)— A Proof-of-Concept Study

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Journal of Biosciences and Medicines 2021年第1期9卷 16-29页

作者： Steven Guo Alexandria Ramos Zhongqiang Li Hong Yao Jian Xu Shaomian Yao Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA USA Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA Division of Electrical and Computer Engineering College of Engineering Louisiana State University Baton Rouge LA USA Department of Mechanical and Industrial Engineering Louisiana State University Baton Rouge LA USA

Oral antibiotics are often prescribed to prevent infection after implant surgery;however, only a small fraction of the antibiotics can reach the implants. Thus, there are concerns about overusing antibiotics. We designed and fabricated porous implants with interconnecting 3D structures (I3D) and hypothesized that such I3D structures could serve as a depository for antimicrobial agents to prevent infection locally. The implants were either treated with antibiotics or coated with silver nanoparticles (AgNPs) by electrodeposition to test this hypothesis. The antimicrobial assay was conducted, and bacterial growth zones of inhibition (ZOIs) were monitored. Overall, I3D implants resulted in larger ZOIs than did the solid implants, and the center I3D (cI3D)-implant produced the largest ZOI. In the antibiotic treatment testing, the diameters of ZOIs of the solid implant vs. I3D implant were about 14 mm vs. 15 to 18 mm on day 2;however, the diameter quickly reduced to 9 mm on day 3 and 5 mm on days 6 and 8 for the solid implant, while no obvious change of the zone was seen for I3D implants. For the AgNPs coated implants, the ZOIs for the I3D implants were generally greater than the solid implant over four weeks of incubation. A significantly larger ZOI (~1 - 2 mm larger on average) was seen for AgNPs coated I3D implants at 0.1 V - 0.01 M, 0.3 V - 0.01 M, and 1.5 V - 0.01 M treatments compared to AgNPs coated solid implants. Given that we have previously shown that I3D implants can reserve chemoattractants to recruit stem cells to enhance osseointegration, we conclude that implants with the I3D structures could be beneficial not only for osseointegration but also in preventing infection.

关键词： dental Implant Antimicrobial Agents Peri-Implantitis Silver Nanoparticles 3D-Printing

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