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Automated Time Based Multi-Criteria Bug Triage Approach:Developer Working Efficiency and Social Network Based Developer Recommendation

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 566-578页

作者： YADAV Asmita SINGH Kumar Sandeep Krishna Engineering College Ghaziabad 201007India jiit Noida 201309India

In software development projects,bugs are common *** report bugs in open source *** is a need to develop high quality developer prediction model that considers developer work satisfaction,keep within limited development cost,and improve bug resolution *** address and resolve bug report as soon as possible is the main focus of triager when a new bug is ***,developer work efficiency is an important factor in *** address these issues,a proposed approach recommends a set of developers that could potentially share their knowledge with each other to fix new bug *** proposed approach is called developer working efficiency and social network based developer recommendation(DweSn).It is a composite model that builds developers'profile by using developer average bug fixing time,work efficiency to fix variety of bugs,as well as the developer's social interactions with other developers.A similarity measure is applied between new bug and bugs in corpus to extract the list of capable developers from the *** proposed approach only selects those developers who are active and less loaded with *** developer with the highest profile score is assigned the *** evaluated our approach on the subset of five large open-source projects including Mozilla,Netbeans,Eclipse,Firefox and OpenOffice,and compared it with the *** results demonstrate that combination of developers'efficiency with their average bug fixing time and interactions in their social network gives good accuracy and efficiently reduces bug tossing *** approach shows an improvement in prediction accuracy,precision,recall,F-score and reduced bug tossing length up to 93.89%,93.12%,93.46%,93.27%and 93.25%,*** proposed approach achieved a 93%hit ratio and 93.34%mean reciprocal rank,indicating that our proposed triager is able to efficiently assign bugs to correct developers.

关键词： open-source repository bug report bug assignment tossing length bug triager developer social network developer recommendation

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Synthesis and Characterization of <i>Citrus limonum</i>Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Journal of Biomaterials and Nanobiotechnology 2020年第4期11卷 215-236页

作者： Harleen Kaur Pranav Pancham Ramneek Kaur Shriya Agarwal Manisha Singh Amity Institute of Biotechnology Amity University Noida U.P. India Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida U.P. India School of Medicine Western Sydney University Campbelltown New South Wales Australia

Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (Smix). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 - 104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi’s model in comparison to burst release of LO alone. Lastly, the stability analysis of the optimised formulation (LO-NE) and LO was estimated through antioxidant assay and subjecting them for thermodynamic stability after 6 months. The results attained, showed higher stability and anti-oxidant capability of LO-NE than LO alo

关键词： Lemon Oil Surfactants Particle Size Analysis Ternary Phase Diagrams Release Kinetics Thermodynamic Stability

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<i>In-Silico</i>Validation and Development of Chlorogenic Acid (CGA) Loaded Polymeric Nanoparticle for Targeting Neurodegenerative Disorders

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Journal of Biomaterials and Nanobiotechnology 2020年第4期11卷 279-303页

作者： Vinayak Agarwal Shriya Agarwal Ramneek Kaur Pranav Pancham Harleen Kaur Siddhi Bhardwaj Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida U.P. India School of Medicine Western Sydney University Campbelltown New South Wales Australia Amity Institute of Biotechnology Amity University Noida U.P. India

Background: Recent decades witnessed a significant growth in terms of phytocompounds based therapeutics, extensively explored for almost all types of existing disorders. They have also been widely investigated in Neurodegenerative disorders (NDDs) and Chlorogenic acid (CGA), a polyphenolic compound having potential anti-inflammatory and anti-oxidative properties, emerged as a promising compound in ameliorating NDDs. Owing to its poor stability, bioavailability and release kinetics, CGA needed a suitable nanocarrier based pharmaceutical design for targeting NDDs. Objective: The current study is aimed at the in-silico validation of CGA as an effective therapeutic agent targeting various NDDs followed by the fabrication of polymeric nanoparticles-based carrier system to overcome its pharmacological limitations and improve its stability. Methods: A successful in-silico validation using molecular docking techniques along with synthesis of CGA loaded polymeric nanoparticles (CGA-NPs) by ionic gelation method was performed. The statistical optimisation of the developed CGA-NPs was done by Box Behnken method and then the optimized formulation of CGA-NPs was characterised using particle size analysis (PSA), Transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) along with in-vitro release kinetics analysis. Results & Conclusion: The results attained exhibited average particle size of 101.9 ± 1.5 nm, Polydispersibility (PDI) score of 0.065 and a ZP of −17.4 mV. On a similar note, TEM results showed a size range of CGA-NPs between 90 - 110 nm with a spherical shape of NPs. Also, the data from in-vitro release kinetics showed a sustained release of CGA from the NPs following the first-order kinetics suggesting the appropriate designing of nanoformulation.

关键词： Antioxidant Anti-Inflammatory Polymeric Nanoparticles Release Kinetics Box Behnken Design Molecular Docking Particle Size Analysis

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Triple-Band Circularly Polarized Dielectric Resonator Antenna (DRA) for Wireless Applications

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Computers, Materials & Continua 2023年第1期74卷 313-325页

作者： Azuwa Ali Mohd Najib Mohd Yasin Ismahayati Adam Ali H.Rambe Mohd Haizal Jamaludin Hasliza A Rahim Corhan Cengiz Mohd Ibrahim Shapiai Abd.Razak Advanced Communication Engineering(ACE)Centre of Excellence Faculty Technology of Electrical EngineeringUniversiti Malaysia PerlisPauhPerlis02600Malaysia Advanced Communication Engineering(ACE)Centre of Excellence Faculty Technology of Electronic EngineeringUniversiti Malaysia PerlisPauhPerlis02600Malaysia Department of Electrical Engineering Universitas Sumatera UtaraMedan20155Indonesia Wireless Communication Center Universiti Teknologi MalaysiaSkudai81310JohorMalaysia Korhan Cengiz College of Information Technology University of FujairahFujairah00000United Arab Emirates Malaysia-Japan International Institute of Technology(M-jiit) Universiti Teknologi MalaysiaKuala Lumpur54100Malaysia

This paper proposes a new dielectric resonator antenna(DRA)design that can generate circularly polarized(CP)triple-band *** CP DRA antenna fed by a probe feed system is achieved with metal strips structure on side of DRA *** design start with conventional rectangular DRA with F shaped metal strips on DRA structure alongside the ***,the F metal strip is enhanced by extending the length of the metal strip to obtain wider impedance *** improvement on the antenna performance is observed by improvised the conventional DRA *** method of removing part of DRA bottom resulted to higher antenna gain with triple band *** primary features of the proposed DRA include wide impedance matching bandwidth(BW)and broadband circular polarization(CP).The primary features of the proposedDRAinclude wide impedance matching bandwidth(BW)and broadband circular polarization(CP).The CP BW values recorded by the proposed antenna were∼11.27%(3.3–3.65 GHz),12.18%(4.17–4.69 GHz),and 1.74%(6.44–6.55 GHz)for impedance-matching BW values of 35.4%(3.3–4.69 GHz),1.74%(5.36–5.44 GHz),and 1.85%(6.41–6.55 GHz)with peak gains of 6.8 dBic,7.6 dBic,and 8.5 dBic,respectively,in the lower,central,and upper *** prototype of the proposed antenna geometry was fabricated and measured.A good agreement was noted between the simulated and the measured results.

关键词： Dielectric resonator antenna(DRA) circularly polarized(CP) parasitic element radiating element

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Analyzing the Prebiotic Potential of Glucosamine for Targeting the Gut Microbiome Health

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Food and Nutrition Sciences 2023年第2期14卷 119-134页

作者： Pranav Pancham Divya Jindal Archita Gupta Deepshikha Yadav Shriya Agarwal Saurabh Jha Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida India Neuroimmunology Laboratory School of Medicine Western Sydney University Campbelltown Australia Birla Institute of Technology Mesra India Indian Institute of Technology-Kanpur Kanpur India Bhartiya Nirdeshak Dravya Division CSIR-National Physical Laboratory New Delhi India Physico-Mechanical Metrology Division CSIR-National Physical Laboratory New Delhi India Academy of Scientific and Innovation Research (AcSIR) Ghaziabad India School of Natural Sciences Macquarie University Sydney Australia Department of Biotechnology School of Engineering and Technology Sharda University Greater Noida India

Recognizing the composition and modulation of the microbiome, a viable therapeutic tool for multi-targeted therapy is a new strategy that has recently been explored. Glucosamine (GS) is being studied for its prebiotic potential in addition to being the most abundant and naturally occurring amino monosaccharide. The current study focuses on glucosamine’s prebiotic potential by assessing the stability of various GS concentrations (1% - 5%) in the gastrointestinal tract (GIT) and its ability to be fermented by the gut microbiota. The results showed that GS stimulated the most growth in L. acidophilus even after a longer incubation time than B. bifidum and L. acidophilus growth was concentration-dependent, with maximum growth at 3% with a simultaneous decrease in pH (5.6 - 1.7). The decrease in GS concentration with time also represented the growth of bacterial species, demonstrating the species’ utilization of GS. Furthermore, at 3%, GS also represented the prebiotic index of 1.9. In addition, the concentration of GS in various simulated GIT fluids was estimated in both fast and fed conditions to examine GS stability at various levels in the gut. The results showed that GS remained unaffected and non-digestible in all of the simulated GIT fluids (salivary, gastric, intestinal, and colonic), but there was a slight decrease in GS concentration (2.8%) in the fasted state of gastric fluid due to low pH levels (1.6). As a result, the findings are conclusive and suggest that GS possesses prebiotic properties.

关键词： Microbiome Enteric Nervous System (ENS) Prebiotic Index Hexosamine Biosynthetic Pathway (HBP) Vagal Afferents Phosphotransferase System

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