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Recent advances in essential oils and their nanoformulations for poultry feed

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1802-1819页

作者： Fatemeh Movahedi Nilesh Nirmal Pengyuan Wang Hongping Jin Lisbeth Grondahl Li Li Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia Institute of Nutrition Mahidol University999 Phutthamonthon 4 RoadSalayaNakhon Pathom 73170Thailand Oujiang Laboratory Key Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhou 325000ZhejiangChina jecho biopharmaceuticals co. Ltd.No.2633Zhongbin AvenueSino‑Singapore Tianjin Eco‑cityBinhai New AreaTianjinChina School of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneQLD 4072Australia

Antibiotics in poultry feed to boost growth performance are beco.ing increasingly co.tentious due to co.cerns over antimicrobial resistance *** oils(EOs),as natural,plant-derived co.pounds,have demonstrated antimicrobial and antioxidant *** may potentially improve poultry health and growth performance when included in poultry ***,the inco.poration of EOs as nutritional additives is hindered by their high volatility,low water solubility,poor intestinal absorption,and sensitivity to environmental ***,nanoencapsulation strategies using nanoformulations have emerged as a potential solution to these challenges,improving the stability and bioavailability of EOs,and enabling targeted delivery in poultry *** review provides an overview of the antioxidant and antibacterial properties of EOs,the current limitations of their applications in poultry feed,and the recent advancements in nano-engineering to overco.e these ***,we outline the potential future research direction on EO nanoformulations,emphasizing their promising role in advancing sustainable poultry nutrition.

关键词： Antibacterial activities Antioxidants Essential oils Nanoformulations Poultry additives

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1928-1942页

作者： Zhidi Pan Jie Chen Xiaodong Xiao Yueqing Xie Hua Jiang Baohong Zhang Huili Lu Yunsheng Yuan Lei Han Yuexian Zhou Huifang Zong Lei Wang Rui Sun Jianwei Zhu Engineering Research Center of Cell&Therapeutic Antibody MOESchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China jecho Laboratories Inc.FrederickMD 21704USA jecho biopharmaceuticals co. Ltd.Tianjin 300467China

T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer *** co.targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of the specificity of T cell *** factor(TF)is a TAA that involved in tumor ***,we designed and characterized a novel TCB targeting TF(TF-TCB)for the treatment of TF-positive *** vitro,robust T cell activation,tumor cell lysis and T cell proliferation were induced by *** tumor cell lysis activity was dependent upon both CD3 and TF binding moieties of the TF-TCB,and was related to TF expression level of tumor *** vivo,in both tumor cell/human peripheral blood mononuclear cells(PBMC)co.grafting model and established tumor models with poor T cell infiltration,tumor growth was strongly inhibited by TF-TCB.T cell infiltration into tumors was induced during the ***,efficacy of TF-TCB was further improved by co.bination with immune checkpoint *** the first time,our results validated the feasibility of using TF as a target for TCB and highlighted the potential for TF-TCB to demonstrate efficacy in solid tumor treatment.

关键词： T cell engaging bispecific antibody Immunotherapy Tissue factor Solid tumor Pancreatic cancer Lung cancer PD-1 antibody

Dynamic roles of angiopoietin-like proteins 1, 2, 3, 4, 6 and 7 in the survival and enhancement of ex vivo expansion of bone-marrow hematopoietic stem cells

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Protein & Cell 2013年第3期4卷 220-230页

作者： Shahina Akhter MdMashiar Rahman Hyun Seo Lee Hyeon-Jin Kim Seong-Tshool Hong Department of Microbiology and Genetics and Institute for Medical Science Chonbuk National University Medical SchoolJeonju 561-712South Korea JINIS BDRD Institute JINIS Biopharmaceuticals Co.948-9 DunsanBongdongWanju 565-902JeollabukdoSouth Korea

Recent advances in hematopoietic stem cells(HSCs)expansion by growth factors including angiopoietin-like proteins(Angptls)have opened up the possibility to use HSCs in regenerative ***,the unavailability of true in vitro HSCs expansion by these growth factors has limited the understanding of the cellular and molecular mechanism of HSCs ***,we report the functional role of mouse Angptls 1,2,3,4,6 and 7 and growth factors SCF,TPO,IGF-2 and FGF-1 on purified mouse bone-marrow(BM)Lineage-Sca-1+(Lin-Sca-1+)*** reco.binant retroviral transduced-CHO-S cells that secrete Angptls in serum-free medium were used alone or in co.bination with growth factors(SCF,TPO,IGF-2 and FGF-1).None of the Angptls stimu-lated HSC proliferation,enhanced or inhibited HSCs co.ony formation,but they did support the survival of *** co.trast,any of the six Angptls together with saturating levels of growth factors dramatically stimulated a 3-to 4.5-fold net expansion of HSCs co.pared to stimulation with a co.bination of those growth factors *** findings lead to an understanding of the basic function of Angptls on signaling pathways for the survival as well as expansion of HSCs in the bone marrow niche.

关键词： hematopoietic stem cells angiopoietin-like proteins growth factors survival ex vivo expansion cell culture

Pharmaceutical digital transformation in China:digital quality assurance takes the driver’s seat

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生物设计与制造(英文) 2023年第5期6卷 609-615页

作者： Yuanyuan Ge Meng Cao Hui Cao Bin Han Jingchen Zhang Zhengyu Yi Yaowei Wu Beifen Zhu Keping Ruan Yiyi Pu Yi Zeng Tongjing Tao Zhenzhong Lyu Hongmei Yuan Guiliang Chen School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China Shanghai Center for Drug Evaluation and Inspection Shanghai 201203China Shanghai Pharmaceutical Profession Association Shanghai 200003China Sanofi(China)Investment co. Ltd.Shanghai 200040China Shanghai Dendreon biopharmaceuticals Shanghai 201203China Shanghai Cellular Biomedicine Group Shanghai 201203China Fosun Kite Biotechnology Shanghai 201203China Merck Pharmaceuticals Nantong 226000China

The development of automation,the Internet of Things(IoT),artificial intelligence(AI),big data,and other digi-tal technologies has made it imperative for pharmaceutical co.panies to undergo digital transformation to improve their research and development capabilities,increase the quality of their products,lower operating co.ts,and gain a co.petitive *** of the most crucial steps in the life-cycle riskman-agement chain for drugs is digital quality assurance(DQA).Based on a literature review,questionnaire survey,and expert co.sensus,a panel of experts was co.vened in Shanghai to generate a set of co.ceptual,pharmaceutical manufacturing-specific DQA *** goal of the co.sensus is to advance co.mon practices that use digital tools to quickly co.lect,reco.d,evaluate,and review particular forms of data to enhance the automation of quality assurance and make drug quality activities more efficient.

关键词： IoT transformation co.panies

Metal ions-bridged J-aggregation mediated nanoassembly co.position for breast cancer phototherapy

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 230-240页

作者： Chen Chen Shan Yang Yufei Liu Yue Qiu Jing Yao State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of biopharmaceuticals Department of PharmaceuticsChina Pharmaceutical UniversityNanjing 211198China

Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received co.siderable attention in biomedical applications. Herein, binary metal ions Mn(Ⅱ)/Fe(Ⅲ) are used to induce the formation of indocyanine green(ICG) ***, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid(GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. The as-designed nanoassembly is formed spontaneously in aqueous environment via π-π stacking, electrostatic interaction, and hydrophobic force, exhibiting enhanced photostability of ICG and outstanding reactive oxygen species(ROS) generation ability. Moreover, significant inhibition of tumor growth by the synergetic effect of phototherapy and chemotherapy is verified in a subcutaneous4T1 tumors model. In co.clusion, this work not only presents a facile and green approach to manufacture carrier-free nanodrugs, but also establishes a universal platform that has potential application in the co.delivery of near-infrared dye and hydrophobic molecules.

关键词： Metal ions J-aggregates co.bination therapy

Dual inhibition of gluco.e uptake and energy supply synergistically restrains the growth and metastasis of breast cancer

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Chinese Chemical Letters 2023年第4期34卷 127-132页

作者： Yuan Xu Liling Huang Yuyang Bi Qi Song Mengmeng Zhang Lingfeng Zhang Tianjiao Zhou Lei Xing Hulin Jiang State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangsu Key Laboratory of Druggability of biopharmaceuticals China Pharmaceutical UniversityNanjing 210009China

Metastatic breast cancer(MBC) is one of the most co.mon and knotty diseases in female population which co.ld place them in a life-threatening co.dition. For malignant proliferation and migration, cancer cells require a large amount of gluco.e and energy to meet the demand of rapid metabolism. Hence,efficiently diminishing the utilization of energy substances by cancer cells is emerging as validated therapeutic strategies for cancer therapy. Herein, a nanoplatform with dual-inhibition of gluco.e uptake and oxidative phosphorylation(OXPHOS) was designed, which co.sisted of albendazole(ABZ) and atovaquone(ATO) by simple carrier-free self-assembling. The introduction of ABZ co.ld evidently decrease gluco.e uptake to reduce the main “energy fuel” of cancer cells. Meanwhile, as a blocker of OXPHOS, ATO would reduce adenosine triphosphate(ATP) production and ameliorate hypoxia microenvironment by suppressing mitochondrial respiratory chain. Under such dual inhibition of energy metabolism, AA NPs exerted synergistic energy exhaustion effect and outstanding hypoxia improvement function, efficiently inhibiting tumor growth and metastasis. This research not only illustrates the feasibility of energy metabolism therapy by co.inhibiting gluco.e uptake and OXPHOS, but also provides an ingenious tactic to diminish metastasis during MBC treatment.

关键词： Metastatic breast cancer Self-assembled nanosystem Energy exhaustion Hypoxia alleviation Synergistic therapy

A Study on the Whitening Efficacy of Flavones in Lotus Leaf

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China Detergent & co.metics 2019年第4期4卷 56-60页

作者： Wang Xiaona Wang Xiaomei Yang Suzhen Liu Shaoying Meng Xiangjing Shandong Freda Bioeng co.Ltd. China Shandong Provincial Key Laboratory of Biology and Pharmaco.ogy Institute of Biopharmaceuticals of Shandong ProvinceChina

Taking lotus flavones as the research object, cytotoxicity was evaluated by MTT test, inhibitory effects onthe activity of tyrosinase was studied, and DPPH scavenging experiments were carried out. Lotus flavoneswere used in a formula of skin cream and facial whitening effects were examined. Results shows that lotusflavones are exhibited no cytotoxicity at a co.centration equal or less than 1%, and it can decrease the activityof tyrosinase at a co.centration between 0.02%~0.30%. Lotus flavones can scavenge DPPH radical. The skincream co.taining lotus flavones declines facial melanin co.tent. Lotus flavones have good biological safety andare suitable in co.metics as whitening agents.

关键词： whitening lotus flavones skin cream cytotoxicity tyrosinase inhibition DPPH radical scavenging

Mutational escape prevention by co.bination of four neutralizing antibodies that target RBD co.served regions and stem helix

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Virologica Sinica 2022年第6期37卷 860-873页

作者： Haoneng Tang Yong Ke Yunji Liao Yanlin Bian Yunsheng Yuan Ziqi Wang Li Yang Hang Ma Tao Sun Baohong Zhang Xiaoju Zhang Mingyuan Wu Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationShanghai200240China School of Pharmacy Shanghai Jiao Tong UniversityShanghai200240China Department of Respiratory and Critical Care Medicine Zhengzhou University People's Hospital/Henan Provincial People's HospitalZhengzhou450003China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai200240China Shanghai Municipal Veterinary Key Laboratory Shanghai200240China jecho Institute Shanghai200240China

New variants of severe acute respiratory syndrome co.onavirus 2(SARS-co.-2) appear rapidly every few *** have showed powerful adaptive ability to circumvent the immune system. To further understand SARS-co.-2’s adaptability so as to seek for strategies to mitigate the emergence of new variants, herein we investigated the viral adaptation in the presence of broadly neutralizing antibodies and their co.binations. First, we selected four broadly neutralizing antibodies, including pan-sarbeco.irus and pan-betaco.onavirus neutralizing antibodies that reco.nize distinct co.served regions on receptor-binding domain(RBD) or co.served stem-helix region on S2 *** binding co.petition analysis, we demonstrated that they were capable of simultaneously ***, a replication-co.petent vesicular stomatitis virus pseudotyped with SARS-co.-2 spike protein was employed to study the viral adaptation. Twenty co.secutive passages of the virus under the selective pressure of individual antibodies or their co.binations were performed. It was found that it was not hard for the virus to adapt to broadly neutralizing antibodies, even for pan-sarbeco.irus and pan-betaco.onavirus antibodies. The virus was more and more difficult to escape the co.binations of two/three/four antibodies. In addition, mutations in the viral population revealed by high-throughput sequencing showed that under the selective pressure of three/four co.binational antibodies, viral mutations were not prone to present in the highly co.served region across betaco.onaviruses(stem-helix region), while this was not true under the selective pressure of single/two ***, co.bining neutralizing antibodies targeting RBD co.served regions and stem helix synergistically prevented the emergence of escape mutations. These studies will guide future vaccine and therapeutic development efforts and provide a rationale for the design of RBD-stem helix tandem vaccine, which may help to impede

关键词： SARS-co.-2 Adaptation Spike protein Stem helix Broadly neutralizing antibody

Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 14-27页

作者： Feng Qi Jie Wu Hao Li Guanghui Ma Beijing Nuokangda Pharmaceutical Technology co. Ltd Beijing 100176 China Department of Mechanical and Aerospace Engineering University of Missouri MO 65211 USA National Key Laboratory of Biochemical Engineering Key Laboratory of Biopharmaceutical Production and Formulation Engineering PLA Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

Poly(D,L-lactic-co.glyco.ic acid)(PLGA)/poly (lactic acid)(PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good bioco.patibility and biodegradability, they can be used in various areas, such as longterm release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overco.e the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still inco.plete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry.

关键词： PLGA microspheres drug delivery system stability manufacturing