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Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第4期8卷 217-220页

作者： GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola Laboratories of Quantitative Medicine Istituto Clinico Humanitas IRCCS20089 RozzanoMilanItaly Department of Pathology Istituto Clinico Humanitas IRCCS20089 RozzanoMilanItaly

Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the *** originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic *** we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer *** application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.

关键词： Liver Angiogenesis Cancer Fractals Geometry Biomarkers

The formation and growth mechanisms of young back-arc spreading ridges from high-resolution bathymetry:The Marsili Seamount(Tyrrhenian Sea,Italy)

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Geoscience Frontiers 2024年第1期15卷 325-338页

作者： Eugenio Nicotra Salvatore Passaro Guido Ventura Dipartimento di Biologia Ecologia e Scienze della Terra Universitàdella Calabria87036 Arcavacata di RendeCosenzaItaly istituto di Scienze Marine CNR 80133 NapoliItaly istituto Nazionale di Geofisica e Vulcanologia 00143 RomaItaly istituto per lo Studio degli impatti Antropici e Sostenibilitáin ambiente marino CNR 91026 Capo GranitolaTrapaniItaly

The formation and growth mechanisms of Mid-Ocean Ridges(MOR)are relatively well known,whereas those of back-arc spreading ridges are comparatively less known because geophysical,geochemical,and morphological data are scarce and of low *** we present a high-resolution bathymetry of the Marsili Seamount(MS;1 Ma-3 ka),which represents the inflated spreading ridge of the 2 Ma old Marsili back-arc basin associated to the subduction of the Ionian Sea below the Calabrian Arc and Tyrrhenian *** is 70 km long,30 km wide,and its height reaches about 3000 m from surrounding *** new digital bathymetric model has a 5 m grid cell size resolution and covers the MS bathymetry from-1670 mbsl to the top at-491 *** conduct morphometric and morphological analyses of the bathymetry and recognize landforms due to volcanic,tectonic,hydrothermal and gravity *** consists of volcanoes related to fissural and central-type activity,this latter located at the northern and southern tips of the main dike *** swarms represent the surface expression of different ridge segments whose strikes are controlled by the larger scale back-arc spreading processes and by the local occurrence of an active hydrothermal *** latter develops in a flat area between two partly overlapping ridge segments where historical volcanism and extensional processes *** ridges represent the embryonic stage of the formation of transform-like *** volcanoes,the northern of which is characterized by a caldera,form at the tips of MS because the decrease in width of the major volcanic fissures promotes vent localization associated with the formation of sill-like reservoirs from which central-type vents may *** processes affecting the MS flanks are due to shallow seafloor *** collapses affecting the northernmost central-type polygenic volcano must be included in the evaluation of the hazard related to potential *** dipping faul

关键词： Back-arc spreading ridge Morphology Tectonics Volcanism Marsili seamount

Percutaneous transarterial embolization of extrahepatic arteroportal fistula

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World Journal of Gastroenterology 2006年第34期12卷 5562-5564页

作者： Gianluca Marrone Settimo Caruso Roberto Miraglia Ilaria Tarantino Riccardo Volpes Angelo Luca istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IsMeTT) Palermo Italy

Arteroportal fistula is a rare cause of prehepatic portal hypertension. A 44-year-old male with hepatitis virus C infection was admitted for acute variceal bleeding. Endoscopy showed the presence of large esophageal varices. The ultrasound revealed a mass near the head of pancreas, which was characterized at the color- Doppler by a turbulent flow, and arterialization of portal vein flow. CT scan of abdomen showed a large aneurysm of the gastroduodenal artery communicating into the superior mesenteric vein. The sinusoidal portal pressure measured as hepatic vein pressure gradient was normal, confirming the pre-hepatic origin of portal hypertension. The diagnosis of extrahepatic portal hypertension secondary to arteroportal fistula was established, and the percutaneous embolization was performed. Three months later, the endoscopy showed absence of esophageal varices and ascites. At the moment, the patient is in good clinical condition, without signs of portal hypertension.

关键词： Portal hypertension Arteroportal fistula Portal shunt Esophageal varices bleeding Embolization Interventional radiology Psudoaneurysm

Simultaneous endoscopic ultrasound fine needle aspiration and endoscopic retrograde cholangio-pancreatography:Evaluation of safety

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World Journal of Gastroenterology 2007年第28期13卷 3861-3863页

作者： Ilaria Tarantino Luca Barresi Marta Di Pisa Mario Traina istituto Mediterraneo Trapianti e Terapie ad alta specializzazione University of Pittsburgh Medical CenterItaly

AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients. METHODS: Patients with the following conditions were considered candidates for EUS-FNA and ERCP: diagnosis of locally advanced or metastatic pancreatic lesion not eligible for surgery, and patients with pancreatic lesion of unknown nature causing jaundice. Data were prospectively collected on the following parameters: indication for FNA, EUS findings, pathological diagnosis, procedure duration of EUS-FNA and combined EUS-FNA and ERCP, and immediate and late complications. RESULTS: From January 2004 to October 2006, 72 patients were deemed eligible for combined EUS and ERCP. In 25/72 EUS-FNA was performed to obtain a pathology diagnosis of lesions causing biliary obstruction, and ERCP sequentially performed to drain the biliary system. No immediate complications occurred except for two mild bleeding episodes post sphincterotomy. No late complications were recorded except for one patient who experienced fever, promptly recovered with antibiotic therapy. CONCLUSION: Simultaneous approach appears to be feasible and safe. When possible, this can be considered the reference standard to avoid double sedation and reduce duration of the procedure and hospital stay.

关键词： Pancreatic mass Endoscopic ultrasound fine needle aspiration Biliary stent Jaundice Endoscopictherapy

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Neural Regeneration Research 2013年第17期8卷 1615-1622页

作者： Letteria Spadaro Lilla Bonanno Giuseppe Di Lorenzo Placido Bramanti Silvia Marino istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi "Bonino Pulejo" Via Provinciale Palermo

Parkinson＇s disease has a negative impact on health-related quality of life in Parkinson＇s disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopaminergic drugs are the variables that most affect health-related quality of life. The ecological model of human development focuses attention on both individual and social environmental factors as targets for health interventions. From this perspective, the aim of this cross-sectional survey was to evaluate the influence of gender, family size and perceived autonomy on health-related quality of life in Parkinson＇s disease patients in nOrtheastern Sicily, Italy. Ninety Parkinson＇s disease patients, attending the Movement Disorders Clinic at IRCCS Centro Neurolesi ＂Bonino-Pulejo＂（Messina）, were consecutively enrolled. The Unified Parkinson Disease Rating Scale motor subscale （UPDRS-Ⅲ） scores, the Parkinson Disease Questionnaire-39 Item scores （as a disease-specific measure of health-related quality of life）, scores on the Short Form （36） Health Survey Questionnaire （as a generic measure）, and answers to a brief checklist were recorded. A total of 85 Parkinson＇s disease patients （49% males and 51% females; mean age 70.8 ± 8.6 years mean UPDRS-Ⅲ 24.15 ± 6.55; mean disease duration 5.52 ± 4.65 years） completed the booklet of questionnaires. In the multivariate regression analysis, we included clinical and social variables as independent predictors of health-related quality of life. Our results suggest a potential compounding effect of ecological intrapersonal and interpersonal levels on health-related quality of life outcomes. Gender, self-evaluated autonomy and family size significantly impacted health-related quality of life. If quality of life is used as an indicator of treatment outcomes, an ecological perspective of the case history will be important to disclose relevant prognostic information and trigger personalized health care interventions.

关键词： neural regeneration neurodegenerative disease health-related quality of life Parkinson's disease ecological model Parkinson's Disease Questionnaire-39 Items social variables the UnifiedParkinson Disease Rating Scale motor subscales caregiver grants-supported paper

Disentangling brain PrP^(C)proteoforms and their roles in physiology and disease

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Neural Regeneration Research 2024年第5期19卷 963-965页

作者： Ilaria Vanni Nonno Romolo Department of Food Safety Nutrition and Veterinary Public HealthIstituto Superiore di SanitàRomeItaly

The cellular prion protein(PrPC),a cell surface glycoprotein of 209 amino acids,has been considerably studied over the decades mainly due to its critical involvement in transmissible spongiform encephalopathies,or prion ***,it is the misfolding and aggregation of PrPC into pathological assemblies-named PrPSc-that constitute prions,the agents causing these unusual neurodegenerative diseases affecting humans and animals(Prusiner,1982).Furthermore,increasing evidence support its relevance also in other neurodegenerative diseases(NDDs),such as Alzheimer’s and Parkinson’s diseases(Corbett et al.,2020).

关键词： diseases involvement glycoprotein

Fractalkine: multiple strategies to counteract glutamate receptors activation leading to neuroprotection

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Neural Regeneration Research 2015年第8期10卷 1214-1215页

作者： Clotilde Lauro Department of Physiology and Pharmacology Istituto Pasteur Fondazione Cenci Bolognetti Sapienza University of Rome

Glutamate（Glu）is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological ***,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors（Glu... 详细信息

关键词： glutamate excitatory impairment homeostasis neuronal Glutamate NMDAR intracellular adenosine microglia

1991-2020 climate normal in the European Alps:focus on high-elevation environments

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Journal of Mountain Science 2023年第8期20卷 2149-2163页

作者： NIGRELLI Guido CHIARLE Marta istituto di Ricerca per la Protezione Idrogeologica Consiglio Nazionale delle RicercheTorino 10135Italy

Alps are an important geographical area of the European continent and,in this area,temperature increase is most ***,the 1991-2020 climate normal in the Alps has still not been thoroughly *** to fill this gap with a focus on high-elevation environments,minimum and maximum daily air temperature acquired by 23 automatic weather station were *** results show that the mean annual values of minimum and maximum temperature for the 1991-2020 climate normal in the Alps are-2.4℃ and 4.4℃,respectively,with a warming rate of 0.5℃/10 *** mean annual temperature comparison between 1961-1990 and 1971-2000,1961-1990 and 1981-2010,1961-1990 and 1991-2020 climate normal show an increase of 0.3℃,0.5℃ and 0.9℃,*** results also confirm that seasonal and annual temperatures are rising through the whole Alpine arc,mainly in summer and *** work highlights that annual minimum and maximum temperature do not seem to be affected by a positive elevation-dependent ***,a positive elevation-dependent warming in the maximum values of the annual minimum temperature was *** anthropogenic emissions maintain the trend of the last decades,the expected mean annual temperature of the 2001-2030 climate normal is-0.2℃,with an increase of 0.5℃ if compared to the 1991-2020 climate normal and with an increase of 1.5℃ if compared to the 1961-1990 climate *** study highlights the warming rate that is now present in the European Alps,provides indications on the warming rate that will occur in the coming years and highlights the importance of carrying out investigations that consider not only the last 30-year climate normal,but also the most recent 30-year climate normal by comparing them with each other.

关键词： Air temperature trend Climate normal Climate change High mountain climate Alps

The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts

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Science China(Technological Sciences) 2018年第5期61卷 643-652页

作者： AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo istituto Nazionale di Fisica Nucleare (INFN) Sezione di Perugia Perugia 06123 Italy Uninettuno University Rome 00186 Italy istituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma Tor Vergata Rome 00133 Italy istituto Nazionale di Fisica Nucleare (INFN) TIFPA Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Trento Povo (TN) 38123 Italy Dipartimento di Fisica Universita di Roma Tor Vergata Rome 00133 Italy IFAC-CNR Sesto Fiorentino (FI) 50019 Italy Dipartimento di Fisica e Astronomia Universita di Bologna Bologna 40127 Italy istituto Nazionale di Fisica Nucleare (INFN) Sezione di Bologna Bologna 40127 Italy istituto Nazionale di Fisica Nucleare (INFN) Sezione di Napoli Naples 80126 Italy istituto Nazionale di Fisica Nucleare (INFN) LNE Frascati (RM) 00044 Italy Agenzia Spaziale Italiana (ASI) SSDC Rome 00133 Italy

CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China).

关键词： earthquake seismic-precursors particle detector Van Allen belts magnetosphere ionosphere space weather cosmic rays