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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

Fatal cases in pediatric patients after post-exposure prophylaxis for rabies:A report of two cases

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 39-42页

作者： Hekmatollah Khoubfekr Mohammad Jokar Vahid Rahmanian Hasan Blouch Mohammad Reza Shirzadi Rouzbeh Bashar Department of Public Health Iranshahr University of Medical SciencesIranshahrIran Faculty of Veterinary Medicine Karaj BranchIslamic Azad UniversityKarajIran Department of Public Health Torbat Jam Faculty of Medical SciencesTorbat JamIran Center for Communicable Diseases Control Ministry of Health and Medical EducationTehranIran WHO Collaborating Center for Reference and research on Rabies Virology DepartmentPasteur Institute of IranTehranIran

Rationale:Rabies is a zoonotic disease with a high mortality,primarily transmitted through the bite of infected mammals,particularly dogs and *** being a well-known disease since ancient times,it continues to cause a significant number of human deaths worldwide,with approximately 65000 fatalities reported *** concerns:We present two fatal cases of rabies in a 12-year-old immigrant boy and a 7-year-old *** first case was subject to a 24-hour delay in receiving appropriate medical attention and rabies preventive measures due to the lack of awareness among emergency hospital staff,leading to the administration of wound dressing *** second case received timely rabies immunoglobulin administration;however,there was a 4-day delay in administering the fourth dose of the rabies vaccine,despite presenting evident symptoms of ***:Postmortem examination of brain samples from both patients confirmed the presence of rabies ***:Post-exposure prophylaxis for ***:Both patients were admitted to the hospital after the manifestation of rabies-related symptoms,with the 12-year-old child seeking medical care 47 days after the animal bite and the 7-year-old child seeking medical care 58 days after the ***,the first patient died after 27 days and the second patient died after 40 days of ***:There is an urgent need for heightened awareness and education among both healthcare professionals and the public regarding the urgency of seeking immediate medical attention after potential rabies *** recognition and initiation of post-exposure prophylaxis are pivotal in preventing the progression of the *** surveillance and reporting systems,coupled with continuous training for healthcare professionals,can contribute to early detection and management of rabies cases.

关键词： Rabies Encephalitis Pediatric patients Rabies prophylaxis Public health awareness

Prediction of vertical displacement for a buried pipeline subjected to normal fault using a hybrid FEM-ANN approach

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKSAR Danial MOHAMMADZADEH S. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia University research and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes is a geotechnical phenomenon threatening buried pipelines and with the potential to cause severe damage to critical ***,effective prediction of pipe displacement is crucial for preventive management *** study aims to develop a fast,hybrid model for predicting vertical displacement of pipe networks when they experience *** this study,the complex behavior of soil and a buried pipeline system subjected to a normal fault is analyzed by using an artificial neural network(ANN)to generate predictions the behavior of the soil when different parameters of it are *** this purpose,a finite element model is developed for a pipeline subjected to normal fault *** data bank used for training the ANN includes all the critical soil parameters(cohesion,internal friction angle,Young’s modulus,and faulting).Furthermore,a mathematical formula is presented,based on biases and weights of the ANN *** results show that the maximum error of the presented formula is 2.03%,which makes the proposed technique efficiently predict the vertical displacement of buried pipelines and hence,helps to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

Er_(2)TiO_(5)@Ag nanocomposites:Enhanced photocatalysis and bacteria inactivation,and cytotoxicity

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Journal of Rare Earths 2024年第5期42卷 851-858,I0002页

作者： Mehdi Nazeri Hossein Sedaghat Reza Rafiei Mohammad Amin Farzin Seyed Mostafa Hosseinpour Mashkani Department of Parasitology and Mycology Kashan University of Medical SciencesKashanIran Department of Microbiology Kashan University of Medical SciencesKashanIran General Medicine Student School of MedicineKashan University of Medical SciencesKashanIran Student research Committee Kashan University of Medical SciencesKashanIran institute for Biomedical Materials and Devices School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyNSW2007Australia

In this study,we successfully synthesized Er_(2)TiO_(5)@Ag nanocomposites(NCPs) using the ultrasonicmediated sol-gel technique to create a multifunctional material with enhanced photocatalytic and antibacterial *** visible light photocatalytic activities of Er_(2)TiO_(5) nanoparticles(NPs) and Er_(2)TiO_(5)@Ag NCPs were systematically evaluated under various conditions,including different concentrations of Basic Blue 41(BB 41) dye and *** results reveal a remarkable improvement in the photocatalytic degradation efficiency of Er_(2)TiO_(5)@Ag NCPs(95%) compared to Er_(2)TiO_(5) NPs(80%).Furthermore,the antibacterial efficacy of Er_(2)TiO_(5) NPs and Er2TiO_5@Ag NCPs were extensively examined against Gram-positive and Gram-negative ***,Er_(2)TiO_(5)@Ag NCPs exhibit significantly higher minimum bactericidal concentration(MBC) values compared to Er_(2)TiO_(5) *** antibacterial effect of Er_(2)TiO_(5)@Ag NCPs is particularly pronounced against *** and Pseudomonas aeruginosa,while demonstrating moderate effects on Escherichia coli and Enterococcus *** assess the biocompatibility of the synthesized materials,we investigated their internalization by MCF-7 ***,both Er_(2)TiO_(5) NPs and Er_(2)TiO_(5)@Ag NCPs are found to be effectively internalized by the cells,suggesting their potential application in biomedical ***,our study unveils the exceptional potential of Er_(2)TiO_(5)@Ag NCPs as a dual-action solution,simultaneously possessing enhanced photocatalytic efficiency and potent antibacterial *** multifunctional nanocomposite not only outperforms Er_(2)TiO_(5) and Ag but also paves the way for innovative applications in sustainable environmental remediation and advanced biomedical technologies,promising a brighter and cleaner future.

关键词： Rare earth catalysis Nanocomposite Er_(2)TiO_(5)@Ag Antibacterial activity Photocatalysis Cytotoxicity

A multi-mechanistic approach to the oil recovery study of a family of amphiphilic polysaccharides

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Petroleum research 2024年第2期9卷 238-249页

作者： Funsho Afolabi Syed MMahmood Lunech Mario Nur Asyraf Md Akhir Bennett Tackie-Otoo Hamid Sharifigaliuk Center of research in Enhanced Oil Recovery Universiti Teknologi PETRONASSeri IskandarMalaysia Center for Subsurface Imaging Universiti Teknologi PETRONASSeri IskandarMalaysia research institute of Petroleum Industry(RIPI) TehranIran

Chemical enhanced oil recovery(cEOR)remains one of the most potent tertiary recovery ***,it is expensive and rarely environmentally ***-based amphiphilic polymers have been suggested as an alternative to eradicating the challenges of conventional cEOR because of cost-effectiveness,and ***,few in-depth studies exist in the literature to investigate the prospects of these materials.A new family of amphiphilic polysaccharides was synthesized by hydrophobic modification of cellulose sulphate,and the EOR functionalities were *** novel biopolymers exhibited the ability to alter rock wetting *** terms of recovery,one of the variants of the synthesized bio amphiphilic polymer(D-I)was able to reduce residual oil saturation to 12%at harsh conditions of 60,000 ppm salinity at 75℃.Micromodel visual analysis revealed that the performance of the novel materials was due to the combination of mobility control,IFT lowering and emulsification,wettability alteration,and *** a performance commensurate to that of a commercial hydrophobically modified polymer,it can be said that the novel amphiphilic polysaccharides can stand as a viable cEOR agent for oilfield applications.

关键词： Bio-based polymers Amphiphilic polysaccharides EOR Cellulose sulphate Environmental sustainability

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla Sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

GAN‐MD:A myocarditis detection using multi‐channel convolutional neural networks and generative adversarial network‐based data augmentation

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 866-878页

作者： Hengame Ahmadi Golilarz Alireza Azadbar Roohallah Alizadehsani Juan Manuel Gorriz Department of Medical Radiation Engineering Faculty of EngineeringLahijan BranchIslamic Azad UniversityLahijanIran Department of Medical Radiation Engineering Lahijan BranchIslamic Azad UniversityLahijanIran institute for Intelligent Systems research and Innovation(IISRI) Deakin UniversityWaurn PondsVictoriaAustralia Data Science and Computational Intelligence institute University of GranadaGranadaSpain

Myocarditis is a significant public health concern because of its potential to cause heart failure and sudden *** standard invasive diagnostic method,endomyocardial bi-opsy,is typically reserved for cases with severe complications,limiting its widespread ***,non‐invasive cardiac magnetic resonance(CMR)imaging presents a promising alternative for detecting and monitoring myocarditis,because of its high signal contrast that reveals myocardial *** assist medical professionals via artificial intelligence,the authors introduce generative adversarial networks‐multi discriminator(GAN‐MD),a deep learning model that uses binary classification to diagnose myocarditis from CMR *** approach employs a series of convolutional neural networks(CNNs)that extract and combine feature vectors for accurate *** authors suggest a novel technique for improving the classification precision of *** generative adversarial networks(GANs)to create synthetic images for data augmentation,the authors address challenges such as mode collapse and unstable *** a reconstruction loss into the GAN loss function requires the generator to produce images reflecting the discriminator features,thus enhancing the generated images'quality to more accurately replicate authentic data ***,combining this loss function with other reg-ularisation methods,such as gradient penalty,has proven to further improve the perfor-mance of diverse GAN models.A significant challenge in myocarditis diagnosis is the imbalance of classification,where one class dominates over the *** mitigate this,the authors introduce a focal loss‐based training method that effectively trains the model on the minority class *** GAN‐MD approach,evaluated on the Z‐Alizadeh Sani myocarditis dataset,achieves superior results(F‐measure 86.2%;geometric mean 91.0%)compared with other deep learning models and traditional machine learning methods.

关键词： 2‐D 3‐D

On the Innovation,Design,Construction,and Experiments of OMEGA-Based SSPS Prototype:The Sun-Chasing Project

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Engineering 2024年第5期36卷 90-101页

作者： Baoyan Duan Yiqun Zhang Guangda Chen Ze Zhao Jianwei Mi Xun Li Lin Yang Xi Li research institute on Mechatronics Xidian UniversityXi’an 710071China research institute of Antenna Xidian UniversityXi’an 710071China

This study systematically introduces the development of the world’s first full-link and full-system ground demonstration and verification system for the OMEGA space solar power satellite(SSPS).First,the OMEGA 2.0 innovation design was ***,field-coupling theoretical models of sunlight concentration,photoelectric conversion,and transmitting antennas were established,and a systematic optimization design method was ***,a beam waveform optimization methodology considering both a high beam collection efficiency and a circular stepped beam shape was ***,a control strategy was developed to control the condenser pointing toward the sun while maintaining the transmitting antenna toward the ***,a high-efficiency heat radiator design method based on bionics and topology optimization was ***,a method for improving the rectenna array’s reception,rectification,and direct current(DC)power synthesis efficiencies is ***,high-precision measurement technology for high-accuracy beam-pointing control was ***,a smart mechanical structure was designed and ***,the developed SSPS ground demonstration and verification system has the capacity for sun tracking,a high concentration ratio,photoelectric conversion,microwave conversion and emission,microwave reception,and rectification,and thus satisfactory results were obtained.

关键词： OMEGA-SSPS Full-link and full-system Beam collection efficiency Circular stepped beam shape Smart structure Field coupling theoretical model `Beam pointing control

Exploring the relationship between ambient sulfur dioxide and semen quality parameters:A systematic review and meta-analysis

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Asian pacific Journal of Reproduction 2024年第1期13卷 12-21页

作者： Seyed Sobhan Bahreiny Mojtaba Aghaei Mohammad Reza Dabbagh Hamid Ghorbani Moslem Javidan Reza Mohammadpour Fard Student research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Medical Basic Sciences research institute Physiology Research CenterDepartment of PhysiologySchool of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Biology Faculty of ScienceShahid Chamran University of AhvazAhvazIran Department of Immunology Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Objective:To investigate the relationship between ambient sulfur dioxide(SO2)exposure and semen quality ***:A systematic literature search was conducted to identify relevant studies investigating the association between SO2 exposure and semen quality *** search encompassed the timeframe from January 2000 to May 2023 and included electronic databases such as Web of Science,Google Scholar,PubMed,Cochrane,and *** effect estimates with 95%confidence intervals(CI)were calculated using percent changes(PC).The meta-analysis included seven studies with 6711 participants and 15087 semen ***:The results revealed a significant negative association between ambient SO2 exposure and certain semen quality *** particular,SO2 exposure was associated with a significant decrease in progressive motility(PC=0.032;95%CI:-0.063 to-0.001;P=0.044)and sperm concentration(PC=-0.020;95%CI:-0.036 to-0.005;P=0.012).However,no statistically significant associations were observed for total sperm count(PC=-0.038;95%CI:-0.079 to 0.003;P=0.070),seminal fluid volume(PC=-0.009;95%CI:-0.048 to-0.030;P=0.662)and sperm motility(PC=-0.17;95%CI:-0.363 to 0.022;P=0.830).In addition,the results of the subgroup analysis revealed specific variables that were associated with the decrease in relevant sperm ***:This systematic review and meta-analysis provides compelling evidence supporting a consistent negative association between exposure to ambient SO2 and semen quality parameters.

关键词： Semen quality Sulfur dioxide Ambient air pollution Meta-analysis