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A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

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Genes & Diseases 2024年第4期11卷 400-410页

作者： Han Chan Fenfen Ni Bo Zhao Huimin Jiang Juanjuan Ding Li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie Gao Xueying Yang Huan Chi Hao Lee Xuelan Chen Xiaoqin Li Jia Jiao Daoqi Wu Gaofu Zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang Qiu Li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

Sintering kinetics involving grain growth and densification of Mg-PSZ nanopowders

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Journal of Iron and Steel Research international 2022年第7期29卷 1138-1144页

作者： Yi-ming She Jie-fu Lang Di An Chao-wei Si Xu-dong Luo Zhi-peng Xie Jie-gang You School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina institute of Advanced Structures Beijing Institute of TechnologyBeijing 100081China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Sintering kinetics have been found to be effective in judging the evolution of *** using magnesium oxide-partially stabilized zirconia(Mg-PSZ)powder prepared by co-precipitation as raw materials,the evolution of densification and grain growth for Mg-PSZ ceramics were *** results indicated that the densification of samples was mainly controlled by grain boundary diffusion in intermediate sintering *** the sintering process,the grain growth mechanisms included normal grain growth,abnormal grain growth and solid solution drag-controlled grain ***,the apparent activation energy for grain growth of Mg-PSZ ceramics is lower than that of ZrO_(2)–Y_(2)O_(3)ceramics in the solid solution drag-controlled grain grow process,which will cause grain to grow *** sintering kinetics and microstructure of Mg-PSZ ceramics were studied,and the kinetic equation of grain growth at different temperatures was *** results show that the strength difference between Mg-PSZ and yttrium oxide-stabilized zirconia is closely related to the easy grain growth of Mg-PSZ ceramics.

关键词： Magnesium oxide-partially stabilized zirconia Sintering kinetics Grain growth mechanism Densification mechanism Sizing nozzle

Hexagonal boron nitride hollow capsules with collapsed surfaces:Chemical vapor deposition with single-source precursor ammonium fluoroborate

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Chinese Physics B 2016年第7期25卷 509-514页

作者：李肖鹏张军郁超刘晓喜 Saleem Abbas 李杰薛彦明唐成春 School of Material science and Engineering Hebei University of Technology World Premier international Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS)

SBA-15（mesoporous SiO2） is used to stabilize and transfer F-in the NH4BF4 CVD reaction for the first time, and a large-scale crystalline h-BN phase can be prepared. We successfully fabricate hollow h-BN capsules with collapsed surfaces in our designed NH4BF4 CVD system. Optimum temperature conditions are obtained, and a detailed formation mechanism is further proposed. The successful SBA-15-assisted NH4BF4 CVD route is of importance and enriches the engineering technology in the h-BN single-source CVD reaction.

关键词： hollow capsule hexagonal boron nitride chemical vapor deposition ammonium fluoroborate

Longitudinal distribution of O_2 nightglow brightness observed by TIEMD/SABER satellite

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science China(Technological sciences) 2012年第5期55卷 1258-1263页

作者： GAO Hong NEE JanBai CHEN GuangMing State Key Laboratory of space Weather Center for Space Science and Applied ResearchChinese Academy of SciencesBeijing 100190China Department of Physics National Central UniversityJhongli 32054TaiwanChina

The global distribution of 1.27 ~tm 02 nightglow brightness observed by the TIMED/SABER satellite has been investigated to find the longitudinal structures for different seasons and latitudes. The results show that the 02 airglow is dominated by wave 4 structure at latitudes between equator and 20°S/N in both hemispheres during most seasons. At mid-latitudes around 40°S/N, the wave 1 structure is observed for most seasons with a small contribution of wave 2 during the June solstice. A comparison of the 02 and OH nightglows shows similarity in their global distributions which can be attributed to their similar photochemical mechanisms.

关键词： 02 nightglow longitude distribution

Tensile properties of a composite–metal single-lap hybrid bonded/bolted joint

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Chinese Journal of Aeronautics 2021年第2期34卷 629-640页

作者： Xiaoqi LI Xiaoquan CHENG Yujia CHENG Zhiyong WANG Wenjun HUANG School of Aeronautic science and Engineering Beihang UniversityBeijing 100191China Istar-space Technology Co. Ltd.Tianjin 300304China AVIC China Helicopter Research ami Development institute Jingdezhen 333001China

Hybrid bonded/bolted(HBB) joint has been widely used in engineering practice because it can overcome the potential weakness of pure bonded and pure bolted joints. However, studies on HBB joint are still at the initial stage. In this paper, tensile properties of a composite–metal singlelap HBB joint was investigated experimentally. And a detailed finite element model(FEM) was established to simulate the tensile behavior of the joint. The model was verified by the experimental results. Then the damage propagation and load transfer mechanism were explored based on the FEM. The results show that the HBB joint can provide multi-load transmission paths and resist damage propagation in the adhesive. The HBB joint has higher strength and energy absorption capacity than the pure bonded joint. And the HBB joint has greater initial damage load and tensile stiffness than pure bolted joint. Adhesive fillets can obviously improve the tensile performances of the HBB joint. Lateral stiffness of the joint boundary and testing machine show obvious effects on tensile performances of single-lap hybrid joints.

关键词： Experimental tests Failure mechanism Finite element model Hybrid(bonded/bolted)joint Tensile properties

Dynamic properties of micro-NPR material and its controlling effect on surrounding rock mass with impact disturbances

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Underground space 2024年第2期15卷 331-352页

作者： Manchao He Jie Hu Tai Cheng Fei Deng Zhigang Tao Hongru Li Di Peng Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining&TechnologyBeijing 100083China Luohe Vocational Technology College Henan 462002China

A novel meta steel with negative Poisson’s ratio effect(termed as micro-NPR steel)is developed for rock support in deep underground *** possesses high strength,high ductility,and high energy absorption *** this paper,static tension and modified dynamic drop hammer tests are performed on this novel material to investigate its mechanical properties *** based on this material,a new generation of micro-NPR anchor cable is developed and applied in field tests subjected to blasting dynamic *** results of laboratory tests reveal that the ultimate elongation of micro-NPR steel under dynamic impacts is more than 30%and it is over 1.5 times that of Q235;the plastic and total energy absorption of micro-NPR are both significantly higher than that of *** test indicates the fine controlling effect of micro-NPR anchor cable on surrounding rock mass under dynamic *** force confirms that micro-NPR cables can distribute and absorb the dynamic energy uniformly around the supported rock when subjected to dynamic disturbance,avoiding local failure induced by excessive stress *** excavation compensation principle and energy-absorbing characteristics are used to explain the support ***,micro-NPR material and anchor cable can control and prevent dynamic disasters in deep underground engineering effectively.

关键词： Micro-NPR steel Energy-absorbing Drop hammer test Anchor cable Field test

Prospects for Jovian seismology with the Lenghu planetary telescope

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Earth and Planetary Physics 2024年第5期8卷 703-710页

作者： YiQing Zou Fei He ShanShan Zheng Lei Yu ZhongHua Yao ZhaoJin Rong Yong Wei Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary sciences University of Chinese Academy of Sciences Anhui institute of Optics and Fine Mechanics Chinese Academy of Sciences

Jupiter is one of the top priorities for deep space exploration in China and other countries. The structure of Jupiter's interior, in particular, is a crucial but still unclear scientific topic. This paper discusses current scientific understanding of Jupiter's interior by summarizing the history of past and current exploration and data analysis. We review recent space-based and ground-based observation methods and analyze their feasibility. To gain new insight into the internal structure of Jupiter, we propose to study Jupiter's innards by planetary seismology. Ground-based observation, namely the Jupiter Seismologic Interferometer Polarization Imager(SIPI) in Lenghu,will be developed to obtain the Doppler velocity distribution on the surface of Jupiter and identify oscillation signals. Lenghu has observation conditions that are not only exceptional in China but even in the world, capable of providing novel insight into the interior of Jupiter. This will also be the first study in China of the interior of Jupiter using asteroseismology, which has significant implications for China's plans to explore Jupiter via spacecraft-mounted instruments.

关键词： Jupiter seismology Jupiter’s interior Jupiter model Jupiter Seismologic Interferometer Polarization Imager (SIPI)

Correlation between ionospheric longitudinal harmonic components and upper atmospheric tides

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Chinese science Bulletin 2010年第35期55卷 4037-4045页

作者： MU WenFeng WAN WeiXing REN ZhiPeng XIONG JianGang beijing National Observatory of space Environment Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Graduate University of Chinese Academy of sciences Beijing 100049 China

There is strong correlation among the ionospheric longitudinal structures of wavenumber-3(WN3),wavenumber-4(WN4),and eastward-propagating diurnal tides with zonal wave numbers s = 2 and 3(DE2 and DE3) in the upper *** total electron content derived from the Global Ionospheric Maps of the Jet Propulsion Laboratory is used to deduce the latitudinally total electron content(ITEC) in the low-latitude ionosphere,and TIDE/TIMED observations are employed to obtain zonal and meridian winds of the mesopause and lower *** Fourier transformation,various ionospheric longitudinal harmonic components and tidal patterns are derived from the ionospheric and upper-atmospheric observations,and we compare the annual/inter-annual variations in ionospheric harmonic components WN3 and WN4 with those in atmospheric tides(DE2 and DE3).It is found that the annual and inter-annual variations in WN3 and WN4 are consistent with those in DE2 and DE3 zonal wind components respectively,while they are inconsistent with those in the meridian *** then decompose the harmonic components into "tidal patterns",finding that the "DE2" and "DE3" patterns are the main parts of WN3 and WN4 *** annual and inter-annual variations are similar to those of atmospheric tidal patterns(DE2 and DE3).Complex correlation results show that correlation between the ionospheric "DE2" in WN3 and the atmospheric tidal DE2 zonal wind component is quite strong in the Northern Hemisphere,while that between the ionospheric "DE3" in WN4 and the atmospheric tidal DE3 zonal wind component is much stronger at low *** the same time,the contribution of the meridian wind component is very *** all,the atmospheric tidal DE2 and DE3 patterns are important factors of the ionospheric WN3 and WN4 structures.

关键词：大气潮汐电离层成分谐波上层低纬度地区喷气推进实验室年际变化

Effects of sintering atmosphere on the physical and mechanical properties of modified BOF slag glass

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international Journal of Minerals,Metallurgy and Materials 2014年第5期21卷 494-502页

作者： Wen-bin Dai Yu Li Da-qiang Cang Yuan-yuan Zhou Yong Fan State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing institute of Multidisciplinary Research for Advanced Materials Tohoku University

This study proposes an efficient way to utilize all the chemical components of the basic oxygen fttrnace （BOF） slag to prepare high value-added glass-ceramics. A molten modified BOF slag was converted from the melting BOF slag by reducing it and separating out iron component in it, and the modified BOF slag was then quenched in water to form glasses with different basicities. The glasses were subsequently sintered in the temperature range of 600-1000℃ in air or nitrogen atmosphere for 1 h. The effects of different atmospheres on the physical and mechanical properties of sintered samples were studied by using differential scanning calorimetry （DSC）, X-ray diffraction （XRD） and scanning electron microscopy （SEM） and by conducting experiment on evaluating the sintering shrinkage, water absorption and bulk density. It is found that the kinetics of the sintering process is significantly affected by sintering atmosphere. In particular, compared with sintering in air atmosphere, sintering in N2 atmosphere promotes the synergistic growth of pyroxene and melilite crystalline phases, which can contribute to better mechanical properties and denser microstructure.

关键词： glass ceramics slags sintering iron oxides physical properties mechanical properties