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Biophoton Emission as a Potential Measure of Organizational Order

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Science China Chemistry 1994年第9期37卷 1099-1112页

作者：顾樵 Popp Fritz-Albert Also in Department of Physics Northwest University Xi'an 710069 PRC international institute of biophysics Technology Centre 67661 Kaiserslautern Germany

Beginning with the quantum theory of biophoton emission,a c-number equation character- izing the excited-state dynamics of a complex system of collective biomolecules in interaction with both the 'pumping'field and the biophoton field is presented,and then the order-growth process of the system in terms of both determinism and statistics is investigated.A general expression describing the order-growth dynamics of biological systems,which reduces in a limiting case to the well-known growth curve,is ob~ *** a Fokker-Planck equation for probability density function of an order parameter q of the system has been *** solution predicts that the system under consideration can evolute from an arbitrary initial state to a pure state characterized by the steady-state order parameter q_***,the evolution of the maximum entropy of the system is discussed,which shows that the system investigated is to keep an absolute maximum of entropy,and at the same time,to minimize its entropy value by reducing the uncertain- ty of the order ***,some agreements of the theoretical results with the corresponding experi- mental observations of order-growth process demonstrated by the biophoton emission are shown,which indi- cates that biophoton emission may serve as a potential measure of the organizational order.

关键词： biophoton emission complex system nonlinear dynamics organizational order maximum entropy

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi Jiang Jingqi Chen institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan international Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Detrimental and synergistic role of epilepsy——Alzheimer’s disease risk factors

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Neural Regeneration Research 2019年第8期14卷 1376-1377页

作者： Mikhail A. Filippov Vasily V. Vorobyov international Medical Cluster Skolkovo Moscow Region Russia institute of Cell biophysics Russian Academy of Sciences Pushchino Moscow Region Russia

Identification of individuals at risk for developing Alzheimers disease (AD) is an important issue for its pretreatment. Perspective studies predicting the disease are based on the genetic approaches emerging from the nucleotide polymorphism analysis in different loci through the entire genome in AD patients. Considerable diversity of genes located in these regions raise the question of this diversity's peculiar role in the disease development. The mechanisms of AD have been shown to be associated with the gene variation, increased beta-amyloid production and concomitant epileptiform activity/epilepsy in particular (Palop and Mucke, 2009).

关键词： Detrimental synergistic role disease risk factors

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady international LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The Nobel Prize: an appetizer before the feast

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Science Bulletin 2016年第22期61卷 1711-1714页

作者： Yan G.Zhao Hong Zhang National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences

Autophagy,which means‘‘self-eating’’,is a process in which a portion of the cytosol is enclosed in a double-membrane autophagosome and delivered to the hydrolytic vacuole/lysosome for recycling(Fig.1).Bulk degradation by autophagy provides energy and materials for cell survival under various stress conditions such as starvation and energy *** also has a scavenging function

关键词： The Nobel Prize an appetizer before the feast

Analysis of the Stakeholder Engagement in the Deployment of Renewables and Smart Grid Technologies

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Journal of Electronic Science and Technology 2015年第3期13卷 221-228页

作者： Valeriia Vereshchagina Mario Gstrein Bernd Teufel international institute of Management in Technology University of Fribourg the international institute of Management in Technology University of Fribourg

The implementation of higher shares of renewables in a global energy mix has to be accompanied by simultaneous deployment of enabling smart grid technologies （SGTs）. This combination will inevitably lead to a revolutionary change in a conventional energy system, particularly, the shifting role of consumers to prosnmers. But resistance may arise from such a dramatic shift, since it is associated with high uncertainty in conjunction with increasing responsibilities of all stakeholders, the urgent need of effective control, and the development of a process. To ensure the positive influence, coherent actions of all players, and appropriate treatment of the spots of resistance, the analysis of the interplay between key stakeholders has been done. The paper introduces the framework for stakeholders＇ analysis, applies it on the European Union （EU） example, and provides recommendations to reduce the resistance of SGTs deployment.

关键词： Communication strategy crowd energy renewable energy smart grid technologies stakeholder analysis.

Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第01期 96-117页

作者： Jianhong Liu Qiang Zhou Yuxiao Lin Xinsheng Zhao Guangmin Zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal University Tsinghua-Berkeley Shenzhen institute & Tsinghua Shenzhen international Graduate School Tsinghua University

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs). The active electrode is one of the most important parts of SC, which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature environment. Compared with the SC electrodes aimed for room-temperature application, the SC electrodes for operating at wide-temperature scene often face greater challenges. In this review, the main challenges of SC electrodes under various temperature conditions, including low, high and cross-fade temperatures, are summarized. The relevant performance decay and failure mechanisms of wide-temperature SC electrodes are analyzed. In addition, this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active materials. Finally, the future directions for exploring reliable wide-temperature SCs are also proposed.

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Influence of driving cycles on exhaust emissions and fuel consumption of gasoline passenger car in Bangkok

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Journal of Environmental Sciences 2009年第5期21卷 604-611页

作者： NUTRAMON Tamsanya SUPACHART Chungpaibulpatana Sirindhorn international institute of Technology Thammasat University

The influence of different driving cycles on their exhaust emissions and fuel consumption rate of gasoline passenger car was investigated in Bangkok based on the actual measurements obtained from a test vehicle driving on a standard chassis dynamometer. A newly established Bangkok driving cycle （BDC） and the European driving cycle （EDC） which is presently adopted as the legislative cycle for testing automobiles registered in Thailand were used. The newly developed BDC is constructed using the driving characteristic data obtained from the real on-road driving tests along selected traffic routes. A method for selecting appropriate road routes for real driving tests is also introduced. Variations of keyed driving parameters of BDC with different driving cycles were discussed. The results showed that the HC and CO emission factors of BDC are almost two and four times greater than those of EDC, respectively. Although the difference in the NOx emission factor is small, the value from BDC is still greater than that of EDC by 10%. Under BDC, the test vehicle consumes fuel about 25% more than it does under EDC. All these differences are mainly attributed to the greater proportion of idle periods and higher fluctuations of vehicle speed in the BDC cycle. This result indicated that the exhausted emissions and fuel consumption of vehicles obtained from tests under the legislative modal-type driving cycle （EDC） are significantly different from those actually produced under real traffic conditions especially during peak periods.

关键词： driving cycle driving pattern driving characteristics microtrip characteristics exhaust emissions fuel consumption