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METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao Min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

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Assessing the efficacy and safety of gemcitabine-induced thrombocytopenia/neutropenia and thrombocytopenia interventions in zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 970-973页

作者： Jialong Deng Ziyuan Zhou Wangjun Liao Qing Lin Yiyue Zhang Innovation Centre of Ministry of education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Hematology The Sixth Affiliated HospitalSchool of MedicineSouth China University of TechnologyFoshanGuangdong 528200China Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Cancer is a major global health issue;in 2020,there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide(Siegel et al.,2023).Despite ongoing research,chemotherapy remains the primary treatment due to its broad anti-cancer effects(Marra and Curigliano,2021).However,intravenous chemotherapeutic drugs commonly induce hematotoxicity,necessitating dose adjustments or treatment ***-induced thrombocytopenia(CIT)and neutropenia(CIN)are the primary manifestations of chemotherapy-induced hematotoxicity,which requires intervention due to the heightened risk of bleeding and infection(Blayney and Schwartzberg,2022).Currently,there are no FDA-approved treatments for CIT(Song and Al-Samkari,2023).While a CIT mouse model using 5-FU has been developed for drug evaluation(Shin et al.,2023),it lacks a comprehensive hematotoxicity assessment and the benefits of high throughput,cost-effectiveness,and ***,it is urgent to develop a high-throughput CIT model for risk assessment and safer chemotherapy strategies with clinical potential.

关键词： chemotherapy treatment visibility

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3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

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BIOCELL 2024年第5期48卷 861-872页

作者： XIAOQI WU YECHUAN HE YEQIN YUAN XIAN TAN LIN ZHU DANLING WANG BINYUAN JIANG Hengyang medical school University of South ChinaHengyang421001China Institute for Future Sciences University of South ChinaChangsha410008China medical Research Center The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China Department of Clinical Laboratory The Affiliated Changsha Central HospitalHengyang Medical SchoolUniversity of South ChinaChangsha410004China

Background:Nasopharyngeal carcinoma(NPC)exhibits a significant prevalence in the southern regions of china,and paclitaxel(PTX)is frequently employed as a medication for managing advanced ***,drug resistance is typically accompanied by a poor *** the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment ***:This study investigated whether 3-Methyladenine(3-MA)could potentiated the effect of PTX and its potential molecular *** were divided into the following categories:Negative control(NC)with the solvent dimethyl sulfoxide(DMSO,0.5%v/v),PTX(400 nM),3-MA(4 mM),and PTX(400 nM)+3-MA(4 mM).The viability of NPC cells was assessed using both the cell counting kit-8(CCK-8)assay and the colony formation *** observation was performed to identify morphological cell *** cytometry was used to assess cell cycle status,mitochondrial membrane potential(MMP),and apoptotic *** blotting was conducted to quantify the protein ***:3-MA enhanced PTX-specific inhibition of NPC cell ***,either alone or in combination with 3-MA,caused cell cycle halt at the G2/M phase in the majority of NPC cells,and the combination treatment of PTX with 3-MA induced a higher rate of NPC cell death compared to PTX *** blotting results revealed the combination of PTX with 3-MA heightened activation of cyclin-dependent kinase 1(CDK1),a key molecule in shifting cells from mitotic arrest to apoptosis,led to a reduction in Myeloid Cell Leukemia 1(MCL-1)expression and an increase in Poly(ADP-ribose)polymerase(PARP)***:The concurrent administration of PTX with 3-MA effectively enhances PTX’s inhibitory impact on NPC and activates the apoptosis signal regulated by CDK1.

关键词： Nasopharyngeal carcinoma Paclitaxel 3-Methyladenine Cell cycle Apoptosis

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The synthesis of fluorescent nanoclusters based on the etching reaction

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Nano Research 2024年第5期17卷 4631-4638页

作者： Hongbin Lin Yitao Cao Qiaofeng Yao Tiankai Chen Huiting Shan Jianping Xie Joint school of National university of Singapore and Tianjin university International Campus of Tianjin UniversityFuzhou 350207China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)and Key Laboratory of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Key Laboratory of Integrated Organic CircuitsMinistry of EducationDepartment of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China

Thiolate-protected atomically precise nanoclusters(NCs)demonstrate a series of unique luminescent characteristics attributed to their various peculiar electronic ***,fluorescent NCs present extraordinary practical values in biosensing and bioimaging research ***,restricted by the types of fluorescent NCs,there are great difficulties in promoting the development of NCs in fluorescent research *** a result,it is of significant necessity for researchers to develop new synthetic pathways to produce high-quality fluorescent *** to the analysis about the structural characteristics of fluorescent NCs,some general features like longer motif and higher ligand-to-metal ratio can be found,consistent to some presented regularities in etching ***,in this work,we used Au_(25)(MHA)_(18)(MHA=6-mercaptohexanoic acid)as a model nanocluster and utilized the etching reaction to systematically explore etching products and their corresponding luminescent ***,we also identified three main reaction processes in the entire etching reaction process,which can generate new metal nanocluster species with various fluorescent ***,the etching reaction will provide a good platform to produce new luminescent metal NC species.

关键词： etching reaction metal nanoclusters fluorescent properties fluorescent conversion

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Sleep Quality and Emotional Adaptation among Freshmen in Elite Chinese Universities during Prolonged COVID-19 Lockdown:The Mediating Role of Anxiety Symptoms

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international Journal of Mental Health Promotion 2024年第2期26卷 105-116页

作者： Xinqiao Liu Linxin Zhang Xinran Zhang school of education Tianjin UniversityTianjin300350China

Under the effects of COVID-19 and a number of ongoing lockdown tactics,anxiety symptoms and poor sleep quality have become common mental health issues among college freshmen and are intimately related to their emotional *** explore this connection,this study gathered data from a sample of 256 freshmen enrolled in an elite university in china in September *** association between sleep quality,anxiety symptoms,and emotional adaptation was clarified using correlation ***,the mediating function of anxiety symptoms between sleep quality and emotional adaptation was investigated using a structural equation *** results reveal that:(1)Chinese elite university freshmen who were subjected to prolonged lockdown had poor sleep quality and mild anxiety symptoms;(2)a significant positive correlation between poor sleep quality and anxiety symptoms was identified;(3)anxiety symptoms were found to have a significant negative impact on emotional adaptation;(4)poor sleep quality had a negative impact on emotional adaptation through anxiety *** research makes a valuable contribution by offering insights into the intricate relationship between sleep quality and emotional adaptation among freshmen in elite Chinese universities during prolonged lockdown conditions,and it is beneficial for schools and educators to further improve school schedules and psychological health initiatives.

关键词： COVID-19 pandemic sleep quality emotional adaptation anxiety symptoms lockdown freshmen

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Confinement of ionomer for electrocatalytic CO2 reduction reaction via efficient mass transfer pathways

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National Science Review 2024年第2期11卷 168-176页

作者： Xiaowei Du Peng Zhang Gong Zhang Hui Gao Lili Zhang Mengmeng Zhang Tuo Wang Jinlong Gong school of Chemical Engineering and Technology Key Laboratory for Green Chemical Technology of the Ministry of Education Tianjin University Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) National Industry-education Platform of Energy Storage Tianjin University Joint school of the National university of Singapore and Tianjin university International Campus of Tianjin University Haihe Laboratory of Sustainable Chemical Transformations

Gas diffusion electrodes（GDEs） mediate the transport of reactants, products and electrons for the electrocatalytic CO2reduction reaction（CO2RR） in membrane electrode assemblies. The random distribution of ionomer, added by the traditional physical mixing method, in the catalyst layer of GDEs affects the transport of ions and CO2. Such a phenomenon results in elevated cell voltage and decaying selectivity at high current densities. This paper describes a pre-confinement method to construct GDEs with homogeneously distributed ionomer, which enhances mass transfer locally at the active centers. The optimized GDE exhibited comparatively low cell voltages and high CO Faradaic efficiencies（FE > 90%） at a wide range of current densities. It can also operate stably for over 220 h with the cell voltage staying almost unchanged. This good performance can be preserved even with diluted CO2feeds, which is essential for pursuing a high single-pass conversion rate. This study provides a new approach to building efficient mass transfer pathways for ions and reactants in GDEs to promote the electrocatalytic CO2RR for practical applications.

关键词： CO2 electroreduction gas diffusion electrode mass transfer ionomer Ag catalyst

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Multi-Branch High-Dimensional Guided Transformer-Based 3D Human Posture Estimation

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Computers, Materials & Continua 2024年第3期78卷 3551-3564页

作者： Xianhua Li Haohao Yu Shuoyu Tian Fengtao Lin Usama Masood school of Mechanical Engineering Anhui University of TechnologyHuainan232001China school of Artificial Intelligence Anhui University of TechnologyHuainan232001China Key Laboratory of Conveyance Equipment(East china Jiaotong university) Ministry of EducationNanchang330013China

The human pose paradigm is estimated using a transformer-based multi-branch multidimensional directed the three-dimensional(3D)method that takes into account self-occlusion,badly posedness,and a lack of depth data in the per-frame 3D posture estimation from two-dimensional(2D)mapping to 3D ***,by examining the relationship between the movements of different bones in the human body,four virtual skeletons are proposed to enhance the cyclic constraints of limb ***,multiple parameters describing the skeleton are fused and projected into a high-dimensional *** a multi-branch network,motion features between bones and overall motion features are extracted to mitigate the drift error in the estimation ***,the estimated relative depth is projected into 3D space,and the error is calculated against real 3D data,forming a loss function along with the relative depth *** article adopts the average joint pixel error as the primary performance *** to the benchmark approach,the estimation findings indicate an increase in average precision of 1.8 mm within the Human3.6M sample.

关键词： Key point detection 3D human posture estimation computer vision deep learning

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Advanced nano-based strategies for mRNA tumor vaccine

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Acta Pharmaceutica Sinica B 2024年第1期14卷 170-189页

作者： Yangqi Qu Jingjing Xu Tong Zhang Qinjun Chen Tao Sun Chen Jiang Key Laboratory of Smart Drug Delivery(Ministry of education) Minhang HospitalState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune *** with the technological breakthroughs in genetic engineering and delivery systems,messenger ribonucleic acid(mRNA)technology has achieved unprecedented development and application over the last few years,especially the emergency use authorizations of two mRNA vaccines during the COVID-19 pandemic,which has saved countless lives and makes the world witness the powerful efficacy of mRNA technology in ***,unlike infectious disease vaccines,which mainly induce humoral immunity,tumor vaccines also need to activate potent cellular immunity to control tumor growth,which creates a higher demand for mRNA delivery to the lymphatic organs and antigen-presenting cells(APCs).Here we review the existing bottlenecks of mRNA tumor vaccines and advanced nano-based strategies to overcome those challenges,as well as future considerations of mRNA tumor vaccines and their delivery systems.

关键词： mRNA vaccine Nanoparticle Tumor vaccine Delivery system Stability Targeting Transfection Immunogenicity

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Advancing cancer nanomedicine with machine learning

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4183-4185页

作者： Xifeng Qin Tun Lu Zhiqing Pang school of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China school of Computer Science Fudan UniversityShanghai 200438China

Nanomedicine,a captivating and highly promising field in biomedicine,is driving the transformation of medical technologies and treatments,catalyzing revolutionary advancements in areas such as cancer therapy,drug delivery,diagnostics,and *** the notable progress in nanomedicine to tackle the complexities of various diseases,the biomedical sector is presented with abundant opportunities for innovation and *** this process,machine learning(ML)and artificial intelligence(AI)emerge as pivotal themes in the realm of science and *** are reshaping our lifestyles and workplaces with unparalleled rapidity and magnitude,while also providing fresh possibilities and potentials for the evolution of nanomedicine。

关键词： Machine learning Artificial intelligence Nanomedicine Drug design Cancer treatment

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Enrichment and reconfiguration of titanium-bearing phase in vortex smelting reduction process of vanadium-titanium magnetite

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Journal of Iron and Steel Research international 2024年第7期31卷 1582-1589页

作者： Yong-chao Han Zhi-he Dou Rui Zhang Ting-an Zhang Shuai Fang Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of education) Shenyang 110819LiaoningChina school of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

To comprehensively utilize the low-iron high-vanadium-titanium magnetite,a new method of vortex smelting reduction of vanadium-titanium magnetite was proposed,and the enrichment and reconstitution regularity of Ti-bearing phases in the slag was investigated through X-ray fluorescence spectrometry,X-ray photoelectron spectroscopy,X-ray diffraction analysis,and optical *** phase diagram revealed that the preferential crystallization of MgTi_(2)O_(5) can be achieved by adjusting the CaO,MgO,and TiO_(2) contents of *** predominant Ti-bearing phases in the slag obtained from the reduction process are MgxTi_(3_x)O_(5)(0≤x≤1)and CaTiO_(3).FeTiO_(3) is present at carbon-iron ratio(CR)=1.3,while MgTi_(2)O4 and TiC are formed at CR=*** enrichment of TiO_(2) in the slag increases first and then decreases as the CR increases,and at CR=1.1,the enrichment of TiO_(2) in the slag reaches 51.3 wt.%.Additionally,the concentrations of MgxTi_(3_x)O_(5)(0≤x≤1)and CaTiO_(3) in the slag,along with the grain width of MgxTi_(3_x)O_(5)(0≤x≤1),decrease with the increase in CR.

关键词： Vanadium-titanium magnetite Vortex smelting reduction Phase reconfiguration TiO_(2)enrichment

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