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Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 221-236页

作者： Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-Jun Dai Fu Ren Ning Li Shang-Yu Lv Yan Zhang Graduate school Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Clinical Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina international Education school International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality *** study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin(THC)on HCC and its mechanism of *** research hypothesis is that THC can inhibit the proliferation,migration,and invasion of HCC cells,and promote their apoptosis by regulating the TP53 target *** To explore the mechanism by which THC inhibits HCC cell proliferation via the TP53 signaling *** Potential targets of THC and HCC were identified from multiple *** core targets were subjected to analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,and visualization processing,using the online platform Metascape to identify the key molecules and signaling pathways involved in the action of THC against *** molecular mechanisms of action of THC against TP53 in the inhibition of HCC cells were verified using cell counting kit-8,Transwell,apoptosis,and western blotting *** Molecular docking results showed that THC had a high score for the TP53 target *** vitro experiments indicated that THC effectively inhibited the proliferation and migration of HCC cells,and affected the expression levels of TP53,MDM2,cyclin B,Bax,Bcl-2,caspase-9,and *** THC induces the apoptosis of HCC cells through the TP53 signaling pathway,thereby inhibiting their proliferation and migration.

关键词： Hepatocellular carcinoma cells Tetrahydrocurcumin TP53 Network pharmacology Molecular docking

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Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

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Science China Chemistry 2025年第1期68卷 317-328页

作者： Qingmin Yang Jian Zhao Yujia Zhang Xingyu Zhou Hao Ren Bowen Hu Zhongli Lei Lixin Chen Peng Yang Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China school of Material and Chemical Engineering Bengbu UniversityBengbu 233030China Anhui Provincial Engineering Laboratory of Silicon-Based Materials Bengbu 233030China Xi’an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China international Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China school of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129China

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular ***,we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal *** method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical ***-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces,resulting in a remarkable~3.1 times improvement in the adsorption capacity of fly ash,a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB).The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins,activated carbon(AC),covalent organic frameworks(COFs),and metal-organic frameworks(MOFs).We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste ***,this strategy could increase the value of waste materials nearly 27 *** addition,this method is generally extendable to other conventional industrial adsorbents such as resin,clay,and Al_(2)O_(3),and enhances their adsorption capabilities at least ***,this work provides a simple and green approach for improving the adsorption performance of solid particles,and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

关键词： amyloid-like protein aggregates surface engineering fly ash solid waste adsorption

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Enhancing the performance of proton-exchange membrane fuel cell by optimizing the hydrophobicity and porosity of cathode catalyst layer

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Science China Technological Sciences 2025年第3期68卷 76-85页

作者： Yan ZHANG Puping JIA Suyi YANG Jinzhan SU Liejin GUO international Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringSchool of Energy & Power Engineering Xi'an Jiaotong University

Appropriate hydrophobicity and porosity of the proton-exchange membrane fuel cell（PEMFC） cathode catalyst layer（CCL） are essential for efficient charge and mass transport. In this study, the effects of the CCL hydrophobicity and porosity on PEMFC performance were comprehensively investigated. Compared to a normal CCL, a cathode hydrophobic duallayer catalyst structure(with a 2:1 Pt loading ratio between the inner and outer layers and 9.3% polytetrafluoroethylene（PTFE）in the outer layer) exhibited a 29.8% increase in power density. Among the tested pore-forming agents, ammonium bicarbonate（NH4HCO3） was the most suitable because of its low pyrolysis temperature. The maximum power density of the CCL with a porous structure（prepared with a Pt/C:NH4HCO3mass ratio of 1:3） was 38.3% higher than that of the normal CCL. By simultaneously optimizing the pore structure and hydrophobicity of the CCL, the maximum power density of the cathode hydrophobic dual-layer CCL（DCL） with pores showed a 44.7% increase compared to that of the normal CCL. This study demonstrates for the first time that simultaneously optimizing cathode porosity and hydrophobicity can enhance PEMFC performance.

关键词： proton-exchange membrane fuel cell cathode catalyst layer membrane electrode assemblies polytetrafluoroethylene pore-forming agent

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Influence of Joint EMSFN and M-EMS on Fluid Flow in the Mold During Continuous Casting

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1345-1355页

作者： Oleksandr Tretiak Qiang Wang De-Wei Li Xiao-Wei Zhu Chun-Lei Wu Ming He Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern University school of international exchange Northeastern University school of Resources and Materials Northeastern University at Qinhuangdao school of Metallurgy Northeastern University

Homogenization of physical properties and the chemical composition through the control of liquid metal flow is essentialduring the continuous casting production of billets. This work was aimed at obtaining improved finished products viacontinuous casting that implements two magnetic fields. These fields were realized via two electromagnetic stirringprocesses implemented in a single process： one in the nozzle and one in the mold. The qualitative effects of applyingdouble electromagnetic stirring （EMS） were verified through numerical simulation of 178 mm × 178 mm square billetsexposed to double electromagnetic fields during the continuous casting process. The accuracy of the numerical calculationswas verified via physical experiments. In addition, the final simulation results were compared with the intermediate results,to determine the true effects of different EMS on the metal flow in the mold. The results revealed that casting using EMSwith different directions of magnetic field in the mold and the nozzle has the best effect on the distribution of the fluid flowand minimal influence on the stability of the meniscus and yields the minimum metal-jet penetration into the mold.

关键词： Continuous casting Submerged nozzle Electromagnetic stirring Microstructure

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Diaphragm-based electrolyzer with a double-layer cathode catalyst structure for stable CO2 electroreduction

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Science China Chemistry 2025年

作者： Peipei Jia Hui Gao Gong Zhang Tuo Wang Jinlong Gong school of Chemical Engineering and Technology Key Laboratory for Green Chemical Technology of Ministry of Education Tianjin University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Haihe Laboratory of Sustainable Chemical Transformations National Industry-Education Platform of Energy Storage Tianjin University Joint school of National University of Singapore and Tianjin University International Campus of Tianjin University Tianjin Normal University

The electrocatalytic CO2reduction reaction（CO2RR） presents a promising approach to achieving carbon neutrality. Currently,anion exchange membranes（AEMs） are widely used in CO2RR electrolyzers. However, the widespread industrial application of CO2RR electrolyzers faces significant challenges due to the poor alkali resistance, high mass transfer resistance, limited electrode surface area, and high costs associated with conventional AEMs. This paper describes the amplification and stable operation of a horizontal electrolyzer achieved via combining a diaphragm, a double-layer cathode catalyst, and a redesigned flow channel. Furthermore, a new pH measurement device has been proposed to detect the ion concentration on the cathode surface, elucidating the relationship between electrolytic cell components, ion concentration, and Faraday efficiency（FE）. The results reveal that the electrolyzer resistance and cell voltage are reduced, and the hydrogen evolution reaction（HER） is effectively reduced due to the high alkali environment and rapid mass transfer enabled by the diaphragm. Furthermore, the uniform flow of electrolytes and rapid desorption of O2bubbles on the anode surface have been achieved through the redesigned flow channel using the computational fluid dynamics（CFD） simulation. Diaphragm-based electrolyzer with a double-layer cathode catalyst structure has been adopted, and the catalytic area has been expanded to 100 cm2. After running for 100 h at a current density of 200 m A/cm2in a 1 mol/L KOH solution, the FECOstill exceeds 90%, with a cell voltage of approximately 3 V.

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Mapping the trends and prospects of battery cathode materials based on patent landscape

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Frontiers in Energy 2023年第6期17卷 822-832页

作者： Chen YANG Xin-Yu MU school of Japanese culture and Economy Xi’an International Studies UniversityXi’an 710128China The Northeast Asian Research Center Xi’an International Studies UniversityXi’an 710128China

Advancing portable electronics and electric vehicles is heavily dependent on the cutting-edge lithium-ion (Li-ion) battery technology, which is closely linked to the properties of cathode materials. Identifying trends and prospects of cathode materials based on patent analysis is considered a kernel to optimize and refine battery related markets. In this paper, a patent analysis is performed on 6 popular cathode materials by comprehensively considering performance comparison, development trend, annual installed capacity, technology life cycle, and distribution among regions and patent assignees. In the technology life cycle, the cathode materials majorly used in electric vehicle have entered maturity stage, while the lithium cobalt oxide (LCO) cathode that is widely used in portable electronics is still in the growth stage. In global patent distributions, China holds more than 50% of total patents. In the top 10 patent assignees of 6 cathode materials, 2 institutes are from China with the rest being Japan (6) and Republic of Korea (2), indicating that the technology of cathode materials in China is relatively scattered while cathode research is highly concentrated in Japan and Republic of Korea. Moreover, the patent distribution has to consider practical issues as well as the impacts of core patents. For example, the high cost discourages the intention of applying international patents. This paper is expected to stimulate battery research, understand technical layout of various countries, and probably forecast innovative technology breakthroughs.

关键词： patent analysis cathode batteries technology life cycle

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Orbital XY models in moiré superlattices

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Chinese Physics B 2025年第2期34卷 19-29页

作者： Yanqi Li Yi-Jie Wang Zhi-Da Song international Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Hefei National Laboratory Hefei 230088China Collaborative Innovation Center of Quantum Matter Beijing 100871China

Moiré superlattices provide a new platform to engineer various many-body problems. In this work, we consider arrays of quantum dots(QD) realized on semiconductor moiré superlattices with a deep moiré potential. We diagonalize single QD with multiple electrons, and find degenerate ground states serving as local degrees of freedom(qudits) in the superlattice. With a deep moiré potential, the hopping and exchange interaction between nearby QDs become irrelevant,and the direct Coulomb interaction of the density–density type dominates. Therefore, nearby QDs must arrange the spatial densities to optimize the Coulomb energy. When the local Hilbert space has a two-fold orbital degeneracy, we find that a square superlattice realizes an anisotropic XY model, while a triangular superlattice realizes a generalized XY model with geometric frustration.

关键词： moirésuperlattices quantum dots XY model

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Theoretical Construction of Palmer's Cultural Linguistics

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学术界 2017年第2期 299-305页

作者： Cui Yao school of Foreign Languages and international Cultural exchange Hainan Tropical Ocean UniversitySanya Hainan 572022

American anthropologist *** put forward a comprehensive theory—cultural linguistics in *** in image and framed in cultural dimension,Palmer originates a new research method for linguistics by integrating three major branches of linguistic anthropology and cognitive linguistics,hopefully to provide a new perspective to study language and culture,enhance understanding between nations,and promote the process of the harmonious world.

关键词：文化层面语言学人类学家图像

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To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 270-290页

作者： Zhuo-Cong Bao Zhao-Dong Liu Ye Zhang Hui-Jun Dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang Graduate school Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina school of Traditional Chinese Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Molecular Morphology Laboratory College of Basic Medical SciencesShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Batch 2022 Clinical MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina international Education school International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in ***,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a focus on the of phosphoinositide 3-kinases(PI3K)/AKT signaling *** To investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and *** Using Metascape,we analyzed the potential targets of tetrahydrocurcumin in *** docking validation was performed using *** Counting Kit-8,wound healing,and transwell assays were performed to evaluate the effects of tetrahydrocurcumin on HepG2 and Huh7 cell migration,invasion,and *** expression of PI3K/AKT signaling pathway-related proteins was detected by western *** Network pharmacology and molecular docking showed that tetrahydrocurcumin has high binding affinity for phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit *** vitro experiments demonstrated that tetrahydrocurcumin suppressed the migration and invasion of liver cancer cells,promoted their apoptosis,and downregulated the expression of p-PI3K,p-AKT,and B cell leukemia/lymphoma 2,while upregulating caspase-3,p53,and B cell leukemia/lymphoma 2 associated *** In summary,tetrahydrocurcumin suppresses PI3K/AKT signaling,promotes apoptosis,and prevents the migration and invasion of liver cancer cells.

关键词： Hepatocellular carcinoma Tetrahydrocurcumin Network pharmacology Molecular docking PI3K/AKT signaling pathway

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On the Natural Ecological Law of Taoism

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学术界 2015年第4期 313-317页

作者： Lu Zheng school of international Education and exchange Zhejiang College of Water Conservancy and Hydropower Hangzhou Zhejiang 310018

The Taoist philosophy on ecological ethics focuses on the independence of the principle that "Tao keeps to nature"and the modern environm ent law; and the integration of the principle that"Tao derives from nature"and the modern law of natural resources show case the Taoist natural philosophy and the ecological ethic principles. Based on the idea of the integration of society and nature and the ecological ethic interaction,this paper discusses the hot points of the present ecological ethic study,attem pting to find the breakthrough of the Taoist philosophy on nature and the value of Taoist philosophy for the ecological cultural renaissance and the peaceful rise of the Chinese nation.

关键词：自然生态法道家哲学调制解调器生态伦理自然资源伦理原则自然哲学文艺复兴

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