检索结果-南通市图书馆

Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru Shi Men Yu Qingxia Huang Huiru Tang State Key Laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan Laboratory for Shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： Acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第1期16卷 187-221页

作者： Jiayi Li Li Gao Fengying Pan Cheng Gong Limeng Sun Hong Gao Jinqiang Zhang Yufei Zhao Guoxiu Wang Hao Liu Joint international Laboratory On Environmental and Energy Frontier Materials School of Environmental and Chemical EngineeringShanghai UniversityShanghaiPeople’s Republic of China centre for Clean Energy Technology University of Technology SydneyBroadwaySydneyNSW 2007Australia

Lithium–sulfur(Li–S)batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost.Nevertheless,the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value.Many methods were proposed for inhibiting the shuttle effect of polysulfide,improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries.Here,we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries.First,the electrochemical principles/mechanism and origin of the shuttle effect are described in detail.Moreover,the efficient strategies,including boosting the sulfur conversion rate of sulfur,confining sulfur or lithium polysulfides(LPS)within cathode host,confining LPS in the shield layer,and preventing LPS from contacting the anode,will be discussed to suppress the shuttle effect.Then,recent advances in inhibition of shuttle effect in cathode,electrolyte,separator,and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries.Finally,we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.

关键词： Shuttle effect Designed strategies Li-S battery Lithium polysulfides

Simulating the Escaping Atmosphere of GJ 436 b with Two-fluid Magnetohydrodynamic Models

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第6期24卷 275-288页

作者： Lei Xing Jianheng Guo Chuyuan Yang Dongdong Yan Yunnan Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory for Structure and Evolution of Celestial Objects Chinese Academy of Sciences international centre of Supernovae Yunnan Key Laboratory

Observations of transmission spectra reveal that hot Jupiters and Neptunes are likely to possess escaping atmospheres driven by stellar radiation. Numerous models predict that magnetic fields may exert significant influences on the atmospheres of hot planets. Generally, the escaping atmospheres are not entirely ionized, and magnetic fields only directly affect the escape of ionized components within them. Considering the chemical reactions between ionized components and neutral atoms, as well as collision processes, magnetic fields indirectly impact the escape of neutral atoms, thereby influencing the detection signals of planetary atmospheres in transmission spectra. In order to simulate this process, we developed a magnetohydrodynamic multi-fluid model based on MHD code PLUTO. As an initial exploration, we investigated the impact of magnetic fields on the decoupling of H+and H in the escaping atmosphere of the hot Neptune GJ436b. Due to the strong resonant interactions between H and H+, the coupling between them is tight even if the magnetic field is strong. Of course,alternatively, our work also suggests that merging H and H+into a single flow can be a reasonable assumption in MHD simulations of escaping atmospheres. However, our simulation results indicate that under the influence of magnetic fields, there are noticeable regional differences in the decoupling of H+and H. With the increase of magnetic field strength, the degree of decoupling also increases. For heavier particles such as O, the decoupling between O and H+is more pronounced. Our findings provide important insights for future studies on the decoupling processes of heavy atoms in the escaping atmospheres of hot Jupiters and hot Neptunes under the influence of magnetic fields.

关键词： hydrodynamics magnetohydrodynamics (MHD) planets and satellites: atmospheres

RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

mLife 2024年第1期3卷 74-86页

作者： Ya-Wen He Zi-Jing Jin Ying Cui Kai Song Bo Chen Lian Zhou State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSJTU-NLBP Joint R&D Centre for Biopesticides and BiofertilizersSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Zhiyuan Innovative Research centre Student Innovation CentreZhiyuan CollegeShanghai Jiao Tong UniversityShanghaiChina

Pseudomonas aeruginosa is a ubiquitous and metabolically versatile microorganism naturally found in soil and water.It is also an opportunistic pathogen in plants,insects,animals,and humans.In response to increasing cell density,P.aeruginosa uses two acylhomoserine lactone(AHL)quorum-sensing(QS)signals(i.e.,N-3-oxo-dodecanoyl homoserine lactone[3-oxo-C12-HSL]and Nbutanoyl-homoserine lactone[C4-HsL]),which regulate the expression of hundreds of genes.However,how the biosynthesis of these two QS signals is coordinated remains unknown.We studied the regulation of these two QS signals in the rhizosphere strain PA1201.PA1201 sequentially produced 3-oxo-C12-HSL and C4-HSL at the early and late growth stages,respectively.The highest 3-oxo-C12-HSL-dependent elastase activity was observed at the early stage,while the highest C4-HSL-dependent rhamnolipid production was observed at the late stage.The atypical regulator RsaL played a pivotal role in coordinating 3-oxo-C12-HSL and C4-HSL biosynthesis and QS-associated virulence.RsaL repressed las/transcription by binding the-10 and-35 boxes of the lasl promoter.In contrast,RsaL activated rhll transcription by binding the region encoding the 5'-untranslated region of the rhll mRNA.Further,RsaL repressed its own expression by binding a nucleotide motif located in the-35 box of the rsaL promoter.Thus,RsaL acts as a molecular switch that coordinates the sequential biosynthesis of AHL QS signals and differential virulence in PA1201.Finally,C4-HSL activation by RsaL was independent of the Las and Pseudomonas quinolone signal(PQS)QS signaling systems.Therefore,we propose a new model of the QS regulatory network in PA1201,in which RsaL represents a superior player acting at the top of the hierarchy.

关键词： N-3-oxo-dodecanoyl homoserine lactone N-butanoyl-homoserine lactone Pseudomonas aeruginosa quorum sensing RsaL

Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1175-1180页

作者： Hao-Dong Qian Xiang Li Tingrui Yin Wei-Feng Qian Chunhui Zhao Cuiju Zhu Hao Xu CCNU-uOttawa Joint Research centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote substitution.The key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote substitution.Thus,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl esters.The reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group compatibility.Moreover,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building blocks.Preliminary mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

A holistic approach to improving safety for battery energy storage systems

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 422-439页

作者： James Close Jonathan E.Barnard Y.M.John Chew Semali Perera Department of Chemical Engineering Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK ioMosaic international Limited 16-18 Queen SquareBath BA12HNUK

The integration of battery energy storage systems(BESS)throughout our energy chain poses concerns regarding safety,especially since batteries have high energy density and numerous BESS failure events have occurred.Wider spread adoption will only increase the prevalence of these failure events unless there is a step change in the management and design of BESS.To understand the causes of failure,the main challenges of BESS safety are summarised.BESS consequences and failure events are discussed,including specific focus on the chain of events causing thermal runaway,and a case study of a BESS explosion in Surprise Arizona is analysed.Based on the technology and past events,a paradigm shift is required to improve BESS safety.In this review,a holistic approach is proposed.This combines currently adopted approaches including battery cell testing,lumped cell mathematical modelling,and calorimetry,alongside additional measures taken to ensure BESS safety including the requirement for computational fluid dynamics and kinetic modelling,assessment of installation level testing of the full BESS system and not simply a single cell battery test,hazard and layers of protection analysis,gas chromatography,and composition testing.The holistic approach proposed in this study aims to address challenges of BESS safety and form the basis of a paradigm shift in the safety management and design of these systems.

关键词： Energy storagesystems Process safety Battery safety Thermal safety

Drainage of paddy terraces impacts structures and soil properties in the globally important agricultural heritage of Hani Paddy Terraces,China

在线全文

学校读者我要写书评

暂无评论

international Soil and Water Conservation Research 2024年第1期12卷 64-76页

作者： Ming Wang Li Rong Yanbo Li Jiangcheng Huang Yuanmei Jiao Xiaoyan Wei Institute of international Rivers and Eco-Security Kunming650500China Yunnan Key Laboratory of international Rivers and Transboundary Eco-Security Kunming650500China Power China Kunming Engineering Corporation Limited Kunming650051China Department of Geography Yunnan Normal UniversityKunming650500China Yunnan Provincial Archives of Surveying and Mapping(Yunnan Provincial Geomatics centre) Kunming650032China

Marginalization and abandonment of paddy terraces are widespread,but their effects on the sustainability of subsequent agricultural production are still unknown.Hani Paddy Terraces,included in Globally Important Agriculture Heritage Systems,are threatened by paddy fields drainage.Here,changes in terrace structure,the productivity of topsoil(0-20 cm),and soil water holding capacity at 0-70 cm depth were determined in a case study of Hani Paddy Terraces in Amengkong River Basin in Yuanyang County in Southwestern China,which had been converted into dryland terraces for 2-14 years.Our results showed that:(1)The degree of terrace structures degradation exhibited a U-shaped curve with increasing time since draining,with those drained for 5-9 years having the best structure;(2)Soil productivity index decreased first and then increased with time after conversion;(3)Maximum water holding capacity at 0-70 cm soil depth dramatically decreased after conversion and such trend became increasingly obvious with increasing time since conversion.Our study revealed that drainage of paddy terraces along with associated changes in crop and field management led to an increase in soil productivity,but degradation of terrace structures and a decrease in water holding capacity will inhibit restoration to paddy terraces.These findings enhance the understanding of the biophysical changes due to marginalization in paddy terraces.

关键词： Hani paddy terraces Terraces marginalization Terrace structure degradation Soil productivity Water holding capacity

Survey of Indoor Localization Based on Deep Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第5期79卷 3261-3298页

作者： Khaldon Azzam Kordi Mardeni Roslee Mohamad Yusoff Alias Abdulraqeb Alhammadi Athar Waseem Anwar Faizd Osman centre for Wireless Technology Faculty of EngineeringMultimedia UniversityCyberjaya63100Malaysia Communication Systems&Networks Research Lab Malaysia-Japan International Institute of TechnologyUniversiti Teknologi MalaysiaKuala Lumpur54100Malaysia Department of Electrical Engineering(DEE) International Islamic UniversityIslamabad44000Pakistan Rohde&Schwarz(M)Sdn Bhd Shah Alam40150Malaysia

This study comprehensively examines the current state of deep learning (DL) usage in indoor positioning.It emphasizes the significance and efficiency of convolutional neural networks (CNNs) and recurrent neuralnetworks (RNNs). Unlike prior studies focused on single sensor modalities like Wi-Fi or Bluetooth, this researchexplores the integration of multiple sensor modalities (e.g.,Wi-Fi, Bluetooth, Ultra-Wideband, ZigBee) to expandindoor localization methods, particularly in obstructed environments. It addresses the challenge of precise objectlocalization, introducing a novel hybrid DL approach using received signal information (RSI), Received SignalStrength (RSS), and Channel State Information (CSI) data to enhance accuracy and stability. Moreover, thestudy introduces a device-free indoor localization algorithm, offering a significant advancement with potentialobject or individual tracking applications. It recognizes the increasing importance of indoor positioning forlocation-based services. It anticipates future developments while acknowledging challenges such as multipathinterference, noise, data standardization, and scarcity of labeled data. This research contributes significantly toindoor localization technology, offering adaptability, device independence, and multifaceted DL-based solutionsfor real-world challenges and future advancements. Thus, the proposed work addresses challenges in objectlocalization precision and introduces a novel hybrid deep learning approach, contributing to advancing locationcentricservices.While deep learning-based indoor localization techniques have improved accuracy, challenges likedata noise, standardization, and availability of training data persist. However, ongoing developments are expectedto enhance indoor positioning systems to meet real-world demands.

关键词： Deep learning indoor localization wireless-based localization

Insights for Africa’s Industrialisation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ChinAfrica 2024年第1期16卷 14-15页

作者： ZHANG JIN CHEN XIAO centre for international Knowledge on Development Beijing

The First Industrial Revolution in the 18th century started the modernisation process marked by profound economic,social,and cultural transformations in the world.Research shows that the process of industrialisation is closely associated with improvements in people’s living standards and their quality of life.Industrialisation,with economic and technological change at its core,is central to modernisation.

关键词： Africa profound economic