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Long-term outcome in patients with obscure gastrointestinal bleeding after negative capsule endoscopy

World Journal of Gastroenterology 2013年第10期19卷 1632-1638页

作者： Seong-Joon Koh Jong Pil Im Ji Won Kim Byeong Gwan Kim Kook Lae Lee Sang Gyun Kim Joo Sung Kim Hyun Chae Jung Department of internal medicine Seoul National University Boramae HospitalSeoul National University College of MedicineSeoul 110-744South Korea Department of internal medicine and liver research institute Seoul National University College of MedicineSeoul 110-744South Korea

AIM:To investigate long-term outcome in obscure gastrointestinal bleeding(OGIB) after negative capsule endoscopy(CE) and identify risk factors for ***:A total of 113 consecutive patients underwent CE for OGIB from May 2003 to June 2010 at Seoul National University ***-five patients(84.1%) with a subsequent follow-up after CE of at least 6 mo were enrolled in this ***-up data were obtained from the patients' medical *** CE images were reviewed by two board-certified gastroenterologists and consensus diagnosis was used in all *** primary outcome measure was the detection of rebleeding after CE,and factors associated with rebleeding were evaluated using multivariate ***:Of the 95 enrolled patients(median age 61 years,range 17-85 years),62 patients(65.3%) were *** median duration of follow-up was 23.7 mo(range 6.0-89.4 mo).Seventy-three patients(76.8%) underwent CE for obscure-overt *** examination of the small bowel was achieved in 77 cases(81.1%).Significant lesions were found in 38 patients(40.0%).The overall rebleeding rate was 28.4%.The rebleeding rate was higher in patients with positive CE(36.8%) than in those with negative CE(22.8%).However,there was no significant difference in cumulative rebleeding rates between the two groups(log rank test;P = 0.205).Anticoagulation after CE examination was an independent risk factor for rebleeding(hazard ratio,5.019;95%CI,1.560-16.145;P = 0.007),regardless of CE ***:Patients with OGIB and negative CE have a potential risk of ***,close observation is required and alternative modalities should be considered in suspicious cases.

关键词： Capsule endoscopy Gastrointestinal hemorrhage Risk factors Prognosis Enteroscopy

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Guidelines for diagnosis and treatment of hepatic fibrosis with integrated traditional Chinese and Western medicine(2019 edition)

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Journal of Integrative medicine 2020年第3期18卷 203-213页

作者： Lie-ming Xu Ping Liu institute of liver Diseases Shanghai University of Traditional Chinese Medicine

In 2006, the Hepatology Committee of Chinese Association of Integrative medicine issued the "Guidelines for the Prevention and Treatment of liver Fibrosis with Integrated Traditional Chinese and Western medicine." In recent years, the fields of Chinese medicine, Western medicine, and integrative medicine have made rapid advances in basic and clinical research into chronic liver disease, and accumulated new evidence for the prevention and treatment of hepatic fibrosis. Therefore, in order to meet clinical needs, liver disease experts of integrated traditional Chinese and Western medicine were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of hepatic fibrosis.

关键词： Hepatic fibrosis Integrated traditional Chinese and Western medicine medicine,Chinese traditional Diagnosis Therapy Practice guideline

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Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology

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World Journal of Gastroenterology 2022年第8期28卷 853-867页

作者： Yoo Min Han Su Jin Chung Seokha Yoo Jong In Yang Ji Min Choi Jooyoung Lee Joo Sung Kim Department of internal medicine and Healthcare research institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Department of Anesthesiology and Pain medicine Seoul National University College of MedicineSeoul 03080South Korea Department of internal medicine and liver research institute Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Helicobacter pylori(***)infection is known to prevent the occurrence of gastroesophageal reflux disease(GERD)by inducing gastric mucosal ***,little is known about the relationship between atrophic gastritis(AG)and *** To confirm the inverse correlation between AG and the occurrence and severity of *** Individuals receiving health checkups who underwent upper gastrointestinal endoscopy at Seoul National University Healthcare System Gangnam Center were *** grade of reflux esophagitis was evaluated according to the Los Angeles *** AG(EAG)was categorized into six *** AG(SAG)was defined as pepsinogen I≤70 ng/m L and pepsinogen I/II ratio≤*** association between the extent of EAG and SAG and the occurrence and severity of GERD was evaluated using multivariate logistic regression *** In total,4684 individuals with GERD were compared with 21901 healthy *** multivariate logistic regression analysis,advanced age,male sex,body mass index>23 kg/m2,presence of metabolic syndrome,current smoking,and alcohol consumption were associated with an increased risk of *** for *** immunoglobulin G antibodies was associated with a decreased risk of *** was an inverse correlation between the extent of EAG and occurrence of GERD:Odds ratio(OR),1.01[95%confidence interval(CI):0.90-1.14]in C1,0.87(0.78-0.97)in C2,0.71(0.62-0.80)in C3,0.52(0.44-0.61)in O1,0.37(0.29-0.48)in O2,and 0.28(0.18-0.43)in ***,the extent of EAG showed an inverse correlation with the severity of *** presence of SAG was correlated with a reduced risk of GERD(OR=0.49,95%CI:0.28-0.87,P=0.014).CONCLUSION The extent of EAG and SAG exhibited strong inverse relationships with the occurrence and severity of *** followed by *** infection may be independently protect against GERD.

关键词： Gastroesophageal reflux disease Reflux esophagitis Helicobacter pylori Atrophic gastritis Pepsinogen

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Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Department of internal medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of internal medicine and liver research institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

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Accuracy of an administrative database for pancreatic cancer by international classification of disease 10th codes: A retrospective large-cohort study

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World Journal of Gastroenterology 2019年第37期25卷 5619-5629页

作者： Young-Jae Hwang Seon Mee Park Soomin Ahn Jong-Chan Lee Young Soo Park Nayoung Kim Departments of internal medicine Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of internal medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongju 28644South Korea Departments of Pathology Seoul National University Bundang HospitalSeoungnam 13620South Korea Department of internal medicine and institute of liver research and Tumor Microenvironment Global Core research Center Seoul National University College of MedicineSeoul 08826South Korea

BACKGROUND Korean National Health Insurance(NHI)claims database provides ***,studies regarding accuracy of administrative database for pancreatic cancer(PC)have not been *** aimed to identify accuracy of NHI database regarding PC classified by international classification of disease(ICD)-10 *** To identify the accuracy and usefulness of administrative database in PC and the accurate ICD codes for PC with *** Study and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of PC were identified in NHI database by international classification of diseases,10th revision edition(ICD-10 codes)supported with V codes.V code is issued by medical doctors for covering 95%of medical cost by Korean *** to pathologic reports,definite or possible diagnoses were defined using medical records,images,and *** A total of 1846 cases with PC and controls were *** PC,only 410(22.2%)cases were identified as specific cancer sites including head in 234(12.7%)cases,tail in 104(5.6%)cases and body in 72(3.9%)*** PC,910(49.3%)cases were diagnosed by definite *** of these were adenocarcinoma(98.0%).The rates of definite diagnosis of PC were highest in head(70.1%)followed by body(47.2%)and tail(43.3%).False-positive cases were pancreatic cystic neoplasm and metastasis to the *** terms of the overall diagnosis of PC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.95%,98.72%,98.70%,and 99.95%,*** accuracy was similar both in terms of diagnostic criteria and tumor *** Korean NHI claims database collected according to ICD-10 code with V code for PC showed good accuracy.

关键词： Korean national health insurance Accuracy Pancreatic cancer International classification of disease Sensitivity Specificity

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Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 571-577页

作者： Eun Hyo Jin Dong Ho Lee Sung-Ae Jung Ki-Nam Shim Ji Yeon Seo Nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung Department of internal medicine and liver research institute Seoul National University College of MedicineSeoul 110-744South Korea Department of internal medicine Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea Department of internal medicine Ewha Womans University College of MedicineSeoul 158-710South Korea

AIM: To analyze predictive factors for lymph node metastasis in early gastric ***: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic ***: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P < 0.0001), diameter(≥ 20 mm, OR = 3.173, P = 0.01), and EGFR overexpression(OR = 2.185, P = 0.044) were independent risk factors for lymph node ***: Female gender, tumor size, lymphovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC.

关键词： Receptor Epidermal growth factor Stomach neoplasms

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Occult infection related hepatitis B surface antigen variants showing lowered secretion capacity

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World Journal of Gastroenterology 2015年第6期21卷 1794-1803页

作者： Hong Kim Seoung-Ae Lee You-Sub Won Hyun Joo Lee Bum-Joon Kim Department of Biomedical Sciences Microbiology and Immunology and Liver Research Institute Seoul National University College of Medicine

AIM:To elucidate the molecular mechanisms underlying hepatitis B virus(HBV)occult infection of genotype ***:A total of 10 types of hepatitis B surface antigen(HBs Ag)variants from a Korean occult cohort were *** a complete HBV genome plasmid mutated such that it does not express HBs Ag and plasmid encoding,each HBs Ag variant was transiently co-transfected into Hu H-7 *** secretion capacity and intracellular expression of the HBV virions and HBs Ags in their respective variants were analyzed using real-time quantitative polymerase chain reaction assays and commercial HBs Ag enzyme-linked immunosorbent assays,***:All variants exhibited lower levels of HBs Ag secretion into the medium compared with the wild *** particular,in eight of the ten variants,very low levels of HBs Ag secretion that were similar to the negative control were *** contrast,most variants(9/10)exhibited normal virion secretion capacities comparable with,or even higher than,the wild *** provided new insight into the intrinsic nature of occult HBV infection,which leads to HBs Ag sero-negativeness but has horizontal ***,most variants generated higher reactive oxidative species production than the wild *** finding provides potential links between occult HBV infection and liver disease ***:The presently obtained data indicate that deficiency in the secretion capacity of HBs Ag variants may have a pivotal function in the occult infections of HBV genotype C.

关键词： Occult infection Hepatitis B virus Hepatitis B sur

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Non-alcoholic steatohepatitis or metabolic-associated fatty liver:time to change

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 123-125页

作者： Gamal Shiha Nasser Mousa Egyptian liver research institute and Hospital(ELRIAH) MansouraEgypt Hepatology and Gastroenterology Unit Internal Medicine Department Tropical medicine Department Faculty of MedicineMansoura UniversityMansouraEgypt

Non-alcoholic fatty liver disease(NAFLD)is a range of liver disease characterized by the occurrence of steatosis in greater than 5%of hepatocytes of people who drink tiny or no *** comprises,a benign non-alcoholic fatty liver(NAFL),and the more serious non-alcoholic steatohepatitis(NASH)described by steatosis,hepatocellular ballooning,lobular inflammation and lastly cirrhosis(1).

关键词： balloon NAFLD liver

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering research Center for Precision medicine and Transformation of Hepatitis and liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related liver failure based on real-world clinical data

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Frontiers of medicine 2021年第3期15卷 495-505页

作者： Ling Dai Xiang Gao Zhihua Ye Hanmin Li Xin Yao Dingbo Lu Na Wu institute of liver Diseases Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China institute of Basic Theory of Chinese medicine Hubei Province Academy of Traditional Chinese MedicineWuhan 430074China Theory and Application research of liver and Kidney in Traditional Chinese medicine Hubei Provincial Key LaboratoryWuhan 430074China Key Laboratory of Treating Chronic liver Diseases from liver and Kidney State Administration of Traditional Chinese MedicineWuhan 430061China

On the basis of real-world clinical data,the study aimed to explore the effect and mechanisms of the treatment plan of“traditional Chinese medicine(TCM)regulating liver regeneration.”A total of 457 patients with HBV-related liver failure were retrospectively *** patients were divided into three groups:the modern medicine control group(MMC group),patients treated with routine medical treatment;the control group combining traditional Chinese and Western medicine(CTW),patients treated with routine medical treatment plus the common TCM formula;and the treatment group of“TCM regulating liver regeneration”(RLR),patients treated with both routine medical treatment and the special TCM formula of *** 8 weeks of treatment,the mortality of patients in the RLR group(12.31%)was significantly lower than those in the MMC(50%)and CTW(29.11%)*** bilirubin level significantly decreased and albumin increased in the RLR group when compared with the MMC and CTW groups(Pliver regeneration in the RLR group compared with the MMC *** treatment can decrease jaundice,improve liver function,and significantly reduce the mortality in patients with HBV-related liver *** mechanism may be related to the role of RLR treatment in influencing cytokines related to liver regeneration.

关键词： hepatitis B virus-related liver failure traditional Chinese medicine liver regeneration liver regeneration microenvironment cytokines

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