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Impact of Plastic Waste on the Human Health in Low-Income Countries: A Systematic Review

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Journal of Environmental Protection 2024年第5期15卷 572-595页

作者： Ramde Wendkoaghenda Sophie Gbandama Koffi Kouame Pacome Gansore Aminata Camara Kelety Tolno Barthélemy Assogba Ange Wenceslas Vinciale Niare Boubacar Patrice Ngangue Institute for Interdisciplinary Training and Research in Health Sciences and Education Ouagadougou Burkina Faso Regional Directorate of Health and Public Hygiene of South-Central Burkina Faso Ministry of Health Ouagadougou Burkina Faso department of Health Promotion and Education Ministry of Health and Public Hygi&#232ne Ouagadougou Burkina Faso department of Dermatology-Venorology Treichville University Hospital F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire department of Infectious and Tropical Diseases Donka National Hospital Faculty of Health Sciences and Techniques Bamako Mali National AIDS Control Program PNLS Ministry of Health and Public Hygiene Abidjan C&#244te d&#8217Ivoire Marketing and Consumer Welfare Research Laboratory Abomey-Calavi University Cotonou Benin Regional Health Directorate of the District of Bamako Ministry of Health and Social Development Bamako Mali department of Family medicine Faculty of Medicine and Odonto Stomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali Faculty of Nursing Sciences Laval University Quebec Canada

Background: Plastic pollution is the accumulation of waste composed of plastic and its derivatives all over the environment. Whether in the form of visible garbage or microparticles, as it slowly degrades, plastic pollution poses significant threats to terrestrial and aquatic habitats and the wildlife that call them home, whether through ingestion, entanglement or exposure to the chemicals contained in the material. Unfortunately, there is a lack of documentation on the impact of plastic waste on human health in low- and middle-income countries (LMICs). Methods: We searched five electronic databases (PubMed, Embase, Global Health, CINAHL and Web of Science) and gray literature, following the preferred reporting elements for systematic reviews and meta-analyses (PRISMA), for the impact of plastic waste on human health in developing countries. We included quantitative and qualitative studies written in English and French. We assessed the quality of the included articles using the Mixed Methods Appraisal tool (MMAT). Results: A total of 3779 articles were initially identified by searching electronic databases. After eliminating duplicates, 3167 articles were reviewed based on title and abstract, and 26 were selected for full-text review. Only three articles were retained. The three articles dealt with practices likely to lead to oral exposure to plastic chemicals in human health, as well as the level of awareness of participants concerning the possible impact of plastic on human health, namely, the use of plastic baby bottles, the use of microwaves to cook food and reheat precooked food, the use of plastic bottles to store water in the refrigerator, water purifier containers with plastic bodies and plastic lunch boxes, the reuse of plastic bags and the inadequacy of treatment facilities. Conclusion: Plastic waste poses different risks to human health at every stage of its life cycle. Hence, strategies must be adopted to raise public awareness of the dangers of plastic

关键词： Human Population Plastic Waste Health Impact Low-Income-Countries (Humans Iatrogenic Disease Plastics Policy Recycling Waste Management)

Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

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Neural Regeneration Research 2022年第9期17卷 2036-2042页

作者： Ya Zheng Dan Zhao Dong-Dong Xue Ye-Ran Mao Ling-Yun Cao Ye Zhang Guang-Yue Zhu Qi Yang Dong-Sheng Xu department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina department of Hepatobiliary Surgery Hebei General HospitalShijiazhuangHebei ProvinceChina department of Rehabilitation Baoshan BranchShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina department of Rehabilitation The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina department of Rehabilitation medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Rehabilitation Engineering Research Center for Integrated Traditional Chinese and Western medicine Ministry of EducationShanghaiChina department of Rehabilitation medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina

Following a spinal cord injury,there are usually a number of neural pathways that remain intact in the spinal *** residual nerve fibers are important,as they could be used to reconstruct the neural circuits that enable motor *** group previously designed a novel magnetic stimulation protocol,targeting the motor cortex and the spinal nerve roots,that led to significant improvements in locomotor function in patients with a chronic incomplete spinal cord ***,we investigated how nerve root magnetic stimulation contributes to improved locomotor function using a rat model of spinal cord *** underwent surgery to clamp the spinal cord at T10;three days later,the rats were treated with repetitive magnetic stimulation(5 Hz,25 pulses/train,20 pulse trains)targeting the nerve roots at the L5-L6 *** treatment was repeated five times a week over a period of three *** found that the nerve root magnetic stimulation improved the locomotor function and enhanced nerve conduction in the injured spinal *** addition,the nerve root magnetic stimulation promoted the recovery of synaptic ultrastructure in the sensorimotor ***,the results suggest that nerve root magnetic stimulation may be an effective,noninvasive method for mobilizing the residual spinal cord pathways to promote the recovery of locomotor function.

关键词： evoked potentials H-reflex motor activity nerve conduction neural plasticity rehabilitation sensorimotor cortex spinal cord injury synapses transcranial magnetic stimulation

Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第15期28卷 1563-1573页

作者： Thaninee Prasoppokakorn Wah-Kheong Chan Vincent Wai-Sun Wong Panyavee Pitisuttithum Sanjiv Mahadeva Nik Raihan Nik Mustapha Grace Lai-Hung Wong Howard Ho-Wai Leung Pimsiri Sripongpun Sombat Treeprasertsuk department of medicine Division of GastroenterologyFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand department of medicine Division of GastroenterologyDivision of Gastroenterology and Hepatology UnitFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia department of medicine and Therapeutics The Chinese University of Hong KongHong KongChina department of medicine Division of General Internal MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand department of Pathology Hospital Sultanah BahiyahAlor SetarKedah 05460Malaysia department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong KongChina department of Internal medicine Prince of Songkla UniversityHat Yai 90110Thailand department of medicine Division of Gastroenterology and HepatologyStanford University School of MedicinePalo AltoCA 94305United States

BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)*** fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in *** To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant *** We collected the data of biopsy-proven NAFLD patients from three Asian centers in three *** the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were *** fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage *** A total of 511 patients with biopsy-proven NAFLD and complete data were included for *** these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)*** median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had *** the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,*** FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.

关键词： Nonalcoholic fatty liver disease Fibrosis-8 score Fibrosis-4 score Nonalcoholic fatty liver disease fibrosis score

Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit

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Cellular & Molecular Immunology 2023年第2期20卷 119-130页

作者： Peng Xiao Ziwei Hu Jiaheng Lang Tianyuan Pan Randall Tyler Mertens Huilun Zhang Ke Guo Manlu Shen Hongqiang Cheng Xue Zhang Qian Cao Yuehai Ke department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina department of Pathology and Pathophysiology and Department of Gastroenterology at Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina Immunological Disease Research Center Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province HangzhouChina department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhouChina department of General medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina department of Immunology Harvard Medical SchoolBostonMAUSA Zhejiang Laboratory for Systems and Precision medicine Zhejiang University Medical CenterHangzhouChina

Mannose is a naturally occurring sugar widely consumed in the daily diet;however,mechanistic insights into how mannose metabolism affects intestinal inflammation remain ***,we reported that mannose supplementation ameliorated colitis development and promoted colitis ***-secreted inflammatory cytokines,particularly TNF-α,induced pathological endoplasmic reticulum stress(ERS)in intestinal epithelial cells(IECs),which was prevented by mannose via normalization of protein *** preserving epithelial integrity,mannose reduced the inflammatory activation of colonic *** the other hand,mannose directly suppressed macrophage TNF-αproduction translationally by reducing the glyceraldehyde 3-phosphate level,thus promoting GAPDH binding to TNF-α***,we found dysregulated mannose metabolism in the colonic mucosa of patients with inflammatory bowel ***,we revealed that activating PMM2 activity with epalrestat,a clinically approved drug for the treatment of diabetic neuropathy,elicited further sensitization to the therapeutic effect of ***,mannose metabolism prevents TNF-α-mediated pathogenic crosstalk between IECs and intestinal macrophages,thereby normalizing aberrant immunometabolism in the gut.

关键词： Colitis Mannose Macrophages Intestinal epithelial cells TNF-alpha Endoplasmic reticulum stress

Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice

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Bone Research 2022年第4期10卷 715-725页

作者： Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative medicine and Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina department of Sports medicine Zhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceHangzhouChina China Orthopedic Regenerative medicine Group(CORMed) HangzhouChina department of Pathology Zhejiang University School of MedicineHangzhouChina Clinical Research Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Center for Reproductive medicine The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina

Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily *** therapies fail to promote functional tissue repair largely due to our limited understanding of HO ***,we investigate the pathological mechanism and propose a potential treatment method for *** assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)***-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon ***-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during ***,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of *** findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO.

关键词： angiogenesis ossification analysis

Amebic liver abscess by Entamoeba histolytica

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World Journal of Clinical Cases 2022年第36期10卷 13157-13166页

作者： Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita department of Emergency and Critical Care medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan department of Sports medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Amebic liver abscesses(ALAs)are the most commonly encountered extraintestinal manifestation of human invasive amebiasis,which results from Entamoeba histolytica(***)spreading *** can be complicated by liver abscess in 9%of cases,and ALAs led to almost 50000 fatalities worldwide in *** there have been fewer and fewer cases in the past several years,ALAs remain an important public health problem in endemic *** causes both amebic colitis and liver abscess by breaching the host’s innate defenses and invading the intestinal *** often enter the circulatory system,where they are filtered in the liver and produce abscesses,and develop into severe invasive diseases such as *** clinical presentation can appear to be colitis,including upper-right abdominal pain accompanied by a fever in ALA *** diagnosis requires nonspecific liver imaging as well as detecting *** antibodies;however,these antibodies cannot be used to distinguish between a previous infection and an acute ***,diagnostics primarily aim to use PCR or enzyme-linked immunosorbent assay to detect *** can be treated medically,and percutaneous catheter drainage is only necessary in approximately 15%of *** indicated treatment is to administer an amebicidal drug(such as tinidazole or metronidazole)and paromomycin or other luminal cysticidal agent for clinical *** is good with almost universal *** which diagnostic methods are most efficacious will necessitate further analysis of similar clinical cases.

关键词： Amebic liver abscess Entamoeba histolytica Polymerase chain reaction Enzyme-linked immunosorbent assay Percutaneous catheter drainage Amebicidal drug

Genetic insights into thymic carcinomas and thymic neuroendocrine neoplasms denote prognosis signatures and pathways

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Chinese Medical Journal 2023年第22期136卷 2712-2721页

作者： Shuyuan Wang Zhitao Gu Lei Zhu Yuchen Han Hong Yu Wentao Fang Baohui Han department of Respiratory and Critical Care medicine Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China department of Pathology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China department of Radiology Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

Background:Thymic carcinomas(TCs)and thymic neuroendocrine neoplasms(TNENs)are two aggressive subtypes of thymic *** therapy for advanced TCs and TNENs has limited *** genomic profiling of TCs and TNENs might provide insights that contribute to the development of new treatment ***:We used gene panel sequencing technologies to investigate the genetic aberrations of 32 TC patients and 15 TNEN patients who underwent surgery at Shanghai Chest Hospital between 2015 and *** samples were sequenced using a 324-gene platform with licensed *** this study,we focused on clinically relevant genomic alterations(CRGAs),which are previously proven to be pathogenic alterations,to identify the pathology-specific mutational patterns,prognostic signatures of TCs and ***:The mutational profiles between TCs and TNENs were *** genetic alterations that ranked highest in TCs were in CDKN2A,TP53,ASXL1,CDKN2B,PIK3C2G,PTCH1,and ROS1,while those in TNENs were in MEN1,MLL2,APC,RB1,and *** analysis showed that mutations of ROS1,CDKN2A,CDKN2B,BRAF,and BAP1 were significantly associated with worse outcomes in TC patients,and that mutation of ERBB2 indicated shortened disease-free survival(DFS)and overall survival(OS)in TNEN *** investigation found that the prognosis-related genes were focused on signal pathways of cell cycle control,chromatin remodeling/DNA methylation,phosphoinositide 3-kinases(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR),and receptor tyrosine kinase(RTK)/RAS/mitogen-activated protein kinase(MAPK)***:We profiled the mutational features of 47 Chinese patients with thymic malignancy of diverse pathologic phenotypes to uncover the integrated genomic landscape of these rare tumors,and identified the pathology-specific mutational patterns,prognostic signatures,and potential therapeutic targets for TCs and TNENs.

关键词： Mutational profile Thymic carcinomas Thymic neuroendocrine neoplasms Pathologic subtypes Prognosis Thymic malignancy

Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate

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Bone Research 2023年第2期11卷 340-353页

作者： Takeshi Oichi Joe Kodama Kimberly Wilson Hongying Tian Yuka Imamura Kawasawa Yu Usami Yasushi Oshima Taku Saito Sakae Tanaka Masahiro Iwamoto Satoru Otsuru Motomi Enomoto-Iwamoto department of Orthopedics School of MedicineUniversity of MarylandBaltimoreMD21201USA Sensory&Motor System medicine Faculty of MedicineThe University of TokyoBunkyo-kuTokyo1138655Japan department of Orthopedics Teikyo University School of MedicineTokyo1738608Japan department of Biochemistry and Molecular Biology Pennsylvania State University College of MedicineHersheyPA17033USA department of Oral Pathology Osaka University Graduate School of DentistrySuitaOsaka5650871Japan

Longitudinal bone growth relies on endochondral ossification in the cartilaginous growth plate,where chondrocytes accumulate and synthesize the matrix scaffold that is replaced by *** chondroprogenitors in the resting zone maintain the continuous turnover of chondrocytes in the growth *** is a leading cause of growth retardation in children;however,after recovery from nutrient deprivation,bone growth is accelerated beyond the normal rate,a phenomenon termed catch-up *** nutritional status is a known regulator of long bone growth,it is largely unknown whether and how chondroprogenitor cells respond to deviations in nutrient ***,using fate-mapping analysis in Axin2CreERT2 mice,we showed that dietary restriction increased the number of Axin2+chondroprogenitors in the resting zone and simultaneously inhibited their *** nutrient deficiency was resolved,the accumulated chondroprogenitor cells immediately restarted differentiation and formed chondrocyte columns,contributing to accelerated ***,we showed that nutrient deprivation reduced the level of phosphorylated Akt in the resting zone and that exogenous IGF-1 restored the phosphorylated Akt level and stimulated differentiation of the pooled chondroprogenitors,decreasing their *** study of Axin2CreERT2 revealed that nutrient availability regulates the balance between accumulation and differentiation of chondroprogenitors in the growth plate and further demonstrated that IGF-1 partially mediates this regulation by promoting the committed differentiation of chondroprogenitor cells.

关键词： progenitor plate maintain

Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator

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CCS Chemistry 2024年第2期6卷 439-449页

作者： Zhen Zou Songlan Pan Qian Xue Ting Chen Ziyun Huang Bei Qing Pengfei Liu Conghui Zhao Yunlin Sun Erhu Xiong Ronghua Yang Key Laboratory of Chemical Biology and Traditional Chinese medicine Research Ministry of EducationCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081 School of Chemistry and Chemical Engineering Hunan Provincial Key Laboratory of CytochemistryChangsha University of Science and TechnologyChangsha 410114 The Second Xiangya Hospital Central South UniversityChangsha 410011

Targeted protein degradation(TPD)is an emerging tool for degrading proteins of interest,which affords an attractive modality for cancer ***,the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or ***,we report an artificial tractor that can induce endocytosis-mediated protein depletion without hijacking a proteolysis-specific *** this design,bispecific aptamer chimeras(BSACs)are established,which can bridge human epidermal growth factor receptor 2(ErbB-2),an important biomarker in a common important biomarker in cancer,with membrane proteins of *** advantage of the property of aptamer-induced endocytosis and digestion of ErbB-2,another membrane protein is translocated into the lysosome in a hitchhike-like manner,resulting in lysosomal proteolysis along with *** strategy frees the TPD from the fundamental limitation of proteolysis-specific actuator and allows simultaneous regulation of the quantity and function of two oncogenic receptors in a cell-type-specific manner,expanding the application scope of TPD-based therapeutics.

关键词： targeted protein degradation aptamer epidermal growth factor receptor 2 lysosome membrane proteins cancer therapy