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Wireless,multimodal sensors for continuous measurement of pressure,temperature,and hydration of patients in wheelchair

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npj Flexible Electronics 2023年第1期7卷 479-493页

作者： Seokjoo Cho Hyeonseok Han Hyunwoo Park Sung-Uk Lee Jae-Hwan Kim Sung Woo Jeon Mengqiu Wang Raudel Avila Zhaoqian Xi Kabseok Ko Minsu Park Jungyup Lee Myungwoo Choi Je-Sang Lee Weon Gi Min Byeong-Ju Lee Soyeong Lee Jungrak Choi Jimin Gu Jaeho Park Min Seong Kim Junseong Ahn Osman Gul Chankyu Han Gihun Lee Seunghwan Kim Kyuyoung Kim Jeonghyun Kim Chang-Mo Kang Jahyun Koo Sung Soo Kwak Sungbong Kim Dong Yun Choi Seokwoo Jeon Hyung Jin Sung Yong Bae Park Minkyu Je Young Tae Cho Yong Suk Oh Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Advanced 3D Printing Technology Development Division Korea Atomic Energy Research InstituteDaejeon 34057Republic of Korea Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023P.R.China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DUT-BSU Joint Institute Dalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China Department of Electronics Engineering Kangwon National UniversityChuncheon 24341Republic of Korea Querrey-Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Sibel Health Inc NilesIL 60714USA Department of Materials Science and Engineering KAIST Institute for The Nanocentury(KINC)Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of planning and development Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of rehabilitation medicine Pusan national university hospitalBusan 49241Republic of Korea Department of AI Convergence Network Ajou UniversitySuwon 16499Republic of Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897Republic of Korea Korea Photonics Technology Institute Gwangju 61007Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea interdisciplinary program in Precision Public Health Korea UniversitySeoul 02841Republic of Korea Center

Individuals who are unable to walk independently spend most of the day in a *** population is at high risk for developing pressure injuries caused by ***,early diagnosis and prevention of these injuries still remain ***,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin *** device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration *** movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body *** evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.

关键词： injuries modal mounted

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两株海洋细菌产生的抗肿瘤活性化合物

两株海洋细菌产生的抗肿瘤活性化合物

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中国化学会第十二届全国天然有机化学学术会议

作者：王聪 Monger Adeep 王立平付鹏 Piyachaturawat Pawinee Chairoungdua Arthit 朱伟明中国海洋大学医药学院海洋药物教育部重点实验室广西民族大学化学化工学院广西林产化学与工程重点实验室广西高校食品安全与药物分析化学重点实验室 Mahidol University Toxicology Graduate ProgramFaculty of Science 贵州省中国科学院天然产物化学重点实验室

海洋细菌尤其是海洋放线菌的生存环境具有高盐、高压、寡营养等特点,其代谢机制独特,可以产生结构新颖、活性显著的次生代谢产物,是新结构活性化合物的重要来源。为了从海洋细菌中获得新的药物后选化合物,我们利用化学与生物活性相结合...

海洋细菌尤其是海洋放线菌的生存环境具有高盐、高压、寡营养等特点,其代谢机制独特,可以产生结构新颖、活性显著的次生代谢产物,是新结构活性化合物的重要来源。为了从海洋细菌中获得新的药物后选化合物,我们利用化学与生物活性相结合的集成筛选方法,开展了海洋细菌的细胞毒活性筛选及其活性代谢产物的研究。对深海来源的放线菌Streptomyces ***-3118和细菌Ochrobactrum ***-2164分别采取前体添加和OSMAC策略对次生代谢产物进行研究。通过各种色谱技术分离得到3个吲哚咔唑类生物碱(1-3),

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Deciphering primate retinal aging at single-cell resolution

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Protein & Cell 2021年第11期12卷 889-898页

作者： Si Wang Yuxuan Zheng Qingqing Li Xiaojuan He Ruotong Ren Weiqi Zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang Yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Advanced Innovation Center for Genomics School of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Institute for Stem Cell and Regeneration CASBeijing 100101China Ministry of Education Key Laboratory of Cell Proliferation and Differentiation Biomedical Pioneering Innovation CenterBeijing 100871China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Disease Genomics and Individualized Medicine Laboratory Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China Stem Cell Research Center Peking University Third HospitalBeijing 100191China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal ***,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance.

关键词： degeneration aging resolution

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Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain

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Environmental Science and Ecotechnology 2022年第4期12卷 26-36页

作者： Zhenfei Yan Chenglian Feng Xiaowei Jin Fangkun Wang Cong Liu Na Li Yu Qiao Yingchen Bai Fengchang Wu John P.Giesy State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China College of Environment Hohai UniversityNanjing210098China China National Environmental Monitoring Centre Beijing100012China Department of Preventive Veterinary Medicine College of Veterinary MedicineShandong Agricultural UniversityTaian271018China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China Department of Veterinary Biomedical Sciences University of SaskatchewanSaskatoonSKCanada toxicology Centre University of SaskatchewanSaskatoonSKCanada Department of Environmental Sciences Baylor UniversityWacoTXUSA

Organophosphate esters(OPEs)are widespread in various environmental media,and can disrupt thyroid endocrine signaling *** by which OPEs disrupt thyroid hormone(TH)signal transduction are not fully ***,we present in vivo-in vitro-in silico evidence establishing OPEs as environmental THs competitively entering the brain to inhibit growth of zebrafish via multiple signaling *** can bind to transthyretin(TTR)and thyroxine-binding globulin,thereby affecting the transport of TH in the blood,and to the brain by TTR through the blood-brain *** GH3 cells were exposed to OPEs,cell proliferation was significantly inhibited given that OPEs are competitive inhibitors of *** diphenyl phosphate was shown to be an effective antagonist of *** exposure to OPEs significantly inhibited the growth of zebrafish by interfering with thyroperoxidase and thyroglobulin to inhibit TH *** on comparisons of modulations of gene expression with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,signaling pathways related to thyroid endocrine functions,such as receptor-ligand binding and regulation of hormone levels,were identified as being affected by exposure to *** were also associated with the biosynthesis and metabolism of lipids,and neuroactive ligand-receptor *** findings provide a comprehensive understanding of the mechanisms by which OPEs disrupt thyroid pathways in zebrafish.

关键词： Organophosphate ester Molecular docking simulation Competitive inhibition assay Thyroid endocrine function Transcriptome sequencing

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Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2384-2391页

作者： Zhijian Xu Danrong Shi Jian-Bao Han Yun Ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang Wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesFirst Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650107China Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Jinan Microecological Biomedicine Shandong Laboratory Jinan250117China

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by *** we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and *** of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the *** necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 *** antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19.

关键词： drugs infected treatment

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中国药理学与毒理学杂志 2017年第10期31卷 951-951页

作者： Brenda M GANNON Michael H BAUMANN Kenner C RICE Gregory T COLLINS Department of Pharmacology University of Texas Health Science CenterSan AntonioTX 78229 Designer Drug Research Unit Intramural Research ProgramNIDA and NIHBaltimoreMD 21224 Drug Design and Synthesis Section Molecular Targets and Medications Discovery BranchNIDA and NIAAABethesdaMD 20814 South Texas Veterans Health Care System San AntonioTX 78229

OBJECTIVE Wide spread abuse of synthetic cathinones found in bath salts preparations has resulted in regulation of some cathinones *** skirt these laws by altering the chemical structures of first-generation cathinones(ie,MDPV,methylone,and mephedrone),resulting in second-generation cathinones(eg,α-PVP,α-PPP,MDPPP,and MDPBP).Although MDPV is a more effective reinforcer than cocaine,little is known about the reinforcing effectiveness of secondgeneration *** test the hypothesis that synthetic cathinones with higher selectivity for DAT relative to SERT are more effective *** Monoamine transporter inhibition was determined using synaptosomes prepared from rat *** relative reinforcing effectiveness of intravenously self-administered MDPV,MDPBP,MDPPP,α-PVP,α-PPP,and cocaine were directly compared through evaluations of (1)dose-response curves under a progressive ratio(PR)schedule of reinforcement and (2)demand curves obtained for each drug in male Sprague-Dawley *** Rank order selectivity for DAT/SERT wasα-PVP>MDPV>α-PPP≈MDPBP>MDPPP>*** of the maximum number of infusions obtained under a PR schedule of reinforcement(α-PVP>MDPV>α-PPP>MDPBP≈MDPPP>cocaine)and the essential value obtained for each drug in demand analyses(α-PVP>MDPV>α-PPP≈MDPBP≈MDPPP>cocaine)suggest relative reinforcing effectiveness is related to DAT/SERT *** These data provide evidence that DAT/SERT selectivity accounts for select synthetic cathinones functioning as more effective reinforcers than cocaine and may predict the abuse-related effects of novel synthetic cathinones in humans.

关键词： synthetic cathinones bath salts self-administration dopamine transporter serotonin transporter

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The past, present, and future of in vivo-implantable recording microelectrodes:the neural interfaces

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中国药理学与毒理学杂志 2023年第7期37卷 553-553页

作者： LIU Kun ZHANG Hao HU Minghui LI Zifa XU Kaiyong CHEN Dan CUI Wenqiang LYU Cui DING Ran GENG Xiwen WEI Sheng Key Laboratory of Traditional Chinese Medicine Classical Theory Ministry of Education Shandong University of Traditional Chinese Medicine Chinese Medicine and Brain Science interdisciplinary Research Center Shandong University of Traditional Chinese Medicine First College of Clinical Medicine Shandong University of Traditional Chinese Medicine Laboratory of Immunology for Environment and Health Shandong Analysis and Test Centre School of Pharmaceutical Sciences Qilu University of Technology Shandong Academy of Sciences Institute for Translational Neuroscience Second Affiliated Hospital of Nantong University

Neural recording electrodes enable the acquisition and collection of electrical signals from neurons, and these recorded neural electrical signals are an important means of understanding neuronal activity. As a major component of the brain-machine interface, neural recording electrodes serve as a bridge between the nervous system and external devices. The extracted information can be used to understand the state of the brain and acts as a feedback signal to regulate external devices, thus providing important information for the clinical treatment of neurological diseases. Moreover, the electrodes can be used as a vehicle for drug injection to directly treat diseases. Since the time that Strumwasser used microwires to achieve long-term recordings of neural activity in hibernating squirrels, implantable electrode technology has gradually improved over three generations of development, and progress has been made in improving the biocompatibility, mechanical performance(size, shape, density, etc.), and signal-to-noise *** neural recording electrodes can acquire signals from cortical and deep neural clusters, with the advantages of high signal-to-noise ratio, information content, and spatial/temporal resolution. However, there is still a need to improve the structure and performance of these electrodes; for example, their high invasiveness and lack of biocompatibility pose technical difficulties in the process of translation to the clinic. This paper reviews the basic requirements for electrodes, main recording methods and signal types, common types of implantable neural recording electrodes, and their challenges and future development directions. With the continuous development of electrode materials, equipment, systems,and neurotechnology, it should be possible to apply neural recording electrodes in clinical practice, to promote safe and efficient treatment of human diseases.

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Realizing transmitted metasurface cloak by a tandem neural network

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Photonics Research 2021年第5期9卷 I0062-I0068页

作者： ZHENG ZHEN CHAO QIAN YUETIAN JIA ZHIXIANG FAN RAN HAO TONG CAI BIN ZHENG HONGSHENG CHEN ERPING LI interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationCollege of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Science and Technology Innovation Center Key Laboratory of Advanced Micro/Nano Electronic Devices&Smart Systems of ZhejiangZhejiang UniversityHangzhou 310027China International Joint Innovation Center ZJU-UIUC Institute Zhejiang UniversityHaining 314400China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Being invisible at will has been a long-standing dream for centuries, epitomized by numerous legends;humans have never stopped their exploration steps to realize this dream. Recent years have witnessed a breakthrough in this search due to the advent of transformation optics, metamaterials, and metasurfaces. However, the previous metasurface cloaks typically work in a reflection manner that relies on a high-reflection background, thus limiting the applications. Here, we propose an easy yet viable approach to realize the transmitted metasurface cloak, just composed of two planar metasurfaces to hide an object inside, such as a cat. To tackle the hard-to-converge issue caused by the nonuniqueness phenomenon, we deploy a tandem neural network(T-NN) to efficiently streamline the inverse design. Once pretrained, the T-NN can work for a customer-desired electromagnetic response in one single forward computation, saving a great amount of time. Our work opens a new avenue to realize a transparent invisibility cloak, and the tandem-NN can also inspire the inverse design of other metamaterials and photonics.

关键词： inverse uniqueness breakthrough

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电镀法实现毫米厚单晶铜板的制备

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Science Bulletin 2023年第15期68卷 1611-1615,M0003页

作者：李兴光张智宏张志斌寇金宗吴慕鸿赵孟泽乔瑞喜丁志强张志强刘放杨晓楠邹定鑫王新强高鹏付莹王恩哥刘开辉 State Key Laboratory for Mesoscopic Physics Frontiers Science Centre for Nano-optoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceState Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China Songshan Lake Materials Laboratory Dongguan 523808China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China International Centre for Quantum Materials Collaborative Innovation Centre of Quantum MatterPeking UniversityBeijing 100871China interdisciplinary Institute of Light-Element Quantum Materials and Research Centre for Light-Element Advanced Materials Peking UniversityBeijing 100871China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Physics Liaoning UniversityShenyang 110036China

在单晶衬底上外延电镀金属为获得高度有序的金属薄膜提供了一种经济高效的方法.在传统外延电镀过程中,随镀层厚度增加,缺陷数量变多,出现孪晶,并进一步导致镀层结构向多晶转变,使得传统单晶衬底上的外延电镀只能获得几微米厚的单晶薄膜... 详细信息

在单晶衬底上外延电镀金属为获得高度有序的金属薄膜提供了一种经济高效的方法.在传统外延电镀过程中,随镀层厚度增加,缺陷数量变多,出现孪晶,并进一步导致镀层结构向多晶转变,使得传统单晶衬底上的外延电镀只能获得几微米厚的单晶薄膜.因此,需要开发一种新的策略来调节电镀过程,实现更厚金属单晶的制备.本文以高指数单晶铜箔(25μm)为阴极,利用外延电镀法成功制备出毫米厚的单晶铜板.研究发现,高指数单晶铜表面独特的原子台阶,能够引导铜原子的有序沉积,减少缺陷、层错或晶格孪晶的形成,进而有助于更厚单晶铜的外延电镀.与相同厚度的多晶铜相比,所制备的单晶铜在电导率、延展性和疲劳性能方面有显着提升.该工作为单晶铜板的规模化生产提供了新的策略,有望推动单晶铜在高速、大功率、柔性电路等领域的高端应用.

关键词：电镀过程多晶转变镀层厚度镀层结构电镀法金属薄膜单晶铜铜原子

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Hyperhomocysteinemia dysregulates plasma levels of polyunsaturated fatty acids-derived eicosanoids

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Life Research 2022年第2期5卷 32-41页

作者： Mohamed Al-Shabrawey Ahmed Elmarakby Yara Samra Mohamed Moustafa Stephen WLooney Krishna Rao Maddipati Amany Tawfik Department of Foundational Medical Studies and Eye Research Center Oakland University William Beaumont School of MedicineRochesterMichiganUSA Eye Research Institute Oakland UniversityRochesterMichiganUSA Department of Oral Biology and Diagnostic Sciences Dental College of GeorgiaAugusta UniversityAugustaGeorgiaUSA Departments of Pharmacology&toxicology Faculty of PharmacyMansoura UniversityMansouraEgypt Department of Biochemistry Faculty of PharmacyMansoura UniversityEgypt Department of Population Health Sciences Medical College of GeorgiaAugusta UniversityAugustaGeorgiaUSA Bioactive Lipids Research program Department of PathologyWayne State UniversityMichiganUSA

Hyperhomocysteinemia(HHcy)contributes to the incidence of many cardiovascular diseases(CVD).Our group have previously established crucial roles of eicosanoids and homocysteine in the incidence of vascular injury in diabetic retinopathy and renal *** cystathionine-β-synthase heterozygous mice(cβs^(+/-))as a model of HHcy,the current study was designed to determine the impact of homocysteine on circulating levels of lipid mediators derived from polyunsaturated fatty acids(PUFA).Plasma samples were isolated from wild-type(WT)and cβs^(+/-)mice for the assessment of eicosanoids levels using LC/*** 12/15-lipoxygenase(12/15-LOX)activity significantly decreased in cβs^(+/-)*** control ***-derived metabolites from both omega-3 and omega-6 PUFA were also reduced in cβs^(+/-)mice compared to WT control(P<0.05).Contrary to LOX metabolites,cytochrome P450(CYP)metabolites from omega-3 and omega-6 PUFA were significantly elevated in cβs^(+/-)mice compared to WT *** acids(EETs)are epoxides derived from arachidonic acid(AA)metabolism by CYP with anti-inflammatory properties and are known to limit vascular injury,however their physiological role is limited by their rapid degradation by soluble epoxide hydrolase(sEH)to their corresponding diols(DiHETrEs).In cβs^(+/-)mice,a significant decrease in the plasma EETs bioavailability was obvious as evident by the decrease in EETs/DiHETrEs ratio relative to WT control ***(COX)metabolites were also significantly decreased in cβs^(+/-)*** control *** data suggest that HHcy impacts eicosanoids metabolism through decreasing LOX and COX metabolic activities while increasing CYP metabolic *** increase in AA metabolism by CYP was also associated with increase in sEH activity and decrease in EETs *** of eicosanoids metabolism could be a contributing factor to the incidence and progression of HHcy-induced CVD.

关键词： homocysteine cystathionine β-synthase eicosanoids cycloxygenase lipoxygenase cytochrome-P450

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