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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Human Somatosensory Processing and Artificial Somatosensation

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Cyborg and Bionic Systems 2021年第1期2021卷 148-158页

作者： Luyao Wang Lihua Ma Jiajia Yang Jinglong Wu Beijing Advanced innovation Center for Intelligent Robots and Systems Beijing Institute of TechnologyBeijingChina School of Mechatronical engineering Beijing Institute of TechnologyBeijingChina Graduate School of interdisciplinary Science and engineering in Health Systems Okayama UniversityOkayamaJapan

In the past few years,we have gained a better understanding of the information processing mechanism in the human brain,which has led to advances in artificial intelligence and humanoid ***,among the various sensory systems,studying the somatosensory system presents the greatest ***,we provide a comprehensive review of the human somatosensory system and its corresponding applications in artificial *** to the uniqueness of the human hand in integrating receptor and actuator functions,we focused on the role of the somatosensory system in object recognition and action ***,the low-threshold mechanoreceptors in the human skin and somatotopic organization principles along the ascending pathway,which are fundamental to artificial skin,were ***,we discuss high-level brain areas,which interacted with each other in the haptic object *** on this close-loop route,we used prosthetic upper limbs as an example to highlight the importance of somatosensory ***,we present prospective research directions for human haptic perception,which could guide the development of artificial somatosensory systems.

关键词： uniqueness integrating gained

Biosynthesis and regulation of diterpenoids in medicinal plants

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Chinese Journal of Natural medicines 2022年第10期20卷 761-772页

作者： REN Junze WU Yu HU Zhanpin CHEN Ruibing ZHANG Lei Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China institute of interdisciplinary Integrative medicine Research School of MedicineNantong UniversityNantong 226001China Biomedical innovation R&D Center School of MedicineShanghai UniversityShanghai 20444China

Plant diterpenoids are widely distributed and abundant natural products with diverse structures and functions in nature,which have been commonly used in pharmaceutical,agricultural and industrial *** recent years,plant diterpenoids have attracted increasing attention,including their biosynthetic pathways,transcriptional regulatory networks,and biological ***,the biosynthetic pathways of diterpenoids are summarized in a modular ***,the regulatory network between diterpene biosynthesis and environmental factors is *** into diterpene metabolism may drive elucidation of complex active diterpene pathways and serve as a knowledge repository for metabolic engineering and cell factory construction.

关键词： Diterpenoid Pharmaceutical value Biosynthesis Regulation Medicinal plant

Influence of freeze-thaw damage gradient on stress-strain relationship of stressed concrete

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Frontiers of Structural and Civil engineering 2023年第9期17卷 1326-1340页

作者： Xiguang LIU Yongjie LEI Yihao SUN Jiali ZHOU Ditao NIU College of Civil engineering Xi’an University of Architecture&TechnologyXi’an 710055China institute for interdisciplinary innovation Research Xi’an 710055China Shaanxi Construction engineering Group Co. Ltd.Xi’an 710055China XAUAT engineering Technology Co.Ltd.Xi’an 710055China

Freeze-thaw damage gradients lead to non-uniform degradation of concrete mechanical properties at different depths.A study was conducted on the stress-strain relationship of stressed concrete with focus on the freeze-thaw damage *** effects of relative freeze-thaw depths,number of freeze-thaw cycles(FTCs)and stress ratios on the stress-strain curves of concrete were *** test results demonstrated that freeze-thaw damage was more severe in the surface layers of concrete than in the deeper *** relative peak stress and strain of concrete degraded bilinearly with increasing *** stress-strain relationship of stressed concrete under FTC was established,and it was found to agree with the experimental results.

关键词： freeze-thaw damage stress ratios stress-strain relationship damage variable

Solar-tracking methodology based on refraction-polarization in Snell's window for underwater navigation

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Chinese Journal of Aeronautics 2022年第3期35卷 380-389页

作者： Pengwei HU Jian YANG Lei GUO Xiang YU Wenshuo LI School of Automation Science and Electrical engineering Beihang UniversityBeijing 100191China Beijing Advanced innovation Center for Big Data-Based Precision medicine Beihang UniversityBeijing 100191China Hangzhou innovation institute Beihang UniversityHangzhou 310051China

Underwater navigation system is an indispensable part for autonomous underwater *** to the indiscernibility of satellite signal,however,the underwater navigation problem is quite challenging,and a satellite-free navigation scheme should be looked *** navigation,inspired by insects’capability of autonomous homing and foraging,is an alternative solution to satellite navigation with great application *** polarization provides an indirect sun compass to animals for orientation ***,it is difficult to apply terrestrial solar-tracking methodologies in underwater situations due to the refraction of polarized skylight at the air–water *** resolve this issue,an underwater solar-tracking algorithm is developed based on the underwater refraction-polarization pattern inside the Snell’s *** employing Snell’s law and Fresnel refraction formula to decouple the refractive ray bending and polarization deflection,the celestial polarization pattern is obtained based on underwater *** further improve the accuracy,the degree of polarization is employed as a weight factor for E-vector.A long-lasting underwater experiment was conducted to validate the effectiveness of the proposed approach,and the results showed the root-mean-square errors of solar zenith and azimuth employing this algorithm were 0.3°and 1.3°,*** experimental results show that the refraction-polarization pattern inside the Snell’s window exhibits immense potential to improve the solar-tracking accuracy for underwater navigation.

关键词： Polarization Refraction Snell’s window Solar position Underwater navigation

Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions

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Science China Chemistry 2018年第3期61卷 281-293页

作者： Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang College of Environmental Science and engineering North China Electric Power University NAAM Research Group Faculty of Science King Abdulaziz University Collaborative innovation Center of Radiation medicine of Jiangsu Higher Education Institutions School for Radiological and Interdisciplinary Sciences Soochow University

An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application.

关键词： mesoporous carbonaceous materials (MCMs) U(VI) adsorption -OH and -COOH groups

Atomic Spin Polarization Controllability Analysis:A Novel Controllability Determination Method for Spin-Exchange Relaxation-Free Co-Magnetometers

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 699-708页

作者： Zhuo Wang Sixun Liu Ruigang Wang Linlin Yuan Jiong Huang Yueyang Zhai Sheng Zou IEEE the Research institute for Frontier Science the Beijing Advanced innovation Center for Big Data-Based Precision medicine Beihang University the School of Instrumentation and Optoelectronic engineering Beihang University the Research institute of Frontier Science Beihang University

This paper investigates the atomic spin polarization controllability of spin-exchange relaxation-free co-magnetometers(SERFCMs).This is the first work in the field of controllability analysis for the atomic spin ensembles systems,whose dynamic behaviors of spin polarization are described by the Bloch *** on the Bloch equations,a state-space model of the atomic spin polarization for SERFCM is first established,which belongs to a particular class of nonlinear *** this class of nonlinear systems,a novel determination method for the global state controllability is proposed and ***,this method is implemented in the process of controllability analysis on the atomic spin polarization of an actual ***,a theoretically feasible and reasonable solution of the control input is proposed under some physical constraints,with whose limitation of realistic conditions,the controller design can be accomplished more practically and more ***,the simulation results demonstrate the feasibility and validation of the proposed controllability determination method.

关键词： Atomic spin polarization Bloch equations controllability determination nonlinear state-space model spin-exchange relaxation-free co-magnetometer(SERFCM)

Pattern-based validation metric for simulation models

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Science China(Information Sciences) 2020年第5期63卷 209-211页

作者： Yuanjun LAILI Lin ZHANG Yongliang LUO Beijing Advanced innovation Center for Big Data-based Precision medicine School of Automation Science and Electrical EngineeringBeihang University China State Shipbuilding Corporation System engineering Research institute

Dear editor,Simulation is one of the most important technologies that aid in the study of real-world phenomena. It helps engineers in making better decisions related to complex systems when mathematical models are partially or even completely unknown. A simulation model is an analog of real-world objects. Only appropriate and qualified models can ensure applicable and valuable simula-

关键词： simulation Pattern-based validation metric for simulation models

Liquid metal biomaterials: translational medicines,challenges and perspectives

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National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu Jincheng Lu Yikuang Xi Xuelin Wang Jing Liu Department of Biomedical engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced innovation Center for Biomedical engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-Biomedical engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics