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A new method for preparing a rat intracerebral hemorrhage model by combining focused ultrasound and microbubbles

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animal Models and Experimental Medicine 2023年第2期6卷 103-110页

作者： Yao He Jie Yang Fengying Hu Min Liao Yuru Nie Xiaoxia Zhu Tao Zhang Keer Song Qinxi Li Xiaojie Li Chenghan Mei Zhe Wu Qiang Lu Zhihui Zhong Laboratory of Nonhuman Primate Disease Modeling research State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduChina Department of Medical Ultrasound West China HospitalSichuan UniversityChengduChina School of Life Science and Technology University of Electronic Science and Technology of ChinaChengduChina School of Bioscience and Technology Chengdu Medical CollegeChengduChina Franklin College of Arts and Science University of GeorgiaAthensGeorgiaUSA

Background:We aimed to prepare a non-invasive,reproducible,and controllable rat model of intracerebral hemorrhage with focused ultrasound(FUS).Methods:A rat intracerebral hemorrhage(ICH)model was established by combining FUS and microbubbles(μBs),and edaravone was used to verify whether the free radical scavenger had a protective effect on the *** brain tissue of each group was sectioned to observe the gross histology,blood-brain barrier(BBB)permeability,cerebral infarction volume,and histopathological ***:Compared with the FUS group,the BBB permeability was significantly increased in the FUS+μBs(F&B)group(p=0.0021).The second coronal slice in the F&B group had an obvious hemorrhage lesion,and the FUS+μBs+edaravone(F&B&E)group had smaller hemorrhage areas;however,ICH did not occur in the FUS *** cerebral infarction volume in the F&B group was significantly larger than that in the FUS group(p=0.0030)and F&B&E group(p=0.0208).HE staining results showed that nerve fibrinolysis,neuronal necrosis,microglia production,and erythrocytes were found in both the F&B group and the F&B&E group,but the areas of the nerve fibrinolysis and neuronal necrosis in the F&B group were larger than the F&B&E ***:A rat ICH model was successfully prepared using theμBs assisted FUS treatment,and edaravone had a therapeutic effect on this *** model can be used to study the pathophysiological mechanism of ICH-related diseases and in preclinical research on related new drugs.

关键词： focused ultrasound(FUS) ICH model microbubbles(μBs) rat

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Journal of Intensive Medicine 2023年第4期3卷 335-344页

作者： Hui Xiang Yuqian Zhao Siqing Ma Qi Li Kianoush B.Kashani Zhiyong Peng Jianguo Li Bo Hu Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina Clinical research Center of Hubei Critical Care Medicine Wuhan 430071HubeiChina Department of Critical Care Medicine Qinghai Provincial People's HospitalXining 810007QinghaiChina Division of Pulmonary and Critical Care Medicine Department of MedicineMayo ClinicRochesterMNUSA Division of Nephrology and Hypertension Department of MedicineMayo ClinicRochesterMNUSA

Background The benefits of early use of norepinephrine in endotoxemic shock remain *** aimed to elucidate the effects of different doses of norepinephrine in early-stage endotoxemic shock using a clinically relevant large animal *** Vasodilatory shock was induced by endotoxin bolus in 30 Bama suckling *** included fluid resuscitation and administration of different doses of norepinephrine,to induce return to baseline mean arterial pressure(MAP).Fluid management,hemodynamic,microcirculation,inflammation,and organ function variables were *** animals were supported for 6 h after endotoxemic *** Infused fluid volume decreased with increasing norepinephrine *** to baseline MAP was achieved more frequently with doses of 0.8µg/kg/min and 1.6µg/kg/min(Panimals administered no or 0.2µg/kg/min norepinephrine(P<0.01),while the percentage of perfused small vessel density(PSVD)was higher in those receiving 0.8µg/kg/min(P<0.05)and serum lactate was higher in the groups administered no and 1.6µg/kg/min norepinephrine(P<0.01).Conclusions The impact of norepinephrine on the macro-and micro-circulation in early-stage endotoxemic shock is dose-dependent,with very low and very high doses resulting in detrimental *** an appropriate norepinephrine dose was associated with improved tissue perfusion and organ function.

关键词： Norepinephrine Fluid resuscitation Endotoxemic shock Microcirculation Side stream dark-field Pigs

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同一健康与人类健康

科学通报 2022年第1期67卷 37-46页

作者：邓强陆家海中山大学公共卫生学院热带病防治研究教育部重点实验室One Health研究中心国家药监局疫苗及生物制品质量监测与评价重点实验室广东省重大传染病预防和控制技术研究中心广州510080

"同一健康"(One health)理念强调跨学科、跨部门、跨地区交流与合作,实现人类健康、动物健康和环境健康的和谐统一.同一健康策略是基于人-动物-环境交界面,实现疾病预防的监测、预警和关口前移等.新型冠状病毒肺炎疫情带给人类沉重灾难... 详细信息

"同一健康"(One health)理念强调跨学科、跨部门、跨地区交流与合作,实现人类健康、动物健康和环境健康的和谐统一.同一健康策略是基于人-动物-环境交界面,实现疾病预防的监测、预警和关口前移等.新型冠状病毒肺炎疫情带给人类沉重灾难,也推动和达成了同一健康理念在各国政府、国际组织间的广泛共识,强调采取行动,携手应对人类健康面临的共同问题.在过去,同一健康组织在全球各个地区都得到了发展.世界各国政府日益支持实施多部门合作的同一健康策略,以最好地应对人-动物-环境层面的健康威胁.本文就同一健康发展历程,以及应用同一健康解决新发传染病、抗生素耐药、环境健康、食源性疾病带来的食品安全等问题进行概述.

关键词：同一健康人类健康新发传染病抗生素耐药食品安全

慢性肾脏病肠道菌群失调的病理机制、治疗策略及中药的干预作用

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中国中药杂志 2017年第13期42卷 2425-2432页

作者：韩文贝刘莹露万毅刚孙伟涂玥杨晶晶吴薇何伟明姚建南京中医药大学中西医结合鼓楼临床医学院中医科江苏南京210008 南京大学医学院附属鼓楼医院中医科江苏南京210008 南京中医药大学附属医院肾内科江苏南京210029 南京中医药大学第二临床医学院中医养生学教研室江苏南京210023 Division of Molecular Signaling Department of Advanced Biomedical ResearchInterdisciplinary Graduate School of Medicine and EngineeringUniversity of Yamanashi

肠道菌群失调是中、晚期慢性肾脏病(chronic kidney disease,CKD)进展至尿毒症的高危因素之一,其特征就是益生菌减少、能产生尿毒素的条件致病菌(产尿素酶菌群、产内毒素菌群以及产代谢毒素菌群)增多。"肠-肾轴(gut-kidney axis)"学说和... 详细信息

肠道菌群失调是中、晚期慢性肾脏病(chronic kidney disease,CKD)进展至尿毒症的高危因素之一,其特征就是益生菌减少、能产生尿毒素的条件致病菌(产尿素酶菌群、产内毒素菌群以及产代谢毒素菌群)增多。"肠-肾轴(gut-kidney axis)"学说和"慢性肾脏病-结肠轴(chronic kidney disease-colonic axis)"概念的核心观点认为,失调的肠道菌群通过加剧尿毒素蓄积和诱导全身性微炎症反应等途径加重肾脏的损伤。初步的临床试验和动物实验的结果显示,以乳酸菌和双歧杆菌制剂为代表的益生菌和以菊粉、低聚半乳糖为代表的益生元,还有鲁比前列酮、活性炭吸附剂等都可以针对CKD患者体内失调的肠道菌群,通过减轻尿毒素蓄积和抑制全身性微炎症反应等途径而改善肾功能。不仅如此,一些经口服或肠道给药的单味中药、中药复方还有中药提取物(大黄素等)在一定程度上也能调节肠道细菌,保护肠道上皮屏障,减轻尿毒素蓄积,延缓CKD进展。其中,大黄类经方——大黄甘草汤(浓缩颗粒TJ-84)改善肾衰竭动物模型体内尿毒素蓄积的靶点不是肾脏,而可能是"肠道菌群所启动的肠-肾轴"。基于此,针对中、晚期CKD患者肠组织中肠道菌群相关的病理因素(紧密连接蛋白、辅助性和调节性T细胞等)的干预性研究可能是今后的重点发展方向之一。

关键词：肠道菌群中药慢性肾脏病肠-肾轴病理机制

research Priorities and the Future of Alfalfa in Latin America

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Journal of Agricultural Science and Technology(A) 2020年第2期10卷 109-113页

作者： Duarte Vilela Daniel Horacio Basigalup Reinaldo de Paula Ferreira Brazilian Agricultural research Corporation(EMBRAPA) Embrapa Dairy CattleJuiz de Fora36.015-300Minas GeraisBrazil National Institute of Agricultural Technology(INTA) Manfredi 5988CórdobaArgentina Brazilian Agricultural research Corporation(EMBRAPA) São Carlos13560-970São PauloBrazil

Agro-food and agro-industrial systems in Latin America must anticipate future trends and ensure permanent adjustment ofresearch priorities to the evolving global needs. Innovations should follow the logic of productive chains, which are highly dependentupon knowledge and technology. Agribusiness sector needs to reinvent itself for efficiently providing new products based on stricterquality controls, traceability, and greater diversification. In the region, alfalfa has an enormous potential to be cultivated for multiplepurposes other than just animal products, going from pharmaceutical and cosmetic industry to human consumption. No singleorganization or isolated group of scientists hold alone the capacity to deal with increasingly complex and dynamic productionsystems in order to efficiently compete in a globalized market. These challenges require an interdisciplinary approach, not only to adomestic level but also to an international one. The present paper proposed the constitution of a virtual alfalfa network platform forarticulating and guiding alfalfa research efforts in Latin America. The network will focus on identifying the most important needs forLatin America, promoting an active interaction among educational and scientific institutions through collaborative research *** platform comprises four main research axes: (1) efficient production (agronomy);(2) animal production (diversified feeds);(3)quality and innocuousness applied (human feeding);(4) novel products (pharmaceutical and cosmetics). During the initial phase, theBrazilian Agricultural research Corporation (EMBRAPA, Brazil) and National Institute of Agricultural Technology (INTA,Argentina) will jointly coordinate the network.

关键词： Alfalfa research priorities Latin America technological innovation international cooperation

A joint call for actions to advance taxonomy in China

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Zoological Systematics 2022年第3期47卷 188-197页

作者： Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu CAS Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Mycology(SKLM) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Department of Marine Organism Taxonomy&Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China State Key Laboratory of Genetic Resources and Evolution&Yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunming 650221China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory of Plant Resource Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China CAS Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 66630

Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China.

关键词： Endangered taxonomists morphology-based taxonomy integrative taxonomy capacity building systematics

Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures

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Biomedical Engineering Frontiers 2021年第1期2卷 89-102页

作者： Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers Department of Materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering University of Texas at ArlingtonArlingtonTX 76019USA Department of Mechanical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Chemistry Northwestern UniversityEvanstonIllinois 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Academy for Advanced interdisciplinary Studies Peking UniversityBeijingChina Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA The Center for Developmental Therapeutics Northwestern UniversityEvanstonIllinois 60208USA Center for Advanced Molecular Imaging Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Neurobiology Northwestern UniversityEvanstonIllinois 60208USA Department of Chemical Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIllinois 60208USA Department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonIllinois 60208USA Northwestern Medicine Feinberg School of MedicineNorthwestern UniversityEvanstonIllinois 60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIllinois 60208USA

Objective and Impact ***-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and *** thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body *** at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the ***,surgical extraction procedures after a period of need can introduce additional risks and ***,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body *** designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical *** with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo *** results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.

关键词： signature constraints multilayer