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Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies

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Cancer Biology & Medicine 2024年第4期21卷 331-346页

作者： Shuangcheng Li Tianci Wang Xinghui Xiao Xiaodong Zheng Haoyu Sun Rui Sun Hongdi Ma Zhigang Tian Xiaohu Zheng Hefei National Research Center for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of immunology University of Science and Technology of ChinaHefei 230027China Hefei TG ImmunoPharma Corporation Limited Hefei 230601China Research Unit of NK Cell Study Chinese Academy of Medical SciencesBeijing 100864China Key Laboratory of Quantitative Synthetic Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Objective: The human cluster of differentiation(CD)300A, a type-I transmembrane protein with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential immune checkpoint for human natural killer(NK) cells targeting hematologic malignancies(HMs).Methods: We implemented a stimulation system involving the CD300A ligand, phosphatidylserine(PS), exposed to the outer surface of malignant cells. Additionally, we utilized CD300A overexpression, a CD300A blocking system, and a xenotransplantation model to evaluate the impact of CD300A on NK cell efficacy against HMs in in vitro and in vivo settings. Furthermore, we explored the association between CD300A and HM progression in ***: Our findings indicated that PS hampers the function of NK cells. Increased CD300A expression inhibited HM lysis by NK cells. CD300A overexpression shortened the survival of HM-xenografted mice by impairing transplanted NK cells. Blocking PS–CD300A signals with antibodies significantly amplified the expression of lysis function-related proteins and effector cytokines in NK cells, thereby augmenting the ability to lyse HMs. Clinically, heightened CD300A expression correlated with shorter survival and an “exhausted” phenotype of intratumoral NK cells in patients with HMs or solid ***: These results propose CD300A as a potential target for invigorating NK cell-based treatments against HMs.

关键词： NK cell CD300A phosphatidylserine immune checkpoint hematologic malignancy

The Investigation of Data Voting Algorithm for Train Air-Braking System Based on Multi-Classification SVM and ANFIS

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Chinese Journal of Electronics 2024年第1期33卷 274-281页

作者： Juhan WANG Ying GAO Yuan CAO Tao TANG School of Electronics and Information Engineering Beijing Jiaotong University graduate Department China Academy of Railway Science National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University

The pressure data of the train air braking system is of great significance to accurately evaluate its operation state. In order to overcome the influence of sensor fault on the pressure data of train air braking system, it is necessary to design a set of sensor fault-tolerant voting mechanism to ensure that in the case of a pressure sensor fault, the system can accurately identify and locate the position of the faulty sensor, and estimate the fault data according to other normal data. A fault-tolerant mechanism based on multi-classification support vector machine(SVM) and adaptive network-based fuzzy inference system(ANFIS) is introduced. Multi-classification SVM is used to identify and locate the system fault state, and ANFIS is used to estimate the real data of the fault sensor. After estimation, the system will compare the real data of the fault sensor with the ANFIS estimated data. If it is similar,the system will recognize that there is a false alarm and record it. Then the paper tests the whole mechanism based on the real data. The test shows that the system can identify the fault samples and reduce the occurrence of false alarms.

关键词： Support vector machines Fault diagnosis Pressure sensors Fuzzy logic Fault tolerance Adaptive systems Fault tolerant systems

Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer

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Particuology 2024年第1期84卷 53-59页

作者： Huatai Zhu Limei Zhang Fujia Kou Jingyang Zhao Jiandu Lei Jing He Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent ***,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon ***,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the *** order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification *** average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic *** vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer ***,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.

关键词： Pectin Chlorogenic acid Ultrasound-emulsion Magnetically driven Colon cancer Colon targeted

Polygenic Profile and Magnitude Impact of Inflammatory Response in Soccer Athletes

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Open Journal of Genetics 2024年第3期14卷 47-76页

作者： Tane Kanope Caleb Guedes Miranda dos Santos Christiano Eduardo Veneroso Andre Fornazieiro Miller Gomes de Assis Eduardo Mendonça Pimenta UFMG Soccer Science Center Program in Sport Sciences School of Physical Education Physiotherapy and Occupational Therapy Federal University of Minas Gerais Belo Horizonte MG Brazil Army Institute of Biology IBEX Rio de Janeiro Brazil graduate program in Physical Education Federal University of Maranho So Lus MA Brazil

The practice of soccer involves carrying-out actions of high intensity, which demand a great generation of eccentric strength, which in turn results in an increase in the inflammatory response after training practice and game matches. The study aimed to investigate, in combination and individually, the association of 28 polymorphisms with the inflammatory responses of soccer athletes. The sample consisted of 47 male under-20 soccer athletes who belong to clubs in the first division of Brazilian soccer. Blood samples were collected at Pre, and 03, 24, and 48 hours after the training session to evaluate the inflammatory responses (hematological analyzes (hemogram), creatine phosphokinase (CK), high sensitivity quantitative C-reactive protein (CRP), tumor necrosis factor-alpha, (TNFα), interleukin 6 (IL-6) and insulin-like growth factor 1 (IGF-1)). DNA was obtained through scraping of buccal cells, where a sterile swab was rubbed on the inner side of the mouth of each participant 06 times. The database was built using the TruSeq DNA PCRFree kit (Illumina®) and the Covaris equipment for shearing genomic DNA (gDNA) by ultrasound. Of the analyzed SNPs, 09 (ACTN3 rs1815739, COL5A1 rs12722, COL5A1 rs3196378, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795, MMP3 rs679620, SLC30A8 rs13266634, SOX15 rs4227) were individually associated with biomarkers and 07 SNPs, (COL5A1 rs12722, COL5A1 rs3196378, COL5A1 rs1800012, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795 and MMP3 rs679620) analyzed in combination, explained 16% to 40% of the variation of inflammatory responses in soccer athletes. The results suggest that the genotypic profile can be taken into account for a more individualized distribution of the training load, along with the elaboration of recovery strategies for high-level athletes between training sessions and games of high physical and physiological demand.

关键词： Polymorphism Genotype Soccer Inflammation

High-power mode-programmable orbital angular momentum beam emitter with an internally sensed optical phased array

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Chinese Optics Letters 2024年第2期22卷 120-127页

作者：龙金虎邓宇高志强常洪祥常琦马阎星吴坚粟荣涛马鹏飞周朴 College of Advanced interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

The high-power mode-programmable orbital angular momentum(OAM)beam has attracted significant attention in a wide range of applications,such as long-distance optical communication,nonlinear frequency conversion,and beam *** beam combining(CBC)of an optical phased array(OPA)can offer a promising solution for both generating the high-power OAM beam and rapidly switching the OAM ***,achieving real-time phase noise locking and formation of desired phase structures in a high-power CBC system faces significant ***,an internal phase-sensing technique was utilized to generate the high-power OAM beam,which effectively mitigated thermal effects and eliminated the need for large optical *** OPA with six elements was employed for experimental *** first effective generation of over 1.5 kW mode-programmable OAM beam in a continuous-wave domain was ***,the results demonstrated that the generated OAM beam could be modulated with multiple *** topological charge can be switched in real time from-1 ***,this OAM beam emitter could function as an OAM beam copier by easily transforming a single OAM beam into an OAM beam *** importantly,a comprehensive analysis was conducted on power scaling,mode switching speed,and expansion of OAM ***,the system’s compact design enabled it to function as a packageable OAM beam *** to the advantages of having high power and programmable modes with multiple dimension modulation in phase structures and intensity distribution,this work can pave the way for producing high-power structured light beams and advancing their applications.

关键词： orbital angular momentum optical vortex optical phased array coherent beam combining

Europium-bearing organic framework with excellent X-ray scintillating luminescence

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Journal of Rare Earths 2024年第2期42卷 251-255,I0001页

作者： Yugang Zhang Lanhua Chen Xia Wang Wei Liu Shu'ao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China School of Environmental and Materials Engineering Yantai UniversityYantai264005China

Two europium-bearing organic frameworks,termed as EuTPO-1 and EuTPO-2(H_(3)TPO=tris(4-carboxylphenyI)-phosphineoxide),are reported in this work.A series of characterizations of EuTPO-1and EuTPO-2,such as X-ray crystallography and photoluminescence spectroscopy,was performed to expatiate their structure and physicochemical *** of them are constructed by dimers of the europium-oxygen subunit of [Eu_(2)O_(16)] and TPO *** from high X-ray stopping attenuation and excellent luminescence efficiency,they emit sufficient luminescence when irradiated with ***,they possess stable light outputs when exposed to high humidities and strong radiation dose,outperforming the commercial scintillator CsI:*** result paves the way for developing new scintillator and enriches the compound of europium-bearing organic framework with X-ray scintillating luminescence.

关键词： Metal-organic frameworks Scintillating material Luminescence efficiency Rare earths

Hepatocellular carcinoma-the role of the underlying liver disease in clinical practice

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World Journal of Gastroenterology 2024年第19期30卷 2488-2495页

作者： Angelo Zambam de Mattos Isadora Zanotelli Bombassaro Arndt Vogel Jose D Debes Department of Internal Medicine Universidade Federal de Ciências da Saúde de Porto AlegreRSPorto Alegre 90020090Brazil graduate program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegreRSPorto Alegre 90050-170Brazil Division of Gastroenterology Hepatology University of TorontoHannover M5R 0A3Canada Department of Medicine University of MinnesotaMinneapolisMN 55455United States

Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated *** particular type of cancer has the distinctive characteristic of mostly happening in individuals with an underlying liver *** makes the management of patients more challenging,since physicians must take into consideration two different conditions,the chronic liver disease and the *** underlying liver disease has several implications in clinical practice,because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC,obstacles in surveillance,and differences in the efficacy of the treatment against HCC.A shift in the prevalence of liver diseases has been evident over the last few years,with viral hepatitis gradually losing the leading position as cause of HCC and metabolic dysfunction-associated steatotic liver disease gaining ***,in an era of personalized medicine,it is imperative that physicians are aware of the underlying liver disease of individuals with HCC and its impact in the management of their tumors.

关键词： Hepatocellular carcinoma Etiology Epidemiology Surveillance Therapy

The mechanism of block form diversification in urban morphological transformation:Case study of grid blocks in Beijing,China

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Frontiers of Architectural Research 2024年第4期13卷 928-943页

作者： Jiankun Liu Atsushi Deguchi School of Architecture Tianjin UniversityTianjin 300072China graduate School of Frontier Science The University of TokyoChiba 277-0882Japan

Beijing is a typical traditional city in China,originating from the uniform and conventional grid plan,but transformed diversely,either on purpose or *** research took the diversification process of grid blocks as an angle to understand the transformation process of Beijing’s urban *** took 194 grid blocks within the 3rd Ring Road of Beijing as research ***,the paper proposed a whole view of Beijing’s grid blocks by 1)visualizing their construction process,2)classifying 5 morphological clusters by 7 indicators(Block size,Block shape regularity,Intensity,Coverage,Network density,Plot shape regularity,Standard deviation of plot size),and 3)investigating their ***,the diversification process of grid blocks was clarified from two layers:the block-boundary layer and the inner-space ***,the mechanism of block form diversification was clarified by exploring the connections between elements in each layer,and the influence of urban development on block form *** study re-defined the diversification process in a more quantitative way from both time and spatial *** concluded that the diversification is influenced by changes in urban planning principles and locations,and emerged thorough the long-term transformation and *** interaction between the boundary and the inner space stimulates the *** based on these,it concluded with a discussion of limitations and potentials on grid blocks’construction and renovation.

关键词： Grid block Urban morphology Diversification Morphological quantification

Gut pathobiome mediates behavioral and developmental disorders in biotoxin-exposed amphibians

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Environmental Science and Ecotechnology 2024年第5期21卷 208-218页

作者： Qianqian Pan Tianxing Lv Haorong Xu Hongda Fang Meng Li Jiaping Zhu Yue Wang Xiaoyan Fan Ping Xu Xiuguo Wang Qiangwei Wang Haruna Matsumoto Mengcen Wang Ministry of Agricultural and Rural Affairs Laboratory of Molecular Biology of Crop Pathogens and Insects Zhejiang UniversityHangzhou310058China Institute of Pesticide and Environmental Toxicology College of Agriculture and BiotechnologyZhejiang UniversityHangzhou310058China Institution of Tea Science Zhejiang UniversityHangzhou310058China The Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao266101China Global Education program for AgriScience Frontiers Graduate School of AgricultureHokkaido UniversitySapporoJapan

Emerging evidence suggests a link between alterations in the gut microbiome and adverse health outcomes in the hosts exposed to environmental ***,the causal relationships and underlying mechanisms remain largely *** we show that exposure to biotoxins can affect gut pathobiome assembly in amphibians,which in turn triggers the toxicity of exogenous *** used Xenopus laevis as a model in this *** exposed to tropolone demonstrated notable developmental impairments and increased locomotor activity,with a reduction in total length by 4.37%e22.48%and an increase in swimming speed by 49.96%e84.83%.Fusobacterium and Cetobacterium are predominant taxa in the gut pathobiome of tropolone-exposed *** tropolone-induced developmental and behavioral disorders in the host were mediated by assembly of the gut pathobiome,leading to transcriptome *** study not only advances our understanding of the intricate interactions between environmental pollutants,the gut pathobiome,and host health but also emphasizes the potential of the gut pathobiome in mediating the toxicological effects of environmental contaminants.

关键词： Gut microbiome Pathobiome Biotoxin pollution Developmental toxicity Behavioral disorders